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Cancer-associated fibroblasts of colorectal cancer: Translationalprospects in liquid biopsy and targeted therapy

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BIOCELL 2023年第10期47卷 2233-2244页

作者： ELYN AMIELA SALLEH YEONG yeh LEE ANDEE DZULKARNAEN ZAKARIA NUR ASYILLA CHE JALIL MARAHAINI MUSA Human Genome Centre School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Internal Medicine School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Surgery School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia

Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts(CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component ofthe tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectalcarcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patientsurvival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinicalapplications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected inblood samples, have been proposed to help in determining patient prognosis and enables the detection of cancerthrough liquid biopsy. Liquid biopsy is gaining traction as it is non-invasive, allows frequent and easy sampling, andshows concordance to tissue biopsy analysis. In addition, CAF-targeted therapy is currently being studied extensivelyto be used as one of the treatment avenues for CRC. Various mechanisms of CAF-targeted therapy have beenreported, including blocking the signaling pathways involving CAFs and cancer cells, thus abolishing the CAF-tumorcell crosstalk and subsequently hindering tumorigenesis. These translational applications of cCAFs and utilization ofCAFs as key targets for CRC therapy, although still in the early phases of development, will potentially improve CRCpatient management in the future.

关键词： Activated fibroblast Colon cancer Liquid biopsy Precision medicine

Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

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World Journal of Stem Cells 2022年第1期14卷 76-91页

作者： Hsi-Lung Hsieh Ming-Chin Yu Li-Ching Cheng Ta-Sen yeh Ming-Ming Tsai Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333Taiwan Research Center for Chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333Taiwan Department of Neurology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of General Surgery Chang Gung Memorial Hospital at LinkouTaoyuan 333Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of General Surgery New Taipei Municipal TuCheng HospitalNew Taipei 236Taiwan Department of General Surgery Chang Gung Memorial HospitalChiayi 613Taiwan

Gastric cancer(GC)is a primary cause of cancer-related mortality worldwide,and even after therapeutic gastrectomy,survival rates remain *** presence of gastric cancer stem cells(GCSCs)is thought to be the major reason for resistance to anticancer treatment(chemotherapy or radiotherapy),and for the development of tumor recurrence,epithelial–mesenchymal transition,and ***,GCSCs have the capacity for self-renewal,differentiation,and tumor *** also synthesize antiapoptotic factors,demonstrate higher performance of drug efflux pumps,and display cell plasticity ***,the tumor microenvironment(TME;tumor niche)that surrounds GCSCs contains secreted growth factors and supports angiogenesis and is thus responsible for the maintenance of the growing ***,the genesis of GCSCs is unclear and exploration of the source of GCSCs is *** this review,we provide up-todate information about GCSC-surface/intracellular markers and GCSC-mediated pathways and their role in tumor *** information will support improved diagnosis,novel therapeutic approaches,and better prognosis using GCSC-targeting agents as a potentially effective treatment choice following surgical resection or in combination with chemotherapy and *** date,most anti-GCSC blockers when used alone have been reported as unsatisfactory anticancer ***,when used in combination with adjuvant therapy,treatment can *** providing insights into the molecular mechanisms of GCSCs associated with tumors in GC,the aim is to optimize anti-GCSCs molecular approaches for GC therapy in combination with chemotherapy,radiotherapy,or other adjuvant treatment.

关键词： Gastric cancer stem cells Stem cell-surface markers Tumor niche Tumor microenvironment

On the number of matchings of graphs formed by a graph operation

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Science China Mathematics 2006年第10期49卷 1383-1391页

作者： yeh Yeong-Nan Institute of Mathematics Academia Sinica

Let G be a simple graph. Define R(G) to be the graph obtained from G by adding a new vertex e* corresponding to each edge e = (a, b) of G and by joining each new vertex e* to the end vertices a and b of the edge e corresponding to it. In this paper, we prove that the number of matchings of R(G) is completely determined by the degree sequence of vertices of G.

关键词： matching, Hosoya index, matching polynomial, oriented incident matrix,skew adjacency matrix.

Knowledge discovery for geographical cellular automata

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Science China Earth Sciences 2005年第10期48卷 1758-1767页

作者： Anthony Gar-On yeh Centre of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

This paper proposes a new method for geographical simulation by applying data mining techniques to cellular automata. CA has strong capabilities in simulating complex systems. The core of CA is how to define transition rules. There are no good methods for defining these transition rules. They are usually defined by using heuristic methods and thus subject to uncer-tainties. Mathematical equations are used to represent transition rules implicitly and have limita-tions in capturing complex relationships. This paper demonstrates that the explicit transition rules of CA can be automatically reconstructed through the rule induction procedure of data mining. The proposed method can reduce the influences of individual knowledge and preferences in de-fining transition rules and generate more reliable simulation results. It can efficiently discover knowledge from a vast volume of spatial data.

关键词： knowledge discovery, cellular automata, geographical simulation, geographical information systems.

Multi-agent systems for simulating spatial decision behaviors and land-use dynamics

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Science China Earth Sciences 2006年第11期49卷 1184-1194页

作者： Anthony Gar-On yeh Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new method to simulate urban land-use dynamics is proposed based on multi-agent systems (MAS). The model consists of a series of environmental layers and multi-agent layers, which can interact with each other. It attempts to explore the interactions between different players or agents, such as residents, property developers, and governments, and between these players and the envi- ronment. These interactions can give rise to urban macro-spatial patterns. This model is used to simulate the land-use dynamics of the Haizhu district of Guangzhou City in 1995―2004. Cellular automata (CA) were also used for the simulation of land use changes as a comparison. The study indicates that MAS has better performance for simulating complex cities than CA.

