Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity
Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity作者机构：Key Laboratory of Marine Drugs The Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao Shandong 266003 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2005年第23卷第11期
页 面：1523-1529页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学]
主 题：antioxidant indomethacin antiinflammation conjugate nonsteroidal antiinflammatory drugs (NSAID)
摘 要：A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.
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