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American Journal of Analytical Chemistry 2010年第3期1卷 135-143页

作者： Soo-Hwan Kim Sang Hun lee Hye Jung lee 不详

A method for the determination of carvedilol in human plasma was developed using a high-performance liquid chromatography with tandem mass spectrometer (HPLC-MS/MS). Plasma samples were deproteinized using acetonitrile and the supernatant was directly injected onto the HPLC column without any preparative steps. Chromatography was performed on a reversed-phase (C18) column with isocratic mobile phase for 2 min. The calibration curve was linear over the range of 2 to100 ng/ml (R2 > 0.9998) and the lower limit of quantitation (LLOQ) was 2 ng/ml. This method showed acceptable precision and accuracy, good recovery from the plasma matrix, and stability during the analytical procedures. When its application to the bioequivalence test of two carvedilol 25 mg tablet formulations in male healthy 28 volunteers, this validated analysis method was appropriate resulting in the bioequivalence of two formulations: no statistically significant difference was observed between the logarithmic transformed area under curve (AUC) and maximum plasma concentration (Cmax) values of the two formulations. The 90% confidence interval for the ratio of the above mentioned two parameters were within the bioequivalence limit of 0.80-1.25. These results suggested that the HPLC-MS/MS analysis method developed was suitable for the carvedilol analysis in human plasma.

关键词： Carvedilol Bioequivalence HPLC-MS/MS Validation

Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin lee Young Uk Cho Jung Woo lee Woon-Hong Yeo Young Min Song Youngmee Jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and Collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery

Emerging Technologies of Liquid Crystal Displays

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光学学报 2003年第S1期23卷 797-798页

作者： Sin-Doo lee Chang-Jae Yu Jae-Hong Park Min-Sik Jung School of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 KoreaSchool of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 KoreaSchool of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 KoreaSchool of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 Korea

The general features and the emerging technologies of liquid crystal displays are described from the viewpoints of wide viewing and fast response technologies. The device applications of liquid crystals for optical co... 详细信息

关键词： of in on it as LCD Emerging Technologies of Liquid Crystal Displays been mode DSG

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Vapor phase epitaxy of PbS single-crystal films on water-soluble substrates and application to photodetectors

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Nano Research 2022年第6期15卷 5402-5409页

作者： Yifan Wang Jing Xia Xuanze Li Fan Ru Xue Chen Ze Hua Ruiwen Shao Xuecong Wang Wenjun Zhang Chun-Sing lee Xiangmin Meng Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China Centre of Material Science and Optoelectronic Engineering University of Chinese Academy of SciencesBeijing 10049China Engineering Research Center for Semiconductor Integrated Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Analysis&Testing Center Beijing Institute of TechnologyBeijing 102488China Beijing Advanced Innovation Center for Intelligent Robots and Systems and Institute of Convergence in Medicine and Engineering Beijing Institute of TechnologyBeijing 100081China Center of Super-Diamond and Advanced Films(COSADF)and Department of Materials Science and Engineering City University of Hong KongHong KongChina Center of Super-Diamond and Advanced Films(COSDAF)and Department of Chemistry City University of Hong KongHong KongChina

Lead sulfide(PbS),a typical functional semiconductor material,has attracted serious attention due to its great potential in optoelectronics ***,controllable growth of PbS single-crystal film still remains a great ***,we report heteroepitaxial growth of large-scale highly crystalline PbS films on alkali salt(NaCl and KCl)substrates via chemical vapor deposition(CVD).Structural characterizations demonstrate that the as-grown PbS films exhibit an atomically sharp interface with the underlying *** epitaxial relationships between the epilayers and substrates were determined to be PbS(100)//NaCl(100)or KCl(100),PbS[010]//NaCl[010]or KCl[010].Owing to the high solubility of alkali salt,the epitaxial PbS films can be rapidly released from the underlying substrates and transferred to other substrates of interest while maintaining good integrity and crystallinity,the process of which is particularly attractive in the fields of electronics and ***,photodetectors based on the transferred PbS films were fabricated,exhibiting a high photoresponsivity of 7.5 A/W,a detectivity of 1.44×10^(12)Jones,and a rapid response time of approximately 0.25 *** work sheds light on the batch production,green transfer,and optoelectronic application of PbS films.

