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Nuclear Science and Techniques 2022年第7期33卷 93-102页

作者： Zi-Yuan Li Zhen Qian Jie-Han He Wei He Cheng-Xin Wu xun-ye Cai Zheng-Yun You Yu-Mei Zhang Wu-Ming Luo School of Physics Sun Yat-Sen UniversityGuangzhou510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai519082China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China

The precise vertex reconstruction for large liquid scintillator detectors is essential.A novel machine learning-based method was successfully developed to reconstruct an event vertex in *** this study,the performance of machine learning-based vertex reconstruction was further improved by optimizing the input images of neural *** separating the information of different types of PMTs and adding the information of the second hit of PMTs,the vertex resolution was improved by approximately 9.4% at 1 MeV and 9.8% at 11 MeV.

关键词： JUNO Liquid scintillator detector Neutrino experiment Vertex reconstruction Machine learning

Digital subtraction angiographic characteristics of progression of moyamoya disease 6 months prior to surgical revascularisation

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Stroke & Vascular Neurology 2020年第1期5卷 97-102页

作者： Peicong Ge Qian Zhang xun ye Xingju Liu Xiaofeng Deng Jia Wang Rong Wang Yan Zhang Dong Zhang Ji Zong Zhao Department of Neurosurgery Beijing Tiantan HospitalBeijingChina

background Evidence on the natural angiographic course of moyamoya disease(MMD)is *** takes about 6 months for waiting for revascularisation *** issue of when to perform subtraction angiography(DSA)for follow-up remains *** investigated the natural course of MMD by DSA and attempted to determine the best interval to perform the follow-up *** This is a single-centre cohort study of Chinese MMD inpatients treated from 1 January 2015 to 31 August *** angiographic findings were evaluated on Suzuki stage and collateral circulation between two follow-ups of the same *** A total of 110 patients who met the criteria were enrolled in this *** a median 6 months follow-up,five patients(4.5%)had progression,four females and one *** interval of progression ranged from 4 to 137 months with a mean of 61.4 *** five patients with progression,four had unilateral lesion(two ipsilateral and two contralateral)and one had bilateral *** circulation was changed in three of five *** The angiographic evidence of progression in MMD was rare in the short-term follow-up,and most patients with progression had initial unilateral *** re-examination may be not needed in patients with bilateral MMD,but needed in unilateral MMD.

关键词： involvement progression characteristics

Moyamoya disease associated with ankylosing spondylitis in a 9-year-old child:a case report

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Chinese Neurosurgical Journal 2017年第3期3卷 188-191页

作者： Fan Yang Peicong Ge xun ye Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University China National Clinical Research Center for Neurological Diseases Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease 6 Tiantanxili DongCheng District Beijing 100050 China Center of Stroke Beijing Institute for Brain Disorders Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease 6 Tiantanxili DongCheng District Beijing 100050 China

Background: Ankylosing spondylitis was reported to associate with an increased risk of cerebrovascular diseases. In this article, we aimed to report the first case of ankylosing spondylitis associated with moyamoya disease treated with encephalo-duroarterio-synangiosis. Case presentation: A 9-year-old boy with ankylosing spondylitis appeared a symptom of repeated transient ischemic attacks which performed as left hemiparesis. Magnetic resonance angiography showed a typical finding of left anterior cerebral artery, bilateral middle cerebral arteries and the supraclinoid portion of the right internal carotid artery stenosis with an abnormal vascular network at the base of the brain, diagnosed with moyamoya disease. He received a medication treatment but did not underwent revascularization surgery. After three months, ankylosing spondylitis symptoms got some relief, whereas transient ischemic attacks was more frequency. Due to the bad cerebral blood flow on acetazolamide computed tomography perfusion and poor clinical manifestation, he underwent a right encephalo-duroarterio-synangiosis. Postoperatively, the symptoms of transient ischemic attacks disappeared. Conclusions: We reported the first case of ankylosing spondylitis associated with moyamoya disease. Moyamoya disease could appear in patients with ankylosing spondylitis. Revascularization surgery probably is an effective treatment for preventing preoperative ischemic events recurrence.

关键词： Ankylosing spondylitis Moyamoya disease Transient ischemic attack

Evaluation of intraoperative MRI-assisted stereotactic brain tissue biopsy: a singlecenter experience in China

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Chinese Neurosurgical Journal 2019年第1期5卷 13-20页

作者： Chang-yu Lu Zong-sheng Xu xun ye Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background:This study aimed to investigate the value of high field-strength intraoperative magnetic resonance imaging(iMRI)-guided stereotactic biopsy in the surgery of intracranial space-occupying ***:A total of 87 patients who underwent stereotactic biopsy of intracranial lesions in the Peking University International Hospital from March 2016 to August 2018 were retrospectively surveyed;among these,50 patients underwent MRI-guided stereotactic biopsy using the Leksell frame(iMRI group)and 37 cases received traditional stereotactic biopsy using the Leksell frame(control group).The accuracy rates and complications of the two groups were ***:A 100%positive diagnosis was observed in all cases(n=50)in the iMRI *** 4 cases,the biopsy site was clearly found to have deviated from the target point,and the biopsy was performed *** control group had 33 cases(86.5%)with positive *** severe complications like neural functional deficit were observed in the iMRI group,while two patients developed bleeding at the puncture site(1 case receiving surgery to remove the hematoma)in the control *** were no deaths in either ***:iMRI-assisted stereotactic biopsy can confirm the target position and adjust the puncture path in real *** to the traditional stereotactic biopsy technique,the iMRI method has a higher positive diagnostic rate,though surgical trauma and complications have no significant difference.