关键词： multi-agent systems, cellular automata, complex systems, cities, land use.

Cystic artery pseudoaneurysm:A case report

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World Journal of Clinical Cases 2023年第1期11卷 242-248页

作者： Yu-Ling Liu Cheng-Ta Hsieh Yao-Jen yeh Hsien Liu Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Division of Neurosurgery Department of SurgerySijhih Cathay General HospitalNew Taipei 22174Taiwan School of Medicine National Tsing Hua UniversityHsinchu 300044Taiwan Department of Medicine School of MedicineFu Jen Catholic UniversityNew Taipei 24205Taiwan Operating Room Technician Ditmanson Medical FoundationChia-yi Christian HospitalChia-yi 600Taiwan Division of General Surgery Department of SurgeryDitmanson Medical FoundationChia-yi Christian HospitalChiayi 600Taiwan

BACKGROUND Cystic artery pseudoaneurysm is a condition rarely encountered by clinicians;this,its etiology and presentation as well as appropriate treatments are not well *** it is treated by removal of the diseased gallbladder and cystic artery,such surgery can be difficult and risky if acute inflammation with bleeding occurs,and not every patient can tolerate the *** SUMMARY An 81-year-old man complained of epigastric pain and tarry stool passage that lasted for 3 *** had a medical history of poor cardiopulmonary *** computed tomographic scan of abdomen showed cystic artery pseudoaneurysm and dilatation of *** of high adverse outcomes related to general anesthesia,the patient was successfully managed with endovascular embolization for this cystic artery pseudoaneurysm and percutaneous drainage for the distended *** A patient with cystic artery pseudoaneurysm may quickly deteriorate with the occurrence of concurrent arterial bleeding and *** report presents the case of a patient who did not undergo surgery due to multiple cardiopulmonary comorbidities and whose condition was managed successfully with embolization and biliary *** embolization and biliary drainage may provide an alternative option to manage this complicated condition.

关键词： Cystic artery pseudoaneurysm Endovascular intervention Embolization Biliary drainage Case report

Trustworthiness Evaluation for Permissioned Blockchain-Enabled Applications

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Computers, Materials & Continua 2022年第11期73卷 2731-2755页

作者： Shi-Cho Cha Chuang-Ming Shiung Wen-Wei Li Chun-Neng Peng Yi-Hsuan Hung Kuo-Hui yeh Department of Information Management National Taiwan University of Science and TechnologyTaiwanChina Department of Information Management National Dong Hwa UniversityHualienTaiwanChina Department of Computer Science and Engineering National Sun Yat-Sen UniversityKaohsiungTaiwanChina

As permissioned blockchain becomes a common foundation of blockchain-based circumstances for current organizations,related stakeholders need a means to assess the trustworthiness of the applications involved *** is extremely important to consider the potential impact brought by the Blockchain technology in terms of security and ***,this study proposes a rigorous security risk management framework for permissioned blockchain-enabled *** framework divides itself into different implementation domains,i.e.,organization security,application security,consensus mechanism security,node management and network security,host security and perimeter security,and simultaneously provides guidelines to control the security risks of permissioned blockchain applications with respect to these security *** addition,a case study,including a security testing and risk evaluation on each stack of a specific organization,is demonstrated as an implementation instruction of our proposed risk management *** to the best of our knowledge,this study is one of the pioneer researches that provide a means to evaluate the security risks of permissioned blockchain applications from a holistic point of *** users can trust the applications that adopted this framework,this study can contribute to the adoption of permissioned blockchain-enabled ***,application providers can use the framework to perform gap analysis on their existing systems and controls and understand the risks of their applications.

关键词： Permissioned blockchain blockchain security blockchain risk evaluation

A concise review about fracture assessments of brittle solids with V-notches

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Frontiers of Structural and Civil Engineering 2019年第2期13卷 478-485页

作者： Hsien-Yang yeh Bin YANG Department of Mechanical and Aerospace Engineering California State UniversityLong BeachCA 90801USA Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

A concise review of recent studies about the fracture assessments of elastic brittle solid materials containing V-notches is presented. In this preliminary and brief survey, elastic stress distributions in V-notched solids are discussed first. The concept of notch stress intensity factor is introduced. Combine the digital image correlation method with numerical computation techniques to analyze the stress distribution near the notches. Fracture criteria such as strain energy density, J-integral, theory of critical distance are used. However, various new materials are developed in different engineering fields, thus, the establishment of reliable and accurate material strength theory or failure criterion is imperative. Therefore, predicting fracture for various modem materials would require more experiments to infer material dependent parameters in the local fracture model.

关键词： fracture assessment brittle solids V-notches review

Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration

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International Journal of Oral Science 2023年第2期15卷 185-203页

作者： Milos Marinkovic Olivia N.Tran Hanzhou Wang Parveez Abdul-Azees David D.Dean Xiao-Dong Chen Chih-Ko yeh Department of Comprehensive Dentistry University of Texas Health Science Center at San AntonioTXUSA Research Service South Texas Veterans Health Care SystemTXUSA Department of Biomedical Engineering University of Texas at San AntonioTXUSA Geriatric Research Education and Clinical CenterSouth Texas Veterans Health Care SystemTXUSA

Salivary gland(SG)dysfunction,due to radiotherapy,disease,or aging,is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of ***,the standard-of-care for this condition remains palliative.A variety of approaches have been employed to restore saliva production,but they have largely failed due to damage to both secretory cells and the extracellular matrix(niche).

关键词： salivary clinical diseases