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Environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke

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Neural Regeneration Research 2021年第12期16卷 2512-2520页

作者： yi-Tong zhu Qun Zhang Hong-Yu Xie Ke-Wei Yu gao-Jing Xu Si-Yue Li yi Wu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina

Fasudil,a Rho-associated protein kinase(ROCK)inhibitor,has a protective effect on the central nervous *** addition,environmental enrichment is a promising technique for inducing the recovery of motor impairments in ischemic stroke *** present study aimed to explore whether environmental enrichment combined with fasudil can facilitate motor function recovery and induce cortical axonal regeneration after ***,a mouse model of ischemic cerebral stroke was established by photochemical embolization of the left sensorimotor *** solution(10 mg/kg per day)was injected intraperitoneally for 21 days after the photothrombotic *** environmental enrichment intervention was performed on days 7-21 after the photothrombotic *** results revealed that environmental enrichment combined with fasudil improved motor function,increased growth-associated protein 43 expression in the infarcted cerebral cortex,promoted axonal regeneration on the contralateral side,and downregulated ROCK,p-LIM domain kinase(LIMK)1,and p-cofilin *** combined intervention was superior to *** findings suggest that environmental enrichment combined with fasudil treatment promotes motor recovery after stroke,at least partly by stimulating axonal *** underlying mechanism might involve ROCK/LIMK1/cofilin pathway *** study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.20160858A232)on February 24,2016.

关键词： axon regeneration biotinylated dextran amines environmental enrichment fasudil growth-associated protein 43 ischemic stroke motor recovery Nissl bodies Rho/ROCK pathway

Influence of the Acoustic Liner in Large Eddy Simulation of Longitudinal Thermoacoustic Instability in a Model Annular Combustor

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Journal of Thermal Science 2024年第2期33卷 710-724页

作者： MENG Sheng ZHANG Man gao yi AECC Commercial Aircraft Engine Co. Ltd.Shanghai200241China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

Although extensive efforts have been made to dampen the thermoacoustic instability,successfully controlling the pressure oscillations in modern gas turbines or aeroengines remains *** influence of the acoustic liner on the longitudinal thermoacoustic mode in a model annular combustor is investigated by Large Eddy Simulation(LES) in this *** result of the self-excited longitudinal thermoacoustic instability without the liner agrees well with the frequency and acoustic analysis of the pressure mode based on experimental *** different bias flow velocities of the liner located downstream of the combustor are then *** results reveal that the existence of the liner influences not only the acoustic field but also the flow *** the bias velocity is large,it leads to intense turbulence-induced fluctuations,and the pressure oscillation is modulated *** shows that the weak coupling between flow and pressure oscillations plays a significant role in the onset of the intermittency of a thermoacoustic *** on the dynamic analysis of the thermoacoustic system with the acoustic liner,this intermittency is caused by the influence of the flow field on the flame-acoustic ***,a low-order modeling method based on Van der Pol(VdP) oscillator with additive stochastic forcing is conducted to reproduce the evolving dynamics of the thermoacoustic *** the numerical cases demonstrated in this work are relatively simpler than those in a practical combustion system,the results are helpful for us to understand the effect of the acoustic liner and show the attractive potential to apply this device to suppress thermoacoustic instability.

关键词： thermoacoustic instability acoustic liner Large Eddy Simulation low-order modeling

Facile one-step synthesis of functionalized biochar from sustainable prolifera-green-tide source for enhanced adsorption of copper ions

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Journal of Environmental Sciences 2018年第11期30卷 185-194页

作者： Yuan gao Xiuzhen zhu Qinyan Yue Baoyu gao Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and Engineering Shandong University Jinan 250100 China Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education) School of Environmental Science and Technology Dalian University of Technology Linggong Road 2 Dalian 116024 China

