检索结果-南通市图书馆

Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition,cytotoxicity,inflammation and lung fibrosis

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第12期29卷 100-114页

作者： Yunan Chen yi Yang Bolong Xu Shunhao Wang Bin Li Juan Ma Jie Gao yi Y.zuo Sijin Liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Mechanical Engineering University of Hawaii at ManoaHonoluluHI 96822USA Beijing Key Laboratory of Bioprocess Beijing Advanced Innovation Center for Soft Matter Science Engineering Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China

Environmental exposure and health risk upon engineered nanomaterials are increasingly concerned. The family of mesoporous carbon nanomaterials（MCNs） is a rising star in nanotechnology for multidisciplinary research with versatile applications in electronics,energy and gas storage, and biomedicine. Meanwhile, there is mounting concern on their environmental health risks due to the growing production and usage of MCNs. The lung is the primary site for particle invasion under environmental exposure to nanomaterials. Here, we studied the comprehensive toxicological profile of MCNs in the lung under the scenario of moderate environmental exposure. It was found that at a low concentration of 10 μg/mL MCNs induced biophysical inhibition of natural pulmonary surfactant. Moreover, MCNs at similar concentrations reduced viability of J774 A.1 macrophages and lung epithelial A549 *** with nature pulmonary surfactant effectively reduced the cytotoxicity of *** the pro-inflammatory responses, MCNs activated macrophages in vitro, and stimulated lung inflammation in mice after inhalation exposure, associated with lung ***, we found that the size of MCNs played a significant role in regulating cytotoxicity and pro-inflammatory potential of this nanomaterial. In general, larger MCNs induced more pronounced cytotoxic and pro-inflammatory effects than their smaller counterparts. Our results provided valuable information on the toxicological profile and environmental health risks of MCNs, and suggested that fine-tuning the size of MCNs could be a practical precautionary design strategy to increase safety and biocompatibility of this nanomaterial.

关键词： Mesoporous carbon nanomaterials Environmental exposure Pulmonary surfactant Inflammation Fibrosis

Anesthetic management of a child with double outlet right ventricle and severe polycythemia: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第11期9卷 2634-2640页

作者： Ling-Can Tan Wei-yi Zhang yi-Ding zuo Hong-Yang Chen Chun-Ling Jiang Department of Anesthesiology West China HospitalSichuan University and The Research Units of West China(2018RU012)Chinese Academy of Medical SciencesChengdu 610041Sichuan ProvinceChina

BACKGROUND Double outlet right ventricle(DORV)is a rare and complex congenital heart defect,and the surgical repairs vary with type and pathophysiology *** to prolonged progressive hypoxemia,severe polycythemia is common in patients with DORV,which ultimately leads to coagulation dysfunction and increases the risk of thrombosis and ***,the anesthetic management is challenging and how to manage severe polycythemia and avoid hypoxia-related complications in such patients is of great *** SUMMARY Herein,we report the anesthetic management of a 10-year-old female patient with a *** lived in the low-oxygen Qinghai-Tibet Plateau,and presented with severe polycythemia(hemoglobin,24.8 g/dL;hematocrit,75%).She underwent a modified Fontan surgery,which was satisfactory and without any perioperative *** anesthetic management highlights the importance of perioperative hemodilution in decreasing the risk of thromboembolism and the importance of correcting coagulopathy in preventing *** Anesthetic management is challenging in rare cyanotic congenital heart disease patients with severe *** is important to adopt perioperative hemodilution and correction of coagulopathy in preventing thrombosis and hemorrhage.

关键词： Cyanotic congenital heart diseases Double outlet right ventricle Modified Fontan surgery Anesthesia Erythrocytosis Case report

Electrospinning/3D printing-integrated porous scaffold guides oral tissue regeneration in beagles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第6期7卷 1000-1017页

作者： Li Yuan Chen Yuan Jiawei Wei Shue Jin yi zuo Yubao Li Xinjie Liang Jidong Li Research Center for Nano-Biomaterials Analytical and Testing CenterSichuan UniversityChengdu 610064China ZXTGY(Jiangsu)Technology Co. Ltd.Suzhou 215400China

The combined use of guided tissue/bone regeneration(GTR/GBR)membranes and bone filling grafts represents a classical therapy for guiding the regeneration and functional reconstruction of oral soft and hard ***,due to its displacement and poor mechanical support,bone meal is not suitable for implantation in the case of insufficient cortical bone support and large dimensional *** combination of GTR/GBR membrane with a three-dimensional(3D)porous scaffold may offer a resolution for the repair and functional reconstruction of large soft and hard tissue *** this study,a novel integrated gradient biodegradable porous scaffold was prepared by bonding a poly(lactic-co-glycolic acid)(PLGA)/fish collagen(FC)electrospun membrane(PFC)to a 3D-printed PLGA/nano-hydroxyapatite(HA)(PHA)*** consistency of the composition(PLGA)ensured strong interfacial bonding between the upper fibrous membrane and the lower 3D *** vitro cell experiments showed that the PFC membrane(upper layer)effectively prevented the unwanted migration of L929 *** in vivo investigations with an oral soft and hard tissue defect model in beagles revealed that the integrated scaffold effectively guided the regeneration of defective oral *** results suggest that the designed integrated scaffold has great potential for guiding the regeneration and reconstruction of large oral soft and hard tissues.

