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Breast cancer animal models and applications

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Zoological Research 2020年第5期41卷 477-494页

作者： Li Zeng wei Li Ce-Shi chen Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunmingYunnan 650204China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Breast cancer is the most common malignancy in women. Basic and translational breast cancer research relies heavily on experimental animal models. Ideally, such models for breast cancer should have commonality with human breast cancer in terms of tumor etiology, biological behavior,pathology, and response to therapeutics. This review introduces current progress in different breast cancer experimental animal models and analyzes their characteristics, advantages, disadvantages, and potential applications. Finally, we propose future research directions for breast cancer animal models.

关键词： Breast cancer Animal models Metastasis Drug development

迷迭香活性成分的提取工艺、功能及其在动物生产中的应用

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饲料研究 2024年第14期47卷 172-176页

作者：翟彩宁陈佩黄镜源王玮琨陕西开放大学陕西西安710100

迷迭香提取物含有有机酸、萜类、黄酮类和酚酸类等生物活性成分,提取方法包括超声辅助水蒸气蒸馏法、有机溶剂萃取法、酶法辅助提取法和超临界CO_(2)萃取法等。迷迭香提取物具有抗肿瘤、抗炎、抑菌、降血脂、抗氧化等生物学功能,在动物... 详细信息

迷迭香提取物含有有机酸、萜类、黄酮类和酚酸类等生物活性成分,提取方法包括超声辅助水蒸气蒸馏法、有机溶剂萃取法、酶法辅助提取法和超临界CO_(2)萃取法等。迷迭香提取物具有抗肿瘤、抗炎、抑菌、降血脂、抗氧化等生物学功能,在动物养殖生产中应用可以提高机体的抗病力,增强机体的免疫力及抗氧化性能,进而改善动物的生产性能及畜产品品质。文章综述了迷迭香活性成分的提取工艺、理化性质、生理功能及其在动物养殖中应用的研究进展,为迷迭香提取物作为安全、绿色、高效的饲料添加剂应用于动物养殖生产中提供参考。

关键词：迷迭香活性成分提取工艺生物学功能动物生产

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有氧运动对育肥期滩羊小肠微生物丰度的影响

饲料研究 2024年第1期47卷 73-79页

作者：赵正伟陈茂良张连全马青宁夏农林科学院动物科学研究所宁夏银川750002 宁夏瑞牧盐池滩羊购销有限公司宁夏吴忠751100

试验旨在探讨有氧运动对育肥期滩羊小肠肠道微生物丰度及功能的影响。选取同期断奶体重(16±2)kg的滩羊母羔羊60只,随机分为3组,每组20只。试验1组滩羊每日运动8~10 km,试验2组滩羊每日运动4~6 km,对照组滩羊全舍饲。试验期130 d。结果... 详细信息

试验旨在探讨有氧运动对育肥期滩羊小肠肠道微生物丰度及功能的影响。选取同期断奶体重(16±2)kg的滩羊母羔羊60只,随机分为3组,每组20只。试验1组滩羊每日运动8~10 km,试验2组滩羊每日运动4~6 km,对照组滩羊全舍饲。试验期130 d。结果显示,与对照组相比,试验1组滩羊十二指肠、空肠和回肠3个部位OTU个数均升高。与对照组相比,试验1组十二指肠和试验2组空肠食糜中变形菌门相对丰度显著升高(P<0.05),试验2组回肠食糜中放线菌门相对丰度显著升高(P<0.05);与对照组相比,试验2组十二指肠食糜中粪球菌属相对丰度显著降低(P<0.05),试验1组和试验2组十二指肠食糜中Solobacterium菌属丰度极显著降低(P<0.01);与对照组相比,试验1组空肠和回肠食糜中真杆菌属、狭窄梭菌属及埃希氏菌-志贺氏菌属相对丰度显著降低(P<0.05),试验2组空肠食糜中真杆菌属相对丰度极显著降低(P<0.01)。研究表明,育肥期滩羊每日有氧运动8~10 km可以提升小肠菌群丰度多样性,提高小肠有益菌菌群丰度,降低有害菌群丰度,改善小肠健康水平。

关键词：滩羊有氧运动 16S rRNA 小肠菌群多样性丰度

黄芩苷通过抑制IL1R2表达对A549肺癌细胞增殖、迁移及凋亡的作用及机制研究

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临床肺科杂志 2024年第7期29卷 1042-1048页

作者：陈静韦小白卫海民高洪元上海市静安区中心医院肿瘤科上海200040

目的探究黄芩苷通过抑制IL1R2在A549肺癌细胞增殖、迁移及凋亡中的作用,并探究可能作用机制。方法体外培养A549肺癌细胞,转染si-IL1R2质粒分为对照组、低表达IL1R2组、黄芩苷+低表达IL1R2组、过表达IL1R2组、黄芩苷+过表达IL1R2组,对照... 详细信息

