Diffractive liquid-crystal optics is a promising optical element for virtual reality(VR)and mixed reality as it provides an ultrathin formfactor and lightweight for human factors and ***,its severe chromatic aberratio...
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Diffractive liquid-crystal optics is a promising optical element for virtual reality(VR)and mixed reality as it provides an ultrathin formfactor and lightweight for human factors and ***,its severe chromatic aberrations impose a big challenge for full-color display *** this study,we demonstrate an achromatic diffractive liquid-crystal device to overcome this longstanding chromatic aberration *** proposed device consists of three stacked diffractive liquid crystal optical elements with specifically designed spectral response and polarization *** concept is validated by both simulations and *** experimental results show a significant improvement in imaging performance with two types of light engines:a laser projector and an organic light-emitting diode display *** addition,our simulation results indicate that the lateral color shift is reduced by~100 times in comparison with conventional broadband diffractive liquid-crystal *** applications for VR-enabled metaverse,spatial computing,and digital twins that have found widespread applications in smart tourism,smart education,smart healthcare,smart manufacturing,and smart construction are foreseeable.
Aggression is vital for animal survival and evolution,but excessive aggression should be suppressed for the sake of individual energy expenditure and social *** level is inluenced by environment,social experience and ...
Aggression is vital for animal survival and evolution,but excessive aggression should be suppressed for the sake of individual energy expenditure and social *** level is inluenced by environment,social experience and internal *** melanogaster provides an ideal genetic system to understand the molecular and neuronal basis of diferent aspects of ***
In this letter,the Ti-doped NbO_(x)-based selector is applied to SiNOx-based resistive random-access memory(RRAM),forming Pt/NbOx(Ti-doped)/SiNO_(x)/Ti one selector-one RRAM device(1S1R),to suppress the sneak path ***...
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In this letter,the Ti-doped NbO_(x)-based selector is applied to SiNOx-based resistive random-access memory(RRAM),forming Pt/NbOx(Ti-doped)/SiNO_(x)/Ti one selector-one RRAM device(1S1R),to suppress the sneak path *** fabricated 1S1R exhibits stable direct current(DC)endurance(>200 cycles),suitable memory window(>40),matched selectivity(>40)and high uniformity of switching parameters.
Objective:Metabolic disorders are regarded as hallmarks of multiple myeloma(MM)and are responsible for rapid cancer cell proliferation and tumor ***,the exact biological roles of metabolites in MM cells have not been ...
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Objective:Metabolic disorders are regarded as hallmarks of multiple myeloma(MM)and are responsible for rapid cancer cell proliferation and tumor ***,the exact biological roles of metabolites in MM cells have not been fully *** study aimed to explore the feasibility and clinical significance of lactate for MM and investigate the molecular mechanism of lactic acid(Lac)in the proliferation of myeloma cells and cell sensitivity to bortezomib(BTZ).Methods:Metabolomic analysis of the serum was carried out to obtain metabolites expression and clinical characteristics in MM *** CCK8 assay and flow cytometry were used to detect cell proliferation,apoptosis,and cell cycle *** blotting was used to detect the potential mechanism and apoptosis-and cycle-related protein ***:Lactate was highly expressed in both the peripheral blood and bone marrow of MM *** was significantly correlated with Durie-Salmon Staging(DS Staging)and the International Staging System(ISS Staging)and the serum and urinary involved/uninvolved free light chain *** with relatively high lactate levels had a poor treatment ***,in vitro experiments showed that Lac could promote the proliferation of tumor cells and decrease the proportion of G0/G1-phase cells,which was accompanied by an increased proportion of S-phase *** addition,Lac could decrease tumor sensitivity to BTZ by disrupting the expression of nuclear factor kappa B subunit 2(NFκB2)and ***:Metabolic changes are important in MM cell proliferation and treatment response;lactate could be used as a biomarker in MM and as a therapeutic target to overcome cell resistance to BTZ.
In response to the current energy and environmental challenges,reducing or replacing reliance on fossil fuels and striving for carbon neutrality seems to be the only viable ***,a cutting-edge,eco-friendly method of ch...
