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Rockall score in predicting outcomes of elderly patients with acute upper gastrointestinal bleeding

World Journal of Gastroenterology 2013年第22期19卷 3466-3472页

作者： Chang-Yuan Wang Jian Qin Jing Wang Chang-yi Sun tao Cao Dan-Dan Zhu Department of Emergency Xuanwu Hospital of Capital Medical University

AIM: To validate the clinical Rockall score in predicting outcomes (rebleeding, surgery and mortality) in elderly patients with acute upper gastrointestinal bleeding (AUGIB). METHODS: A retrospective analysis was undertaken in 341 patients admitted to the emergency room and Intensive Care Unit of Xuanwu Hospital of Capital Medical University with non-variceal upper gastrointestinal bleeding. The Rockall scores were calculated, and the association between clinical Rockall scores and patient outcomes (rebleeding, surgery and mortality) was assessed. Based on the Rockall scores, patients were divided into three risk categories: low risk ≤ 3, moderate risk 3-4, high risk ≥ 4, and the percentages of rebleeding/death/surgery in each risk category were compared. The area under the receiver operating characteristic (ROC) curve was calculated to assess the validity of the Rockall system in predicting rebleeding, surgery and mortality of patients with AUGIB. RESULTS: A positive linear correlation between clinical Rockall scores and patient outcomes in terms of rebleeding, surgery and mortality was observed (r =0.962, 0.955 and 0.946, respectively, P = 0.001). High clinical Rockall scores > 3 were associated with adverse outcomes (rebleeding, surgery and death). There was a significant correlation between high Rockall scores and the occurrence of rebleeding, surgery and mortality in the entire patient population (χ 2 = 49.29, 23.10 and 27.64, respectively, P = 0.001). For rebleeding, the area under the ROC curve was 0.788 (95%CI: 0.726-0.849, P = 0.001); For surgery, the area under the ROC curve was 0.752 (95%CI: 0.679-0.825, P = 0.001) and for mortality, the area under the ROC curve was 0.787 (95%CI: 0.716-0.859, P = 0.001). CONCLUSION: The Rockall score is clinically useful, rapid and accurate in predicting rebleeding, surgery and mortality outcomes in elderly patients with AUGIB.

关键词： Rockall score Acute upper gastrointestinal bleeding Prognosis Elderly patients

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Exosomal miR-155 from gastric cancer induces cancerassociated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ

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Cancer Biology & Medicine 2022年第9期19卷 1301-1314页

作者： ying Liu Meng Wang Ting Deng Rui Liu tao Ning Ming Bai Guoguang ying Haiyang Zhang yi Ba Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Objective:The aim of this research was to identify whether exosomes were involved in impairing adipogenesis in cancer-associated cachexia(CAC)by detecting the adipodifferentiation capacity and the expressions of adipogenic proteins in gastric cancer(GC)-associated ***:Western blotting and RT-PCR were used to investigate the expressions of C/EPBβ,C/EPBα,PPARγ,and UCP1 in adipose mesenchymal stem cells(A-MSCs)to evaluate the function of exosomal ***/c nude mice were intravenously injected in vivo with GC exosomes with different levels of miR-155 to determine changes in adipodifferentiation of ***:Exosomes derived from GC cells suppressed adipogenesis in A-MSCs as characterized by decreased lipid ***,A-MSCs co-cultured with GC exosomes exhibited increased ATP production through brown adipose differentiation characterized by highly dense mitochondria and enhanced UCP1 expression(P<0.05).Mechanistically,exosomal miR-155 secreted from GC cells suppressed adipogenesis and promoted brown adipose differentiation by targeting C/EPBβ,accompanied by downregulated C/EPBαand PPARγand upregulated UCP1(P<0.05).Moreover,overexpression of miR-155 in GC exosomes improved CAC in vivo,which was characterized by fat loss,suppressed expressions of C/EPBβ,C/EPBα,and PPARγin A-MSCs,and high expression of UCP1(P<0.05).Decreasing the level of miR-155 in injected GC exosomes abrogated the improved CAC ***:GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβof A-MSCs,which played a crucial role in CAC.