关键词： High field-strength Stereotactic technique Brain biopsy Intraoperative magnetic resonance

Centrifuge model tests of the formation mechanism of coarse sand debris flow

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Journal of Chongqing University 2014年第3期13卷 77-89页

作者：周建周韵鸿 LI ye-xun WANG Zi-han Department of Geotechnical Engineering Tongji University Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji University The Second Engineering Company of CCCC Third Harbor Engineering Co.Ltd. School of civil engineering Hebei University of Technology

Using the self-developed visualization test apparatus, centrifuge model tests at 20 g were carried out to research the macro and microscopic formation mechanism of coarse sand debris flows. The formation mode and soil-water interaction mechanism of the debris flows were analyzed from both macroscopic and microscopic points of view respectively using high digital imaging equipment and micro-structure analysis software Geodip. The test results indicate that the forming process of debris flow mainly consists of three stages, namely the infiltration and softening stage, the overall slide stage, and debris flow stage. The essence of simulated coarse sand slope forming debris flow is that local fluidization cause slope to wholly slide. The movement of small particles forms a transient stagnant layer with increasing saturation, causing soil shear strength lost and local fluidization. When the driving force of the saturated soil exceeds the resisting force, debris flow happens on the coarse sand slope immediately.

关键词： coarse sand debris flow centrifuge model tests formation mode water-soil interaction mechanism

Clinical and pathological changes in cerebral arteriovenous malformations after stereotactic radiosurgery failure

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Chinese Medical Journal 2008年第12期121卷 1076-1079页

作者： LIU Wei-ming ye xun ZHAO Yuan-li WANG Shuo ZHAO Ji-zong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Stereotactic radiosurgery is an altemative to resection of intracranial cerebral arteriovenous malformations （AVMs）, while it will fail in some cases. This study aimed to evaluate the changes after stereotactic radiosurgery for AVMs.Methods Nineteen cases with cerebral AVMs had failure after stereotactic radiosurgery therapy. The symptoms and angiography were assessed. All patients underwent microsurgery. Pathologic examination was performed for all cases and electron microscopic examination was carried out in 6 patients.Results Seven cases had hemorrhage from 12 to 98 months after stereotactic radiosurgery, 5 had headache, 4 had refractory encephalon edema, 2 had epilepsy as a new symptom and 1 had a pressure cyst 5 years after radiosurgery. Angiography in 18 cases, 8-98 months after radiation therapy, demonstrated no significant changes in 5 cases, slight reduction in 9, near complete obliteration in 1 and complete obliteration in 3. An abnormal vessel was found on pathologic examination in 17 cases, even one case had obliterated in angiography. Electron microscopy examination showed vessel wall weakness, but the vessels remained open and blood circulated. One case died because of a moribund state before surgery. The other 18 cases had no new neurological deficiencies, seizure control and no hemorrhage occurred after microsurgery at an average follow-up of 3 years.Conclusion Stereotactic radiotherapy for AVMs should have a long period follow-up. If serious complications occur, microsurgery can be performed as salvage treatment.

关键词： cerebral arteriovenous malformations stereotactic radiosurgery microsurgery complications

Long-term outcomes of brainstem arteriovenous malformations after different management modalities: a single-centre experience

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Stroke & Vascular Neurology 2021年第1期6卷 65-73页

作者： Yu Chen Ruinan Li Li Ma Xiangyu Meng Debin Yan Hao Wang xun ye Hengwei Jin Youxiang Li Dezhi Gao Shibin Sun Ali Liu Shuo Wang Xiaolin Chen Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Stroke Center Beijing Institute for Brain DisordersBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Gamma-Knife Center Beijing Tiantan HospitalBeijingChina

