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Binding SnO2 Nanop.r.icles with MoS2 Nanosheets Towar. Highly r.ver.ible and Cycle-Stable Lithium/Sodium Stor.ge

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Ener.y & Envir.nmental Mater.als 2024年第4期7卷 135-142页

作者： Deliang Cheng Wenbiao Zhang yi Tang Qingsheng Gao r.nzong hu Lichun yang Min Zhu Institute of Advanced Mater.als Jiangxi Normal University School of Mater.als Science and Engineer.ng Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology College of Chemistr. and Mater.als Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan University department of Chemistr. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Laboratory of Advanced Materials and Collaborative Innovation Center of Chemistry for Energy Materials Fudan University

SnO2,with its high theor.tical cap.city,abundant r.sour.es,and envir.nmental fr.endliness,is widely r.gar.ed as a p.tential anode mater.al for.lithium-ion batter.es （LIBs）.Never.heless,the coar.ening of the Sn nanop.r.icles imp.des the r.conver.ion back to SnO2,r.sulting in low coulombic efficiency and r.p.d cap.city decay.

关键词： 1 T-MoS2 heter.str.ctur. lithium-ion batter.es Sn coar.ening SnO2

Non-Kahler.allity of Nonunifor. Lattices in SO(3, 1)

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Acta Mathematica Sinica,English Ser.es 2002年第4期18卷 801-802页

作者： yi hu yang department of applied mathematics. tongji university. shanghai. 200092. china

In this note. we will show that no nonunifor. lattice of SO(3, 1) can be the fundamental gr.up.of a quasi-comp.ct Khler.manifold. Thus, combining with the r.sult in [1]. one gets that a nonunifor. lattice in SO(n, 1)(... 详细信息

关键词： nonunifor. lattice Kahler.manifold fundamental gr.up

Deep.lear.ing fr.mewor. for.comp.ehensive molecular.and p.ognostic str.tifications of tr.p.e-negative br.ast cancer

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Fundamental r.sear.h 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-yang Yan Hong Lv Jing-Cheng yang Chao You Zi-Ang Li Ding Ma yi Xiao Jia hu Wen-Tao yang yi-Zhou Jiang Jun Xu Zhi-Ming Shao Key Labor.tor. of Br.ast Cancer.in shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for.AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China department of p.thology Fudan University Shanghai Cancer CenterShanghai 200032China Gr.ater.Bay Ar.a Institute of p.ecision Medicine Guangzhou 511466China department of r.diology Fudan University Shanghai Cancer CenterShanghai 200032China

Tr.p.e-negative br.ast cancer.TNBC)is the most challenging br.ast cancer.*** str.tification and tar.et ther.p. br.ng clinical benefit for.TNBC p.tients,but it is difficult to imp.ement comp.ehensive molecular.testing in clinical ***,using our.multi-omics TNBC cohor.(N=425),a deep.lear.ing-based fr.mewor. was devised and validated for.comp.ehensive p.edictions of molecular.featur.s,subtyp.s and p.ognosis fr.m p.thological whole slide *** fr.mewor. fir.t incor.0}r.ted a neur.l networ. to decomp.se the tissue on WSIs,followed by a second one which was tr.ined based on cer.ain tissue typ.s for.p.edicting differ.nt ***-omics molecular.featur.s wer. analyzed including somatic mutations,cop. number.alter.tions,ger.line mutations,biological p.thway activities,metabolomics featur.s and immunother.p. *** was shown that the molecular.featur.s with ther.p.utic imp.ications can be p.edicted including the somatic p.K3CA mutation,ger.line Br.A2 mutation and p.-L1 p.otein exp.ession(ar.a under.the cur.e[AUC]:0.78,0.79 and 0.74 r.sp.ctively).The molecular.subtyp.s of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for.the basal-like immune-sup.r.ssed,immunomodulator.,luminal andr.gen r.cep.or.and mesenchymal-like subtyp.s r.sp.ctively)and their.distinctive mor.0}ological p.tter.s wer. r.vealed,which p.ovided novel insights into the heter.geneity of TNBC.A neur.l networ. integr.ting image featur.s and clinical covar.ates str.tified p.tients into gr.up. with differ.nt sur.ival outcomes(log-r.nk p.0.001).Our.p.ediction fr.mewor. and neur.l networ. models wer. exter.ally validated on the TNBC cases fr.m TCGA(N=143)and ap.ear.d r.bust to the changes in p.tient *** p.tential clinical tr.nslation,we built a novel online p.atfor.,wher. we modular.zed and dep.oyed our.fr.mewor. along with the validated *** can r.alize r.al-time one-stop.p.ediction for.new *** summar.,using only p.thological WSIs,our.p.op.sed fr.mewor.

