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World Journal of Gastroenterology 2014年第27期20卷 9121-9127页

作者： Jing Li Liang Huang Cai-Feng Liu Jie Cao Jian-Jun yan Feng Xu Meng-Chao Wu yi-qun yan Department of Hepatic Surgery Ⅰ Eastern Hepatobiliary Surgery Hospital Second Military Medical University

AIM: To investigate the risk factors and surgical outcomes for spontaneous rupture of Barcelona Clinic Liver Cancer (BCLC) stages A and B hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Rupture Risk factor Tumor location Surgical outcome

Value of abdominal ultrasound scan, CT and MRI for diagnosing inferior vena cava tumour thrombus in renal cell carcinoma

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Chinese Medical Journal 2009年第19期122卷 2299-2302页

作者： GUO Hong-feng SONG yi NA yan-qun Department of Urology Peking University First Hospital Institute of Urology Peking University Beijing 100034 China

Background We used abdominal ultrasound scan （USS）, computed tomography （CT） and magnetic resonance imaging （MRI） findings in venous spread of renal cell carcinoma （RCC） to determine the superior extent of inferior vena cava （IVC） thrombus and IVC wall invasion and compared them with surgical and pathological reports. Methods From January 1999 to August 2007, 25 patients were diagnosed with RCC with IVC tumour thrombus. Before their operation, all patients had USS, contrast enhanced CT and MRI to find the superior extent of tumour thrombus and IVC wall invasion. All postprocessing techniques were performed by experienced radiologists. Two pathologists reported on all pathology specimens. The superior extent of tumour thrombus was confirmed by the senior surgeon at each operation, using the levels of thrombus defined according to 2004 Mayo Clinic classification. The radiographic results were compared with surgical and pathological findings. Results All patients had radical nephrectomy and tumour thrombus excision. Eight patients had RCC on the left side and 17 on the right side. According to the clinical and pathological findings, 6 patients had level I tumour thrombus, 9 level II, 5 level III and 5 level IV. Six patients had IVC wall invasion. No patient had evidence of lymph node or distant metastases. Of the 25 patients, USS correctly diagnosed the superior extent of tumour thrombus in 18/25, CT 23/25 and MRI 23/25. USS found 1 case of IVC wall invasion preoperatively. Conclusions Multidectector computed tomography and magnetic resonance imaging are comparable and more effective than abdominal ultrasound in diagnosing inferior vena cava tumour thrombus in renal cell carcinoma. None of the three methods can detect inferior vena cava wall invasion.

关键词： ultrasound computed tomography magnetic resonance imaging inferior vena cava renal cell carcinoma

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Predictors and clinical outcomes for spontaneous rupture of hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第48期18卷 7302-7307页

作者： Qian Zhu Jing Li Jian-Jun yan Liang Huang Meng-Chao Wu yi-qun yan Department of Hepatobiliary Surgery Jingmen First People's Hospital First Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

AIM:To determine the risk factors for hepatocellular carcinoma(HCC) rupture,and report the management and long-term survival results of patients with spontaneous rupture of ***:Among 4209 patients with HCC who were diagnosed at Eastern Hepatobiliary Surgery Hospital from April 2002 to November 2006,200(4.8%) patients with ruptured HCC(case group) were studied retrospectively in term of their clinical characteristics and prognostic *** one-stage therapeutic approach to manage ruptured HCC consisted of initial management by conservative treatment,transarterial embolization(TACE) or hepatic *** of various treatments in the case group were evaluated and compared with the control group(202 patients) without ruptured HCC during the same study *** data were expressed as mean ± SD or me-dian(range) where appropriate and compared using the unpaired t *** variables were compared using the Chi-square test with Yates correction or the Fisher exact test where *** overall survival rate in each group was determined using the Kaplan-Meier method and a log-rank ***:Compared with the control group,more patients in the case group had underlying diseases of hypertension(7.5% vs 3.0%,P =0.041) and liver cirrhosis(87.5% vs 56.4%,P 5 cm(83.0% vs 57.4%,P ying diseases of hypertension(P = 0.002) and liver cirrhosis(P 5 cm(P < 0.001),vascular thrombus(P = 0.002) and extrahepatic invasion(P < 0.001) were predictive for spontaneous rupture of *** the 200 patients with spontaneous rupture of HCC,105 patients underwent hepatic resection,33 received TACE,and 62 were managed with conservative *** median survival time(MST) of all patients with spo

关键词： Hepatocellular carcinoma Spontaneous rupture Predictors Hepatectomy Overall survival Disease-free survival

Can sorafenib be discontinued in hepatocellular carcinomapatients with a complete response to treatment?

