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Docetaxel, cisplatin, and 5-fluorouracil compared with epirubicin,cisplatin, and 5-fluorouracil regimen for advanced gastric cancer:A systematic review and meta-analysis

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World Journal of Clinical Cases 2019年第5期7卷 600-615页

作者： Bo Li Lian Chen Hong-Liang Luo Feng-Ming yi yi-ping wei Wen-Xiong Zhang Department of Thoracic Surgery The Second Affiliated Hospital of Nanchang University Jiangxi Medical College Nanchang University Department of Gastrointestinal Surgery The Second Affiliated Hospital of Nanchang University Department of Digestive Oncology The Second Affiliated Hospital of Nanchang University

BACKGROUND As the first-line regimens for the treatment of advanced gastric cancer, both docetaxel, cisplatin, and 5-fluorouracil(DCF) and epirubicin, cisplatin, and 5-fluorouracil(ECF) regimens are commonly used in clinical practice, but there is still controversy about which is *** To compare the efficacy and safety of DCF and ECF regimens by conducting this *** Computer searches in PubMed, EMBASE, Ovid MEDLINE, Science Direct, Web of Science, The Cochrane Library and Scopus were performed to find the clinical studies of all comparisons between DCF and ECF regimens. We used progression-free survival(PFS), overall survival(OS), objective response rate(ORR), disease control rate(DCR), and adverse effects(AEs) as endpoints for *** Our meta-analysis included seven qualified studies involving a total of 598 patients. The pooled hazard ratios between the DCF and ECF groups were comparable in PFS(95%CI: 0.58-1.46, P = 0.73), OS(95%CI: 0.65-1.10, P = 0.21),and total AEs(95%CI: 0.93-1.29, P = 0.30). The DCF group was significantly better than the ECF group in terms of ORR(95%CI: 1.13-1.75, P = 0.002) and DCR(95%CI: 1.03-1.41, P = 0.02). However, the incidence rate of grade 3-4 AEs was also greater in the DCF group than in the ECF group(95%CI: 1.16-1.88, P = 0.002),especially for neutropenia and febrile *** With better ORR and DCR values, the DCF regimen seems to be more suitable for advanced gastric cancer than the ECF regimen. However, the higher rate of AEs in the DCF group still needs to be noticed.

关键词： Gastric cancer Chemotherapy Docetaxel Epirubicin Cisplatin 5-fluorouracil

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Correlation of angiotensin converting enzyme gene polymorphism with perioperative myocardial protection under extracorporeal circulation

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 995-999页

作者： wei Yang Xiao Dong Bin Li Xiao-Qiang Zhang Yuan Zeng yi-ping wei Jian-Liang Zhou Yan-Hua Tang Jian-Jun Xu Department of Cardiothoracic Surgery Second Affiliated Hospital to Nanchang University

Objective:To observe the expression of angiotensin converting enzyme(ACE),angiotensinⅡ(AngⅡ),cardiac troponin 详细信息

Objective:To observe the expression of angiotensin converting enzyme(ACE),angiotensinⅡ(AngⅡ),cardiac troponin

关键词： Angiotensin converting enzyme ACE gene polymorphism Cardiopulmonary bypass perioperative Myocardial injury Myocardial markers

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One-stage resection of four genotypes of bilateral multiple primary lung adenocarcinoma:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10301-10309页