目的探究黄芩苷通过抑制IL1R2在A549肺癌细胞增殖、迁移及凋亡中的作用,并探究可能作用机制。方法体外培养A549肺癌细胞,转染si-IL1R2质粒分为对照组、低表达IL1R2组、黄芩苷+低表达IL1R2组、过表达IL1R2组、黄芩苷+过表达IL1R2组,对照组正常培养细胞,含有黄芩苷的实验组采用200mol/L的黄芩苷处理24h。实时荧光定量PCR(qRT-PCR)法测定IL1R2表达;采用CCK-8法、Transwell、流式细胞法分别观察细胞增殖、迁移能力及凋亡情况;采用Western Blotting法观察各组白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-ɑ(TNF-ɑ)表达。结果IL1R2低表达组干扰后A549细胞的增殖受到抑制,IL1R2过表达组则明显促进细胞增殖;低表达IL1R2组较对照组细胞迁移个数降低,过表达IL1R2组细胞迁移个数较对照组升高,与低表达IL1R2组细胞迁移个数相比,黄芩苷+低表达IL1R2组细胞迁移个数降低明显;与过表达IL1R2组迁移个数相比,黄芩苷+过表达IL1R2组细胞迁移个数降低;与对照组相比,过表达IL1R2组、黄芩苷+过表达IL1R2组细胞凋亡率均降低;黄芩苷+过表达IL1R2组较过表达IL1R2组细胞凋亡率升高;低表达IL1R2组IL-1β、IL-6、TNF-α等细胞因子表达明显下降,过表达IL1R2组各组细胞因子表达明显升高,黄芩苷+过表达IL1R2组各组细胞因子表达较过表达IL1R2组降低。结论黄芩苷通过抑制IL1R2表达抑制肺癌细胞的A549肺癌细胞增殖、迁移,促进肺癌细胞凋亡。

关键词：黄芩苷 IL1R2 肺癌A549细胞增殖迁移

Variations in the effective and bankfull discharge for suspended sediment transport due to dam construction

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Frontiers of Earth Science 2022年第2期16卷 446-464页

作者： Fan chen Li chen wei ZHANG Jing YUAN Kanghe ZHANG State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Changjiang Institute of Survey PlanningDesign and ResearchWuhan 430010China Bureau of Hydrology Changjiang Water Resources CommissionWuhan 430010China

A varied class method is applied to calculate the effective discharges and their variations after the Three Gorges Dam(TGD)construction based on the mean daily flow discharge and suspended sediment concentration field data from 1981 to *** comparison,the bankfull discharges are also determined according to the cross-section profiles and flow discharge-stage *** results show that a bimodal effective discharge curve usually exists at the fixed sites,which generates two effective discharges(Q_(e1) and Q_(e2))within the moderate flow *** the quasi-equilibrium circumstances of the pre-dam period,effective discharges are closely related to the mean annual runoff,with a narrow range of regional variations in occurrence *** analyses draw the conclusion that the relatively higher unsaturation degrees of the pre-dam effective discharges caused by dam interception and riverbed coarsening are the primary cause of the increase in effective discharges from Yichang to Shashi,while the more frequent low and medium discharges due to flow regulation drive the decrease in effective discharges from Jianli to *** slightly elevated flood levels and descending bankfull levels collaboratively result in the decrease of bankfull discharges from Yichang to Shashi,while the lowered bed elevation causes the increase in bankfull discharges from Luoshan to ***,the bankfull discharge in the Middle and Lower Yangtze River is larger than effective discharge and approaches the 1.5-year recurrence interval discharge.

关键词： effective discharge bankfull discharge unsaturation degree flow-sediment regimes Middle and Lower Yangtze River Three Gorges Dam

Giant Magnetic Entropy Change in Manganese Perovskites near Room Temperature

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Chinese Physics Letters 2001年第8期18卷 1114-1116页

作者： ZHONG wei chen wei WANG Jin-Hui DU You-wei National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093 Department of Physics Hebei Normal UniversityShijiazhuang 050091

A large magnetic entropy change about twice as high as that of pure gadolinium metal near room temperature has been discovered in manganese perovskites La_(0.837)Ca_(0.098)Na_(0.038)Mn_(0.987)O_(3.00)(8.3 J·kg^(-1)·K^(-1),at 256K)and La_(0.822)Ca_(0.096)K_(0.043)Mn_(0.974)O_(3.00)(6.8 J·kg^(-1)·K^(-1),at 265 K)under a magnetic field of 1.5 *** phenomenon indicates that manganese perovskites have potential applications for magnetic refrigerants in an extended temperature range even near room temperature.

关键词： temperature. manganese magnetic

基于二维JanusGeS双层铁电隧道结的电子输运

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物理学进展 2024年第4期44卷 197-207页

作者：孙康别洁吕洋洋陈爽法伟南京大学固体微结构物理国家重点实验室物理学院和人工微结构科学与技术协同创新中心南京210093 南京大学匡亚明学院南京210023 香港城市大学材料科学与工程学系中国香港999077 南京大学材料科学与工程学院固体微结构物理国家重点实验室南京210093 东南大学量子材料与器件教育部重点实验室南京211189

二维范德华Janus材料两侧为不同原子,使得其具有内禀的结构不对称性和面外极化。一类新型的二维Janus材料GeS被发现可用于制备低能耗、高响应速度的铁电隧道结。基于第一性原理计算,我们发现JanusGeS双层有三种堆叠模式,它们的横向滑动... 详细信息

