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Embolization combined with endoscopic variceal ligation for the treatment of esophagogastric variceal bleeding in patients with cirrhosis

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Chinese Medical Journal 2007年第1期120卷 36-40页

作者： HUANG Liu-ye CUI jun wu Cheng-rong LIU Yun-xiang Department of Gastroenterology Yuhuangding Hospital MedicalCollege of Qingdao University Yantai 264000 China

Background Esophagogastric variceal bleeding caused by cirrhosis is a kind of emergent condition in the clinic. This study was conducted to explore the therapeutic effect and superiority of embolization of gastric fundus vadces combined with endoscopic variceal ligation （EVL） of esophageal varices for the treatment of patients with esophagogastric variceal bleeding caused by cirrhosis. Methods Totally 172 patients were diagnosed by endoscopic examination within 24 hours of hospitalization with active gastric fundus variceal bleeding and grade II above esophageal varices caused by cirrhosis. Other causes leading to upper digestive tract bleeding were excluded. Patients were randomly divided into a control group （n=82） and a therapy group （n=-90） following a random number table method. For the former, embolization for gastric fundus varices was performed, then an EVL for esophageal varices was performed 2 months later. For the therapy group, embolization for gastric fundus varices and EVL for esophageal varices were performed at the same time. Results The rate of emergency hemostasis in the therapy group was 100.0%, higher than that in the control group （87.8%, P〈0.05）. The rate of early rebleeding in the therapy group was 6.7% while the rate in the control group was 23.6% （P〈0.05）. No complications related to treatment occurred in both groups. Conclusion Embolization for gastric fundus varices combined with EVL for esophageal varices is a safe and effective method for the treatment of patients with esophagogastric variceal bleeding caused by cirrhosis.

关键词： esophagogastric varices embolization endoscopic variceal ligation cirrhosis

Narrow-band imaging in the diagnosis of early esophageal cancer and precancerous lesions

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Chinese Medical Journal 2009年第7期122卷 776-780页

作者： HUANG Liu-ye CUI jun wu Cheng-rong LIU Yun-xiang XU Ning Department of Gastroenterology Yantai Yuhuangding HospitalAffiliated to Medical College of Qingdao University YantaiShandong 264000 China

Background In the recent years, the incidence of esophageal cancer in China has increased. The key point for raising the survival rate is the diagnosis and treatment at an early stage. Narrow-band imaging （NBI） can enhance the contrast of the mucous membrane of the esophagus without staining. This study aimed to explore the value of NBI in the diagnosis of early esophageal cancer and precancerous lesions. Methods The esophagus was examined with ordinary endoscopy and NBI endoscopy. Pit patterns and blood capillary forms were examined with routine magnifying endoscopy and NBI endoscopy. Finally, a 1.2% Lugoul＇s iodine solution was used to stain the esophageal mucosal surface and a biopsy was taken at all the sites where NBI or iodine staining was positive. NBI and iodine staining scales were compared with pathologic diagnosis, which was considered as the gold standard. Results A total of 90 cases （138 lesions in total） were diagnosed as early esophageal cancer or precancerous lesions; 104 lesions （75.4%） were detected with ordinary endoscopy, 120 lesions （87.0%） were detected with NBI endoscopy, and 138 lesions （100%） were detected with iodine staining. The lesion detection rate of NBI was significantly lower than that of iodine staining （X2=17.176, P 〈0.01）. However, there was no significant difference between NBI and iodine staining for the diagnosis of high grade intraepithelial neoplasia （X2=1.362, P 〉0.05）, while the detection rate of NBI was significantly lower than that of iodine staining for the diagnosis of low grade intraepithelial neoplasia （X2=13.388, P 〈0.01）. The pit pattern and blood capillary form of early esophageal cancer and precancerous lesions could be demonstrated clearer with NBI than with ordinary endoscopy. Conclusions NBI can enhance the contrast of the mucous membrane of the esophagus without staining. The combination of NBI and iodine staining can raise the diagnostic rate of early esophageal cancer and precancerous lesions.

关键词： esophageal neoplasms endoscopy narrow-band imaging

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun ye-jun wu Qiu-Sha Huang Hai-Xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang Xiao-jun Huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying wu Shan ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

缺血性脑卒中治疗时间窗后辅助溶栓治疗的进展

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解剖学报 2019年第6期50卷 850-856页

作者：吴冶君陈春花北京大学医学部基础医学院人体解剖学与组织胚胎学系

组织纤溶酶原激活物(t PA)溶栓是缺血性脑卒中治疗的金标准,然而,t PA的治疗时间窗和超过治疗时间窗后再应用所致的致命性副作用限制其的临床应用。为了解决t PA应用的限制性,可联合应用t PA与其他药物或非药物的介入方式治疗,且部分联... 详细信息

