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The transcription factor NAC102 confers cadmium tolerance by regulating WAKL11 expression and cell wall pectin metabolism in Arabidopsis

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Journal of Integrative Plant Biology 2023年第10期65卷 2262-2278页

作者： Guang Hao Han Ru Nan Huang Li hong hong Jia Xi Xu yi guo hong Yu Huan Wu Wei Wei Chen Research Center for Plant RNA Signaling College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 310036China Warwick‐Hangzhou RNA Signaling Joint Laboratory School of Life SciencesUniversity of WarwickWarwick CV47ALUnited Kingdom State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China

Cadmium(Cd) toxicity severely limits plant growth and development. Moreover, Cd accumulation in vegetables, fruits, and food crops poses health risks to animals and humans. Although the root cell wall has been implicated in Cd stress in plants, whether Cd binding by cell wall polysaccharides contributes to tolerance remains controversial, and the mechanism underlying transcriptional regulation of cell wall polysaccharide biosynthesis in response to Cd stress is unknown. Here, we functionally characterized an Arabidopsis thaliana NAC-type transcription factor, NAC102, revealing its role in Cd stress responses. Cd stress rapidly induced accumulation of NAC102.1, the major transcript encoding functional NAC102, especially in the root apex. Compared to wild type(WT) plants, a nac102 mutant exhibited enhanced Cd sensitivity, whereas NAC102.1-overexpressing plants displayed the opposite phenotype. Furthermore, NAC102 localizes to the nucleus, binds directly to the promoter of WALL-ASSOCIATED KINASE-LIKE PROTEIN11(WAKL11), and induces transcription, thereby facilitating pectin degradation and decreasing Cd binding by pectin. Moreover, WAKL11 overexpression restored Cd tolerance in nac102mutants to the WT levels, which was correlated with a lower pectin content and lower levels of pectin-bound Cd. Taken together, our work shows that the NAC102-WAKL11 module regulates cell wall pectin metabolism and Cd binding, thus conferring Cd tolerance in Arabidopsis.

关键词： cadmium stress cell wall NAC102 transcriptional regulation WAKL

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Novel approaches towards conquering hepatitis B virus infection

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World Journal of Gastroenterology 2007年第6期13卷 830-836页

作者： guo-yi Wu hong-Song Chen Hepatology Institute People's Hospital Peking University Beijing 100044 China

Currently approved treatments for hepatitis B virus （HBV） infection include the immunomodulatory agent, IFN-α, and nucleos（t）ide analogues. Their efficacy is limited by their side effects, as well as the induction of viral mutations that render them less potent. It is thus necessary to develop drugs that target additional viral antigens. Chemicals and biomaterials by unique methods of preventing HBV replication are currently being developed, including novel nucleosides and newly synthesized compounds such as capsid assembling and mRNA transcription inhibitors. Molecular therapies that target different stages of the HBV life cycle will aid current methods to manage chronic hepatitis B （CriB） infection. The use of immunomodulators and gene therapy are also under consideration. This report summarizes the most recent treatment possibilities for CHB infection. Emerging therapies and their potential mechanisms, efficacy, and pitfalls are discussed.

关键词： Hepatitis B virus Antiviral drugs Drugevaluation Immunomodulatory agents Gene therapy

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Follow-up of children born after intracytoplasmic sperm injection with epididymal and testicular spermatozoa

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Chinese Medical Journal 2013年第11期126卷 2129-2133页

作者： guo yi-hong DONG Rui-na SU ying-chun LI Jing ZHANG Ya-jie SUN ying-pu Reproductive Medicine Center First Affiliated Hospital ofZhengzhou University Zhengzhou Henan 450052 China

