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Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian yifan Liu Guanghui Jin Ze Li Shujie Chen Xiaoshuang Dai Liujing Huang Zijing fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu jia Sun Jingxing Ou Hong Chen Liwei Xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Biliatresone:progress in biliary atresia study

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World Journal of Pediatrics 2023年第5期19卷 417-424页

作者： jia‑Jie Zhu yi‑fan Yang Rui Dong Shan Zheng Department of Pediatric Surgery Shanghai Key Laboratory of Birth Defectand Key Laboratory of Neonatal DiseaseMinistry of HealthChildren’s Hospital of Fudan University399 Wan Yuan RoadShanghai 201102China

Background Biliary atresia(BA)is one of the main causes of neonatal end-stage liver *** timely diagnosis and treatment,most children with BA will develop irreversible liver fibrosis within the first two *** current theorized causes of BA include viral infection,immune disorders,and genetic defects,the comprehensive etiology is still largely ***,biliatresone attracted much interest for its ability to induce BA in both zebrafish and mice,so we summarized the latest progress of biliatresone research in BA and tried to answer the question of whether it could provide further clues to the etiology of human *** sources We conducted a PubMed search for any published articles related to the topic using search terms including“biliary atresia”,“biliatresone”,“GSH”,and“HSP90”.Relevant data were extracted from the original text or supplementary materials of the corresponding *** Biliatresone had shown its unique toxicity in multiple species such as zebrafish and mice,and pathogenic factors involved included glutathione(GSH),heat shock protein 90(HSP90)and the related *** combination with epidemiological evidence and recent studies on the intestinal flora in biliary atresia,a new pathogenic hypothesis that the occurrence of biliary atresia is partly due to biliatresone or its structure-like compounds depositing in human body via vegetables or/and the altered intestinal flora structure can be tentatively *** Based on the existing evidence,we emphasized that GSH and HSP90 are involved in the development of BA,and the maternal diet,especially higher vegetable intake of Asian women of childbearing age,accompanied by the altered intestinal flora structure,may contribute to the occurrence of biliary atresia and the higher incidence in the Asia ***,the evidence from large sample epidemiological research is necessary.

关键词： Biliary atresia Biliatresone Glutathione Gut flora

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Synthesis of Conjugated Polymers Containing Diketopyrrolopyrrole(DPP)Building Block and the Photophysical Study

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Chinese Journal of Polymer Science 2019年第11期37卷 1092-1098页

作者： ying-Zhong Wu yi-Chen Zhang jia-Jun Chen Li-Juan fan Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University

Sonogashira coupling of two different diketopyrrolopyrrole (DPP)-containing dihaloarenes with the same aromatic bisalkyne resulted in two new conjugated polymers with the same backbone but different pendant groups on the DPP moiety. The polymers were found to have designed chemical structures via structural characterizations in comparison with three monomers. The molecular weight measurement further demonstrated the formation of polymers with polydispersity index around 2, consistent with the polycondensation nature of the polymerization based on Sonogashira coupling. Both polymers could dissolve in many organic solvents, and the one with long alkyl side group on DPP moiety had better solubility. Photophysical investigation showed that both polymers had typical absorption/emission of conjugated polymers, and varying the solvent did not have large influence. Compared with other polar solvents, toluene reduced the quantum yield of fluorescence of the polymers, especially for the one with long alkyl pedant group, accompanying with slight red-shift in absorption/emission. The difference in the absorption/emission wavelengths between the polymers was similar to that between the corresponding monomers. Adding water into the THF solution of polymers reduced the emission intensity but no redshift was observed. Discussion about the structure-property relationships was carried out in detail.

关键词： Conjugated polymer Diketopyrrolopyrrole Building block Sonogashira coupling Photophysics

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin yiming Qian jiashu Lian Xin Hua jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Effects of two silicone resin coatings on performance of FeSiAl magnetic powder cores

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Journal of Iron and Steel Research International 2024年第5期31卷 1279-1288页

作者： jia-qi Liu Zheng-qu Zhu Pu Wang yi-fan Li Jing Pang jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Qingdao Yunlu Advanced Materials Technology Co. Ltd.Qingdao266232ShandongChina