二维范德华Janus材料两侧为不同原子,使得其具有内禀的结构不对称性和面外极化。一类新型的二维Janus材料GeS被发现可用于制备低能耗、高响应速度的铁电隧道结。基于第一性原理计算,我们发现JanusGeS双层有三种堆叠模式,它们的横向滑动和垂直位移都可以调节隧道结中的电子输运。此外,基于GeGe接触的GeS双层的铁电隧道结表现出最高的开/关比。我们的研究将滑移铁电的概念扩展到一类新型的二维范德华Janus材料,并揭示了这些材料在实际器件中可能的电阻开关机制。我们的工作为基于二维范德华Janus材料的低能耗、快速开关纳米器件的设计提供了理论指导。

关键词：二维范德华Janus材料滑移铁电性铁电隧道结阻态开关

Landslide susceptibility modeling based on ANFIS with teaching-learning-based optimization and Satin bowerbird optimizer

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Geoscience Frontiers 2021年第1期12卷 93-107页

作者： wei chen Xi chen Jianbing Peng Mahdi Panahi Saro Lee College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Coal Resources Exploration and Comprehensive Utilization Ministry of Natural ResourcesXi’an 710021China Department of Geological Engineering Chang’an UniversityXi’an 710054China Division of Science Education College of Education#4-301Gangwondaehak-gil Chuncheon-siKangwon National UniversityGangwon-do 24341South Korea Geoscience Platform Research Division Korea Institute of Geoscience and Mineral Resources(KIGAM)124Gwahak-ro Yuseong-guDaejeon 34132South Korea Department of Geophysical Exploration Korea University of Science and Technology217 Gajeong-ro Yuseong-guDaejeon 34113South Korea

As threats of landslide hazards have become gradually more severe in recent decades,studies on landslide prevention and mitigation have attracted widespread attention in relevant domains.A hot research topic has been the ability to predict landslide susceptibility,which can be used to design schemes of land exploitation and urban development in mountainous *** this study,the teaching-learning-based optimization(TLBO)and satin bowerbird optimizer(SBO)algorithms were applied to optimize the adaptive neuro-fuzzy inference system(ANFIS)model for landslide susceptibility *** the study area,152 landslides were identified and randomly divided into two groups as training(70%)and validation(30%)***,a total of fifteen landslide influencing factors were *** relative importance and weights of various influencing factors were determined using the step-wise weight assessment ratio analysis(SWARA)***,the comprehensive performance of the two models was validated and compared using various indexes,such as the root mean square error(RMSE),processing time,convergence,and area under receiver operating characteristic curves(AUROC).The results demonstrated that the AUROC values of the ANFIS,ANFIS-TLBO and ANFIS-SBO models with the training data were 0.808,0.785 and 0.755,*** terms of the validation dataset,the ANFISSBO model exhibited a higher AUROC value of 0.781,while the AUROC value of the ANFIS-TLBO and ANFIS models were 0.749 and 0.681,***,the ANFIS-SBO model showed lower RMSE values for the validation dataset,indicating that the SBO algorithm had a better optimization ***,the processing time and convergence of the ANFIS-SBO model were far superior to those of the ANFIS-TLBO ***,both the ensemble models proposed in this paper can generate adequate results,and the ANFIS-SBO model is recommended as the more suitable model for landslide susceptibility assessment in the study area

关键词： Landslide susceptibility Step-wise weight assessment ratio analysis Adaptive neuro-fuzzy fuzzy inference system Teaching-learning-based optimization Satin bowerbird optimizer

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聚乳酸立构复合晶的加工成型进展

塑料 2024年第5期53卷 82-85,171页

作者：黄晴宜石暄陈伟罗岑怡赵志新陈宝书李正秋西华大学材料科学与工程学院四川成都610039

由于聚乳酸(PLA)分子链刚性较大,运动能力较弱,分子链间缠结位点较少,其耐热性较差。生产中,常诱导PLA形成高熔点且相互嵌套的透明立构复合晶(SC-PLA),改善其耐热性能。SC-PLA的主要制备方法包括溶液法及熔体法,但是,SC-PLA晶在热力学... 详细信息

由于聚乳酸(PLA)分子链刚性较大,运动能力较弱,分子链间缠结位点较少,其耐热性较差。生产中,常诱导PLA形成高熔点且相互嵌套的透明立构复合晶(SC-PLA),改善其耐热性能。SC-PLA的主要制备方法包括溶液法及熔体法,但是,SC-PLA晶在热力学上属于亚稳态,二次成型加工过程中难以保持稳定。加工过程为赋予材料热历史的过程,其中,应力诱导无需添加成核剂,并且,工艺步骤简单,具有精准的局部结构调控能力,因此,得到了研究人员的广泛关注。综述了剪切、压应力场及拉伸应力场作用下,SC-PLA的成型加工原理与分子链构型构象及性能的变化。总结了影响SC-PLA生成比例的因素,进一步分析SC-PLA的性能上限,拓展其在不同领域的高性能化应用。

关键词：立构复合聚乳酸应力场制备方法结构性能