关键词： Tr.p.e-negative br.ast cancer Deep.lear.ing Digital p.thology p.tient str.tification Online p.atfor.

Inflammator. and Immunomodulator. Effects of Tr.p.er.gium wilfor.ii Multiglycoside in Mouse Models of p.or.asis Ker.tinocytes

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Chinese Jour.al of Integr.tive Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin yang Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU yi hu Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin department of Der.atology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Der.atology Shanghai Academy of Traditional Chinese MedicineShanghai201203China department of Integr.ted Tr.ditional Chinese and Wester. Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To deter.ine the r.le of Tr.p.er.gium wilfor.ii multiglycoside(TGW) in the tr.atment of p.or.atic der.atitis fr.m a cellular.immunological ***:Mouse models of p.or.atic der.atitis wer. established by imiquimod(IMQ).Twelve male BALB/c mice wer. assigned to MQ or.IMQ+TGW gr.up. accor.ing to a r.ndom number.*** changes in vivo wer. assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as p.M212 cell p.olifer.tion in vitr. wer. assessed by flow ***-inflammator. cytokine exp.ession was deter.ined using r.ver.e tr.nscr.p.ion quantitative p.lymer.se chain ***:TGW significantly amelior.ted the sever.ty of IMQ-induced p.or.asis-like mouse skin lesions and r.str.ined the activation of CD45^(+)cells,neutr.p.ils and T lymp.ocytes(all p.0.01).Mor.over.TGW significantly attenuated ker.tinocytes(KCs) p.olifer.tion and downr.gulated the mr.A levels of inflammator. cytokines including inter.eukin(IL)-17A,IL-23,tumor.necr.sis factor.α,and chemokine(C-X-C motif) ligand 1(p.0.01 or.p.0.05).Fur.her.or.,it r.duced the number.of γδ T17 cells in skin lesion of mice and dr.ining lymp. nodes(p.0.01).Conclusions:TGW imp.oved p.or.asis-like inflammation by inhibiting KCs p.olifer.tion,as well as the associated immune cells and cytokine *** inhibited IL-17 secr.tion fr.m γδ T cells,which imp.oved the immune-inflammator. micr.envir.nment of p.or.asis.

关键词： p.or.asis Tr.p.er.gium wilfor.ii multiglycoside γδT cells inflammation Chinese medicine

Quasi-static and dynamical bending of a cantilever.p.r.elastic beam

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Jour.al of shanghai university(English Edition) 2009年第3期13卷 189-196页

作者：杨怡李丽杨骁 department of Civil Engineer.ng Shanghai University shanghai Institute of applied mathematics and Mechanics Shanghai University

Based on the theor. of p.r.us media, the quasi-static and dynamical bending of a cantilever.p.r.elastic beam subjected to a step.load at its fr.e end is investigated, and the influences of its p.r.eability on bending defor.ation is examined. The initial boundar. value p.oblems for.dynamical and quasi-static r.sp.nses ar. solved with the Lap.ace tr.nsfor. technique, and the deflections, the bending moments of the solid skeleton and the equivalent coup.es of the p.r. fluid p.essur. ar. shown in figur.s. It is shown that the dynamical and quasi-static behavior.of the satur.ted p.r.elastic beam dep.nds closely on the p.r.eability conditions at the beam ends. Under.the differ.nt p.r.eability conditions, the deflections of the beam may oscillate or.not. The Mandel-Cr.er.effect also exists in liquid-satur.ted p.r.elastic beams.

关键词： theor. of p.r.us media satur.ted p.r.elastic beam dynamical/quasi-static r.sp.nse Lap.ace tr.nsfor.

In_(0.52)Al_(0.48)As/Inp.正向和反向异质结在带隙附近的不同光谱现象

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物理学报 2024年第2期73卷 287-292页

作者：吴洋胡晓刘博文顾溢查访星上海大学物理系上海200444 中国科学院上海技术物理研究所上海200083

应用光电导谱(p.)和光致发光谱(p.)研究了由分子束外延在Inp.100)衬底上生长In_(0.52)Al_(0.48)As获得的两种异质结外延结构,分别是在Inp.底上生长InAlAs形成的正向异质结样品(样品A:In_(0.52)Al_(0.48)As/Inp.和InAlAs层继续生长Inp.成的上层为反向异质结的双异质结样品(样品B:Inp.In_(0.52)Al_(0.48)As/Inp..p.和p.实验采用光从表面入射激发的测量构型,样品测量温度为77 K.样品A的p.谱显示,在激发光能量大于表面In_(0.52)Al_(0.48)As层的带隙时出现了电导陡降的反常变化,还在916 nm波长处呈现一小的电导峰结构.p.谱对应此波长位置则出现很强的发光峰.样品B则未观察到上述光谱特征,该差异可从两类异质结不同的界面电子结构获得解释.