Background To evaluate the safety of intracytoplasmic sperm injection （ICSI） with epididymal or testicular sperm, this study compared children born after ICSI treatment with epididymal or testicular sperm with children conceived after ICSI with ejaculated sperm. Methods This retrospective study included 317 children born after ICSI with percutaneous epididymal sperm aspiration （PESA）, 103 children born after ICSI with testicular sperm aspiration （TESA）, and a control group of 1008 children born after ICSI with ejaculated sperm. All of the patients received their assisted reproductive treatment in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2004 to December 2011. Data, such as the rate of stillbirths, perinatal mortality, gestational age, birth weight, and the rate of congenital malformations of the three groups, were compared. Results PESA and TESA children were not different from ICSI children in the rate of stillbirths, perinatal mortality, infant mortality rate, gestational age, the rate of prematurity, and the rate of malformations （P〉0.05）. A slight increase in birth defects was reported in the TESA group compared with those in the control group, but there was no significant difference between the groups （P〉0.05）. Conclusion ICSI with epididymal or testicutar sperm does not lead to more stillbirths or congenital malformations compared with ICSI using ejaculated sperm.

关键词： intracytoplasmic sperm injection epididymal spermatozoa testicular spermatozoa birth defects

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The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han yi-Yang guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

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旅游管理专业人才培养模式的有效形式

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湖南师范大学社会科学学报 2010年第4期39卷 103-105页

作者：郭一红湖南商学院旅游管理学院湖南长沙410205

培养具有较强创新精神和服务意识的应用型旅游管理人才是旅游业发展的当务之急,而现行的旅游管理专业人才培养模式却难以实现既定的目标。我们通过分析现行旅游管理专业人才培养模式与社会需求之间的矛盾,阐述加强旅游管理专业应用型人... 详细信息

培养具有较强创新精神和服务意识的应用型旅游管理人才是旅游业发展的当务之急,而现行的旅游管理专业人才培养模式却难以实现既定的目标。我们通过分析现行旅游管理专业人才培养模式与社会需求之间的矛盾,阐述加强旅游管理专业应用型人才培养的必要性,并提出了培养高素质旅游管理应用型人才的有效形式。

关键词：旅游管理专业人才培养模式创新应用型人才

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微孔通道深宽比与曲率半径对龙虾眼光学系统成像的影响

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光子学报 2019年第2期48卷 122-130页

作者：彭松武韦飞郭亦鸿叶依众中国科学院国家空间科学中心北京100190 中国科学院大学北京100149 中国科学院空间态势感知技术重点实验室北京100190 天基空间环境探测北京市重点实验室北京100190

在同一单色平行光源照射下研究微孔通道深度与宽度比值、球面曲率半径对观测视场、空间分辨率和光学灵敏度等成像指标的影响.结果表明:随着微孔通道深度与宽度比值的增加,空间角分辨能力逐渐变强,像面总光强逐渐变弱,在比值达到25∶1时... 详细信息

在同一单色平行光源照射下研究微孔通道深度与宽度比值、球面曲率半径对观测视场、空间分辨率和光学灵敏度等成像指标的影响.结果表明:随着微孔通道深度与宽度比值的增加,空间角分辨能力逐渐变强,像面总光强逐渐变弱,在比值达到25∶1时,聚焦光线有效面积达到最大值;在同一微孔尺寸下,元件曲率半径的变化对空间角分辨率影响较小,更大的曲率半径有更大的有效面积,但同时要求更大的元件体积.

关键词： X射线成像龙虾眼系统深宽比曲率半径角分辨率

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Effects of Partially N-acetylated Chitosans to Elicit Resistance Reaction on Brassica napus L.

