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Zebrafish as a disease model for studying human hepatocellular carcinoma

World Journal of Gastroenterology 2015年第42期21卷 12042-12058页

作者： Jeng-Wei Lu yi-jung Ho yi-ju yang Heng-An Liao Shih-Ci Ciou Liang-In Lin Da-Liang Ou Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Institute of Preventive Medicine National Defense Medical Center Graduate Institute of Life Sciences National Defense Medical Center Institute of Biotechnology National Tsing Hua University Department of Laboratory Medicine National Taiwan University Hospital Graduate Institute of Oncology College of Medicine National Taiwan University

Liver cancer is one of the world's most common cancers and the second leading cause of cancer deaths. Hepatocellular carcinoma(HCC), a primary hepatic cancer, accounts for 90%-95% of liver cancer cases. The pathogenesis of HCC consists of a stepwise process of liver damage that extends over decades, due to hepatitis, fatty liver, fibrosis, and cirrhosis before developing fully into HCC. Multiple risk factors are highly correlated with HCC, including infection with the hepatitis B or C viruses, alcohol abuse, aflatoxin exposure, and metabolic diseases. Over the last decade, genetic alterations, which include the regulation of multiple oncogenes or tumor suppressor genes and the activation of tumorigenesis-related pathways, have also been identified as important factors in HCC. Recently, zebrafish have become an important living vertebrate model organism, especially for translational medical research. In studies focusing on the biology of cancer, carcinogen induced tumors in zebrafish were found to have many similarities to human tumors. Several zebrafish models have therefore been developed to provide insight into the pathogenesis of liver cancer and the related drug discovery and toxicology, and to enable the evaluation of novel smallmolecule inhibitors. This review will focus on illustrativeexamples involving the application of zebrafish models to the study of human liver disease and HCC, through transgenesis, genome editing technology, xenografts,drug discovery, and drug-induced toxic liver injury.

关键词： Cancer model Hepatocellular carcinoma Liver diseas

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Plateau Marsh Methane Oxidation as affected by Inorganic N

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Pedosphere 2004年第2期14卷 195-204页

作者： WANGZhi-Ping DUANyi yangju-Rong LILing-Hao HANXing-Guo LaboratoryofQuantitativeVegetationEcology InstituteofBotanyChineseAcademyofSciencesBeijing100093（China）／E-mail：wangzp5@*** StateKeyLaboratoryofGasGeochemistry LanzhouInstituteofGeology.ChineseAcademyofSciencesLanzhou730000（China） CollegeofResourceandEnvironment BEijingNormailUniversityBeijing100875（China）

In a series of laboratory incubations using soils of two contrasting sitesfrom a temperate marsh on the Qinghai-Tibet Plateau, potential methane (CH_4) oxidation rates weremeasured to study the effects of inorganic N inputs on CH_4 oxidation. For adrained site, subsurfacepeat (5--15 cm) at an initial 20 mu L CH_4 L^(-1) showed a significantly different (P ying mineral soil layers (15--30 and 30--50 cm) also had a strongCH_4 oxidation capacity at about an initial 2 000 mu L CH_4 L^(-1). With a waterlogged site, theCH_4 oxidation rate in an aerobic incubation was significantly greater (P < 0 05) in the surfacesoil layer (0--5 cm) compared to the 15--30 and 30--50 cm depths. There was generally no or a veryweak effect from addition of NO_3^- on CH_4 oxidation. In marked contrast, NH_4^+ salts, such as(NH_4)_2SO_4, NH_4Cl and NH_4NO_3, exhibited strong inhibitions, which varied as a function of theadded salts and the initial CH_4 level Increasing NH_4^+ usually resulted in greater inhibition andincreasing initial CH_4 concentrations resulted in less NH_4^+ inhibition on CH4 oxidation innatural high-altitude, low-latitude wetlands could be as important as has been reported foragricultural and forest soils. The NH_4^+ effects on the CH_4 oxidation rate need to be furtherinvestigated in a wide range of natural wetland soil types.

