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World Journal of Clinical Cases 2024年第18期12卷 3575-3581页

作者： Jian-Ru liu Yan Huang Xiang-ying Ouyang wen-yi liu ying Xie Department of Periodontology Peking University School and Hospital of StomatologyBeijing 100081China

BACKGROUND Intrabony defects beneath non-keratinized mucosa are frequently observed at the distal site of terminal ***,the application of regenerative treatment using the modified wedge-flap technique is considered impractical for these specific dental *** SUMMARY This article proposes a modified surgical procedure aimed at exposing the distal intrabony defect by making a vertical incision in the keratinized buccal *** primary objective is to maintain gingival flap stability,thereby facilitating periodontal *** described technique was successfully employed in a case involving the left mandibular second molar,which presented with an intrabony defect without keratinized gingiva at the distal *** this case,an incision was made on the disto-buccal gingival tissue,creating a tunnel-like separation of the distal non-keratinized soft tissue to expose the intrabony ***,bone grafting and guided tissue regeneration surgeries were performed,resulting in satisfactory bone fill at 9 mo *** This technique offers a regenerative opportunity for the intrabony defects beneath non-keratinized mucosa and is recommended for further research.

关键词： Non-keratinized mucosa Regenerative therapy Vertical incision Tunnel-like separation Case report

Healthcare practice strategies for integrating personalized medicine:Management of COVID-19

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World Journal of Clinical Cases 2021年第29期9卷 8647-8657页

作者： wen-yi liu Ching-wen Chien Tao-Hsin Tung Department of Health Policy and Management Bloomberg School of Public HealthJohns Hopkins UniversityMD 21205United StatesShanghai Bluecross Medical Science InstituteShanghai 201100Shanghai ProvinceChina Institute for Hospital Management Tsing Hua UniversityShenzhen CampusShenzhen 518055Guangdong ProvinceChina Evidence-based Medicine Center Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

Personalized medicine is the tailor-made clinical treatment to the individual characteristics of each *** may be considered an extension of traditional approaches to knowing and treating *** medicine has the potential to change the way of identification and management of health *** disease 2019(COVID-19)is an infectious disease that primarily affects the patients’*** first case of pneumonia of unknown cause was reported in Wuhan,China on December 31,*** thus,we are quickly approaching the era of personalized *** review discusses the practices currently used in the management of COVID-19 and how they relate to person-alized medicine.

关键词： Healthcare Personalized medicine COVID-19 SARS-CoV-2

Twistronics in graphene-based van der Waals structures

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Chinese Physics B 2020年第11期29卷 1-16页

作者： Ya-Ning Ren Yu Zhang yi-wen liu Lin He Center for Advanced Quantum Studies Department of PhysicsBeijing Normal UniversityBeijing 100875China

The electronic properties of van der Waals(vd W) structures can be substantially modified by the moiré superlattice potential, which strongly depends on the twist angle among the compounds. In twisted bilayer graphene(TBG), two lowenergy Van Hove singularities(VHSs) move closer with decreasing twist angles and finally become highly non-dispersive flat bands at the magic angle(~1.1°). When the Fermi level lies within the flat bands of the TBG near the magic angle,Coulomb interaction is supposed to exceed the kinetic energy of the electrons, which can drive the system into various strongly correlated phases. Moreover, the strongly correlated states of flat bands are also realized in other graphene-based vd W structures with an interlayer twist. In this article, we mainly review the recent scanning tunneling microscopy(STM)advances on the strongly correlated physics of the magic-angle TBG(MATBG) and the small-angle twisted multilayer graphene. Lastly we will give out a perspective of this field.

关键词： twisted bilayer graphene correlated states superconductivity

Asymmetric synthesis of emericellamide B

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Chinese Chemical Letters 2015年第10期26卷 1209-1215页

作者： Rong-Guo Ren Jing-yi Ma Zhuo-Ya Mao yi-wen liu Bang-Guo Wei Department of Chemistry and Institutes of Biomedical Sciences Fudan University School of Pharmacy Fudan University

Asymmetric total synthesis of emericellamide B（9.4%, 17 longest linear steps） is detailed in this report. In this synthetic route, the highly methylated（2R,3R,4S,6S）-3-hydroxy-2,4,6-trimethyldodecanoic acid（HTMD） unit was effectively prepared through the asymmetric methylation, Wittig and Horner–Wadsworth–Emmons reaction. Moreover, pentafluorophenyl diphenylphophinate（FDPP） proved to be an effective condensation reagent for the macrolactamization between C14 and C18.

