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Scleral TGF-β1 and Smad3 expression is altered by TCM Bu Jing yi shi Tablets in guinea pigs with form-deprivation myopia

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Journal of Traditional Chinese Medical Sciences 2016年第2期3卷 124-132页

作者： Ya Mo yi Wang Bin Cao Jiajia Zhang Guoting Ren Ting Yang Department of Ophthalmology The Affiliated Hospital of Chengdu University of TCMChengdu 610072China Department of Pathology The Affiliated Hospital of Chengdu University of TCMChengdu 610072China

Objective:To explore whether the traditional Chinese medicine(TCM)Bu Jing yi shi Tablets alters the expression of scleral TGF-b1 and Smad3 in guinea pigs with formdeprivation myopia(FDM).Methods:Sixty-five guinea pigs were randomly divided into control,model,low-,medium-,and high-dose treatment *** for the control group,FDM was induced by covering the right eye of each animal with opaque *** treatment groups were gavaged with different suspension concentrations of Bu Jing yi shi *** and axial length were performed before and after myopia *** the end of the experiment,all right eyes were extracted,and scleral sections were prepared for staining and TGF-b1 and Smad3 *** thickness and area,the scleral fibroblast quantity,and scleral TGFb1 and Smad3 expressions were ***:The 5 FDM groups had the same initial axial length and diopter,the final diopter and axial length of the model group were significantly increased compared with the control group and treatment groups(P<.01).The axial length of each treatment group decreased as the dose decreased compared with the model group(P<.01);the total scleral area(P<.05 e.01)and the number of scleral fibroblasts(P<.01)in the model group were significantly lower than the treatment *** the TGF-b1 and Smad3 integral optical densities in the model group were significantly lower than the control and medium-and high-dose treatment groups(P<.01).TGF-b1 and Smad3 mRNAs in the model group were decreased compared with the control group,but increased in expression after treatment.

关键词： TCM Form-deprivation myopia Sclera TGF-b1 Smad3

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About the Energy of the Universe

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Chinese Physics Letters 1996年第6期13卷 409-411页

作者： FENG shi-xiang DUAN yi-shi Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 Institute of Theoretical Physics Lanzhou UniversityLanzhou 730000

We use the general covariant conservation law of energy-momentum,which is general covariant and therefore preferable to the non-covariant conservation laws,to analyse the energy of the universe and obtained vanishing ... 详细信息

关键词： energy vanishing discussions

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Global Classical Solutions to the Equations of Two-dimensional MHD Transverse Flow

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Acta Mathematica Sinica,English Series 2006年第5期22卷 1371-1384页

作者： yi Peng shi State Key Laboratory for Turbulence and Complex System Peking University Beijing 100871 P. R. China

A new method for constructing the symmetric form for the hyperbolic systems is introduced. Then a new symmetric form of the equations of MHD transverse flow is constructed by adding an additional equation. With this new form, we obtain the local existence of smooth solution including the case that the initial density may tend to the vacuum state at infinity. Furthermore, the uniformly a priori estimation for the classical solutions is established and the global smooth solutions for a kind of initial data are obtained.

关键词： MHD transverse flow global classical solution

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利伐沙班在犬和猫临床应用的研究进展

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动物医学进展 2025年第1期46卷 97-102页

作者：王炜江蓝路心怡付诗懿刘亦婷韦力煣俞峰刘波中国农业大学动物医学院北京100193 中国农业大学教学动物医院北京100193

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够... 详细信息

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够特异性抑制活性凝血因子X从而抑制血栓形成。近年来人医领域对利伐沙班的相关临床研究逐渐丰富,涉及单用利伐沙班或使用双通路抑制疗法防治不同类型的动、静脉血栓栓塞,可为其应用于兽医临床提供据。犬、猫临床使用利伐沙班的研究正相继开展,论文就犬、猫血栓栓塞疾病发病情况、防治现状,利伐沙班的药理学特性及其在人医、兽医领域的临床试验研究进展进行综述,以期为兽医临床上利伐沙班的进一步研究提供参考。

关键词：新型口服抗凝药利伐沙班血栓栓塞犬猫

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New Virus,New Challenge

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The Innovation 2020年第1期1卷 110-112页

作者： yi shi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina

The ongoing COVID-19 pandemic has made us to consider the emergence of potential viral diseases in the *** can carry vast and diverse virus species,most of which we do not understand yet,and the spillover events of the viruses from the unknown pool in animals to human population always occurred in the *** effectively prevent and control the emerging viral diseases,we should make efforts to explore the unknown virus species in nature and prepare in advance.

关键词： diseases carry diverse

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Topological Structure of Phase Vortex in Resonating Valence Bond Superconductivity

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Communications in Theoretical Physics 2006年第1X期46卷 33-36页

作者： shi Xu-Guang DUAN yi-shi College of Basic Science and Technology Beijing Forestry University Beijing 100083 China Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

In this paper, based on the Schrfdinger equation and the ψ mapping theory, the accurate expression for the gradient of resonating valence bond superconducting phase Θ^2s is found. The expression of Δ↓Θ^2s is just the velocity flow without considering the coefficient. The curl of Δ↓Θ^2s is where the vortex lies, and has important relation to δ2（ψ） and an important relation to the zero points of resonating valence bond superconducting order parameter ψ. The topological structure of the vortex is characterized by the ψ-mapping topological numbers Hopf-index and Brouwer degrees. The Ginzberg-Landau equation in resonating valence bond state also is discussed in this theory. The magnetic property is discussed also.