作者： De-Yuan Zhang Jing Liu Yang Zhang Jia-Yue Ye Sheng Hu Wen-Xiong Zhang Dong-Liang Yu yi-ping wei Department of Thoracic Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The incidence of multiple primary lung cancer(MPLC)in China is 0.52%-2.45%.Most primary lung cancer cases have reported two lesions or three in rare *** report a rare case of bilateral simultaneous multiple primary lung adenocarcinoma of four different *** SUMMARY A 58-year-old woman was admitted to our hospital on June 29,2021,and upon physical examination,four multiple pulmonary nodules were identified in both *** computed tomography(CT)images revealed the presence of ground glass nodules,predicted to be high-risk cancer lesions by artificial *** the guidance of three-dimensional reconstruction of preo-perative CT images,the nodules were resected under *** pathological investigation revealed that the nodule types were adenocarcinoma in situ,invasive alveolar adenocarcinoma,and microinvasive *** excised nodules were further sequenced using high-throughput sequencing(semiconductor sequencing method)of 26 lung cancer genes to confirm that the four lesions were not *** patient was discharged on postoperative day 8,that is,on July 15,*** month later,she returned to the hospital for followup and *** CT examination showed that she had re-covered well,and no obvious exudation and effusion were found in both pleural *** of postoperative pulmonary function showed that her forced vital capacity was 1.40 L(preoperative value,2.27 L)and forced expiratory volume was 1.24 L(preoperative value,2.23 L).CONCLUSION The surgical plan for multiple pulmonary nodules should be carefully *** carefully selected patients with concurrently occurring multiple lung nodules in both lungs,sublobectomy is a safe and feasible plan for concurrent bilateral resection of the *** sequencing is necessary for MPLC diagnosis and treatment.

关键词： Multiple primary lung adenocarcinoma Three-dimensional reconstruction Sublobar resections High-throughput sequencing Case report

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Electrochemical behavior of C-(60) modified electrode in aqueous solutions

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Chinese Journal of Chemistry 1994年第2期12卷 117-122页

作者： SHI, Zhan-Ling MAO, yi-ping TONG, wei JIN, Li-TongDepartment of chemistry, East China Normal University, 3663 Zhong Shan Road (N), Shanghai 200062,China Department of chemistry East China Normal University 3663 Zhong Shan Road (N) Shanghai 200062 China

The construction of adsorptive type C60 modified electrode and its electrochemical reduction and oxidation behavior in aqueous solutions are described in this report. Four pairs of one-electron transfer reduction and oxidation cyclic voltammetry is obtained in aqueous solution containing 30% CH3CN and 2% (C2H5)4NOH. It is reported in this paper that the C60 modified electrode also catalyzes the electrochemical reduction of dissolved oxygen in 40% DMF and 2% (C2H5)4NOH aqueous solution and this might open a new field for the potential applications of C60 in electrochemistry and electroaualytical chemistry.

关键词： C60 modified electrode electrochemistry.

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Reoperation of biliary tract by laparoscopy:Experiences with 39 cases

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World Journal of Gastroenterology 2008年第19期14卷 3081-3084页

作者： Li-Bo Li Xiu-Jun Cai yi-ping Mou Qi wei Department of General Surgery Sir Run Run Shaw Hospital Institute of Microinvasive Surgery Medical College of Zhejiang University Hangzhou No. 3 East Qingchun Road Hangzhou 310016 Zhejiang Province China

AIM:To evaluate the safety and feasibility of biliary tract reoperation by laparoscopy for the patients with retained or recurrent stones who failed in endoscopic sphincterotomy. METHODS:A retrospective analysis of data obtained from attempted laparoscopic reoperation for 39 patients in a single institution was performed, examining open conversion rates, operative times, complications, and hospital stay. RESULTS:Out of the 39 cases, 38 (97%) completed laparoscopy, 1 required conversion to open operation because of difficulty in exposing the common bile duct. The mean operative time was 135 min. The mean post-operative hospital stay was 4 d. Procedures included laparoscopic residual gallbladder resection in 3 cases, laparoscopic common bile duct exploration and primary duct closure at choledochotomy in 13 cases, and laparoscopic common bile duct exploration and choledochotomy with T tube drainage in 22 cases. Duodenal perforation occurred in 1 case during dissection and was repaired laparoscopically. Retained stones were found in 2 cases. Postoperative asymptomatic hyperamlasemia occurred in 3 cases. There were no complications due to port placement, postoperative bleeding, bile or bowel leakage and mortality. No recurrence or formation of duct stricture was observed during a mean follow-up period of 18 mo. CONCLUSION:Laparoscopic biliary tract reoperation is safe and feasible if it is performed by experiencedlaparoscopic surgeons, and is an alternative choice for patients with choledocholithiasis who fail in endoscopic sphincterectomy.