关键词： Cyclic depsipeptide Antifungal agents Emericellamide Total synthesis Macrolactamization

Mechanical properties and microstructure of in situ formed Ti_(2)AlN/TiAl(WMS)composites

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Rare Metals 2021年第1期40卷 190-194页

作者： Wan-Liang Liang Rui Hu yi-wen liu Tie-Bang Zhang Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

The Ti_(2)AlN-reinforced TiAl(WMS)composites with different contents of Ti_(2)AlN were prepared by an in situ method of reactive arc-melting *** to the results of X-ray diffraction(XRD)analysis,the Ti_(2)AlNreinforced WMS composites consist ofγ-TiAl,α_(2)-Ti_(3)Al,and Ti_(2)AlN *** analysis results indicate that Ti_(2)AlN reinforcements with rod-like in shape form in the WMS matrix with aα_(2)/γlamellar structure containing some bulk y *** volume fraction of Ti_(2)AlN increasing,the grain size of the composites decreases significantly and the elasticity modulus(E)*** compressive strength and compressive fracture strain of the composite with 3 vol%Ti_(2)AlN have a maximum value of 1,654 MPa and 22.5%,respectively,which are approximately improved by 45.84%and 29.31%,respectively,compared with that of the unreinforced WMS alloy.

关键词： Ti_(2)AlN/TiAl(WMS)composites Reactive arc-melting Microstructure Compressive properties

Dynamics of an ultrasound contrast agent microbubble near spherical boundary in ultrasound field

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Chinese Physics B 2019年第11期28卷 204-209页

作者： Ji-wen Hu Lian-Mei Wang Sheng-You Qian wen-yi liu Ya-Tao liu Wei-Rui Lei School of Mathematics and Physics University of South ChinaHengyang 421001China School of Physics and Electronics Hunan Normal UniversityChangsha 410081China

The goal of this article is to establish the conditions of excitation where one has to deal with ultrasound contrast agent(UCA) microbubbles pulsating near biological tissues with spherical boundary in ultrasound field for targeted drug delivery and cavitation-enhanced thrombolysis, etc., and contributes to understanding of mechanisms at play in such an interaction. A modified model is presented for describing microbubble dynamics near a spherical boundary(including convex boundary and concave boundary) with an arbitrary-sized aperture angle. The novelty of the model is such that an oscillating microbubble is influenced by an additional pressure produced by the sound reflection from the boundary wall. It is found that the amplitude of microbubble oscillation is positively correlated to the curve radius of the wall and negatively correlated to the aperture angle of the wall and the sound reflection coefficient. Moreover, the natural frequency of the microbubble oscillation for such a compliable wall increases with the wall compliance, but decreases with the reduction of the wall size, indicating distinct increase of the natural frequency compared to a common rigid wall. The proposed model may allow obtaining accurate information on the radiation force and signals that may be used to advantage in related as drug delivery and contrast agent imaging.

关键词： ultrasound contrast agent(UCA) microbubble spherical boundary ultrasound natural frequency

Interaction of yttrium barrier and calcium-rich phase on production and properties of WC precursor powders and alloys

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Journal of Rare Earths 2024年第1期42卷 228-236,I0008页

作者： wen He Dunqiang Tan Zhiqiang yi Zhiqiang liu School of Materials Science and Engineering Nanchang UniversityNanchang330031China Instrumental Analysis Center of Nanchang Hangkong University Nanchang330063China