关键词： Exosomes adipose mesenchymal stem cells miR-155 cachexia gastric cancer

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飞行器结构密封胶界面性能表征与失效过程

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失效分析与预防 2024年第2期19卷 109-116页

作者：陈鑫李振威徐明鸽贺译贤陶林北京强度环境研究所北京100076 天津航天瑞莱科技有限公司天津300462 同济大学航空航天与力学学院上海200092

密封胶是飞行器结构的重要组成部分,是结构密封安全性的基本保障。如果密封胶的性能参数不达标,则可能达不到其设计目标。对新型HM109改性聚硫密封胶进行测试分析,利用有限元软件开展模拟计算,使用Cohesive单元实现对密封胶层的模拟。... 详细信息

密封胶是飞行器结构的重要组成部分,是结构密封安全性的基本保障。如果密封胶的性能参数不达标,则可能达不到其设计目标。对新型HM109改性聚硫密封胶进行测试分析,利用有限元软件开展模拟计算,使用Cohesive单元实现对密封胶层的模拟。通过观察胶层失效过程,确定飞行器密封结构在大载荷情况下密封胶层失效的过程;通过对比试验结果和模拟计算结果,验证有限元分析的可靠性。结果表明:试验所测得的参数应用于有限元模拟所得结果与试验结果基本一致,拉伸和剪切模拟最大载荷与试验平均结果误差分别约为3.74%、1.50%,模拟结果具有可靠性。

关键词：密封胶性能测试有限元分析密封失效

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人脐带间充质干细胞对传统胎盘屏障模型屏障功能的影响及作用机制

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药物评价研究 2024年第5期47卷 1002-1009页

作者：韩巧巧王泽郭宇竹孙英辉赵天宇慈小燕崔涛傅鹏伊秀林闫凤英安徽医科大学药学院安徽合肥230032 天津药物研究院有限公司药物成药性评价与系统转化全国重点实验室天津300301 澳门科技大学药学院中国澳门999078 天津市细胞技术创新中心天津和创生物技术有限公司天津300301 中国医学科学院药物代谢新技术创新单元北京100730

目的通过构建体外胎盘屏障模型,研究人脐带间充质干细胞(hUC-MSC)对传统胎盘屏障模型功能的影响及其可能的分子机制。方法将hUC-MSC、人脐静脉内皮细胞(HUVEC)和人滋养层细胞(HTR-8)共同培养于transwell中建立体外胎盘屏障模型,设置对照... 详细信息

目的通过构建体外胎盘屏障模型,研究人脐带间充质干细胞(hUC-MSC)对传统胎盘屏障模型功能的影响及其可能的分子机制。方法将hUC-MSC、人脐静脉内皮细胞(HUVEC)和人滋养层细胞(HTR-8)共同培养于transwell中建立体外胎盘屏障模型,设置对照组(HUVEC+HTR-8)、forskolin组(HUVEC+HTR-8+forskolin)、MSC组(HUVEC+HTR-8+hUC-MSC)、MSC+forskolin组(HUVEC+HTR-8+hUC-MSC+forskolin),通过测量跨膜电阻值、荧光黄CH的渗透性以及P-糖蛋白(P-gp)的活性,评估各组体外胎盘屏障模型的功能;利用实时荧光定量PCR(qRT-PCR)和Western blotting检测各组体外胎盘屏障模型中P-gp、紧密连接蛋白5(Claudin-5)、闭合小环蛋白-1(ZO-1)、ZO-2、血小板-内皮细胞黏附分子(CD31)的mRNA及蛋白表达水平;利用LC-MS/MS检测阿替洛尔、米诺地尔、美托洛尔3种渗透性工具药透过各组体外胎盘屏障模型的表观渗透系数(Papp),验证模型的功能完整性。结果与对照组相比,forskolin、MSC、MSC+forskolin组的跨膜电阻值均显著增高(P<0.05、0.001)、P-gp外排功能均增强、荧光黄的Papp值均显著降低(P<0.05、0.01、0.001),且二者联用后作用效果尤为显著,表明该模型具备完整的屏障功能,且MSC+forskolin屏障功能最好;qRT-PCR和Western blotting结果显示,与对照组相比,forskolin组P-gp、ZO-1、ZO-2、CD31的表达显著增加(P<0.05、0.01、0.001),MSC组P-gp、Claudin5、ZO-1和CD31的表达也显著增加(P<0.05、0.01、0.001);联合应用后,各蛋白的mRNA及蛋白表达水平均更显著增加(P<0.01、0.001),表明hUC-MSC增强传统胎盘屏障功能;与对照组相比,各实验组的Papp值均降低,MSC+forskolin组3个工具药均差异显著,美托洛尔差异最显著。结论hUC-MSC通过增强传统胎盘屏障模型中紧密连接蛋白和外排蛋白的表达,进一步增强了传统胎盘屏障模型的屏障功能。

