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Hemophagocytic lymphohistiocytosis triggered by relapsing polychondritis:A case report

World Journal of Orthopedics 2024年第8期15卷 813-819页

作者： Mi-Ran Han Jeong-Hwan Hwang Seungah Cha So-yeon Jeon Kyu Yun Jang Namsu Kim Chang-Hoon lee Department of Internal Medicine Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Pathology Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Laboratory Medicine Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare,life-threatening disorder caused by abnormal histiocytes and T cell *** adults,it is predominantly associated with infections,cancers,and autoimmune *** polychondritis(RP),another rare disease,is diagnosed based on symptoms without specific tests,featuring cartilage inflammation characterized by swelling,redness,and pain,rarely inducing *** SUMMARY A 74-year-old woman visited the emergency room with a fever of 38.6℃.Blood tests,cultures,and imaging were performed to evaluate *** showed increased fluorescent antinuclear antibody levels and mild cytopenia,with no other specific *** revealed lymph node enlargement was observed;however,biopsy results were *** re-evaluation of the physical exam,inflammatory signs suggestive of RP were observed in the ears and nose,prompting a tissue biopsy for ***,persistent fever accompanied by cytopenia prompted a bone marrow examination,revealing hemophagocytic *** finding no significant results in blood culture,viral markers,and tissue examination of enlarged lymph nodes,HLH was diagnosed by *** involved methylprednisolone followed by *** two months,bone marrow examination confirmed resolution of hemophagocytosis,with normalization of hyperferritinemia and *** Thorough physical examination enabled diagnosis and treatment of HLH trig gered by RP in patients presenting with fever of unknown origin.

关键词： Hemophagocytic lymphohistiocytosis Relapsing polychondritis Autoimmune disease Fever of unknown origin Steroid Case report

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Delphi study for developing a checklist of adverse events associated with acupotomy

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Journal of Integrative Medicine 2024年第5期22卷 579-587页

作者： Hyungsun Jun Haebeom lee Sang-Hoon Yoon Chan-Young Kwon Damin Jeon Jun-Hwan lee Jungtae leem Department of Diagnostics College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea Days Inc. Seoul 06247Republic of Korea Chung-yeon Korean Medicine Clinic Seoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-Eui University College of Korean MedicineBusan 47227Republic of Korea Chonnam National University Hwasun Hospital Hwasun 58128Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Korean Convergence Medical Science KIOM SchoolUniversity of Science&Technology(UST)Daejeon 34054Republic of Korea Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolBostonMA 02115USA Research Center of Traditional Korean Medicine College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea

Background Acupotomy,a more invasive procedure than acupuncture,involves the use of a thicker needle with an integrated knife at the tip,necessitating safety *** aimed to define relevant adverse events(AEs)and create a standardized form of the ACUPOtomy-related AEs CHECKlist(ACUPOCHECK).Methods Before conducting the Delphi process,a systematic review and pilot prospective study were conducted to gather information on previously reported *** these data,pilot versions of the ACUPOCHECK and Delphi questionnaires were *** Delphi questionnaire involved selecting types of AE for inclusion,establishing separate criteria for acupotomy-related AEs,and achieving a consensus on AE *** Korean doctors with experience in acupotomy or AE research were recruited to participate in each Delphi *** was considered to have been reached if the critical value for the content validity ratio met or exceeded *** The final ACUPOCHECK was developed using four rounds of the Delphi method and one face-to-face consensus *** included 12 local AEs(pain,hemorrhage,bruise,hematoma,edema,pruritus,rash,infection,nerve damage,dysesthesia,movement impairment,and pneumothorax)and 14 systemic AEs(disease aggravation,needle fatigue,sleepiness,procedural nausea,procedural vomiting,procedural headache,procedural dizziness,sweating,procedural shock,syncope,dyspnea,procedural pain,sleep disorder,and postprocedural infection).Separate criteria were established for pain,hemorrhage and bruising:pain was defined as pain that occurrs during daily activities and persists for longer than 72 h,hemorrhage as bleeding that continues for≥3 min despite pressure application,and bruising as having a bruise with a diameter of≥3 ***-ended descriptions were allowed for AEs not covered by the checklist,and severity and causality were assessed using the Common Terminology Criteria for Adverse Events and modified World Health Organization-Uppsala Monitoring C

关键词： Acupotomy Delphi technique Patient safety Safety management Adverse event

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Efficient photovoltaic effect in graphene/h-BN/silicon heterostructure self-powered photodetector

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Nano Research 2021年第6期14卷 1967-1972页

作者： Ui yeon won Boo Heung lee Young Rae Kim won Tae Kang Ilmin lee Ji Eun Kim Young Hee lee Woo Jong Yu Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Center for Integrated Nanostructure Physics Institute for Basic Science(IBS)Suwon16419Republic of Korea