Objective The aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations(AVMs)after different management *** The authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and *** rupture risk was represented by annualised haemorrhagic *** were divided into five groups:conservation,microsurgery,embolisation,stereotactic radiosurgery(SRS)and embolisation+*** outcomes were evaluated by the modified Rankin Scale(mRS).Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured *** All of 61 brainstem AVMs(12 unruptured and 49 ruptured)were followed up for an average of 4.5 *** natural annualised rupture risk was 7.3%,and the natural annualised reruptured risk in the ruptured cohort was 8.9%.13 cases were conservative managed and 48 cases underwent intervention(including 6 microsurgery,12 embolisation,21 SRS and 9 embolisation+SRS).In the selection of interventional indication,diffuse nidus were often suggested conservative management(p=0.004)and nidus involving the midbrain were more likely to be recommended for intervention(p=0.034).The risk of subsequent haemorrhage was significantly increased in partial occlusion compared with complete occlusion and conservative management(p<0.001,p=0.036,respectively).In the subgroup analysis,the follow-up mRS scores of different management modalities were similar whether in the rupture cohort(p=0.064)or the unruptured cohort(p=0.391),as well as the haemorrhage-free survival(p=0.145).In the adjusted Bonferroni correction analysis of the ruptured cohort,microsurgery and SRS could significantly improve the obliteration rate compared with conservation(p<0.001,p=0.001,respectively)and SRS may have positive effect on avoiding new-onset neurofunctional deficit compared with microsurgery and embolisation(p=0.003,p=0.003,respectively).Conclusio

关键词： brainstem modalities conservative

Preliminary exploration of the development of a collagenous artificial dura mater for sustained antibiotic release

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Chinese Medical Journal 2013年第17期126卷 3329-3333页

作者： WANG Hao DONG Hui KANG Cheng-gui LIN Cheng ye xun ZHAO Yuan-li Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Beijing TianXinFu Medical Appliance Company Ltd. China

Background Intracranial infection is one of the most common complications of open craniocerebral injury and of conventional craniotomy in neurosurgery. The presence of blood-brain barrier leads to lower drug concentrations in the cerebrospinal fluid than in the venous blood. Increasing the intravenous dosage or frequency carries the risk of systemic adverse reactions or infections in other parts of the body. Developing an artificial dura mater （ADM） for sustained antibiotic release for use during neurosurgery can solve the problems perfectly. Methods Three types of drug-loaded ADMs made of collagen and containing cefuroxime sodium, ceftriaxone sodium, or norvancomycin were prepared. The antibacterial activity and sustained release characteristics of the ADMs were examined using bacteriostatic and release tests. Results Single-layered collagen based ADMs （40 mm×50 mm×5 mm） containing 18 mg cefuroxime sodium or ceftriaxone sodium were not suitable for continued development because of drug preservation and stability issues. Using smaller ADMs （20 mm30 mm×7 mm）, containing 4.86 mg of norvancomycin, with increased collagen density and a three-layered film with two outer drug-free films above and below the antibiotic layer resulted in sustained cumulative release of 2.91 mg （59.9%） of norvancomycin over 72 hours. The similar factor （f2） comparison method proved that products from a same batch were statistically significant similar （f2 〉50）. Conclusions Artificial ADMs made of collagen can be processed to provide a mature dural repair material for the sustained release of norvancomycin. This system may provide a basis for developing sustained release materials for other drugs.

关键词： intracranial infection drug release antibiotics artificial dura mater

从侵犯商业秘密罪看全球化背景下刑民法之界域

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河北法学 2009年第10期27卷 112-116页

作者：胡业勋西南财经大学法学院四川成都610074

1997年侵犯商业秘密罪进入刑法典以来,司法实践中出现了很多问题。这就需要对侵犯商业秘密罪进行立罪反思,当前在侵犯商业秘密罪之立罪上,存在着立罪理念困惑、立罪依据迷茫以及立罪技巧混沌等问题。其症结在于侵犯商业秘密罪上存在着... 详细信息

1997年侵犯商业秘密罪进入刑法典以来,司法实践中出现了很多问题。这就需要对侵犯商业秘密罪进行立罪反思,当前在侵犯商业秘密罪之立罪上,存在着立罪理念困惑、立罪依据迷茫以及立罪技巧混沌等问题。其症结在于侵犯商业秘密罪上存在着刑民之交叉互动,未能对其进行界定,面对着全球化背景的冲击,必须在刑民之间厘定一条相对明晰的界域,来达到更好的对商业秘密保护之目的。

关键词：商业秘密立罪刑民交叉

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EUV波段CCD相机及其空间分辨率测试

光学精密工程 2005年第Z1期13卷 56-59页

作者：巩岩宋谦叶彬浔中国科学院国家天文台

研究了EUV波段CCD相机及其空间分辨率测试。EUV波段相机由荧光屏、MCP像管、光锥和可见光CCD构成,CCD像元大小为14μm,像元数2 048×2 048。在北京同步辐射装置光束线软X射线光学实验束线站3W1B上,利用透射网栅法对相机进行了空间分辨... 详细信息

研究了EUV波段CCD相机及其空间分辨率测试。EUV波段相机由荧光屏、MCP像管、光锥和可见光CCD构成,CCD像元大小为14μm,像元数2 048×2 048。在北京同步辐射装置光束线软X射线光学实验束线站3W1B上,利用透射网栅法对相机进行了空间分辨率测试,结果显示这种结构的CCD相机在17.1 nm波长处,空间分辨率达到19μm,相当于极限分辨率为26 lp/mm。

关键词： EUV MCP CCD 空间分辨率