关键词：人脐带间充质干细胞人脐静脉内皮细胞人滋养层细胞胎盘屏障 P-糖蛋白

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Synthesis and CDK2 kinase inhibitory activity of 7/7′-azaindirubin derivatives

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Chinese Chemical Letters 2010年第3期21卷 297-300页

作者： Wang, Zhao Hui Dong, ying Wang, tao Shang, Ming Hong Hua, Wei yi Yao, Qi Zheng China Pharmaceut Univ Sch Pharm Nanjing 210009 Peoples R China China Pharmaceut Univ Dept Organ Chem Nanjing 210009 Peoples R China China Pharmaceut Univ Jiangsu Ctr Drug Screening Nanjing 210009 Peoples R China

A series of novel 7 -azaindirubin(1a-g) and 7-azaindirubin(2a,2c,2e and 2f) derivatives were designed and *** structures were characterized by ~1H NMR and MS spectroscopy as well as by elemental *** inhibitory properties against CDK2/cylinA were evaluated in *** contrast to indirubin,some of the described azaindirubins emerged as potent inhibitors of CDK2/cylinA and compound 2b had more potent *** tests also showed that nitrogen atom at 7-position of azaindirubi...

关键词： 7 -Azaindirubin 7-Azaindirubin Synthesis CDK2/cyclinA Inhibition

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BET in hematologic tumors:Immunity,pathogenesis,clinical trials and drug combinations

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Genes & Diseases 2023年第6期10卷 2306-2319页

作者： tao Ma Yan Chen Zhi-Gang yi Yan-Hong Li Jun Bai Li-Juan Li Lian-Sheng Zhang Department of Hematology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Department of Hematology Lanzhou University Second HospitalLanzhouGansu 730000China

The bromodomain and extra-terminal(BET)proteins act as“readers”for lysine acetylation and facilitate the recruitment of transcriptional elongation *** protein is associated with transcriptional elongation of genes such as c-MYC and BCL-2,and is involved in the regulation of cell cycle and ***,BET inhibitors(BETi)have regulatory effects on immune checkpoints,immune cells,and cytokine *** role of BET proteins and BETi in a variety of tumors has been *** paper reviews the recent research progress of BET and BETi in hematologic tumors(mainly leukemia,lymphoma and multiple myeloma)from cellular level studies,animal studies,clinical trials,drug combination,*** has a promising future in hematologic tumors,and future research directions may focus on the combination with other drugs to improve the efficacy.

关键词： BET BRD4 Clinical trials Hematologic tumors Immunity MYC

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Simultaneous determination of 35 constituents and elucidation of effective constituents in a multi-herb Chinese medicine formula Xiaoer-Feire-Kechuan

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Journal of Pharmaceutical Analysis 2021年第6期11卷 717-725页

作者： Zhanpeng Shang Lulu Xu yi Kuang Yan Lin Shuang Liu Long Sun tao Bo Min Ye Xue Qiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Pharmaceutical Sciences Guizhou Medical UniversityGuizhou550025China Thermo Fisher Scientific Beijing100102China

Xiaoer-Feire-Kechuan(XFK) is an 11-herb Chinese medicine formula to treat cough and pulmonary *** complicated composition rendered its chemical analysis and effective-component *** this study,we combined quantitative analysis and bioactivity test to reveal the antiinflammatory constituents of ***,UPLC-DAD and UHPLC/Q-Orbitrap-MS methods were established and validated to quantify 35 analytes(covering 9 out of 11 herbs) in different XFK *** reaction monitoring mode built in Q-Orbitrap-MS was used to improve the sensitivity and ***,anti-inflammatory activities of the 35 analytes were analyzed using in vitro COX-2 inhibition ***,major analytes forsythosides H,I,A(8-10),and baicalin(15)(total contents varied from 21.79 to 91.20 mg/dose in different formulations) with significant activities(inhibitory rate ≥ 80%) were proposed as the anti-inflammatory constituents of *** present study provided an effective strategy to discover effective constituents of multi-herb formulas.

