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The neuronal basis of how sexual experience modulates male aggression

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National Science Review 2014年第4期1卷 473-474页

作者： Xinhua Liang yi rao Chuan Zhou School of Life Sciences Peking University

Aggression is vital for animal survival and evolution,but excessive aggression should be suppressed for the sake of individual energy expenditure and social *** level is inluenced by environment,social experience and internal *** melanogaster provides an ideal genetic system to understand the molecular and neuronal basis of diferent aspects of ***

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High uniformity and stability of 1S1R directly stacked for high-density cross-point memory applications

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Rare Metals 2022年第11期41卷 3671-3676页

作者： Zhi-ying Yu Jia-yi Zhao Guo-Kun Ma Ao Chen Da-Lei Chen yi-Heng rao Hao Wang Hubei Yangtze Memory Laboratories Wuhan430205China School of Microelectronic Hubei UniversityWuhan430062China School of Physics and Technology Wuhan UniversityWuhan430072China

In this letter,the Ti-doped NbO_(x)-based selector is applied to SiNOx-based resistive random-access memory(RRAM),forming Pt/NbOx(Ti-doped)/SiNO_(x)/Ti one selector-one RRAM device(1S1R),to suppress the sneak path *** fabricated 1S1R exhibits stable direct current(DC)endurance(>200 cycles),suitable memory window(>40),matched selectivity(>40)and high uniformity of switching parameters.

关键词： Ti stability high

Lactate Decreases Bortezomib Sensitivity and Predicts Poor Clinical Outcomes of Multiple Myeloma

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Current Medical Science 2023年第4期43卷 679-688页

作者： Na-ya MA Qiong LI Xin-lei LI Yun-jing ZENG De-zhi HUANG yi-shuo DUAN Jing XIA Bang-dong LIU Ling-yi rao Jun rao Xi ZHANG Medical Center of Hematology Xinqiao HospitalArmy Medical UniversityChongqing 400037China State Key Laboratory of Trauma Burns and Combined InjuryArmy Medical UniversityChongqing 400037China National Clinical Research Center for Hematologic Diseases First Affiliated Hospital of Soochow UniversitySoochow 215031China

Objective:Metabolic disorders are regarded as hallmarks of multiple myeloma(MM)and are responsible for rapid cancer cell proliferation and tumor ***,the exact biological roles of metabolites in MM cells have not been fully *** study aimed to explore the feasibility and clinical significance of lactate for MM and investigate the molecular mechanism of lactic acid(Lac)in the proliferation of myeloma cells and cell sensitivity to bortezomib(BTZ).Methods:Metabolomic analysis of the serum was carried out to obtain metabolites expression and clinical characteristics in MM *** CCK8 assay and flow cytometry were used to detect cell proliferation,apoptosis,and cell cycle *** blotting was used to detect the potential mechanism and apoptosis-and cycle-related protein ***:Lactate was highly expressed in both the peripheral blood and bone marrow of MM *** was significantly correlated with Durie-Salmon Staging(DS Staging)and the International Staging System(ISS Staging)and the serum and urinary involved/uninvolved free light chain *** with relatively high lactate levels had a poor treatment ***,in vitro experiments showed that Lac could promote the proliferation of tumor cells and decrease the proportion of G0/G1-phase cells,which was accompanied by an increased proportion of S-phase *** addition,Lac could decrease tumor sensitivity to BTZ by disrupting the expression of nuclear factor kappa B subunit 2(NFκB2)and ***:Metabolic changes are important in MM cell proliferation and treatment response;lactate could be used as a biomarker in MM and as a therapeutic target to overcome cell resistance to BTZ.

关键词： lactate biomarker multiple myeloma bortezomib NF-kappa B pathway

Highly efficient chemicalproductionviaelectrified,transient high-temperature synthesis

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eScience 2024年第4期4卷 41-53页

作者： yichen Dong yi rao Hanwen Liu Hao Zhang Rong Hu yingquan Chen Yonggang Yao Haiping Yang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In response to the current energy and environmental challenges,reducing or replacing reliance on fossil fuels and striving for carbon neutrality seems to be the only viable ***,a cutting-edge,eco-friendly method of chemical synthesis via transient Joule heating(JH)demonstrated significant promise across various domains,including methane reforming,ammonia synthesis,volatile organic compounds removal,plastic recycling,the synthesis of functional carbon materials from repurposed solid waste,*** this review,the advantages,and latest developments in thermochemical synthesis by flash and transient JH are comprehensively *** the ongoing heating process of conventional furnaces that consume fossil fuels,dynamic and transient JH can get significantly higher reaction rates,energy efficiency,flexibility,and ***,the transient reaction mechanism,data science optimization,and scale-up production models are discussed,and prospects for the integration of the electrified chemical industry with renewable energy for carbon neutrality and long-term energy storage are also envisioned.

关键词： Electrified chemicalsynthesis Transient heating Low-carbon production Gas-phasereaction Solid waste

Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP Ⅱ

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Chinese Journal of Structural Chemistry 2006年第7期25卷 854-860页

作者： rao yi-Jian YUAN Cai BIAN Chuan-Bing HOU Xiao-Min LI Yong-Dong ZHAO Geng-Xiang YE Xiao-Ming HUANG Zi-Xiang HUANG Ming-Dong State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

Sarl is a small GTPase involved in COPⅡ vesicle transport. Previous studies showed that H79G mutation of Sarl can lock Sarl in its GTP-bound active conformation, stabilize coat assembly, and prevent the disassembly of COP Ⅱ vesicle coats by reducing Sec23/24 GAP- stimulated hydrolysis. We show here that the replacement of His79 by glycine induces a large conformation change in switch Ⅱ and results in the lost of hydrogen bond between His79 and its associated nucleophilic water molecule that was hypothesized to reduce the GAP-stimulated hydrolysis during the COP Ⅱ assembly and disassembly. These results confirm that the switch Ⅱ conformation is important for COP Ⅱ disassembly through coat-controlled GTP hydrolysis.