关键词： Minimally invasive surgery Reoperation Choledocholithiasis Laparoscopic common bile duct exploration

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Endovascular treatment of central venous stenosis and obstruction in hemodialysis patients

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Chinese Medical Journal 2013年第3期126卷 426-430页

作者： SHI Ya-xue YE Meng LIANG wei ZHANG Hao ZHAO yi-ping ZHANG Ji-wei Department of Vascular Surgery Renji Hospital Shanghai Jiao Tong University School of Medcine Shanghai 200001 China

Background Central venous stenosis and obstruction （CVD） is a serious and prevalent challenge to both resolve the venous hypertension symptoms and maintain the pantency of the ipsilateral hemodialysis access in hemodialysis patients. This study aimed to summarize our experience of the endovascular management of the central venous stenosis or obstruction in hemodialysis patients. Methods Twenty-four haemodialysis cases of central vein stenosis or obstruction with ipsilateral functional vascular access in our hospital between July 2006 and February 2012 were treated by interventional therapy and the data were analyzed retrospectively. Results Eighteen males and six females with mean age of （66.4±13.8） years and manifesting with arm swelling and venous hypertension were enrolled; 62.5% of them had a history of catheterization. Venography showed stenotic lesion in 10 cases including eight cases of brachiocephalic vein stenosis and two cases of subclavian vein stenosis and 14 cases of obstruction lesions including seven cases of short brachiocephalic obstruction and seven cases of long segment obstruction. Interventional therapy was performed and the technique success rate was 83.3%. Percutaneous transluminal angioplasty （PTA） was performed in nine cases and stent was performed in 11 cases firstly. The symptoms of venous hypertension were resolved after intervention in all the cases. There was no major complication and death perioperatively. During follow-up, reintervention was done, the primary patency rates were （88.9±10.5）%, （64.8±10.5）% and （48.6±18.7）% at 3 months, 6 months and 1 year after treatment in the PTA group; （90.0±9.5）% and （77.1±14.4）% at 6 months and 1 year after treatment in the stent group, respectively. The secondary patency rates were （48.6±18.7）% in the PTA group and （83.3±15.2）% in the stent group 1 year after treatment, respectively. There was no significant difference between the two groups （primary patency, P=0.20; secondary patency, P=0.10）. Co

关键词： central venous stenosis hemodialysis percutaneous angioplasty stent

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恒星巡天光谱中天光残留成分的自动识别与检测

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光谱学与光谱分析 2017年第1期37卷 273-277页

作者：安冉潘景昌衣振萍韦鹏山东大学(威海)机电与信息工程学院山东威海264209 中国科学院光学天文重点实验室国家天文台北京100012

天光作为一种主要的噪声,叠加在目标天体光谱之中,降低了光谱的信噪比。经过减天光处理后,若光谱中仍含有大量强度高的天光残差将不利于对目标光谱的后续分析。自动识别减天光异常恒星光谱的研究较少,目前只能通过人工检测的方法去寻找... 详细信息

天光作为一种主要的噪声,叠加在目标天体光谱之中,降低了光谱的信噪比。经过减天光处理后,若光谱中仍含有大量强度高的天光残差将不利于对目标光谱的后续分析。自动识别减天光异常恒星光谱的研究较少,目前只能通过人工检测的方法去寻找减天光异常的光谱,效率较低。首先对影响减天光结果的因素进行分析,找出减天光异常光谱的特征,然后提出一种简单有效的方法能够自动识别LAMOST巡天经过Pipeline处理之后仍然存在减天光异常的恒星光谱并检测其位置。该方法先对光谱进行归一化处理,然后通过检测天光线附近是否有一定强度的类似发射线或吸收线的残留来判定该天光线位置是否出现减天光异常,最后得出光谱中所有的减天光异常的天光位置。通过对LAMOST光谱数据的实验表明,这种方法可以有效识别出减天光异常的光谱和发现不同残留强度的天光线异常位置,并且该方法简单易懂,识别效率高,可以应用于大量的减天光异常光谱的识别与检测问题。

关键词：减天光天光残留检测连续谱归一化郭守敬望远镜(LAMOST)

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H pylori are associated with chronic cholecystitis

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World Journal of Gastroenterology 2007年第7期13卷 1119-1122页