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Hepatoma Research 2015年第1期1卷 109-110页

作者： Jing Li Liang Huang yi-qun yan Department of Hepatic Surgery I Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

INTRODUCTION Sorafenib is a multi-kinase inhibitor that inhibits angiogenesis by targeting the vascular endothelial growth factor receptor 2 and platelet-derived growth factor receptor pathways while blocking cell proliferation by targeting the Ras/mitogen-activated protein kinase signaling *** global phase III trials[Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol(SHARP)[1]and Asia-Pacific trial[2]]showed that sorafenib prolonged the survival of patients with advanced hepatocellular carcinoma(HCC).The results of these studies were rapidly disseminated worldwide and were enthusiastically accepted by physicians specializing in liver cancer *** on the positive results of the SHARP trial,[1]the EU and USA approved sorafenib for advanced HCC in October and November 2007,*** was also approved for patients with unresectable and metastatic HCC in July 2008 in China,but patients have to pay the cost by themselves.

关键词： patients sorafenib hepatocellular

Precautions in caudate lobe resection: Report of 11 cases

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World Journal of Gastroenterology 2008年第17期14卷 2767-2770页

作者： Zeng-Qing Wen yi-qun yan Jia-Mei yang Meng-Chao Wu First Department of Hepatic Surgery Eastern HepatobiliarySurgery Hospital Second Military Medical University Shanghai200438 China

AIM： To find the precautions against the safety in caudate lobe resection. METHODS： The clinical data obtained from 11 cases of primary liver cancer in caudate lobe who received hepatectomy successfully were retrospectively analyzed. Four safe procedures were used in resection of primary liver cancer in caudate lobe：（1） selection of appropriate skin incision to obtain excellent exposure of operative field; （2） adequate mobilization of the liver to allow the liver to be displaced upwards to the left or to the right; （3） preparatory placement of tapes for total hepatic vascular exclusion, so that this procedure could be used to control the fatal bleeding of the liver when necessary; （4） selection of the ideal route for hepatectomy based on the condition of the tumor and the combined removal of multiple lobes if necessary. Among the 11 cases, simple occlusion of vessels of porta hepatis was used in caudate Iobectomy for 6 cases, while in the other cases, the vessels were intermittently occluded several times or total hepatic vascular isolation was used in the caudate Iobectomy. Combined partial right hepatectomy was done for 3 cases, combined left lateral Iobectomy for 2 cases and caudate Iobectomy alone for 6 cases. RESULTS： Operation was successful for all the 11 cases. Intermittent inflow occlusion was performed for all patients for 15 min at 5-min intervals. Blockade was performed twice in 3 patients and total hepatic vascular exclusion was performed in one of the three patients. Blockade was performed three times in one patient, including a total hepatic vascular exclusion. Total hepatic vascular exclusion was performed only in one patient. The mean blood loss was 300 mL. Ascites and pleural effusion occurred in 4 patients, jaundice in 1 patient. Six patients died of tumor recurrence in 6, 11, 12, 13, 15, 19 mo after operation, respectively. The other 5 patients have survived more than 16 mo since the operation. CONCLUSION： Caudate Iobectomy for liver cance

关键词： Caudate lobe Primary liver cancer Hepatectomy Porta hepatis Vascular exclusion

Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection

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World Journal of Gastroenterology 2012年第47期18卷 7021-7025页

作者： Liang Huang Jing Li Jian-Jun yan Cai-Feng Liu MengChao Wu yi-qun yan Department of Hepatic SurgeryⅠ Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

AIM:To investigate the risk factors for postoperative liver insufficiency in patients with Child-Pugh class A liver function undergoing liver ***:A total of 427 consecutive patients undergoing partial hepatectomy from October 2007 to April 2011 at a single center(Department of Hepatic SurgeryⅠ,Eastern Hepatobiliary Surgery Hospital,Shanghai,China) were included in the *** the patients had preoperative liver function of Child-Pugh class A and were diagnosed as having primary liver cancer by postoperative *** was performed by the same team and hepatic resection was carried out by a clamp crushing method.A clamp/unclamp time of 15 min/5 min was adopted for hepatic inflow ***' records of demographic variables,intraoperative parameters,pathological findings and laboratory test results were *** liver insufficiency and failure were defined as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,clinically apparent ascites,prolonged coagulopathy requiring frozen fresh plasma,and/or hepatic *** incidence of postoperative liver insufficiency or liver failure was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive ***:Among the 427 patients,there were 362 males and 65 females,with a mean age of 51.1 ± 10.4 *** patients(86.4%) had a background of viral hepatitis and 234(54.8%) patients had liver *** for partial hepatectomy included hepatocellular carcinoma(391 patients),intrahepatic cholangiocarcinoma(31 patients) and a combination of both(5 patients).Hepatic resections of ≤ 3 and ≥ 4 liver segments were performed in 358(83.8%) and 69(16.2%) patients,***(4.0%) patients developed liver insufficiency after hepatectomy,of whom 10 patients manifested as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,6 patients had clinic

关键词： Prealbumin Hepatectomy Liver insufficiency Child-Pugh class A Primary liver cancer

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi qun yi Yao Liu yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