组织纤溶酶原激活物(t PA)溶栓是缺血性脑卒中治疗的金标准,然而,t PA的治疗时间窗和超过治疗时间窗后再应用所致的致命性副作用限制其的临床应用。为了解决t PA应用的限制性,可联合应用t PA与其他药物或非药物的介入方式治疗,且部分联合治疗方案经实验验证可以减轻治疗时间窗外应用t PA所致并发症,尤其是出血性转化(HT)。联合应用药物的作用机制包括保护血脑屏障,增强血管生成作用和保护脑血管。非药物介入方式则包括干细胞移植和有多方面生物效应的气体治疗。tPA与上述治疗方式的联合应用旨在减轻滞后t PA治疗所致的副作用和脑卒中所诱发的神经性缺损和行为损伤。因此,辅助治疗是一种创新的治疗形式,可解决tPA治疗的限制因素,并可能延长缺血性脑卒中的治疗时间窗。

关键词：辅助治疗组织纤溶酶原激活物治疗时间窗出血性转化基质金属蛋白酶

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网络型自然垄断环节投资监管研究

经济纵横 2019年第1期 90-98页

作者：王磊伍业君中国宏观经济研究院市场与价格研究所北京100038 中国铁路总公司铁道党校北京100088

网络型自然垄断环节投资监管是政府经济性监管的重要内容。随着我国网络型自然垄断环节的价格监管改革持续推进,对网络型自然垄断环节的投资监管也开始提上议事日程。长期以来,网络型自然垄断环节投资监管存在混淆宏观投资管理和微观投... 详细信息

网络型自然垄断环节投资监管是政府经济性监管的重要内容。随着我国网络型自然垄断环节的价格监管改革持续推进,对网络型自然垄断环节的投资监管也开始提上议事日程。长期以来,网络型自然垄断环节投资监管存在混淆宏观投资管理和微观投资监管职能、法律法规对投资监管尚无相对明确的规定、缺乏科学的投资监管手段和方法、价格监管对受监管企业投资行为的响应被动,以及缺乏有效的投资监管监督机制等问题。对此,应在借鉴国际经验的基础上,结合我国实际,转变观念和认识,科学定位网络型自然垄断环节投资监管职能,通过体制机制改革,完善价格监管体系,健全投资激励与约束机制,完善投资监管治理体制,推进投资监管治理走向现代化。

关键词：网络型自然垄断环节投资监管投资宏观调控价格监管监管现代化

地区经济复杂度影响经济增长的机理分析——基于中国省级面板数据的实证研究

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云南财经大学学报 2012年第5期28卷 51-60页

作者：王磊伍业君中国社会科学院研究生院北京102488 中国铁道部党校北京100088

已有关于经济体复杂度的文献都聚焦于出口产品技术含量的测度及其决定因素的分析上,而对经济体复杂度与经济增长之间的关系,尤其是地区经济复杂度对经济增长的影响机理缺乏深入的研究。利用四位码企业生产层面的数据,首次测度了中国地... 详细信息

已有关于经济体复杂度的文献都聚焦于出口产品技术含量的测度及其决定因素的分析上,而对经济体复杂度与经济增长之间的关系,尤其是地区经济复杂度对经济增长的影响机理缺乏深入的研究。利用四位码企业生产层面的数据,首次测度了中国地区的经济复杂度,在此基础上,运用联立方程模型对经济复杂度驱动地区经济增长的机理进行了实证分析。结果显示,经济复杂度主要通过地区专业化驱动地区经济增长。除人力资本以外,要素投入、外商直接投资、出口以及交通基础设施都直接或间接地对地区经济增长和地区专业化产生正面影响。

关键词：生产结构经济复杂度地区专业化经济增长联立方程模型

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比较优势演化、产业升级与中等收入陷阱

广东商学院学报 2012年第4期27卷 23-30页

作者：伍业君王磊中国社会科学院工业经济研究所北京102488

在比较优势演化模型的基础上,构建产业升级的路径选择模型,该模型给出了产业升级的充分必要条件。充分条件是产品空间中存在升级的目标产品,而且企业具备生产新产品的能力;必要条件是生产新产品的成本增速快于其价格增速。在中等收入阶... 详细信息

在比较优势演化模型的基础上,构建产业升级的路径选择模型,该模型给出了产业升级的充分必要条件。充分条件是产品空间中存在升级的目标产品,而且企业具备生产新产品的能力;必要条件是生产新产品的成本增速快于其价格增速。在中等收入阶段产业升级的必要条件容易得到满足,但必要条件的满足使得企业实现升级跳跃的临界距离变小;同时,如果向新产品跳跃的能力不足,则会使跳跃的充分条件得不到满足,这两者增加了产业升级断档的可能性,即增加了经济增长停滞的风险,而这正是中等收入陷阱的形成机理。

关键词：中等收入陷阱产业升级比较优势演化

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-Jian wu Ying Cheng Xiao-jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure