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Treatment of advanced rectal cancer after renal transplantation

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World Journal of Gastroenterology 2011年第15期17卷 2058-2060页

作者： Hai-yi Liu Xiao-Bo Liang Yao-ping Li yi Feng Dong-Bo Liu Wen-Da Wang Department of Anal and Colorectal Surgery Shanxi Cancer Hospital Affiliated Cancer Hospital of Shanxi Medical University Taiyuan 030013 Shanxi Province China

Renal transplantation is a standard procedure for endstage renal disease today. Due to immunosuppressive drugs and increasing survival time after renal transplantation, patients with transplanted kidneys carry an increased risk of developing malignant tumors. In this case report, 3 patients with advanced rectal cancer after renal transplantation for renal failure were treated with anterior resection or abdominoperineal resection plus total mesorectal excision, followed by adjuvant chemotherapy. One patient eventually died of metastasized cancer 31 mo after therapy, although his organ grafts functioned well until his death. The other 2 patients were well during the 8 and 21 mo followup periods after rectal resection. We therefore strongly argue that patients with advanced rectal cancer should receive standard oncology treatment, including operation and adjuvant treatment after renal transplantation. Colorectal cancer screening in such patients appears justified.

关键词： Rectal cancer Renal transplantation Endstage renal disease Treatment Screening

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基于图像融合模型的矢量逆半调算法

吉林大学学报（工学版） 2008年第6期38卷 1474-1479页

作者：郑海红曾平西安电子科技大学计算机学院西安710071

针对矢量误差分散半调图提出了一种彩色逆半调算法。首先，分析了基于矩阵增益模型的误差分散系统，发现矢量逆半调问题可等效为相关性高频噪声的抑制问题；然后利用K—L变换去除相关性并基于Laplacian金字塔构造图像融合模型，该模型... 详细信息

针对矢量误差分散半调图提出了一种彩色逆半调算法。首先，分析了基于矩阵增益模型的误差分散系统，发现矢量逆半调问题可等效为相关性高频噪声的抑制问题；然后利用K—L变换去除相关性并基于Laplacian金字塔构造图像融合模型，该模型能将未知特性的高频噪声转化为易处理的脉冲噪声；最后使用维纳滤波器和中值滤波器去噪。实验表明，该算法能克服色偏，减少杂色，较准确地再现连续色调图像，逆半调图像的峰值信噪比传统算法提高2～3dB。

关键词：信息处理技术逆半调误差分散矩阵增益模型图像融合模型

Effect of sevoflurane pretreatment on alveolar oxygenation function and systemic inflammatory response activation during one-lung ventilation

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Journal of Hainan Medical University 2017年第11期23卷 63-66页

作者： Yan-Bin Xie ping Chen yi-Fei Chen Long-ping Chen Anesthesiology Department Mianyang Central Hospital in Sichuan ProvinceMianyang CitySichuan Province621000

Objective:To study the effect of sevoflurane pretreatment before one-lung ventilation on pulmonary compliance, oxygenation function and systemic inflammatory ***:104 patients who accepted one-lung ventilation operation in Mianyang Central Hospital between April 2014 and December 2015 were selected and randomly divided into the sevoflurane group who accepted sevoflurane pretreatment combined with routine anesthesia and the control group who accepted routine anesthesia, and the pulmonary compliance and oxygenation function parameters during one-lung ventilation as well as the contents of inflammatory mediators in serum and the contents of inflammation regulation molecules in alveolar lavage fluid were ***: At T1, T2 and T3, Cdyn and PaO2/FiO2 levels of sevoflurane group were significantly higher than those of control group, and serum ICAM-1, IL-6, IL-8 and TNF-α contents were significantly lower than those of control group while IL-10 contents were significantly higher than those of control group;after operation, AQP-1, p38MAPK, TLR4 and NF-κB contents in collapsed alveolar lavage fluid of sevoflurane group were significantly lower than those of control ***: Sevoflurane pretreatment before one-lung ventilation can improve the pulmonary compliance and oxygenation function, and inhibit the activation of inflammatory response.