关键词： heteroepitaxial growth lead sulfide(PbS) single-crystal film photodetector transferable

Nuclear and chloroplast genome diversity revealed by low-coverage whole-genome shotgun sequence in 44 Brassica oleracea breeding lines

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Horticultural Plant Journal 2021年第6期7卷 539-551页

作者： Sampath Perumal Nomar Espinosa Waminal Jonghoon lee Hyun-Jin Koo Boem-soon Choi Jee Young Park Kyounggu Ahn Tae-Jin Yang Department of Agriculture Forestry and BioresourcesPlant Genomics and Breeding Instituteand Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Global Institute for Food Security University of Saskatchewan421 Downey RoadSaskatoonSK S7N 4L8Canada Agriculture and Agri-Food Canada 107 Science PlaceSaskatoon S7N 0X2Canada Chromosome Research Institute Department of Life ScienceSahmyook UniversitySeoul 01795Republic of Korea Joeun Seeds.Co. LtdGoesan-GunChungcheongbuk-Do 367-833Republic of Korea Phyzen Genomics Institute 13Seongnam-daero 331beon-gilBundang-guSeongnam-siGyeonggi-do 13558Republic of Korea

Whole-genome shogun sequence(WGS)data generated by next-generation sequencing(NGS)platforms are a valuable resource for crop *** produced 5–6×WGS coverage of 44 Brassica oleracea breeding lines representing seven subspecies/morphotypes:cabbage,broccoli,cauliflower,kailan,kale,Brussels sprout,and kohlrabi to systematically evaluate the nuclear and chloroplast(Cp)diversity in the 44 *** breeding *** then exploited the impact of low-coverage NGS by evaluating nuclear genome diversity and assembly,annotation of complete chloroplast(Cp)genomes and 45 S nuclear ribosomal DNA(45S nrDNA)sequences,and copy number variation for major *** genome diversity analysis has revealed a total of 496463 SNPs and 37493 indels in the nuclear genome across the 44 ***,some SNPs showed subspecies enrichment at certain chromosomal *** assembly of complete Cp genomes contained 153361–153372 bp with 37 variants including SNPs and *** 45S nrDNA transcription unit was 5802 bp long with a total of 31 SNPs from the 44 *** phylogenetic tree inferred from the nuclear and Cp genomes coincided and clustered broccoli,cauliflower,and kailan in one group and cabbage,Brussels sprout,kale,and kohlrabi in another *** morphotypes diverged during the last 0.17 million *** Cp genome diversity reflected the unique cytoplasm of each subspecies,and revealed that the cytoplasm of many breeding lines was replaced and intermingled via inter-subspecies crosses during the breeding process *** polymorphic Cp markers provide a classification system for the cytoplasm types in ***,copy numbers of major transposable elements(TEs)showed high diversity among the 44 accessions,indicating that many TEs have become active ***,we demonstrated a comprehensive utilization of low-coverage NGS data and might shed light on the genetic diversity and evolution of diverse *** morphotypes.

关键词： Brassica oleracea subspecies Chloroplast genome Nuclear ribosomal DNA Genetic diversity Phylogeny

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Mechanical properties and flame retardancy of surface modified magnesium oxysulfate(5Mg(OH)_(2)·MgSO_(4)·3H_(2)O)whisker for polypropylene composites

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Journal of Materiomics 2018年第2期4卷 149-156页

作者： Eui-Su Kim Ye Chan Kim Jungwoo Park Youngjun Kim Sung-Hoon Kim Kwang Jin Kim Jonghwan Suhr Youngkwan lee Seong Hoon lee Dae-Sik Kim Soo-Hyun Kim Ju-Ho Yun In-Kyung Park Jae-Do Nam School of Chemical Engineering Department of Polymer Science and EngineeringSungkyunkwan UniversitySuwon16410Republic of Korea Department of Mechanical Engineering University of NevadaLas Vegas4505 S.Maryland ParkwayLas VegasNV89154United States Department of Energy Science Sungkyunkwan UniversitySuwon16410Republic of Korea Perceived Materials Research Team Hyundai Motor Group18280HwaseongRepublic of Korea Korea Institute of Science and Technology Seoul02792Republic of Korea Korea Automotive Technology Institute Cheonan31214Republic of Korea

Magnesium oxysulfate(MOS)whisker is considered as a promising inorganic material recently attracting a great attention for being used as a reinforcing filler for polymer composites due to high aspect ratio and extremely-low bulk *** this study,the MOS was treated with 3-methacryloyloxypropyl-trimethoxy silane(MPS)via sol-gel condensation reactions,which successfully allowed melt mixing with polypropylene(PP)up to 30 wt%of *** tensile strength at yield and modulus of the MOS/PP composites were substantially increased by 50.8%and 362%,respectively,when compared with the pristine *** a novel finding,the flame retardancy of MOS was proved by identifying water evolution at elevated temperatures giving out 9 wt%of water in 250-320℃and 14 wt%in 350-420℃in two *** work demonstrated that the MOS could be an excellent filler for PP not only increasing the mechanical properties in a great extent but also imposing flame retarding capability.

