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Anti-hepatitis C virus therapy in chronic kidney disease patients improves long-term renal and patient survivals

World Journal of Clinical Cases 2019年第11期7卷 1270-1281页

作者： yi-chun chen chung-yi Li Shiang-Jiun Tsai Yen-chun chen Division of Nephrology Department of Internal Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi County 622 Taiwan School of Medicine Tzu Chi University Hualien 970 Taiwan Department and Graduate Institute of Public Health College of Medicine National Cheng Kung University Tainan 701 Taiwan Department of Public Health College of Public Health China Medical University Taichung 404 Taiwan Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi County 622 Taiwan Division of Hepato-Gastroenterology Department of Internal Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi County 622 Taiwan

BACKGROUND Hepatitis C virus (HCV) infection is a documented risk factor for chronic kidney disease (CKD) and progression to end-stage renal disease (ESRD). However, to date there are no reports on the long-term hard endpoints (ESRD and death) of anti-HCV therapy [interferon-based therapy (IBT) or new direct-acting antivirals] in CKD patients. Direct-acting antivirals are not available in Taiwan’s singlepayer national health insurance database currently released for research. Therefore, we hypothesized that a retrospective analysis of the long-term outcomes of IBT in CKD patients will serve as a proxy for direct-acting antivirals to increase our understanding of progression to ESRD following HCV infection. AIM To evaluate the long-term outcomes (ESRD and death) of anti-HCV therapy, especially IBT, in HCV-infected patients with stage 1-5 CKD. METHODS We analyzed 93894 Taiwan Residents adults diagnosed with CKD and without HBV infection. Of these, 4.9% were infected with HCV. Of the 4582 HCV-infected CKD patients, 482 (10.5%) received IBT (treated cohort). They were matched 1:4 with 1928 untreated HCV-infected CKD patients (untreated cohort) by propensity scores and year, which further matched 1:2 by propensity scores with 3856 CKD patients without HCV infection (uninfected cohort). All participants were followed until the occurrence of ESRD, death, or the end of 2012. The association between HCV infection, IBT use, and risks of ESRD and death was analyzed using competing risk analysis. RESULTS Taking the uninfected cohort as a reference, the adjusted hazard ratios for ESRD, after adjusting for competing mortality, were 0.34 (0.14-0.84, P = 0.019) and 1.28 (1.03-1.60, P = 0.029) in the treated and untreated cohorts, respectively. The treated cohort had a 29%(0.54-0.92, P = 0.011) decrease in mortality compared to the untreated cohort, in which the mortality was 31%(1.18-1.45, P < 0.001) higher than in the uninfected cohort. The reduced risks of ESRD (0.14, 0.03–0.58,

关键词： Hepatitis C virus Chronic kidney disease End-stage renal disease Antihepatitis C virus therapy Cohort study

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Nationwide cohort study suggests that nucleos(t)ide analogue therapy decreases dialysis risk in Taiwan Residents chronic kidney disease patients acquiring hepatitis B virus infection

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World Journal of Gastroenterology 2018年第8期24卷 917-928页

作者： yi-chun chen chung-yi Li Shiang-Jiun Tsai Yen-chun chen Department of Internal Medicine Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi County 622Taiwan School of Medicine Tzu Chi UniversityHualien 970Taiwan Department and Graduate Institute of Public Health College of MedicineNational Cheng Hung UniversityTainan 701Taiwan Department of Public Health College of Public HealthChina Medical UniversityTaichung 404Taiwan Department of Medical Research Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi County 622Taiwan Division of Hepato-Gastroenterology Department of Internal MedicineDalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi County 622Taiwan

AIM To investigate the risk of end-stage renal disease(ESRD) in hepatitis B virus(HBV)-infected patients with chronic kidney disease(CKD) with and without nucleos(t)ide analogue(NA) *** This nationwide cohort study included 103444 Taiwan Residents CKD adults without hepatitis C virus infection from the Taiwan Longitudinal Health Insurance Database 2005 between 1997 and 2012. We identified 2916 CKD patients who acquired HBV infection and did not receive NAs(untreated cohort), and they were propensitymatched 1:4 with 11664 uninfected counterparts. We also identified 442 CKD patients who acquired HBV infection and received NAs(treated cohort), and they were propensity-matched 1:3 with 1326 untreated counterparts. The association between HBV infection, NA use, and ESRD was analyzed using competing risk *** Multivariable Cox regression analysis showed a 1.67-fold higher risk(P < 0.0001) of ESRD in the untreated cohort(16-year cumulative incidence, 10.1%) than in the matched uninfected cohort(16-year cumulative incidence, 6.6%), which was independent of cirrhosis or diabetes. The treated cohort(16-year cumulative incidence, 2.2%) had an 87% lower ESRD risk(P < 0.0001) compared with the matched untreated cohort(16-year cumulative incidence, 11.9%). The number needed to treat for one fewer ESRD after NA use at 12 years was 12. Multivariable stratified analyses verified these associations in all *** This study suggests that untreated HBV infection and NA therapy are associated with increased and decreased risk of ESRD, respectively, in CKD patients. Identification of HBV status and targeted monitoring for ESRD development are important in CKD patients living in HBV-endemic areas.