关键词： Sarl switch Ⅱ COP Ⅱ disassembly crystal structure

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互惠利他理论的社会蕴意研究

广东社会科学 2010年第2期 60-66页

作者：饶异仲恺农业工程学院人文社科系

特里弗斯提出互惠利他理论之后,艾克斯罗德和汉密尔顿合作运用博弈论研究了策略在合作进化过程中的性质,指出利益部分冲突时个体采取合作而不是背叛的策略是有机体竞争中的制胜之策,从而进一步发展了互惠利他理论。该理论的实质内涵是... 详细信息

特里弗斯提出互惠利他理论之后,艾克斯罗德和汉密尔顿合作运用博弈论研究了策略在合作进化过程中的性质,指出利益部分冲突时个体采取合作而不是背叛的策略是有机体竞争中的制胜之策,从而进一步发展了互惠利他理论。该理论的实质内涵是基于回报的合作。这一理论有力地解释了政治和经济现象,为促进社会的合作和发展提供了重要的启示。

关键词：互惠利他理论企业盈利国际合作

Liquid phase epitaxy magnetic garnet films and their applications

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Chinese Physics B 2018年第8期27卷 62-71页

作者： yi-Heng rao Huai-Wu Zhang Qing-Hui Yang Dai-Nan Zhang LI-Chuan Jln Bo Ma Yu-Juan Wu University of Electronic Science and Technology of China Chengdu 610054China University of Delaware NewarkDE 19716USA

Liquid phase epitaxy （LPE） is a mature technology. Early experiments on single magnetic crystal films fabricated by LPE were focused mainly on thick films for microwave and magneto-optical devices. The LPE is an excellent way to make a thick film, low damping magnetic garnet film and high-quality magneto-optical material. Today, the principal challenge in the applied material is to create sub-micrometer devices by using modern photolithography technique. Until now the magnetic garnet films fabricated by LPE still show the best quality even on a nanoscale （about 100 nm）, which was considered to be impossible for LPE method.

关键词： liquid phase epitaxy (LPE) magnetic garnet magneto-optical spintronics magnonics

Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrin αvβ3 expression with a targeted molecular imaging modality

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World Journal of Hepatology 2024年第11期16卷 1290-1305页

作者： Xiao-Quan Huang Ling Wu Chun-Yan Xue Chen-yi rao Qing-Qing Fang ying Chen Cao Xie Sheng-Xiang rao Shi-Yao Chen Feng Li Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology Minhang HospitalFudan UniversityShanghai 201100China Department of Pharmacy Fudan UniversityShanghai 200032China Department of Radiology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently *** To develop an integrin αvβ3-targeted molecular imaging modality to differentiate *** Integrinαvβ3 expression was assessed in Human LO2 hepatocytes Scultured with palmitic and oleic acids(FFA).Hepatic integrinαvβ3 expression was analyzed in rabbits fed a high-fat diet(HFD)and in rats fed a high-fat,high-carbohydrate diet(HFCD).After synthesis,cyclic arginine-glycine-aspartic acid peptide(cRGD)was labeled with gadolinium(Gd)and used as a contrast agent in magnetic resonance imaging(MRI)performed on mice fed with *** Integrin αvβ3 was markedly expressed on FFA-cultured hepatocytes,unlike the control *** integrin αvβ3 expression significantly increased in both HFD-fed rabbits and HFCD-fed rats as simple fatty liver(FL)progressed to *** distribution of integrinαvβ3 in the liver of NASH cases largely overlapped with albumin-positive staining *** comparison to mice with simple FL,the relative liver MRI-T1 signal value at 60 minutes post-injection of Gd-labeled cRGD was significantly increased in mice with steatohepatitis(P<0.05),showing a positive correlation with the NAFLD activity score(r=0.945;P<0.01).Hepatic integrin αvβ3 expression was significantly upregulated during NASH development,with hepatocytes being the primary cells expressing integrin αvβ*** After using Gd-labeled cRGD as a tracer,NASH was successfully distinguished by visualizing hepatic integrin αvβ3 expression with MRI.

关键词： Non-alcoholic steatohepatitis Cyclic peptides Magnetic resonance imaging Non-invasive diagnosis Hepatic integrinαvβ3

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神经细胞迁移导向的分子机制

生理科学进展 2000年第3期31卷 198-204页

作者：饶毅吴瑛美国华盛顿大学解剖和神经生物学系儿科系及分子生物学和药理学系中国科学院神经科学研究所

自 1 9世纪以来的研究表明 ,在胚胎发育期间和出生后 ,包括人在内的哺乳动物神经系统的大部分神经细胞 (也许是所有神经细胞 )都要经过一定距离的迁移运动才能抵达它们发挥功能的部位。这些细胞如何知道往哪个方向迁移呢 ?我们在分子水... 详细信息

自 1 9世纪以来的研究表明 ,在胚胎发育期间和出生后 ,包括人在内的哺乳动物神经系统的大部分神经细胞 (也许是所有神经细胞 )都要经过一定距离的迁移运动才能抵达它们发挥功能的部位。这些细胞如何知道往哪个方向迁移呢 ?我们在分子水平对这个问题进行了研究。 1 999年发表的结果给出这样一个答案 :脑内存在导向性分子 ,可以指导神经细胞的迁移方向 ;具体的发现是 ,一个叫Slit的分泌性蛋白质 ,对神经细胞有排斥性作用 ,它的浓度梯度指导神经细胞迁移的方向。

关键词：细胞迁移分子浓度梯度哺乳动物神经细胞 Slit