关键词： ψ-mapping theory phase vortex GL-equation RVB superconductivity

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Effects of rafting on the meso deformation and fracture behaviour of a Ni-based single crystal superalloy at room temperature: In-situ observation and simulation

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Science China(Technological Sciences) 2024年第7期67卷 2133-2146页

作者： TAN Long YANG XiaoGuang shi DuoQi FAN YongSheng shi yi School of Energy and Power Engineering Beihang UniversityBeijing 102206China Research Institute of Aero-Engine Beihang UniversityBeijing 102206China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 102206China School of Materials Science&Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Microstructural rafting of Ni-based single-crystal(SC) superalloys is inevitable at elevated temperatures during long-term service with mechanical loading, which significantly affects the mechanical behaviour of the material. In this study, the effects of rafting on the mesodeformation and fracture behaviour of a Ni-based SC superalloy under cyclic and tensile loads were investigated using in situ scanning electron microscopy(SEM), digital image correlation(DIC), and crystal plasticity finite element method(CP-FEM) simulations. The results indicated that the tensile strength decreased significantly in the rafted specimens. In the cyclic tests, both the virgin and rafted specimens showed an increase in the maximum shear strain with cycle number. The interaction of cross-slip bands was captured by in situ SEM-DIC around the micro-notch of the virgin specimens during the tensile test, while a more homogeneous local deformation field was observed in the rafting specimens. In addition,the fracture behaviour was strongly influenced by the rafting morphology. The crack exhibited instantaneous and long-range fracture features along the octahedral plane as it propagated in the rafting specimen, whereas it deflected over a short distance between the crystallographic planes at an early stage in the virgin specimen, which is consistent with the CP-FEM ***, the CP-FEM results for the crack initiation direction on(111) dominant slip plane were consistent with the in situ SEM observations.

关键词： in-situ SEM-DIC Ni-based SC superalloys microstructural rafting deformation crack path CP-FEM

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On the density of Birkhoff sums for Anosov diffeomorphisms

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Science China Mathematics 2022年第2期65卷 319-330页

作者： Shaobo Gan yi shi Mingyang Xia School of Mathematical Sciences Peking UniversityBeijing 100871China

Let f : M → M be an Anosov diffeomorphism on a nilmanifold. We consider Birkhoff sums for a Holder continuous observation along periodic orbits. We show that if there are two Birkhoff sums distributed at both sides o... 详细信息

关键词： Anosov diffeomorphism Birkhoff sum periodic point nilmanifold

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Prescribed fast tracking control for flexible air-breathing hypersonic vehicles:An event-triggered case

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Chinese Journal of Aeronautics 2021年第11期34卷 200-215页

作者： Xingling SHAO yi shi Wendong ZHANG Jiang ZHAO The Key Laboratory of Instrumentation Science&Dynamic Measurement Ministry of EducationNorth University of ChinaTaiyuan 030051China School of Instrument and Electronics North University of ChinaTaiyuan 030051China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China

In this paper,a prescribed fast tracking control scheme is proposed for Flexible Airbreathing Hypersonic Vehicles(FAHV)subject to lumped disturbances and limited *** maintain tracking errors of velocity and altitude converge to a predefined region with a prescribed time and release the transient intense fluctuations encountered in classical Prescribed Performance Control(PPC)using a fast decaying rate,a tracking differentiator-based PPC is presented,where the reaching time and the maximum time differentiation of preselected envelopes can be regulated as a prior via fixing an acceleration factor,so that a guaranteed fast convergence speed can be realized with reduced ***,to avoid the excessive occupation of limited resources(energy and communication)and guarantee a remarkable tracking accuracy,switching event-triggered mechanisms are constructed for FAHV control realization,which provide a promising way to pursue a desired level of tracking performance with a low energy ***,Uncertainty and Disturbance Estimators(UDE)and Sigmoid function-based Tracking Differentiators(STD)are employed to provide disturbance estimation and reference derivation with a low computational ***,robust control laws are designed to compensate for the sampling error induced by event-triggered conditions,meanwhile Zeno phenomena can be effectively *** simulation results and comparisons validate the effectiveness of the proposed scheme.

关键词： Flexible air-breathing hypersonic vehicle Prescribed performance control Switching event-triggered Tracking differentiator Uncertainty and disturbance estimator

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AlN precipitation during steel solidification using CA model

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Journal of Iron and Steel Research International 2022年第11期29卷 1789-1799页

作者： Lei Cui yi-han shi Xiang-ning Meng Key Laboratory for Ecological Metallurgy of Multi-Metallic Ores Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

Based on the principles of metal solidification and cellular automaton(CA),as well as AlN precipitation thermodynamics and kinetics,a CA model of interdendritic AlN precipitation was established by coupling a large-size mesh describing the dendrite growth of Fe-C-Al-N alloys and a small-size mesh representing AlN precipitation based on transient chemical *** results of single dendrite growth stimulated by this model were compared with the Lipton-Glicksman-Kurz solution to verify the correctness of the matrix dendrite growth *** AlN morphology and dimensions obtained from the CA model simulations are following the experimental *** presence of equiaxed dendrite in the computational domain results in a significant coarsening of the columnar dendrite and a uniform solute distribution around them,and the AlN solid phase fraction *** of AlN precipitation at different wetting angles were also performed,and it was found that the solid phase fraction of AlN decreased with the increase in wetting ***,it is confirmed that the established model is an effective method to simulate interdendritic AlN precipitation.

关键词： Metal solidification Cellular automaton Wetting angle AlN precipitation Dendrite growth

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