关键词： hepatitis B virus chronic kidney disease end-stage renal disease nucleos(t)ide analogue cohort study

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Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity

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Chinese Journal of Chemistry 2005年第11期23卷 1523-1529页

作者： ZHANG, yi-chun chen, Ping-Tao GUAN, Hua-Shi LI, ying-Xia Key Laboratory of Marine Drugs The Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao Shandong 266003 China

A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.

关键词： antioxidant indomethacin antiinflammation conjugate nonsteroidal antiinflammatory drugs (NSAID)

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Crystallization Behavior of Biodegradable Poly(ethylene adipate) Modulated by a Benign Nucleating Agent： Zinc Phenylphosphonate

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Chinese Journal of Polymer Science 2017年第4期35卷 558-568页

作者： Rong Liang yi-chun chen chun-qiu Zhang Jing yin Xue-lei Liu Lu-kai Wang Rui Kong Xin Feng 杨进军 School of Environmental Science and Safety Engineering Tianjin University of Technology Tianjin 300384 China School of Mechanical Engineering Tianjin University of Technology Tianjin 300384 China

Zinc phenylphosphonate （PPZn）, a benign and biocompatible nucleating agent, was prepared and incorporated into the biodegradable poly（ethylene adipate）（PEA） to investigate its effect on the crystallization behavior, crystallization kinetics and spherulite morphology of PEA. Upon addition of PPZn, the crystallization temperature and crystallinity of PEA in the non-isothermal crystallization process increased significantly. Analysis of crystallization kinetics by Avrami equation suggests that the crystallization time shortened greatly and crystallization rate increased markedly after addition of PPZn. In the presence of PPZn, the spherulite size decreased and spherulite density increased significantly. It suggests that PPZn is an efficient nucleating agent for the crystallization of PEA. The accelerated crystallization in the presence of PPZn is mainly attributed to the epitaxial nucleation of PEA crystals on the surface of PPZn crystals, that is, a perfect lattice matching between PEA crystal and PPZn crystal occurs.

关键词： Crystallization kinetics Epitaxial growth Poly(ethylene adipate) Nucleating agent

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White Organic Light Emitting Devices Based on Multiple Emissive Nanolayers

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Nano-Micro Letters 2010年第4期2卷 242-246页

作者： M.V.Madhava Rao Yan Kuin Su T.S.Huang yi-chun chen Institute of Microelectronics Department of Electrical Engineeringand Advanced Optoelectronic Technology CenterNational Cheng Kung University

In this paper,a white organic light-emitting device(WOLEDs) with multiple-emissive-layer structure has been *** device has a simple structure of indium tin oxide(ITO)/NPB(20 nm)//DPVBi(20 nm)/CDBP:x Ir(btp)2acac(10 nm)/Alq3(25 nm)/BCP(5 nm)/Cs F(1 nm)/Al(150 nm)(x= 0.15,2.5 and 3.0 wt%),where NPB and BCP are used as the hole-injecting layer,electron transporting and hole blocking layer,*** light emission was realized in an OLED with 2.5% Ir(btp)2acac doping *** device exhibits peak efficiency of 1.93 cd/A at 9 V and maximum brightness of 7005 cd/m^2 at 14 *** Commission International de I'Eclairage(CIE)(1931) coordinates of white emission are well within the white zone,which moves from(0.35,0.33) to(0.26,0.30) when the applied voltage is varied from 5 V to 14 V.

关键词： Multilayer structure Organic light-emitting device White emission

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Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81

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World Journal of Gastroenterology 2009年第2期15卷 240-244页

作者： Zhan-Fei Tian Hong Shen Xi-Hua Fu yi-chun chen Hubert E Blum Thomas F Baumert Xi-Ping Zhao Department of Infectious Diseases 161 Hospital of PLA Wuhan 430030 Hubei Province China Department of Infectious Diseases Tongji Hospital Tongji Medical College Huazhong Science & Technology University Wuhan 430030 Hubei Province China Department of Medicine II University of Freiburg D-79106 Freiburg Germany Inserm U748 Universit6 Louis Pasteur Service d'Hepatogastroenterologie 3 Rue Koeberle F-67000 Strasbourg France

AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs.