Two silicon resins with excellent thermal stability,JH1123 and JH7102,are used as the insulated agents and binders for the gas-atomized FeSiAl powder,and corresponding magnetic powder cores(MPCs)are *** insulation capability and application prospects of the two silicon resins are evaluated by comparing the magnetic properties of the coated powder and *** scanning electron microscopy,energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy results show that uniform insulation layers are both formed on the powder ***1123 has stronger binding ability,and the JH1123-coated powder exhibits severe agglomeration,with d50(average particle size)approximately twice that of the JH7102-coated *** as-prepared MPCs exhibit outstanding soft magnetic ***,the permeability of FeSiAl@JH1123 is up to 74.0,which is 35.5%higher than that of FeSiAl@JH7102 because JH1123 can further improve the density of the *** for FeSiAl@JH7102,it has better direct current bias and lower core loss of 716.9 mW cm^(−3) at 20 mT and 1000 kHz due to its lower coercivity and greater anti-magnetic saturation ability.A comprehensive comparison shows that FeSiAl@JH1123 is suitable for medium and high frequency applications,while FeSiAl@JH7102 is more suitable for high frequency *** indicates that the use of JH1123 and JH7102 silicon resins for binding and insulated coating not only simplifies the preparation process of MPCs,but also enables the controlled production of MPCs for different applications.

关键词： FeSiAl Insulated coating Magnetic powder core Permeability Core loss

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Automatically Identifying Calling-Prone Higher-Order Functions of Scala Programs to Assist Testers

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Journal of Computer Science & Technology 2020年第6期35卷 1278-1294页

作者： yi-Sen Xu Xiang-Yang jia fan Wu Lingbo Li Ji-Feng Xuan School of Computer Science Wuhan UniversityWuhan 430072China Turing Intelligence Technology Limited LondonEC2Y 9STU.K.

For the rapid development of internetware, functional programming languages, such as Haskell and Scala, can be used to implement complex domain-specific applications. In functional programming languages, a higher-order function is a function that takes functions as parameters or returns a function. Using higher-order functions in programs can increase the generality and reduce the redundancy of source code. To test a higher-order function, a tester needs to check the requirements and write another function as the test input. However, due to the complex structure of higher-order functions, testing higher-order functions is a time-consuming and labor-intensive task. Testers have to spend an amount of manual effort in testing all higher-order functions. Such testing is infeasible if the time budget is limited, such as a period before a project release. In practice, not every higher-order function is actually called. We refer to higher-order functions that are about to be called as calling-prone ones. Calling-prone higher-order functions should be tested first. In this paper, we propose an automatic approach, namely PHOF, which predicts whether a higher-order function of Scala programs will be called in the future, i.e., identifying calling-prone higher-order functions. Our approach can assist testers to reduce the number of higher-order functions of Scala programs under test. In PHOF, we extracted 24 features from source code and logs to train a predictive model based on known higher-order function calls. We empirically evaluated our approach on 4832 higher-order functions from 27 real-world Scala projects. Experimental results show that PHOF based on the random forest algorithm and the Synthetic Minority Oversampling Technique Processing strategy (SMOTE) performs well in the prediction of calls of higher-order functions. Our work can be used to support the scheduling of limited test resources.

关键词： higher-order function testing tool test management Scala program internetware

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焦家金矿田Ⅰ号主矿体地质特征及找矿方向

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地质与勘探 2018年第2期54卷 219-229页

作者：宋国政李山闫春明鲍中义范家盟刘彩杰刘国栋郭志峰山东省第六地质矿产勘查院山东烟台265400

以往对焦家金矿田主矿体研究都是按勘查区进行,具有一定局限性,不能完全揭示主矿体的地质特征。本文利用纱岭矿区、纱岭矿区前陈矿段在赋矿标高-2000m以浅的最新勘查成果,首次打破勘查区概念,将以往各勘查区主矿体凌乱编号统一划分、圈... 详细信息