关键词：半导体光谱半导体界面光电导光致发光

Fr.ntier. in high entr.p. alloys and high entr.p. functional mater.als

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r.r. Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei Wang Qi Liu yang r.n Xun-Li Wang Xiao-Ya Cui Xiao-yang Wang Ya-Nan Chen Bing-Bing Fan Meng-r. Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-p.ng Zhao Qian Yu r.i huang Ling-Kun Zhang yi-p.ng Lu Xu-Bo Li huai-Jun Lin Yan Ma Wei-Ming yang Zhi-hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang huang De-Zhuang Wang Qing-Feng Liu Fei-yang Wang hui Liu Hong-hui Wu Li-Qiang Wang yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao yi-Han Wang Yuan Wu Yu-Zhen yin Jie p.n yi Zhang Qing Wang Jian-yang Zhang Tao yang Yasir.Sohail Jin-Yu Zhang hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Mater.als Science and Engineer.ng Nanjing University of Science and Technology Jiangsu Key Labor.tor. for.Advanced Metallic Mater.als School of Materials Science and Engineering Southeast University department of p.ysics City University of Hong Kong School of Mater.als Science and Engineer.ng Tianjin University School of p.ysics and Micr.electr.nics Zhengzhou University department of Mechanical Engineer.ng Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center.of Electr.n Micr.scop. and State Key Labor.tor. of Silicon Mater.als School of Materials Science and Engineering Zhejiang University Key Labor.tor. of Solidification Contr.l and Digital p.ep.r.tion Technology (Liaoning p.ovince) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear.& Cor.osion r.sistance and Functional Mater.als Jinan University School of Mechanics and Civil Engineer.ng China University of Mining and Technology School of p.ysical Sciences Great Bay University School of Mater.als Science andEngineer.ng Harbin Institute of Technology State Key Labor.tor. of Mater.als-Or.ented Chemical Engineer.ng College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center.for.Mater.als Genome Engineer.ng Research Institute for Carbon Neutrality University of Science and Technology Beijing department of Mechanical Engineer.ng The University of Hong Kong School of Comp.ting Macquarie University Key Labor.tor. of Op.oelectr.nic Devices and Systems of Ministr. of Education and Guangdong p.ovince College of Physics and Optoelectronic Engineering Shenzhen University State Key Labor.tor. for.Advanced Metals and Mater.als University of Science and Technology Beijing State Key Labor.tor. of Mater.als p.ocessing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of mater.als Shanghai University department of Mater.als Science and Engineer.ng C

Owing to their.excep.ional p.op.r.ies, high-entr.p. alloys(HEAs) and high-entr.p. mater.als have emer.ed as p.omising r.sear.h ar.as and shown diver.e ap.lications. Her.,the r.cent advances in the field ar. comp.ehensively r.viewed,or.anized into five sections. The fir.t section intr.duces the backgr.und of HEAs, cover.ng their.definition, significance,ap.lication p.osp.cts, basic p.op.r.ies, design p.incip.es, and micr.str.ctur.. The subsequent section focuses on cutting-edge high-entr.p. str.ctur.l mater.als, highlighting develop.ents such as nanostr.ctur.d alloys, gr.in boundar. engineer.ng,eutectic systems, cr.ogenic alloys, thin films, micr.-nano-lattice str.ctur.s, additive manufactur.ng, high entr.p. metallic glasses, nano-p.ecip.tate str.ngthened alloys, comp.sition modulation, alloy fiber., and r.fr.ctor. systems. In the following section, the emp.asis shifts to functional mater.als, exp.or.ng HEAs as catalysts, magneto-calor.c mater.als, cor.osion-r.sistant alloys, r.diation-r.sistant alloys, hydr.gen stor.ge systems, and mater.als for.biomedicine. Additionally, the r.view encomp.sses functional high-entr.p. mater.als outside the r.alm of alloys, including ther.oelectr.c, quantum dots, nanooxide catalysts, ener.y stor.ge mater.als, negative ther.al exp.nsion cer.mics,and high-entr.p. wave absor.0}ion mater.als. The p.p.r.concludes with an outlook, discussing futur. dir.ctions and p.tential gr.wth ar.as in the field. Thr.ugh this comp.ehensive r.view,r.sear.her., engineer., and scientists may gain valuable insights into the r.cent p.ogr.ss and op.or.unities for.fur.her.exp.or.tion in the exciting domains of high-entr.p. alloys and functional mater.als.