作者： Dong-Feng Chen Lu Hu, ping yi wei-Wen Liu Dian-Chun Fang Hong Cao Department of Gastroenterology DapingHospitalThird Military Medical University Chongqing 400042China

AIM： To study whether H pylon are associated with chronic cholecystitis. METHODS： The subjects were divided into three groups： H pylori-infected cholecystitis group, H pylorinegative cholecystitis group and control group. Pathologic changes of the gallbladder were observed by optic and electronic microscopes and the levels of interleukin-1, 6 and 8 （IL-1, 6 and 8） were detected by radioimmunoassay. RESULTS： Histological evidence of chronic cholecystitis including degeneration, necrosis, inflammatory cell infiltration, were found in the region where H pylori colonized. Levels of IL-1, 6 and 8 in gallbladder mucosa homogenates were significantly higher in H py/oriinfected cholecystitis group than those in Hpylorinegative cholecystitis group and control group. CONCLUSION： H pylon infection may be related to cholecystitis.

关键词： H pylori Chronic cholecystitis Interleukin Colonization Gallbladder mucosa

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Helicobacter pylori damages human gallbladder epithelial cells in vitro

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World Journal of Gastroenterology 2008年第45期14卷 6924-6928页

作者： Dong-Feng Chen Lu Hu ping yi wei-Wen Liu Dian- Chun Fang Hong Cao Department of Gastroenterology Daping Hospital Third Military Medical University Chongqing 400042 China

AIM: To study the mechanism by which Helicobacter pylori (H pylori) damages human gallbladder epithelial cells (HGBEC). METHODS: H pylori isolated from gallbladder were cultured in a liquid medium. Different concentration supernatants and sonicated extracts of H pylori cells were then added to HGBEC in a primary culture. The morphological changes in HGBEC as well as changes in the levels of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and glutamyltransferase (GGT) were ***: According to the culture curve of HGBEC, it was convenient to study the changes in HGBEC by adding H pylori sonicated extracts and H pylori culture supernatants. Both H pylori sonicated extracts and H pylori culture supernatants had a significant influence on HGBEC morphology, i.e. HGBEC grew more slowly, their viability decreased and their detachment increased. Furthermore, HGBEC ruptured and died. The levels of ALP (33.84 ± 6.00 vs 27.01 ± 4.67, P < 0.05), LDH (168.37 ± 20.84 vs 55.51 ± 17.17, P < 0.01) and GGT (42.01 ± 6.18 vs 25.34 ± 4.33, P < 0.01) significantly increased in the HGBEC culture supernatant in a time-and concentration-dependent. The damage to HGBEC in H pylori culture liquid was more significant than that in H pylori sonicated extracts. CONCLUSION: H pylori induces no obvious damage to HGBEC.

关键词： Alkaline phosphatase Glutamyltransferase Helicobacter pylori Human gallbladder epithelial cells Lactate dehydrogenase

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H pylori exist in the gallbladder mucosa of patients with chronic cholecystitis

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World Journal of Gastroenterology 2007年第10期13卷 1608-1611页

作者： Dong-Feng Chen Lu Hu ping yi wei-Wen Liu Dian-Chun Fang Hong Cao Department of Gastroenterology Daping HospitalThird Military Medical University Chongqing 400042 China

AIM:To study whether H pylori locate in the gallbladder mucosa of patients with chronic ***:Using Warthy-Starry(W-S)silver stain and immunohistochemistry stain with anti-H pylori antibodies,we screened paraffin specimens in 524 cases of cholecystitis.H pylori urease gene A(HPUA)and H pylori urease gene B(HPUB)were analyzed by polymerase chain reaction(PCR)in the fresh tissue specimens from 81 cases of ***:H pylori-like bacteria were found in 13.55% of the gallbladders of the cholecystitis patients using W-S ***,bacteria positive for H pylori antibodies were also found in 7.1% of the gallbladders of patients with cholecystitis by *** 81 gallbladders,11 were positive for both HPUA and HPUB,4 were positive for HPUA only and 7 were positive for HPUB ***:H pylori exist in the gallbladders of patients with chronic cholecystitis.

关键词： Hpylori Gallbladder mucosa Chronic cholecystitis Polymerase chain reaction Hpylori urease gene

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