关键词： Magnesium oxysulfate Surface modification Mechanical properties Flame retardant

Ischemic colitis due to obstruction of mesenteric and splenic veins: A case report

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World Journal of Gastroenterology 2008年第14期14卷 2272-2276页

作者： Seong-Su Hwang Woo-Chul Chung Kang-Moon lee Hyun-Jin Kim Chang-Nyol Paik Jin-Mo Yang Department of Radiology St. Vincent Hospital the Catholic University Suwon-si Gyeonggi-do 442-723 Korea Department of Internal Medicine St. Vincent Hospital the Catholic University Suwon-si Gyeonggi-do 442-723 Korea

Ischemic injury to the bowel is a well known disease entity that has a wide spectrum of pathological and clinical findings. A sudden drop in the colonic blood supply is essential to its development. We encountered a 41-year-old male patient, who presented with abdominal pain and bloody diarrhea. A colonoscopy showed markedly edematous mucosa with tortuous dilatation of the veins and a deep ulceration at the rectosigmoid junction. On an abdominal computed tomography (CT) scan and CT angiography, the mesenteric and splenic veins were absent with numerous venous collaterals for drainage. The patient gradually responded to oral aminosalicylate therapy, and was in remission after nine months. In most cases, non-occlusive ischemic injury is caused by idiopathic form and occlusive ischemia is caused by abnormalities of arteries and acute venous thrombosis. However, chronic venous insufficiency due to obstruction of macrovascular mesenteric vein rarely causes ischemia of the bowel. This report describes the first case of ischemic colitis caused by obstruction of the mesenteric and splenic veins.

关键词： Ischemic colitis Mesenteric vein Splenic vein

Two-Terminal Lithium-Mediated Artificial Synapses with Enhanced Weight Modulation for Feasible Hardware Neural Networks

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Nano-Micro Letters 2023年第5期15卷 236-253页

作者： Ji Hyun Baek Kyung Ju Kwak Seung Ju Kim Jaehyun Kim Jae Young Kim In Hyuk Im Sunyoung lee Kisuk Kang Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Recently,artificial synapses involving an electrochemical reaction of Li-ion have been attributed to have remarkable synaptic ***-terminal synaptic transistors utilizing Li-ion intercalation exhibits reliable synaptic characteristics by exploiting the advantage of nondistributed weight updates owing to stable ion ***,the three-terminal configurations with large and complex structures impede the crossbar array implementation required for hardware neuromorphic ***,achieving adequate synaptic performances through effective Li-ion intercalation in vertical two-terminal synaptic devices for array integration remains ***,two-terminal Au/LixCoO_(2)/Pt artificial synapses are proposed with the potential for practical implementation of hardware neural *** Au/LixCoO_(2)/Pt devices demonstrated extraordinary neuromorphic behaviors based on a progressive dearth of Li in LixCoO_(2)*** intercalation and deintercalation of Li-ion inside the films are precisely controlled over the weight control spike,resulting in improved weight control *** types of synaptic plasticity were imitated and assessed in terms of key factors such as nonlinearity,symmetricity,and dynamic ***,the LixCoO_(2)-based neuromorphic system outperformed three-terminal synaptic transistors in simulations of convolutional neural networks and multilayer perceptrons due to the high linearity and low programming *** impressive performances suggest the vertical two-terminal Au/LixCoO_(2)/Pt artificial synapses as promising candidates for hardware neural networks.

关键词： Artificial synapse Neuromorphic Li-based Two-terminal Synaptic plasticity

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Signaling pathways in osteogenesis and osteoclastogenesis:Lessons from cranial sutures and applications to regenerative medicine

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Genes & Diseases 2015年第1期2卷 57-68页

作者： Justin B.Maxhimer James P.Bradley Justine C.lee Division of Plastic and Reconstructive Surgery UCLA David Geffen School of MedicineCAUSA Division of Plastic and Reconstructive Surgery Temple University/St.Christopher’s Hospital for ChildrenPAUSA Division of Plastic and Reconstructive Surgery Greater Los Angeles VA Healthcare SystemUSA

One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial *** only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances,the molecular mechanisms elucidated from these studies have provided basic knowledge of bone *** work has translated to methods and advances in bone tissue *** this review,we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine.

关键词： Craniosynostosis OPG Osteoclast RANK RANKL Tissue engineering Osteogenesis Signaling

Computation speedup in the dynamic simulation of MEMS by macromodels

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Progress in Natural Science:Materials International 2003年第3期 61-69页

作者： lee Kwok Hong,LIM Siak Piang,lee Heow Pueh Department of Mechanical Engineering National University of Singapore Singapore 119260 Department of Mechanical Engineering National University of Singapore Singapore 119260 Institute of High Performance Computing Singapore 117528

A doubly clamped microbeam actuated by electrostatic force with squeezed gas film damping is a well-known and stan-dard micro-device in microelectromechanical system (MEMS) for many researchers to demonstrate how reduced-order dynamic macromod-el is an effective way to faithfully capture the device behaviors. However it still takes time to directly recompute the time-dependant nonlin-ear terms in macromodels which are generated by a proper orthogonal decornposition (POD) method with Galerkin procedure at every timestep during the macromodel simulation. This paper proposes two methods for speeding up the computation of macromodel simulations. Inthe first method, the computation speedup is achieved based on the concept of precomputation upon the basis functions are available. In thesecond method, cubic splines approximation is used to interpolate the basis functions and their first and second derivatives, and spatial inte-gration is performed by application of the Gaussian quadrature. Numerical results sh

关键词： MEMS macromodels modei order reduction proper orthogonai decomposition.