关键词： One-lung ventilation Sevoflurane pretreatment Compliance Oxygenation function Inflammatory response

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利用k近邻区间距离的异步抗差航迹关联算法

系统工程与电子技术 2022年第5期44卷 1475-1482页

作者：衣晓曾睿曹昕莹海军航空大学航空作战勤务学院山东烟台264001 中国人民解放军92325部队山西大同037001

针对异步和系统误差并存情况下的航迹关联问题,提出利用航迹序列k近邻区间距离的异步抗差航迹关联算法。定义区间序列与区间点的k近邻区间距离度量,提出系统误差区间化方法,通过不等长航迹区间序列间的灰色关联度,利用经典分配法进行航... 详细信息

针对异步和系统误差并存情况下的航迹关联问题,提出利用航迹序列k近邻区间距离的异步抗差航迹关联算法。定义区间序列与区间点的k近邻区间距离度量,提出系统误差区间化方法,通过不等长航迹区间序列间的灰色关联度,利用经典分配法进行航迹关联判定。与传统算法相比,对系统误差先验信息的要求低。仿真结果表明,算法能以较高正确率实现稳定关联,具有良好的抗差性。算法亦可处理异步不等速率航迹关联问题,无需时域配准,具有明显的优势。

关键词：航迹关联抗差关联 k近邻区间距离灰色关联度区间化

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纳米薄膜润滑的分子动力学模拟

哈尔滨工业大学学报 2006年第9期38卷 1426-1430页

作者：曾凡林孙毅哈尔滨工业大学航天科学与力学系哈尔滨150001

针对广泛存在于微机电系统和精密机械中的纳米薄膜润滑问题,首先建立了作为润滑剂的正十六烷长链分子间的作用力模型;接着运用分子动力学模拟的方法得到了润滑剂在6种不同的剪切速率下的应力、速度和温度分布;研究了摩擦过程中特殊的物... 详细信息

针对广泛存在于微机电系统和精密机械中的纳米薄膜润滑问题,首先建立了作为润滑剂的正十六烷长链分子间的作用力模型;接着运用分子动力学模拟的方法得到了润滑剂在6种不同的剪切速率下的应力、速度和温度分布;研究了摩擦过程中特殊的物理现象.结果表明:随着剪切速率的变化,润滑剂的温度和所受到的剪切应力不断变化;润滑剂的分层和层间滑移现象在各种剪切速率下都会发生,是纳米薄膜润滑中的普遍现象.此研究对理解和研究纳米润滑薄膜的作用机理有促进作用.

关键词：纳米薄膜润滑正十六烷分子动力学模拟

Optimal strategy of switching from clopidogrel to ticagrelor in Chinese acute coronary syndrome patients with complicated coronary artery disease: the switching from clopidogrel to ticagrelor (SHIFT-CACS) study

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Chinese Medical Journal 2019年第19期132卷 2292-2299页

作者： ying Yao ping Wang Xiao-zeng Wang Xin Zhao Wei Zhao Tie-Nan Zhou Lei Zhang Department of Cardiology Institute of Cardiovascular ResearchGeneral Hospital of Northern Theater CommandShenyangLiaoning 110840China Department of Clinical Pharmacy Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China

Background:The dose and time point for switching from clopidogrel to ticagrelor remain controversial,especially for Chinese acute coronary syndrome(ACS)patients with complicated coronary artery disease(CAD).Hence,the purpose of this study was to further explore the optimal dose and time point for the switching strategy to balance the increase in platelet inhibition and the decrease in adverse events in Chinese ACS patients with complicated CAD managed by percutaneous coronary intervention(PCI).Methods:From July 2017 to December 2017,the prospective,randomized,open-label study(the SwitcHIng from clopidogrel to ticagrelor study)assigned the eligible Chinese ACS patients with complicated CAD managed by PCI(n=102)for 90 mg of ticagrelor at 12 h(T-90 mg-12 h),90 mg of ticagrelor at 24 h(T-90 mg-24h)or 180 mg ticagrelor at 24 h(T-180 mg-24 h)after the last dose of *** primary endpoint was the comparison of maximal platelet aggregation(MPA)values at 2 h after switching strategies among the three *** addition,the MPA values at baseline,8 h and before discharge and the rates of high ontreatment platelet reactivity were evaluated,the incidences of bleeding episodes and dyspnea during hospitalization and at 30-day follow-up in our study were also *** MPA was measured by light transmittance aggregometry in our study.A repeatedmeasures analysis of variance(ANOVA)model and one-way ANOVA were used to compare data for the primary ***:The MPA values were significantly decreased in the T-180 mg-24 h group compared with the T-90 mg-12 h group(P=0.017)and decreased numerically compared with the T-90 mg-24 h group(P=0.072)at 2 *** particular,the MPA values were markedly reduced in the T-90 mg-24 h group compared with the T-90 mg-12 h group at 8 h after switching treatment(P=0.002).There was no significant difference among the three groups in all bleedings and dyspnea ***:The optimal treatment strategy recommended in this study for

关键词： Clopidogrel Drug substitution Pharmacology Ticagrelor

Structural, elastic, and electronic properties of sodium atoms encapsulated type-I silicon–clathrate compound under high pressure