关键词： Electrospinning 3D printing Gradient porous scaffold Oral tissue regeneration

Target tracking method of Siamese networks based on the broad learning system

在线全文

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2023年第3期8卷 1043-1057页

作者： Dan Zhang C.L.Philip Chen Tieshan Li yi zuo Nguyen Quang Duy Navigation College Dalian Maritime UniversityDalianChina Innovation and Entrepreneurship Education College Dalian Minzu UniversityDalianChina Computer Science and Engineering College South China University of TechnologyGuangzhouChina Department of Computer and Information Science Faculty of Science and TechnologyUniversity of MacaoMacaoChina School of Automation Engineering University of Electronic Science and Technology of ChinaChengduChina Faculty of Navigation Vietnam Maritime UniversityHaiphongVietnam

Target tracking has a wide range of applications in intelligent transportation,real‐time monitoring,human‐computer interaction and other ***,in the tracking process,the target is prone to deformation,occlusion,loss,scale variation,background clutter,illumination variation,etc.,which bring great challenges to realize accurate and real‐time *** based on Siamese networks promotes the application of deep learning in the field of target tracking,ensuring both accuracy and real‐time ***,due to its offline training,it is difficult to deal with the fast motion,serious occlusion,loss and deformation of the target during ***,it is very helpful to improve the performance of the Siamese networks by learning new features of the target quickly and updating the target position in time *** broad learning system(BLS)has a simple network structure,high learning efficiency,and strong feature learning *** at the problems of Siamese networks and the characteristics of BLS,a target tracking method based on BLS is *** method combines offline training with fast online learning of new features,which not only adopts the powerful feature representation ability of deep learning,but also skillfully uses the BLS for re‐learning and re‐*** broad re‐learning information is used for re‐detection when the target tracking appears serious occlusion and so on,so as to change the selection of the Siamese networks search area,solve the problem that the search range cannot meet the fast motion of the target,and improve the *** results show that the proposed method achieves good results on three challenging datasets and improves the performance of the basic algorithm in difficult scenarios.

关键词： broad learning system siamese network target tracking

Endophytic Colletotrichum species from Bletilla ochracea (Orchidaceae), with descriptions of seven new speices

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fungal Diversity 2013年第4期61卷 139-164页

作者： Gang Tao zuo-yi Liu Fang Liu Ya-Hui Gao Lei Cai State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Guizhou Institute of Plant Protection Guiyang 550006People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guiyang 550006People’s Republic of China

Thirty-six strains of endophytic Colletotrichum species were isolated from leaves of Bletilla ochracea Schltr.(Orchidaceae)collected from 5 sites in Guizhou,*** different species,including 7 new species(namely ***,***,***,***,***-altitudum and *** and ***),8 previously described species(***,***,***,***,***,***,*** and ***)and 2 sterile mycelia were *** of the taxa were identified based on morphology and phylogeny inferred from multi-locus sequences,including the nuclear ribosomal internal transcribed spacer(ITS)region,partial genes ofβ-tubulin(TUB2),actin(ACT)and glyceraldehyde-3-phosphate dehydrogenase(GAPDH).Comprehensive morphological descriptions and illustrations are provided for new *** investigation indicates a high diversity of Colletotrichum species in ***.

关键词： Fungal diversity Phylogeny Systematics Taxonomy

Analysis of insecticide thiacloprid by ion chromatography combined with online photochemical derivatisation and fluorescence detection in water samples

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2014年第3期25卷 415-418页

作者： Qamar Subhani Zhong-Ping Huang zuo-yi Zhu Lu-Ye Liu Yan Zhu Department of Chemistry Xixi CampusZhejiang University Thermofisher Scientific

This study describes a novel application of ion chromatography coupled with post-column photochemically induced fluorimetry derivatisation in alkaline medium and fluorescence detection （IC-hv-FD） for the determination of neonicotinoid pesticide, thiacloprid. In an aqueous medium, this compound showed fluorescence with an excitation maximum at 236 nm and an emission maximum at 353 nm. The 10 mmol/L NaOH with 10% （v/v） acetonitrile solution pumped at flow rate of 1.0 mL/min was used for the chromatographic elution to isocratically separate thiacloprid on an Ion Pac~＇ AS 11 （250 mm x 4 mm i.d; 13 p^m particle size, Dionex） anion-exchange column. The linear concentration range of application was 0.04-10.0 mg]L, with a relative standard deviation （RSD, n = 7） of 1.7% （for a level of 2.0 mg/L） and detection limit （LOD, SiN = 3） of 9.9 p^g]L. The procedure was applied with satisfactory results to the analysis of thiacloprid in ground and lake water samples. Pesticide average spiked recoveries ran^ed between 95.5% and 114.0%.