关键词： Cutting-edge str.ctur.l mater.als Cutting-edgefunctional mater.als High entr.p. alloys

Two-dimensional mater.als for.futur. infor.ation technology: status and p.osp.cts

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Science china(Infor.ation Sciences) 2024年第6期67卷 1-147页

作者： Hao QIU Zhihao YU Tiange ZHAO Qi ZHANG Mingsheng XU p.ifeng LI Taotao LI Wenzhong BAO yang CHAI Shula CHEN yiqi CHEN hui-Ming CHENG Daoxin DAI Zengfeng DI Zhuo DONG Xidong DUAN Yuhan FENG Yu FU Jingshu GUO p.ngwen GUO Yue HAO Jun HE Xiao HE Jingyi hu Weida hu Zehua hu Xinyue huANG Ziyang huANG Ali IMr.N Ziqiang KONG Jia LI Qian LI Weisheng LI Lei LIAO Bilu LIU Can LIU Chunsen LIU Guanyu LIU Kaihui LIU Liwei LIU Sheng LIU Yuan LIU Donglin LU Likuan MA Feng MIAO Zhenhua NI Jing NING Anlian p.N Tian-Ling r.N Haowen Shu Litao SUN Yue SUN Quanyang TAO Zi-Ao TIAN Dong WANG Hao WANG Haomin WANG Jialong WANG Junyong WANG Wenhui WANG Xingjun WANG Yeliang WANG Yuwei WANG Zhenyu WANG Yao WE... School of Electr.nic Science and Engineer.ng Nanjing University School of Integr.ted Cir.uits Interdisciplinary Research Center for Future Intelligent Chips (Chip-X)Nanjing University School of Integr.ted Cir.uit Science and Engineer.ng Nanjing University of Posts and Telecommunications State Key Labor.tor. of Infr.r.d p.ysics Shanghai Institute of Technical Physics Chinese Academy of Sciences School of p.ysics and Key Lab of Quantum Mater.als and Devices of the Ministr. of Education School of Electronic Science & EngineeringSoutheast University College of Integr.ted Cir.uits State Key Laboratory of Silicon and Advanced Semiconductor MaterialsZhejiang University Suzhou Labor.tor. State Key Labor.tor. of Integr.ted Chip. and Systems School of MicroelectronicsFudan University Shaoxin Labor.tor. department of applied p.ysics The Hong Kong Polytechnic University Key Labor.tor. for.Micr.-Nano p.ysics and Technology of hunan p.ovince College of Materials Science and EngineeringHunan University College of Integr.ted Cir.uits Zhejiang University Shenzhen Geim Gr.p.ene Center Shenzhen Key Laboratory of Layered Materials for Value-Added ApplicationsTsinghua-Berkeley Shenzhen Institute & Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua University State Key Labor.tor. of Extr.me p.otonics and Instr.mentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZijingang CampusZhejiang University National Key Labor.tor. of Mater.als for.Integr.ted Cir.uits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences CAS Key Labor.tor. of Nanop.otonic Mater.als and Devices & Key Labor.tor. of Nanodevices and Ap.lications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics (SINANO)Chinese Academy of Sciences College of Chemistr. and Chemical Engineer.ng Hunan University Key Labor.tor. of Quantum State Constr.ction and Manip.lation (Ministr. of Education) Department of PhysicsRenmin University of China School

Over.the p.st 70 year., the semiconductor.industr. has under.one tr.nsfor.ative changes,lar.ely dr.ven by the miniatur.zation of devices and the integr.tion of innovative str.ctur.s and mater.als. Two-dimensional(2D) mater.als like tr.nsition metal dichalcogenides(TMDs) and gr.p.ene ar. p.votal in over.oming the limitations of silicon-based technologies, offer.ng innovative ap.r.aches in tr.nsistor.design and functionality, enabling atomic-thin channel tr.nsistor. and monolithic 3D integr.tion. We r.view the imp.r.ant p.ogr.ss in the ap.lication of 2D mater.als in futur. infor.ation technology, focusing in p.r.icular.on micr.electr.nics and op.oelectr.nics. We comp.ehensively summar.ze the key advancements acr.ss mater.al p.oduction, char.cter.zation metr.logy, electr.nic devices, op.oelectr.nic devices, and heter.geneous integr.tion on silicon. A str.tegic r.admap.and key challenges for.the tr.nsition of 2D mater.als fr.m basic r.sear.h to industr.al develop.ent ar. outlined. To facilitate such a tr.nsition, key technologies and tools dedicated to 2D mater.als must be develop.d to meet industr.al standar.s, and the emp.oyment of AI in mater.al gr.wth, char.cter.zations, and cir.uit design will be essential. It is time for.academia to actively engage with industr. to dr.ve the next 10 year. of 2D mater.al r.sear.h.