The use of biochars formed by hydrothermal carbonization for the treatment of contaminated water has been greatly limited, due to their poorly developed porosity and low content of surface functional groups. Also, the most common modification routes inevitably require post-treatment processes, which are time-consuming and energy-wasting. Hence, the objective of this research was to produce a cost-effective biochar with improved performance for the treatment of heavy metal pollution through a facile one-step hydrothermal carbonization process coupled with ammonium phosphate, thiocarbamide, ammonium chloride or urea, without any posttreatment. The effects of various operational parameters, including type of modification reagent, time and temperature of hydrothermal treatment, and ratio of modification reagent to precursor during impregnation, on the copper ion adsorption were examined. The adsorption data fit the Langmuir adsorption isotherm model quite well. The maximum adsorption capacities （mg/g） of the biochars towards copper ions followed the order of 40-8h-1.0-APBC （95.24）〉 140-Sh-O-BC （12.52）〉 140-8h-1.0-TUBC （12.08）〉 140-Sh-1.0-ACBC （7.440）〉 140-Sh-1.0-URBC （5.277）. The results indicated that biochars modified with ammonium phosphate displayed excellent adsorption performance toward copper ions, which was 7.6-fold higher than that of the pristine biochar. EDX and FT-IR analyses before and after adsorption demonstrated that the main removal mechanism involved complexation between the phosphate groups on the surface of the modified biochars and copper ions.

关键词： Hydrothermal carbonization Functionalized biochar Adsorption Heavy metal

Fixed-Time Leader-Following Formation Control of Fully-Actuated Underwater Vehicles Without Velocity Measurements

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Journal of Systems Science & Complexity 2022年第2期35卷 559-585页

作者： gao Zhenyu ZHANG yi GUO Ge School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004China

This paper is concerned with formation control of fully-actuated underwater vehicles(FUVs),focusing on improving system convergence speed and overcoming velocity measurement *** employing the fixed-time control theory and command filtering technique,a full state feedback formation algorithm is proposed,which makes the follower track the leader in a given time with all signals in the system globally practically stabilized in fixed *** avoid degraded control performance due to inaccurate velocity measurement,a fixed-time convergent observer is designed to estimate the velocity of *** the authors give an observer-based fixed-time control method,with which acceptable formation performance can be achieved in fixed time without velocity *** effectiveness and performance of the proposed method are demonstrated by numerical simulations.

关键词： Fixed-time control formation control fully-actuated underwater vehicles(FUVs) state feedback control velocity observer

Pressure Analysis of the Initial Process of Diffusion Combustion Surge in a 350 kW Gas Boiler

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Journal of Thermal Science 2022年第2期31卷 582-589页

作者： gao Han zhu Tong PAN Deng School of Mechanical Engineering Tongji UniversityShanghai 201804China

In order to meet the increasingly stringent requirements for nitrogen oxides(NOx)emissions from gas boilers,flue gas recirculation(FGR)technology is commonly used to achieve ultra-low NOx ***,under some ultra-low NOx combustion conditions with FGR,a surge phenomenon occurs in the boiler,which causes a flameout and should be *** this study,the diffusion combustion surge of gas boiler with a rated power of 350 k W and equipped with FGR device was *** characteristic analysis results of the initial process of combustion surge showed that the high-frequency component of pressure is closely related to combustion stability and its change can provide reference for the occurrence of ***,the initial process of surge was analyzed by wavelet packet entropy *** indicated that the wavelet packet entropy of pressure signals could effectively reflect the stability of combustion in the furnace,and it could also be used to study the occurrence of surge.

关键词： diffusion combustion flue gas recirculation wavelet packet entropy surge gas boiler

Chlorinated Effects of Double-Cable Conjugated Polymers on the Photovoltaic Performance in Single-Component Organic Solar Cells

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Chinese Journal of Polymer Science 2023年第2期41卷 187-193页

作者： Han-yi Bao Zhao-Fan Yang Yan-Jiao Zhao Xiang gao Xin-zhu Tong yi-Nuo Wang Feng-Bo Sun Jian-Hong gao Wei-Wei Li Zhi-Tian Liu Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials Hubei Key Laboratory of Plasma Chemistry and Advanced MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan430205China Beijing Advanced Innovation Center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic Composite Beijing University of Chemical TechnologyBeijing100029China

The recently emerged double-cable conjugated polymers have come into focus due to their significantly improved power conversion efficiencies (PCEs) in single-component organic solar cells (SCOSCs). In this work, the effect of chlorination in double-cable conjugated polymers with linear benzodithiophene backbone and pendant perylene bisimide on the photovoltaic performance in SCOSCs has been studied. After introducing chlorine atoms into conjugated side chains, the highest occupied molecular orbital level of the conjugated polymers is down-shifted, thus resulting in a higher open-circuit voltage. As a result, the chlorinated double-cable conjugated polymer exhibits improved photovoltaic performance from 3.46% to 3.57%.