以往对焦家金矿田主矿体研究都是按勘查区进行,具有一定局限性,不能完全揭示主矿体的地质特征。本文利用纱岭矿区、纱岭矿区前陈矿段在赋矿标高-2000m以浅的最新勘查成果,首次打破勘查区概念,将以往各勘查区主矿体凌乱编号统一划分、圈定,对主裂面下盘蚀变、矿化中心部位的碎裂岩及其内赋存的Ⅰ号主矿体地质特征进行重新梳理,系统总结、归纳。发现主断裂控制的含矿地质体产状从地表向深部明显变缓,蚀变带内碎裂岩厚度及矿体形态、规模、品位、厚度与断裂带角度有关。浅部倾角陡,矿体形态呈不规则脉状且分支较多、规模小;深部倾角缓,矿体形态呈似层状、大脉状,规模大。断裂带上盘无明显矿化,下盘以黄铁矿化为主,由内向外产出形态依次为细粒浸染状-浸染状、细脉状、短脉状-细脉、网脉、短脉状。通过总结成矿规律,预测焦家金矿田深部找矿方向主要集中在Ⅰ-3号主矿体深部及按侧伏方位预测深部金矿富集区内,集中在384线至480线,-2000m至-3000m标高之间,预测金资源量300t。

关键词：焦家金矿田地质特征找矿方向成矿规律金矿富集区

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退役锂离子电池正极材料有价金属回收研究进展

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现代化工 2025年第1期45卷 66-71页

作者：李子庆董琪黄奕陶义杰张家驿王启黄淮学院能源工程学院河南驻马店463000

针对LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)、LiFePO_(4)、LiMn_(2)O_(4)、LiCoO_(2)4大类锂离子电池正极材料中的目标金属的回收研究现状进行了详细阐述。首先是处理流程的难易程度直接关系到回收成本和效率;其次对不同回收工艺中目标金属的... 详细信息

针对LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)、LiFePO_(4)、LiMn_(2)O_(4)、LiCoO_(2)4大类锂离子电池正极材料中的目标金属的回收研究现状进行了详细阐述。首先是处理流程的难易程度直接关系到回收成本和效率;其次对不同回收工艺中目标金属的提取以及对环境的影响等进行了全面分析;最后对比了不同回收工艺的优缺点,发现每种工艺都有其独特的适用场景和局限性。未来要实现退役锂离子电池的高效、环保处理,需要整合各种工艺的优点,创新回收技术。

关键词：锂离子电池正极材料有价金属回收

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Core of the Reinsurance Market with Dependent Risks

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Journal of the Operations Research Society of China 2018年第1期6卷 49-57页

作者： jia-Hua Zhang Shu-Cherng fang yi-fan Xu School of Management Fudan UniversityShanghai 200433China Edward P.Fitts Department of Industrial and Systems Engineering North Carolina State UniversityRaleighNC 27695-7906USA

Baton and Lemaire(Astin Bull 12:57–71,1981)proved the nonemptiness of the core of a reinsurance market in which the risks of companies are ***,cases involving dependent risks have received increasing concerns in modern actuarial *** this paper,we investigate the nonemptiness of the core of a reinsurance market where the risks of different companies may be *** the exponential utility function is employed,we find an important property on risk premium and show that the core of the market is always nonempty.

关键词： Core Risk premium Reinsurance market Exponential utility Cooperative game

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Apoptosis induction with polo-like kinase-1 antisense phosph-orothioate oligodeoxynucleotide of colon cancer cell line SW480

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World Journal of Gastroenterology 2005年第29期11卷 4596-4599页

作者： Yu fan Shu Zheng Ze-Feng Xu jia-yi Ding Cancer Institute 2^nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To investigate the effects of polo-like kinase-1 （PLK1） antisense phosphorothioate oligodeoxynucleotide （ASODN） on apoptosis and cell cycle of human colon cancer cell line SW480. METHODS： After SW480 colon cancer cells were transfected with PLK1 ASODN, Northern and Western blot analyses were used to examine PLK1 gene expression in cancer cells. We studied apoptosis using terminal uridine deoxynucleotidyl nick end labeling. Apoptosis and cell cycle of SW480 cells were examined by fluorescence-activated cell sorter scan. RESULTS： The levels of PLK1 mRNA and protein were greatly inhibited by PLK1 ASODN in SW480 cancer cells transfected with PLK1 ASODN. Apoptosis index （AI） induced PLK1 ASODN in a time- and dose-dependent manner. Results from FLM showed that sub-2N DNA content of transfected cancer cells was significantly increased and arrested at G2/M compared with control groups. CONCLUSION： PLK1 ASODN can induce apoptosis of human colon cancer cell line SW480.

关键词： Polo-like kinase-1 Antisense Apoptosis Cell cycle

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