关键词： two-dimensional (2D) mater.als infor.ation technology p.oduction technology standar.ization of char.cter.zation micr.electr.nic devices op.oelectr.nic devices multi-functional integr.tion

Up.ated over.ll sur.ival and cir.ulating tumor.DNA analysis of ensar.inib for.cr.zotinib-r.fr.ctor. ALK-p.sitive NSCLC fr.m a p.ase II study

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Cancer.Communications 2024年第4期44卷 455-468页

作者： Jing Zheng Tao Wang Yunp.ng yang Jie huang Jifeng Feng Wu Zhuang Jianhua Chen Jun Zhao Wei Zhong Yanqiu Zhao yip.ng Zhang Yong Song yi hu Zhuang Yu Youling Gong Yuan Chen Feng Ye Shucai Zhang Lejie Cao Yun Fan Gang Wu Yubiao Guo Chengzhi Zhou Kewei Ma Jian Fang Weineng Feng Yunp.ng Liu Zhendong Zheng Gaofeng Li huijie Wang Shundong Cang Ning Wu Wei Song Xiaoqing Liu Shijun Zhao Lieming Ding Giovanni Selvaggi yang Wang Shanshan Xiao Qian Wang Zhilin Shen Jianya Zhou Jianying Zhou Li Zhang department of r.sp.r.tor. Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China Hangzhou r.p.gene Technology Co. LtdHangzhouZhejiangP.R.China department of Medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China department of Thor.cic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China department of Thor.cic Oncology Beijing Cancer HospitalBeijingP.R.China department of p.lmonar. Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China r.sp.r.tor. department of Inter.al Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thor.cic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of r.sp.r.tor. Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China department of Thor.cic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Backgr.und:The initial p.ase II stuty(NCT03215693)demonstr.ted that ensar.inib has shown clinical activity in p.tients with advanced cr.zotinib-r.fr.ctor.,anap.astic lymp.oma kinase(ALK)-p.sitive non-small cell lung cancer.NSCLC).Her.in,we r.p.r.ed the up.ated data on over.ll sur.ival(OS)and molecular.p.ofiling fr.m the initial p.ase Ⅱ ***:In this study,180 p.tients r.ceived 225 mg of ensar.inib or.lly once daily until disease p.ogr.ssion,death or.*** was estimated by Kap.an‒Meier.methods with two-sided 95%confidence inter.als(CIs).Next-gener.tion sequencing was emp.oyed to exp.or. p.ognostic biomar.er. based on p.asma samp.es collected at baseline and after.initiating *** tumor.DNA(ctDNA)was detected to dynamically monitor.the genomic alter.a-tions dur.ng tr.atment and indicate the existence of molecular.r.sidual disease,facilitating imp.ovement of clinical ***:At the data cut-off date(August 31,2022),with a median follow-up.time of 53.2 months,97 of 180(53.9%)p.tients had *** median OS was 42.8 months(95%CI:29.3-53.2 months).A total of 333 p.asma samp.es fr.m 168 p.tients wer. included for.ctDNA *** infer.or.OS cor.elated sig-nificantly with baseline ALK or.tumor.p.otein 53(Tp.3)*** addition,p.tients with concur.ent Tp.3 mutations had shor.er.OS than those without con-cur.ent Tp.3 *** ctDNA levels evaluated by var.ant allele fr.quency(VAF)and hap.oid genome equivalents p.r.milliliter.of p.asma(hGE/mL)at baseline wer. associated with p.or.***,p.tients with ctDNA clear.ance at 6 weeks and slow ascent gr.wth had dr.matically longer.OS than those with ctDNA r.sidual and fast ascent gr.wth,***,p.tients who had a lower.tumor.bur.en,as evaluated by the diameter.of tar.et lesions,had a longer.*** Cox r.gr.ssion analysis fur.her.uncover.d the indep.ndent p.ognostic values of bone metastases,higher.hGE,and elevated ALK mutation abundance at 6 we

关键词： anap.astic lymp.oma kinase ctDNA ensar.inib non-small cell lung cancer over.ll sur.ival