关键词： Double-cable conjugated polymer Chlorination Single-component organic solar cells

Least H-eigenvalue of adjacency tensor of hypergraphs with cut vertices

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Frontiers of Mathematics in China 2020年第3期15卷 451-465页

作者： yizheng FAN zhu zhu yi WANG School of Mathematical Sciences Anhui UniversityHefei 230601China

Let G be a connected hypergraph with even uniformity,which contains cut *** G is the coalescence of two nontrivial connected sub-hypergraphs(called branches)at a cut *** A(G)be the adjacency tensor of *** least H-eigenvalue of A(G)refers to the least real eigenvalue of A(G)associated with a real *** this paper,we obtain a perturbation result on the least H-eigenvalue of A(G)when a branch of G attached at one vertex is relocated to another vertex,and characterize the unique hypergraph whose least H-eigenvalue attains the minimum among all hypergraphs in a certain class of hypergraphs which contain a fixed connected hypergraph.

关键词： Hypergraph adjacency tensor least H-eigenvalue eigenvector perturbation

Spin excitations in nickelate superconductors

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Science China(Physics,Mechanics & Astronomy) 2020年第8期63卷 114-122页

作者： Tao Zhou yi gao ZiDan Wang Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials Guangdong Provincial Engineering Technology Research Center for Quantum Precision MeasurementSchool of Physics and Telecommunication Engineeringand Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Department of Physics and HKU-UCAS Joint Institute for Theoretical and Computational Physics at Hong Kong The University of Hong KongHong Kong 999077China

Applying a three-band model and the random phase approximation,we theoretically study the spin excitations in nickelate superconductors,which have been newly *** spin excitations were found to be incommensurate in the low energy *** spin resonance phenomenon emerged as the excitation energy *** intensity can be maximized at the incommensurate or commensurate momentum,depending on the out-of-plane *** spin excitations reverted to incommensurate at higher *** also discuss the similarities and differences in the spin excitations of nickelate and cuprate *** predicted results can be later validated in inelastic neutron scattering experiments.

关键词： nickelates superconductivity d-wave pairing spin susceptibility

A critical role of PvFtsH2 in the degradation of photodamaged D1 protein in common bean

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Horticulture Research 2021年第1期8卷 1592-1601页

作者： Kun Xu Jinlong zhu Hong Zhai Hongyan Wu yi gao Yuzhuo Li Xiaobin zhu Zhengjun Xia Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and AgroecologyThe Innovative Academy of Seed DesignChinese Academy of SciencesHaping Road 138Nangang District150081 Harbin CityHeilongjiang ProvinceChina University of Chinese Academy of Sciences BeijingChina

Light is required for initiating chloroplast biogenesis and photosynthesis;however,the photosystem II reaction center(PSII RC)can be *** this study,we characterized pvsl1,a seedling-lethal mutant of Phaseolus *** mutant showed lethality when exposed to sunlight irradiation and a yellow-green leaf phenotype when grown in a growth chamber under low-light *** developed 124 insertion/deletion(INDEL)markers based on resequencing data of Dalong1 and PI60234,two local Chinese common bean cultivars,for genetic *** identified Phvul.002G190900,which encodes the PvFtsH2 protein,as the candidate gene for this pvsl1 mutation through fine-mapping and functional analysis.A single-base deletion occurred in the coding region of Phvul.002G190900 in the pvsl1 mutant,resulting in a frameshift mutation and a truncated protein lacking the Zn^(2+)metalloprotease *** expression of Phvul.002G190900 at the transcriptional level was detected,while no change in the subcellular localization signal was *** seedlings of pvsl1 exhibited hypersensitivity to photoinhibition *** the pvsl1 mutant,abnormal accumulation of the D1 protein indicated a failure to rapidly degrade damaged D1 protein in the PSII *** results of this study demonstrated that PvFtsH2 is critically required for survival and maintaining photosynthetic activity by degrading photodamaged PSII RC D1 protein in common bean.

关键词： critical initiating insertion