关键词： Multi-herb formulas Effective constituents Xiaoer-Feire-Kechuan formula(XFK) Parallel reaction monitoring(PRM) Cyclooxygenase-2(COX-2)

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Selective coordination and localized polarization in graphene quantum dots: Detection of fluoride anions using ultra-low-field NMR relaxometry

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Chinese Chemical Letters 2021年第12期32卷 3921-3926页

作者： Yongqiang Li yi Xiao Quan tao Mengmeng Yu Li Zheng Siwei Yang Guqiao Ding Hui Dong Xiaoming Xie State Key Laboratory of Functional Materials of Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences(CAS)Shanghai 200050China CAS Center for Excellence in Superconducting Electronics(CENSE) Chinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The development of ultra-sensitive methods for detecting anions is limited by their low charge to radius ratios, microenvironment sensitivity, and p H sensitivity. In this paper, a magnetic sensor is devised that exploits the controllable and selective coordination that occurs between a magnetic graphene quantum dot(GQD) and fluoride anion(F–). The sensor is used to measure the change in relaxation time of aqueous solutions of magnetic GQDs in the presence of F–using ultra-low-field(118 μT) nuclear magnetic resonance relaxometry. The method was optimized to produce a limit of detection of 10 nmol/L and then applied to quantitatively detect F–in domestic water samples. More importantly, the key factors responsible for the change in relaxation time of the magnetic GQDs in the presence of F–are revealed to be the selective coordination that occurs between the GQDs and F–as well as the localized polarization of the water protons. This striking finding is not only significant for the development of other magnetic probes for sensing anions but also has important ramifications for the design of contrast agents with enhanced relaxivity for use in magnetic resonance imaging.

关键词： Graphene quantum dots Coordination Polarization Relaxometry Magnetic sensor Nuclear magnetic resonance Fluoride anion

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Targeted sequencing and integrative analysis of 3,195 Chinese patients with neurodevelopmental disorders prioritized 26 novel candidate genes

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Journal of Genetics and Genomics 2021年第4期48卷 312-323页

作者： tao Wang yi Zhang Liqui Liu Yan Wang Huiqian Chen Tianda Fan Jinchen Li Kun Xia Zhongsheng Sun Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410083China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China DIAGenes Precision Medicine Beijing 102600China National Clinical Research Centre for Geriatric Disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangshaHunan 410083China Shanghai Adeptus Biotechnology Shanghai 200126China Institute of Genomic Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Neurology Xiangya HospitalCentral South UniversityChangsha Hunan410083China CAS Center for Excellence in Brain Science and Intelligences Technology(CEBSIT) Shanghai 200031China School of Basic Medical Science Central South UniversityChangshaHunan410083China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Integrated Management of Pest Insects and Rodents Chinese Academy of SciencesBeijing 100101China

Neurodevelopmental disorders(NDDs)are a set of complex disorders characterized by diverse and cooccurring clinical *** genetic contribution in patients with NDDs remains largely ***,we sequence 519 NDD-related genes in 3,195 Chinese probands with neurodevelopmental phenotypes and identify 2,522 putative functional mutations consisting of 137 de novo mutations(DNMs)in 86 genes and 2,385 rare inherited mutations(RIMs)with 22 X-linked hemizygotes in 13 genes,2 homozygous mutations in 2 genes and 23 compound heterozygous mutations in 10 ***,the DNMs of16,807 probands with NDDs are retrieved from public datasets and combine in an integrated analysis with the mutation data of our Chinese NDD probands by taking 3,582 in-house controls of Chinese origin as *** prioritize 26 novel candidate ***,six of these genes d ITSN1,UBR3,CADM1,RYR3,FLNA,and PLXNA3 d preferably contribute to autism spectrum disorders(ASDs),as demonstrated by high co-expression and/or interaction with ASD genes confirmed via rescue experiments in a mouse ***,these genes are differentially expressed in the ASD cortex in a significant manner and involved in ASD-associated ***,our study expands the genetic spectrum of Chinese NDDs,further facilitating both basic and translational research.

关键词： De novo mutations X-linked variants Rare inherited variants Homozygous mutations Neurodevelopmental disorders Autism spectrum disorders Candidate genes

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Mechanical-force-promoted peptide assembly: a general method

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Nuclear Science and Techniques 2018年第9期29卷 192-196页

作者： Yue Yuan Qi-Qi-Ge Du Yu-Jiao Wang Jun Hu Shi-tao Lou yi Zhang State Key Laboratory of Precision Spectroscopy East China Normal University Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences School of Life Sciences Inner Mongolia Agricultural University

A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope(AFM) operated in a liquid. By scanning solid surfaces with an AFM tip, we showed that peptide monomers assemble at a higher rate in the tip-scanned area compared to other regions. The promotion is attributed to the mechanical force applied by the scanning tip. This kind of mechanical-force-promoted assembly was also observed with different peptides on various substrates. The force promoting peptide assembly provides a simple and practical solution for preparing and building peptide and protein architectures for future nanodevices.

关键词： Self-assembly Peptide Nanomechanical stimulus Support lipid bilayers Atomic force microscope

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