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In response to the current energy and environmental challenges,reducing or replacing reliance on fossil fuels and striving for carbon neutrality seems to be the only viable ***,a cutting-edge,eco-friendly method of chemical synthesis via transient Joule heating(JH)demonstrated significant promise across various domains,including methane reforming,ammonia synthesis,volatile organic compounds removal,plastic recycling,the synthesis of functional carbon materials from repurposed solid waste,*** this review,the advantages,and latest developments in thermochemical synthesis by flash and transient JH are comprehensively *** the ongoing heating process of conventional furnaces that consume fossil fuels,dynamic and transient JH can get significantly higher reaction rates,energy efficiency,flexibility,and ***,the transient reaction mechanism,data science optimization,and scale-up production models are discussed,and prospects for the integration of the electrified chemical industry with renewable energy for carbon neutrality and long-term energy storage are also envisioned.
Sarl is a small GTPase involved in COPⅡ vesicle transport. Previous studies showed that H79G mutation of Sarl can lock Sarl in its GTP-bound active conformation, stabilize coat assembly, and prevent the disassembly o...
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Sarl is a small GTPase involved in COPⅡ vesicle transport. Previous studies showed that H79G mutation of Sarl can lock Sarl in its GTP-bound active conformation, stabilize coat assembly, and prevent the disassembly of COP Ⅱ vesicle coats by reducing Sec23/24 GAP- stimulated hydrolysis. We show here that the replacement of His79 by glycine induces a large conformation change in switch Ⅱ and results in the lost of hydrogen bond between His79 and its associated nucleophilic water molecule that was hypothesized to reduce the GAP-stimulated hydrolysis during the COP Ⅱ assembly and disassembly. These results confirm that the switch Ⅱ conformation is important for COP Ⅱ disassembly through coat-controlled GTP hydrolysis.
Liquid phase epitaxy (LPE) is a mature technology. Early experiments on single magnetic crystal films fabricated by LPE were focused mainly on thick films for microwave and magneto-optical devices. The LPE is an exc...
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Liquid phase epitaxy (LPE) is a mature technology. Early experiments on single magnetic crystal films fabricated by LPE were focused mainly on thick films for microwave and magneto-optical devices. The LPE is an excellent way to make a thick film, low damping magnetic garnet film and high-quality magneto-optical material. Today, the principal challenge in the applied material is to create sub-micrometer devices by using modern photolithography technique. Until now the magnetic garnet films fabricated by LPE still show the best quality even on a nanoscale (about 100 nm), which was considered to be impossible for LPE method.
BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently *** To develop an integrin αvβ3-targeted molecular im...
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BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently *** To develop an integrin αvβ3-targeted molecular imaging modality to differentiate *** Integrinαvβ3 expression was assessed in Human LO2 hepatocytes Scultured with palmitic and oleic acids(FFA).Hepatic integrinαvβ3 expression was analyzed in rabbits fed a high-fat diet(HFD)and in rats fed a high-fat,high-carbohydrate diet(HFCD).After synthesis,cyclic arginine-glycine-aspartic acid peptide(cRGD)was labeled with gadolinium(Gd)and used as a contrast agent in magnetic resonance imaging(MRI)performed on mice fed with *** Integrin αvβ3 was markedly expressed on FFA-cultured hepatocytes,unlike the control *** integrin αvβ3 expression significantly increased in both HFD-fed rabbits and HFCD-fed rats as simple fatty liver(FL)progressed to *** distribution of integrinαvβ3 in the liver of NASH cases largely overlapped with albumin-positive staining *** comparison to mice with simple FL,the relative liver MRI-T1 signal value at 60 minutes post-injection of Gd-labeled cRGD was significantly increased in mice with steatohepatitis(P<0.05),showing a positive correlation with the NAFLD activity score(r=0.945;P<0.01).Hepatic integrin αvβ3 expression was significantly upregulated during NASH development,with hepatocytes being the primary cells expressing integrin αvβ*** After using Gd-labeled cRGD as a tracer,NASH was successfully distinguished by visualizing hepatic integrin αvβ3 expression with MRI.
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