关键词： ammonium inhibition inorganic N methane oxidation plateau marsh

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DQ催化剂在连续法装置上制备的聚丙烯的结构和性能

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石油化工 2002年第4期31卷 259-261页

作者：夏先知杜宏斌王新生张天一杨菊秀李天益北京化工研究院北京100013

应用GPC、1 3CNMR、DSC等方法 ,对用DQ球形催化剂在环管连续法工艺聚丙烯生产装置上制备的几种典型牌号聚丙烯均聚物、无规共聚物、多相共聚物的结构进行了研究 ,并测定了树脂的物理机械性能。结果表明 ,3种类型的聚合物都具有较宽的相... 详细信息

应用GPC、1 3CNMR、DSC等方法 ,对用DQ球形催化剂在环管连续法工艺聚丙烯生产装置上制备的几种典型牌号聚丙烯均聚物、无规共聚物、多相共聚物的结构进行了研究 ,并测定了树脂的物理机械性能。结果表明 ,3种类型的聚合物都具有较宽的相对分子质量分布 (大于 6) ;无规共聚物中乙烯的质量分数达 4 0 5 % ,有利于制造用于包装的膜类产品 ;多相共聚物中的 [E]序列摩尔分数为 14 0 4% ;多相共聚物具有较好的物理机械性能 ,尤其具有较高的冲击强度 ,有利于加工制品耐冲击性能的提高。

关键词：连续法装置制备聚丙烯结构性能 DQ球形催化剂

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外给电子体对DQ催化剂聚合性能的影响

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石油化工 2003年第3期32卷 212-215页

作者：杜宏斌夏先知王新生张天一杨菊秀李天益北京化工研究院北京100013

研究了使用不同的外给电子体进行丙烯聚合时,DQ催化剂活性、氢调敏感性、立体定向性以及聚合物相对分子质量和相对分子质量分布的变化。结果表明,使用环己基-甲基-二甲氧基硅烷,聚合物的等规度可调性好;使用二环戊基-二甲氧基硅烷,DQ催... 详细信息

研究了使用不同的外给电子体进行丙烯聚合时,DQ催化剂活性、氢调敏感性、立体定向性以及聚合物相对分子质量和相对分子质量分布的变化。结果表明,使用环己基-甲基-二甲氧基硅烷,聚合物的等规度可调性好;使用二环戊基-二甲氧基硅烷,DQ催化剂活性更高,立体定向性更强;使用二异丁基-二甲氧基硅烷,DQ催化剂的氢调敏感性更好。

关键词：外给电子体 DQ催化剂聚合性能影响聚丙烯丙烯聚合

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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How moisture loss affects coal porosity and permeability during gas recovery in wet reservoirs?

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International Journal of Mining Science and Technology 2017年第6期27卷 899-906页

作者： Teng Teng Gao Feng ju yang Xue yi School of Mechanics and Civil Engineering China University of Mining and Technology Xuzhou 221116 China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology Xuzhou 221116 China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology at Beijing Beijing 100083 China

Moisture in coal seams changes gas adsorption capacity, induces coal deformation, and affects coal porosity. However, fewer studies have investigated the dynamic process of moisture loss. In this study, a fully coupled multi-physical model for coal deformation, gas flow and moisture loss was implemented. It validated the coal-gas-moisture interactions of the decay of gas adsorption capacity and the coal ***, the proposed model was applied to a simulation of coal seam gas recovery from wet reservoir and solved using the finite method in COMSOL Multiphysics 3.5. Analyses of the component factors and the sensitive parameters of moisture loss on coal porosity and permeability were comprehensively studied at last. The results reveal that moisture loss enhances coal porosity and permeability. The decay of gas adsorption capacity decreases coal permeability while the coal shrinkage promotes it. The decrease of the adsorption decay coefficient and the increase of the initial density of saturated water vapor and water evaporation constant can enhance the permeability of wet coal seams.

关键词： Coal seam gas Porosity and permeability Coal-gas-moisture interaction Moisture loss Numerical simulation

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Machine learning methods for predicting CO_(2) solubility in hydrocarbons

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Petroleum Science 2024年第5期21卷 3340-3349页

作者： yi yang Binshan ju Guangzhong Lü yingsong Huang School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of EducationBeijing100083China Key Laboratory of Geological Evaluation and Development Engineering of Unconventional Natural Gas Energy Beijing100083China Shengli Oilfield Company SINOPECDongying257015ShandongChina

The application of carbon dioxide(CO_(2)) in enhanced oil recovery(EOR) has increased significantly, in which CO_(2) solubility in oil is a key parameter in predicting CO_(2) flooding performance. Hydrocarbons are the major constituents of oil, thus the focus of this work lies in investigating the solubility of CO_(2) in hydrocarbons. However, current experimental measurements are time-consuming, and equations of state can be computationally complex. To address these challenges, we developed an artificial intelligence-based model to predict the solubility of CO_(2) in hydrocarbons under varying conditions of temperature, pressure, molecular weight, and density. Using experimental data from previous studies,we trained and predicted the solubility using four machine learning models: support vector regression(SVR), extreme gradient boosting(XGBoost), random forest(RF), and multilayer perceptron(MLP).Among four models, the XGBoost model has the best predictive performance, with an R^(2) of ***, sensitivity analysis and evaluation of the relative impacts of each input parameter indicate that the prediction of CO_(2) solubility in hydrocarbons is most sensitive to pressure. Furthermore, our trained model was compared with existing models, demonstrating higher accuracy and applicability of our model. The developed machine learning-based model provides a more efficient and accurate approach for predicting CO_(2) solubility in hydrocarbons, which may contribute to the advancement of CO_(2)-related applications in the petroleum industry.