关键词： Hepatitis C virus E2 protein Tupaia CD81,Bind Enzyme-linked immunosorbent assay

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Regulating metal-acid double site balance on mesoporous SiO2-Al2O3 composite oxide for supercritical n-decane cracking

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Petroleum Science 2024年第4期21卷 2881-2891页

作者： Liu-Ling chen Jun Zhang chun-Guang Li Li-Qun Fei Bo Wang chen-Qi Zhang yi Jiao Jian-Li Wang Institute of New Energy and Low-Carbon Technology Sichuan University Engineering Research Center of Combustion and Cooling for Aerospace Power Ministry of Education School of Chemical Engineering Sichuan University State Key Laboratory of Industrial Vent Gas Reuse Southwest Institute of Chemical Co. Ltd Science and Technology on Scramjet Laboratory Beijing Power Machinery Research Institute

The balance between metal and acid sites directly affects the preparation of high-performance cracking catalysts with high heat sink and low ***,how to control acid-metal sites balance and its relationship with cracking performance are reported *** this work,a series of Pt/Al2O3-SiO2dual sites catalysts with different metal to acid active sites ratio(CM/CSA) were constructed by ethanolassisted impregnation method and the impact on n-decane cracking under supercritical conditions was systematically and deeply *** results showed that the conversion and carbon deposition increased gradually with varied CM/CSAand reached the balance at CM/CSAof *** proper ratio CM/CSA（0.13） can balance the deep dehydrogenation coking over metal active sites and high heat sink of cracking over acid active sites,the chemical heat sink reaches amazing 1.75 MJ/kg and carbon deposition is only22.03 mg/cm2at 750℃.Meanwhile,the few metal sites at low CM/CSAand the few strong acid sites at high CM/CSAare the main factors limiting the cracking *** CM/CSAlimit the activation of C-H bond and deep dehydrogenation of coking precursor,resulting in relative low cracking activity and carbon deposition,while high CM/CSAlimit the activation of C-C bond and increase the deep *** this contribution,design and construction of metal-acid dual sites can not only provide the technical solution for the preparation of high heat sink and low coking cracking catalyst,but also deepen the understanding of the cracking path of hydrocarbon fuel.

关键词： Metal-acid dual sites balance Catalytic cracking Hydrocarbon fuels Chemical heat sink Carbon deposition

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Eigenstate properties of the disordered Bose-Hubbard chain

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Frontiers of physics 2024年第4期19卷 57-72页

作者： Jie chen chun chen Xiaoqun Wang Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Physics Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Many-body localization(MBL)of a disordered interacting boson system in one dimension is studied numerically at the filling faction *** von Neumann entanglement entropy Svn is commonly used to detect the MBL phase transition but remains challenging to be directly *** on the U(1)symmetry from the particle number conservation,Svn can be decomposed into the particle number entropy S_(n) and the configuration entropy *** light of the tendency that the eigenstate's S_(c) nears zero in the localized phase,we introduce a quantity describing the deviation of S from the ideal thermalization distribution;finite-size scaling analysis illustrates that it shares the same phase transition point with Sv but displays the better critical *** observation hints that the phase transition to MBL might largely be determined by S and its fluctuations Notably,the recent experiments[***,et al.,Science 364,256(2019);***,et al.,***.19,481(2023)]demonstrated that this deviation can potentially be measured through the Sn ***,our investigations reveal that the thermalized states primarily occupy the low-energy section of the spectrum,as indicated by measures of localization length,gap ratio,and energy density *** low-energy spectrum of the Bose model closely resembles the entire spectrum of the Fermi(or spin XXZ)model,accommodating a transition from the thermalized to the localized ***,owing to the bosonic statistics,the high-energy spectrum of the model allows the formation of distinct clusters of bosons in the random potential *** analyze the resulting eigenstate properties and briefly summarize the associated *** distinguish between the phase regions at the low and high energies,a probing quantity based on the structure of S_(VN) is also *** work highlights the importance of symmetry combined with entanglement in the study of *** this regard,for the disordered Heisenberg XXZ

关键词： entanglement entropy decomposition U(1)symmetry thermalization-to-localization transition

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A homopolymolybdate-supported plate-like 2D cobalt network constructed from a new pyrazole-amide-pyridyl ligand: highly electrochemical activity in both capacitive performance and the detection of Cr(Ⅵ)

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Tungsten 2024年第2期6卷 422-427页

作者： Xiu-Li Wang Yong-Zhen chen Zhi-Han Chang Yu-chun Lin Jing-yi Ma College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[N,N'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new homopolymolybdate-based two-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed between the 2D metal–organic networks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 F·g^(−1)(current density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)with low detection limit(0.042μmol·L^(−1))and high *** insertion ofβ-Mo_(8)anions between the unique 2D metal−organic networks improves the active area of polyoxometalates,which further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic network Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

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Clinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events:a narrative review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 583-595页

作者： chun-Li chen yi-Zhe cheng Zhi-Han Zhang Ge Wang Xiao-Yan Peng Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Ophthalmology and Visual Science Key Laboratory Beijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510600Guangdong ProvinceChina

●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field *** previous studies have explained the possible pathogenesis and clinical features of primary ***,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special *** associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular *** related retinal injury is laser photocoagulation,surgery,and *** primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and ***,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with *** possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s *** MEWDS-related features in secondary MEWDS are still evanescent under most *** prognosis and treatment depend on the severity of *** studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal *** pathogenic studies should be conducted in the *** diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.

关键词： multiple evanescent white dot syndrome punctate inner choroidopathy multifocal choroiditis secondary multiple evanescent white dot syndrome

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