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Chinese Physics B 2015年第10期24卷 400-407页

作者：张伟陈青云曾召益蔡灵仓 School of Science Southwest University of Science and Technology Laboratory for Shock Wave and Detonation Physics Research Institute of Fluid PhysicsChinese Academy of Engineering Physics School of National Defense Science and Technology Southwest University of Science and Technology College of Physics and Electronic Engineering Chongqing Normal University

We calculated the structural, elastic, and electronic properties of alkali metal Na atoms doped type-I silicon-clathrate compound（Na8Si46） under pressure using first-principles methods. The obtained dependencies of bond lengths and bond angles on pressure show heterogeneous behaviors which may bring out a structural transition. By using the elastic stability criteria from the calculated elastic constants, we confirm that the Na8Si46 is elastically unstable under high pressure. Some of the mechanical and thermal quantities include bulk modulus, shear modulus,Young＇s modulus, Debye temperature,sound velocity, melting point, and hardness, which are also derived from the elastic constants. The calculated total and partial electron densities of states of Na8Si46 indicate a weak interaction between the encapsulated Na atoms and the silicon framework. Moreover, the effect of pressure on its electronic structure is also investigated, which suggests that pressure is not a good choice to enhance the thermoelectricity performance of Na8Si46.

关键词： clathrate compound elastic constants electronic structure density functional theory

Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis

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World Journal of Gastroenterology 2008年第5期14卷 764-770页

作者： yin-ying Lu Chun-ping Wang Lin Zhou Yan Chen Shu-Hui Su Yong-yi Feng Yong-ping Yang Department of Gastroenterology 302 Hospital of Chinese PLA Beijing 100039 China

AIM:To determine the platelet-activating factor (PAF) synthesis and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. METHODS:Kupffer cells, isolated from the livers of control and CCl4-induced cirrhotic rats, were placed in serum-free medium overnight. PAF saturation binding, ET-1 saturation and competition binding were assayed. ET-1 induced PAF synthesis, mRNA expression of PAF, preproendothelin-1, endothelin A (ETA) and endothelin B (ETB) receptors were also determined. RESULTS:A two-fold increase of PAF synthesis (1.42 ± 0.14 vs 0.66 ± 0.04 pg/μg DNA) and a 1.48-fold increase of membrane-bound PAF (1.02 ± 0.06 vs 0.69 ± 0.07 pg/μg DNA) were observed in activated Kupffer cells of cirrhotic rats. The application of ET-1 to Kupffer cells induced PAF synthesis in a concentration-dependent manner in both cirrhotic and normal rats via ETB receptor, but PAF synthesis in the activated Kupffer cells was more effective than that in the normal Kupffer cells. In activated Kupffer cells, PAF receptor expression and PAF binding capacity were markedly enhanced. Activated Kupffer cells raised the [125I]-ET-1 binding capacity, but changed neither the affinity of the receptors, nor the expression of ETA receptor. CONCLUSION:Kupffer cells in the course of CCl4-induced cirrhosis are the main source of increased PAF. ET-1 is involved endogenously in stimulating the PAF synthesis in activated Kupffer cells via ETB receptor by paracrine. ETA receptor did not appear in activated Kupffer cells, which may exacerbate the hepatic and extrahepatic complications of cirrhosis.

关键词： Platelet activating factor Kupffer cells Receptor Cirrhosis

Transforming Activity of a Novel Mutant of HPV16 E6E7 Fusion Gene

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Virologica Sinica 2011年第3期26卷 206-213页

作者： Qiang Xie Zhi-xiang Zhou Ze-lin Li yi zeng （College of Life Science and Bioengineering Beijing University of Technology Beijing 100124 China）

An optimized recombinant HPV16 E6E7 fusion gene (HPV16 ofE6E7) was constructed according to codon usage for mammalian cell expression, and a mutant of HPV16 ofE6E7 fusion gene (HPV16 omfE6E7) was generated by site-directed mutagenesis at L57G, C113R for the E6 protein and C24G, E26G for the E7 protein for HPV16 ofE6E7 [patent pending (CN 101100672)]. The HPV16 omfE6E7 gene constructed in this work not only lost the transformation capability to NIH 3T3 cells and tumorigenicity in SCID mice, but also maintained very good stability and antigenicity. These results suggests that the HPV16 omfE6E7 gene should undergo further study for application as a safe antigen-specific therapeutic vaccine for HPV16-associated tumors.

关键词： Human papillomavirus (HPV) E6 E7 Gene optimization Gene mutation Transformation