关键词： CO_(2)solubility Machine learning Support vector regression Extreme gradient boosting Random forest Multi-layer perceptron

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高产α-葡萄糖苷酶黑曲霉的微波选育及发酵条件优化

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食品科学 2014年第15期35卷 145-150页

作者：易菊阳梁钰婷陆兵吴昊黄桂华陈桂光梁智群广西大学生命科学与技术学院亚热带农业资源保护与利用国家重点实验室广西南宁530004

采用微波诱变技术对黑曲霉J2进行选育,得到1株α-葡萄糖苷酶活力较高的突变菌株ANY-4,酶活力达到305 U/mL,比出发菌株提高了38.6%,且稳定性良好。通过单因素和正交试验得到最适培养条件为:玉米淀粉80 g/L、玉米浆干粉40 g/L、初始pH 4.... 详细信息

采用微波诱变技术对黑曲霉J2进行选育,得到1株α-葡萄糖苷酶活力较高的突变菌株ANY-4,酶活力达到305 U/mL,比出发菌株提高了38.6%,且稳定性良好。通过单因素和正交试验得到最适培养条件为:玉米淀粉80 g/L、玉米浆干粉40 g/L、初始pH 4.5、装液量50 mL/500 mL、接种量3%、培养温度36℃、摇床转速240 r/min、培养时间40 h。在最优培养条件下进行发酵,α-葡萄糖苷酶活力达到427 U/mL,比优化前提高了40%。

关键词： α-葡萄糖苷酶微波诱变黑曲霉发酵条件优化

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Targeting the mechano-microenvironment and liver cancer stem cells:a promising therapeutic strategy for liver cancer

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Cancer Biology & Medicine 2023年第11期20卷 816-829页

作者： Xiaorong Fu yi Zhang Qing Luo yang ju Guanbin Song School of Biology and Engineering Guizhou Medical UniversityGuiyang 550000China College of Bioengineering Chongqing UniversityChongqing 400030China Department of Mechanical Science and Engineering Nagoya University.Nagoya 4648603Japan

Over the past 2 decades,cancer stem cells(CSCs)have been identified as the root cause of cancer occurrence,progression,chemoradioresistance,recurrence,and *** CSCs is a novel therapeutic strategy for cancer management and *** cancer(LC)is a malignant disease that can endanger human *** are increasingly suggesting that changes in the liver mechanical microenvironment are a primary driver triggering the occurrence and development of liver *** this review,we summarize current understanding of the roles of the liver mechano-microenvironment and liver cancer stem cells(LCSCs)in liver cancer *** also discuss the relationship between the mechanical heterogeneity of liver cancer tissues and LCSC recruitment and ***,we highlight potential mechanosensitive molecules in LCSCs and mechanotherapy in liver *** the roles and regulatory mechanisms of the mechano-microenvironment and LCSCs may provide fundamental insights into liver cancer progression and aid in further development of novel therapeutic strategies.

关键词： Liver cancer mechano microenvironment cancer stem cells tumor heterogeneity mechanotherapy

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赤霉素联合层积法对石香薷种子发芽的影响

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贵州农业科学 2011年第4期39卷 78-80页

作者：钱凤明段林东王放银欧燕周树雄郑霞易菊阳湖南省邵阳学院湖南邵阳422000

为探索提高石香薷发芽率的方法,实现石香薷的大规模人工栽培,以新鲜的石香薷种子为试验材料,采用正交试验L9(34)研究赤霉素(GA3)浸种浓度、浸种时间、层积温度和层积基质对种子发芽的影响。结果表明:GA3浸种浓度对种子发芽影响最大,层... 详细信息

为探索提高石香薷发芽率的方法,实现石香薷的大规模人工栽培,以新鲜的石香薷种子为试验材料,采用正交试验L9(34)研究赤霉素(GA3)浸种浓度、浸种时间、层积温度和层积基质对种子发芽的影响。结果表明:GA3浸种浓度对种子发芽影响最大,层积温度次之,层积基质影响最小;并筛选出了各因素的最佳水平组合:GA3600.00 mg/L,浸种30 h,层积温度为变温(夜晚最低温16.2℃,白天最高温28℃),基质为河沙。对最佳因素组合进行验证表明,在最佳因素组合条件下,石香薷种子的发芽率达95.50%。

关键词：石香薷种子 GA3联合层积法发芽率

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