关键词： ThiaclopridPhotochemical derivatisationFluorescenceIon chromatography

Optical and Electric and Structural Properties of Ti_(1-x)Al_(x)N Thin Films

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 1998年第7期15卷 533-534页

作者： LI zuo-yi XIONG Rui YANG Xiao-fei HU zuo-qi XU ying LIN Geng-qi LU Zhi-hong Department of Solid State Electronics Huazhong University of Science and TechnologyWuhan 430074 Shanghai Institute of Metallugy Chinese Academy of SciencesShanghai 200050

A sequence of Ti_(1-x)Al_(x)N films has been prepared by rf reactive magnetron *** optical and electric properties versus aluminum content x have been *** suitable for magneto-optic protective layers have been achieved in Ti_(1-x)Al_(x) N thin films with aluminum content x>0.75.X-ray diffraction results show that Ti_(1-x)Al_(x) N thin films in this study are a bcc structure up to x=0.75,further increase in the aluminum content gives a wurtzite *** of the results show that the optical and electric properties of Ti_(1-x)Al_(x) N films might be related to the crystal structure.

关键词： structure films

Prediction calculations for the first criticality of the HTR-PM using the PANGU code

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第9期32卷 9-15页

作者： Ding She Bing Xia Jiong Guo Chun-Lin Wei Jian Zhang Fu Li Lei Shi zuo-yi Zhang Institute of Nuclear and New Energy Technology(INET) Tsinghua UniversityBeijing 100084China

The high-temperature reactor pebble-bed mod-ule(HTR-PM)is a modular high-temperature gas-cooled reactor demonstration power *** first criticality experiment is scheduled for the latter half of *** performing the first criticality experiment,a prediction calculation was performed using PANGU *** paper presents the calculation details for predicting the HTR-PM first criticality using PANGU,including the input model and parameters,numerical results,and uncertainty *** accuracy of the PANGU code was demonstrated by comparing it with the high-fidelity Monte Carlo solution,using the same input *** should be noted that k eff can be significantly affected by uncertainties in nuclear data and certain input parameters,making the criticality calculation ***,the PANGU is used to pre-dict the critical loading height of the HTR-PM first criti-cality under design conditions,which will be evaluated in the upcoming experiment later this year.

关键词： HTR-PM First criticality Prediction PANGU

Effect of Antibacterial Enoxacin on the Properties of Injectable Nano-hydroxyapatite/Polyurethane Cement for Bone Repairing

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2022年第2期19卷 483-496页

作者： Jinzheng Zhang Xiaoyu Lei Jiajing Tang Jie Chen Qing Zhao Wei Fang yinglong Zhang Yubao Li yi zuo Research Center for Nano-Biomaterials Analytical and Testing CenterSichuan UniversityChengdu 610064People’s Republic of China

Biomaterial-associated infection(BAI)is a kind of serious post-operative complication in orthopaedic ***-loaded bone cement shines a light on BAI prevention for convenient manipulation and complex *** this aim,we designed an antibacterial bone cement based on Nano-hydroxyapatite/Polyurethane(PUHA)loading with antibiotic Enoxacin(EN).The distinct shear-thinning behavior of the prepolymers was observed,indicating a good *** PUHA bone cement possessed a suitable curing speed,and the addition of EN might slightly expedite the curing process and enhance the mechanical *** EN release profile indicated that the EN-loaded bone cement could reach the minimum inhibitory concentration in 2 h,and sustainedly released EN for almost 8 days,exhibiting an antibacterial delivery *** test further confirmed the antibacterial ability of EN-loaded bone cement is in a dose-dependent ***,the osteogenic performance of drug-loaded bone cement with high dosage is not as good as antibacterial *** the EN concentration of antibacterial cement was lower than 32μg·mL^(-1),the proliferation and osteogenic differentiation of rat mesenchymal stem cells could be significantly ***,this study verified the potential of the EN-loaded PUHA bone cement in anti-infection and osteogenesis for bone repairing.

关键词： Antibacterial bone cement Nano-hydroxyapatite/polyurethane Enoxacin Shear-thinning behavior Osteogenesis