Prevention and management of pleural effusion following hepatectomy in primary liver cancer

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 375-378页

作者： Jian-Jun yan, Xiang-Hua Zhang, Kai-Jian Chu, Liang Huang, Fei-Guo Zhou and yi-qun yan Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China. Yiqunyan@***

Postoperative pleural effusion occurs frequently after hepatectomy. The risk factors, prevention and management of postoperative pleural effusion in patients with primary liver cancer (PLC) who have undergone hepatectomy and the value of the argon beam coagulator (ABC) for the prevention of pleural effusion are studied. METHODS:A total of 523 patients with PLC at our institution who had had right hepatectomy from July 2000 to June 2004 were studied retrospectively. Comparative analysis was made to identify the factors contributing to postoperative pleural effusion and the efficacy of various managements. RESULTS:Of the 523 patients whose livers were dissociated using argon beam cutting and/or coagulation, 20(3.8%) developed pleural effusions;whereas in the other 467 patients underwent hepatectomy with suture ligation of the diaphragmatic secondary wound surface during the same period, 49(10.5%) had pleural effusion (Pying cirrhosis. CONCLUSIONS: Dissociation of the liver by argon beam cutting and/or coagulation can save suture ligation of the diaphragmatic secondary wound surface and may also prevent postoperative pleural effusion. Pleural drainage using an indwelling central-venous-catheter (CVC) in the pleural cavity is safe and efficacious.

关键词： primary liver cancer hepatectomy postoperative pleural effusion argon beam cut and/or coagulation central venous catheter

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Arterial blood supply of hepatocellular carcinoma is associated with efficacy of sorafenib therapy

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Hepatoma Research 2016年第1期2卷 87-91页

作者： Xiang-Hua Zhang Qian Zhu Jing Li Liang Huang Jian-Jun yan Feng Xu Jun Li yi-qun yan Department of Hepatic Surgery I Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Department of Hepatobiliary Surgery Jingmen First People’s HospitalJingmen 448000HubeiChina

Aim:There are some previous reports concerning the relationship between prognosis of patients treated with sorafenib and parameters of computed tomography(CT)and magnetic resonance imaging(MRI).This study presents monocentric experience with sorafenib in the treatment of hepatocellular carcinoma(HCC)patients and will try to identify predictive factors for survival based on the correlation of results from imaging and ***:A total of 38 HCC patients treated from April 2009 to December 2010 with sorafenib were included in this *** were classified as good arterial supply and poor arterial supply according to the enhancement intensity on CT scan or *** data were collected and survival time was analyzed by Kaplan-Meier method.A Cox’s regression model was performed to reveal predictive factors for ***:Among the 38 patients treated with sorafenib,mean age was 53.3±11.1 years and 35(92.1%)were *** in 17 patients were classified as good arterial supply,while the remaining 21 patients belonged to poor arterial *** median survival time(MST)was 10.7 months[95%confidence interval(CI),8.7-12.7]and the 1-year overall survival(OS)was 41.0%.The MST and 1-year OS in patients with a good arterial supply of tumors were 12 months(range:4-20 months)and 52.9%,compared with that of 7 months(range:1-16 months)and 23.8%in patients with a poor arterial supply of tumors(P=0.002).Patients who had tumors at Barcelona Clinic Liver Cancer(BCLC)stage B had longer MST and higher OS than those who had tumors at BCLC stage C,but there was no statistical difference between these two *** multivariate analysis,only arterial supply of the tumors remained statistically predictive for OS(hazard ratios 0.22,95%CI,0.07-0.67,P=0.008).Conclusion:Arterial blood supply is an independent predictor for survival in patients treated with sorafenib,and patients with a good arterial supply of tumors benefit more than those with a poor arterial supply of tumo

关键词： Arterial blood supply hepatocellular carcinoma sorafenib

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端曲面齿轮副复合运动规律及受力分析

吉林大学学报（工学版） 2017年第1期47卷 157-162页

作者：林超刘毅魏艳群朱才朝重庆大学机械传动国家重点实验室重庆400044

根据微分几何和齿轮啮合原理的相关理论,分析了端曲面齿轮副复合运动的两种不同的传动形式,并采用仿真分析验证了其运动规律。计算并分析了端曲面齿轮副复合运动时的受力状况以及该齿轮副啮合过程中压力角的变化情况。搭建了验证其运动... 详细信息

根据微分几何和齿轮啮合原理的相关理论,分析了端曲面齿轮副复合运动的两种不同的传动形式,并采用仿真分析验证了其运动规律。计算并分析了端曲面齿轮副复合运动时的受力状况以及该齿轮副啮合过程中压力角的变化情况。搭建了验证其运动规律的试验平台,使用激光位移传感器测量该齿轮副的位移,将试验结果与理论值和仿真结果进行对比,验证了计算结果的正确性。

关键词：机械设计复合运动端曲面齿轮受力分析

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