Graphene(Gr)/Si-based optoelectronic devices have attracted a lot of academic attention due to the simpler fabrication processes,low costs,and higher performance of their two-dimensional(2D)/three-dimensional(3D)hybrid interfaces in Schottky junction that promotes electron-hole ***,due to the built-in potential of Gr/Si as a photodetector,the Iph/Idark ratio is often hindered near zero-bias at relatively low illumination *** is a major drawback in self-powered *** this study,we have demonstrated a self-powered van der Waals heterostructure photodetector in the visible range using a Gr/hexagonal boron nitride(h-BN)/Si structure and clarified that the thin h-BN insertion can engineer asymmetric carrier transport and avoid interlayer coupling at the *** dark current was able to be suppressed by inserting an h-BN insulator layer,while maintaining the photocurrent with minimal decrease at near *** a result,the normalized photocurrent-to-dark ratio(NPDR)is improved more than 104 ***,both Iph/Idark ratio and detectivity,increase by more than 104 times at−0.03 V drain *** proposed Gr/h-BN/Si heterostructure is able to contribute to the introduction of next-generation photodetectors and photovoltaic devices based on graphene or silicon.

关键词： graphene hexagonal boron nitride van der Waals heterostructure self-powered Research

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Treatment of syringomyelia using uncultured umbilical cord mesenchymal stem cells: A case report and review of literature

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World Journal of Stem Cells 2022年第4期14卷 303-309页

作者： Hyunjun Ahn Sang yeon lee won-Ju Jung Kye-Ho lee Stem Cell Treatment and Research Institute(STRI) bio Beauty and Health Company(bBHC)Seoul 04420South Korea Stem Cell Treatment 97.7 Beauty and Health ClinicSeoul 04420South Korea

BACKGROUND Syringomyelia is a disease caused by the formation of a cavity inside the spinal cord and is accompanied by such symptoms as pain,paresthesia,and urination and defecation disorders,and in severe cases causes various ***,there are only surgical methods for the treatment of syringomyelia,but these methods carry the possibility of failure,recurrence,and side *** SUMMARY The patient was a 59-year-old woman who suffered from pain due to *** treatment,the patient received transplant of uncultured umbilical cord-derived mesenchymal stem *** intended,the patient's pain was relieved after ***,an additional benefit was found in that the size of the cavity also *** 2 years from the last treatment,the patient's cavity had almost completely disappeared and her syringomyelia was deemed *** Using uncultured umbilical cord-derived mesenchymal stem cells may be a new treatment alternative for syringomyelia.

关键词： Syringomyelia Umbilical cord mesenchymal stem cells Cell therapy Allogenic stem cells Chiari malformations Case report

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Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation:A case report

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World Journal of Stem Cells 2021年第8期13卷 1151-1159页

作者： Hyunjun Ahn Sang yeon lee won Ju Jung Kye-Ho lee bio Beauty&Health Company(bBHC)-Stem Cell Treatment&Research Institute(STRI) Seoul 04420South Korea 97.7 Beauty&Health(B&H)Clinics Seoul 04420South Korea

BACKGROUND Stroke is one of the major causes of disability and death *** treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neuronal cells of the ***,mesenchymal stem cells(MSCs)have been studied as a therapeutic alternative for stroke,and various preclinical and case studies have been *** SUMMARY A 55-year-old man suffered an acute stroke,causing paralysis in the left upper and lower *** intravenously transplanted the minimally manipulated human umbilical cord-derived MSCs(MM-UC-MSCs)twice with an 8-d *** 65 wk after transplantation,the patient returned to his previous occupation as a veterinarian with no adverse *** MM-UC-MSCs transplantation potentially treats patients who suffer from acute ischemic stroke.

关键词： Acute ischemic stroke Behavioral disorder Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells:Three case reports and review of literature

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World Journal of Clinical Cases 2021年第15期9卷 3741-3751页

作者： Hyunjun Ahn Sang yeon lee won Ju Jung Kye-Ho lee bio Beauty&Health Company(bBHC)-Stem Cell Treatment&Research Institute(STRI) Seoul 04420South Korea Department of Functional Genomics University of Science and Technology KRIBB SchoolDeajeon 34113South Korea 97.7 Beauty&Health(B&H)Clinics Seoul 04420South Korea

BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair *** appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis),and complete loss of hair over the entire body(alopecia universalis).Recently,mesenchymal stem cells(MSCs)have been identified as a therapeutic alternative for autoimmune *** this reason,preclinical and case studies of AA and related diseases using MSCs have been *** SUMMARY Case 1:A 55-year-old woman suffered from AA in two areas of the *** was given 15 rounds of minimally manipulated umbilical cord-MSCs(MM-UC-MSCs)over 6 *** AA gradually improved 3 mo after the first *** patient was cured,and AA did not *** 2:A 30-year-old woman,with history of local steroid hormone injections,suffered from AA in one area on the *** was given two rounds of MM-UC-MSCs over 1 *** AA immediately improved after the first *** patient was cured,and AA did not *** 3:A 20-year-old woman,who was diagnosed with alopecia universalis at the age of 12,was given 14 rounds of MM-UC-MSCs over 12 *** hair began to grow about 3 mo after the first *** patient was cured,and alopecia universalis did not *** MM-UC-MSC transplantation potentially treats patients who suffer from AA and related diseases.