In order to reduce or eliminate the adverse effects of calcium impurity,the interaction of Ca and rare earth Y co-doping on the preparation of WC-Co cemented carbides was investigated.X-ray diffraction,scanning electron microscopy and transmission electron microscopy were employed to analyze the phase compositions,particle sizes and morphologies of them,*** results show that the second type of"yttrium barrier effect"is observed and the adverse influence of Ca-rich phase on tungsten powder can be eliminated by *** flexural strength and fracture toughness of YG6-0.01%Ca+0.09%Y alloy are 2199.5 MPa and 11.49 MPa·m^(1/2),showing improvement of 6.5% and 2.7% compared to YG6 alloy,*** evolutions of Ca-rich phase and Y-rich phase at the every alloy preparation stage of WO_(3),W,WC and cemented carbides are ***,the strengthening mechanism of WC-Co cemented carbide with co-addition of Ca and Y is proposed.

关键词： Yttrium barrier effect Ca-rich phase WC-Co cemented Carbide Microstructures Mechanisms Rare earths

Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

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Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo Dai Yu Peng wen Hu yi liu Hui Wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

Human melanopsin-AAV2/8 transfection to retina transiently restores visual function in rd1 mice

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 655-661页

作者： Ming-Ming liu Jia-Man Dai wen-yi liu Cong-Jian Zhao Bin Lin Zheng-Qin yin Southwest Hospital Southwest Eye Hospital Third Military Medical University Chongqing 400038 China Key Lab of Visual Damage and Regeneration and Restoration of Chongqing Chongqing 400038 China Departments of Anatomy and Ophthalmology Li Ka Shing Faculty of Medicine the University of Hong Kong Hong Kong 200131 China

AIM： To explore whether ectopic expression of human melanopsin can effectively and safely restore visual function in rd1 mice.· METHODS： Hematoxylin-eosin staining of retinal sections from rd1 mice was used to detect the thickness of the outer nuclear layer to determine the timing of surgery. We constructed a human melanopsinAAV2/8 viral vector and injected it into the subretinal space of rd1 mice. The Phoenix Micron IV system was used to exclude the aborted injections, and immunohistochemistry was used to validate the ectopic expression of human melanopsin. Furthermore, visual electrophysiology and behavioral tests were used to detect visual function 30 and 45 d after the injection. The structure of the retina was compared between the human melanopsin-injected group and phosphate buffer saline（PBS）-injected group.·RESULTS： Retinas of rd1 mice lost almost all of their photoreceptors on postnatal day 28（P28）. We therefore injected the human melanopsin-adeno-associated virus（AAV） 2/8 viral vector into P30 rd1 mice. After excluding aborted injections, we used immunohistochemistry of the whole mount retina to confirm the ectopic expression of human melanopsin by co-expression of human melanopsin and YFP that was carried by a viral vector. At30 d post-injection, visual electrophysiology and the behavioral test significantly improved. However,restoration of vision disappeared 45 d after human melanopsin injection. Notably, human melanopsin-injected mice did not show any structural differences in their retinas compared with PBS-injected mice.·CONCLUSION： Ectopic expression of human melanopsin effectively and safely restores visual function in rd1

关键词： human melanopsin retinal degenerative diseases visual restoration

Relationship Between Short-chain Fatty Acids and Parkinson’s Disease:A Review from Pathology to Clinic

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Neuroscience Bulletin 2024年第4期40卷 500-516页

作者： wen-Xiang Duan Fen Wang Jun-yi liu Chun-Feng liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhou215004China Department of Neurology Dushu Lake Hospital affiliated to Soochow UniversitySuzhou215125China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversitySuzhou215123China

Parkinson’s disease(PD)is a complicated neurodegenerative disease,characterized by the accumulation ofα-synuclein(α-syn)in Lewy bodies and neurites,and massive loss of midbrain dopamine *** evidence suggests that gut microbiota and microbial metabolites are involved in the development of *** these,short-chain fatty acids(SCFAs),the most abundant microbial metabolites,have been proven to play a key role in brain-gut *** this review,we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor *** research should focus on further elucidating the role of SCFAs in neuroinflammation,as well as developing novel strategies employing SCFAs and their derivatives to treat PD.

关键词： Parkinson’s disease Short-chain fatty acids Microbial metabolites Brain-gut-microbiota axis