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Agricultural Sciences in China 2002年第5期1卷 516-519页

作者： ZHANG Xue-kun, TANG Zhang-lin, CHEN Li, guo yi-hong, CHEN Yun-ping and LI Jia-na(Agronomy Department, Southwest Agricultural University , Chongqing 400716 , China) Agronomy Department Southwest Agricultural University Chongqing 400716 China

The effects to elicit resistance reaction on oilseed rape (Brassica napus L. cv Xinongchangjiao ) by four partially N-acetylated chitosan 7B, 8B, 9B and 10B (Degree of acetylation (D. A.) is 30% , 20% , 10%, 0%, respectively) and Glycol chitosan (GC, D.A. is 0%) were investigated and compared. Results showed that chitosan were similar to salicylic acid (SA), and could induce resistance reaction, but the reaction was influenced by the degree of acetylation of chitosan. Fully deacetylated chitosans, 10B and GC, elicited chitinase activity, but partially acetylated chitosan, 7B, 8B and 9B, inhibited chitinase activity. Phenyalanine ammonia-lyase (PAL) was also elicited. Elicitor activity increased with on increasing degree of acetylation, 7B induced highest PAL activity among all chitosans. All chitosans induced peroxidase (POD) in a similar level. After elicited by glycol chitosan, like SA treatment, the seedlings increased disease resistance to Sclerotinia sclerotiorum significantly.

关键词： Brassica napus L. Chitosan Degree of acetylation Resistance reaction

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Study on SHBG Gene Polymorphisms and Male Infertility Disease in Henan Han Population

Study on SHBG Gene Polymorphisms and Male Infertility Diseas...

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第十二次全国医学遗传学学术会议

作者： CUI Yuan-rong MA Yu-fei guo yi-hong LI Xiao-wen CHEN Hui Reproductive Center the Third Affiliated Hospital of Zhengzhou University Department of Cell Biology and Medical Genetics College of Basic Medical SciencesZhengzhou University Reproductive Center the First Affiliated Hospital of Zhengzhou University

Objective To study the relationship between SHBG Gene Polymorphisms and Male Infertility *** Our study use the method of polymerase chain reaction - restriction fragment length polymorphism(PCR-RFLP) to compare SHBG Gene Polymorphisms’ difference between control-case *** In Henan Han population,SHBG rs6259 A allele frequency was significantly higher in male infertility group than those in control group(P <0.05),and CC genotype frequency of rs727428 locus was significantly lower than those in control group(P <0.05).Conclusion SHBG Gene Polymorphisms was associated to male infertility disease.

关键词： SHBG gene polymorphism male infertility

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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基础FSH水平对不同年龄患者行供精人工授精结局的影响

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中国妇幼保健 2014年第29期29卷 4780-4783页

作者：王笑郭艺红郑州大学第一附属医院河南郑州450052

目的：探讨年龄、血基础卵泡刺激素（bFSH）水平对不孕妇女行供精人工授精（AID）结局的影响。方法：回顾性分析郑州大学第一附属医院生殖中心2008年1月-2013年12月成功接受供精人工授精治疗的不孕妇女的年龄、bFSH水平与临床妊娠率、... 详细信息

目的：探讨年龄、血基础卵泡刺激素（bFSH）水平对不孕妇女行供精人工授精（AID）结局的影响。方法：回顾性分析郑州大学第一附属医院生殖中心2008年1月-2013年12月成功接受供精人工授精治疗的不孕妇女的年龄、bFSH水平与临床妊娠率、流产率的关系。结果：①3247个AID周期中，〈35岁组和≥35岁组诱导排卵的妊娠率分别为28．76％，16．04％；自然周期的妊娠率分别为28．88％，16．93％，不同年龄诱导排卵妊娠率及自然周期妊娠率比较，差异有统计学意义（P〈0．05）。②〈35岁患者中，bFSH≤10IU／L组诱导排卵和自然周期的妊娠率均高于bFSH〉10IU／L组（P〈0．05），流产率对比均无统计学差异（P〉0．05）。③≥35岁患者中，bFSH≤10IU／L组与bFSH〉10IU／L组诱导排卵或自然周期的妊娠率、流产率均无统计学差异（P〉0．05）。结论：年龄是影响AID助孕结局的重要因素之一；基础FSH水平对年龄〈35岁患者妊娠结局有一定预测作用；诱导排卵并未明显增加AID妊娠率；AID助孕技术并未增加流产风险。

关键词：供精人工授精年龄卵泡刺激素临床妊娠率流产率

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