关键词： Alopecia areata Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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Risks of non-conservative design according to ASME B31.1 for high-temperature piping subjected to long-term operation in the creep range

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Nuclear Science and Techniques 2019年第5期30卷 59-69页

作者： Hyeong-yeon lee Seok-Kwon Son Min-Gu won Ji-Young Jeong Korea Atomic Energy Research Institute National Fusion Research Institute School of Mechanical Engineering Sungkyunkwan University

This study investigates the risks of non-conservative piping design according to ASME B31.1 for hightemperature piping subjected to long-term operation at high temperature in a creep regime based on a sensitivity analysis of the hold time. Design evaluations of hightemperature piping were conducted over a range of hold times in the creep regime according to ASME B31.1,which implicitly considers the creep effects, and the French high-temperature design code of the RCC-MRx, which explicitly considers the creep effects. Conservatisms were quantified among the codes in terms of the hold times. In the case of B31.1, the design evaluation results do not change depending on the hold time at high temperature,whereas in the case of RCC-MRx, they do. It was shown that the design limits of RCC-MRx were exceeded when the hold time exceeded certain values, whereas those of B31.1 were satisfied regardless of the hold times. Thus, the design evaluations according to B31.1 did not consistently yield conservative results and might lead to non-conservative results in the case of long-term operations in the creep range.

关键词： ASME B31.1 Creep Hold time Hightemperature piping RCC-MRx Sensitivity analysis

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Psoriasis treatment using minimally manipulated umbilical cordderived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6798-6803页

作者： Hyunjun Ahn Sang yeon lee won-Ju Jung Jia Pi Kye-Ho lee bio Beauty&Health Company(bBHC)-Stem Cell Treatment and Research Institute(STRI) Seoul 04420South Korea Department of Functional Genomics University of Science and Technology KRIBB SchoolDeajeon 34113South Korea Stem Cell Treatment 97.7 B&H ClinicSeoul 04420South Korea

BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal *** 2%of the world’s population suffers from psoriasis but there are no clear therapeutics ***,mesenchymal stem cells(MSCs)have been regarded as a therapeutic alternative for autoimmune diseases,as they possess immunosuppressive effects without *** umbilical cord-derived MSCs effectively regulate immune cells and are characterized by low immunogenicity,which has many advantages in treating immune *** SUMMARY The patient was a 47-year-old male,diagnosed with psoriasis in *** had received various treatments for 25 years,but the psoriatic condition was not significantly *** was given three rounds of minimally manipulated umbilical cord-derived MSCs over 2 *** erythema gradually *** months after the 1st round,all erythema completely disappeared,and the psoriasis did not *** Minimally manipulated umbilical cord-derived MSC transplantation can potentially treat patients who suffer from psoriasis.

关键词： Psoriasis Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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Recovery from Bell’s palsy after treatment using uncultured umbilical cord-derived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2023年第12期11卷 2817-2824页

作者： Hyunjun Ahn won-Ju Jung Sang yeon lee Kye-Ho lee Stem Cell Treatment and Research Institute bio Beauty and Health CompanySeoul 04420South Korea Stem Cell Treatment 97.7 Beauty and Health ClinicSeoul 04420South Korea

BACKGROUND Bell’s palsy is an idiopathic facial palsy with an unknown cause,and 75%of patients heal ***,the other 25%of patients continue experiencing mild or severe disabilities,resulting in a reduced quality of ***,various treatment methods have been developed to treat this ***,there is controversy regarding their effectiveness,and new alternative treatments are *** SUMMARY The patient suffered from left-sided facial paralysis due to Bell’s palsy for 7 *** patient received an uncultured umbilical cord-derived mesenchymal stem cell transplant eight times for *** follow-up for 32 mo,the paralysis was cured,and there was no *** Uncultured umbilical cord-derived mesenchymal stem cell transplantation may be a potential treatment for patients with Bell’s palsy who do not spontaneously recover.

关键词： Bell’s palsy Facial palsy Umbilical cord-mesenchymal stem cells Allogenic Case report

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Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health 2024年第7期16卷 703-716页

作者： Md. Habibur Rahman yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian Seong Hoon Goh Yundeok Kim Cheol-Su Kim Doo-Sup Kim Kyu-Jae lee Department of Convergence Medicine Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Neurosurgery Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Internal Medicine Division of Hematology-Oncology Wonju Severance Christian Hospital Wonju Republic of Korea Department of Orthopaedic Surgery Wonju College of Medicine Yonsei University Wonju Republic of Korea

1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.

关键词： Knee Osteoarthritis Low-Intensity Continuous Ultrasound Stimulator Clinical Trial Visual Analogue Scale Western Ontario and McMaster Universities Osteoarthritis Index

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