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“Slow walk”mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel

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Bioactive Materials 2023年第7期25卷 256-272页

作者： Jing Sun yau tsz chan Ki Wai Kevin Ho Li Zhang Liming Bian Rocky S.Tuan Yangzi Jiang Institute for Tissue Engineering and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongAnd Prince of Wales HospitalShatinHong Kong Special Administrative Region of China Department of Mechanical and Automation Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Center for Neuromusculoskeletal Restorative Medicine Hong Kong Special Administrative Region of China

Meniscus,the cushion in knee joint,is a load-bearing tissue that transfers mechanical forces to extracellular matrix(ECM)and tissue resident *** mechanoresponse of human tissue resident stem/progenitor cells in meniscus(hMeSPCs)is significant to tissue homeostasis and regeneration but is not well *** study reports that a mild cyclic tensile loading regimen of~1800 loads/day on hMeSPCs seeded in 3-dimensional(3D)photocrosslinked gelatin methacryloyl(GelMA)hydrogel is critical in maintaining cellular ***,a“slow walk”biomimetic cyclic loading regimen(10%tensile strain,0.5 Hz,1 h/day,up to 15 days)is applied to hMeSPCs encapsulated in GelMA hydrogel with a magnetic force-controlled loading *** loading significantly increases cell differentiation and fibrocartilage-like ECM deposition without affecting cell *** analysis reveals 332 mechanoresponsive genes,clustered into cell senescence,mechanical sensitivity,and ECM dynamics,associated with interleukins,integrins,and collagens/matrix metalloproteinase *** cell-GelMA constructs show active ECM remodeling,traced using a green fluorescence tagged(GFT)-GelMA *** enhances nascent pericellular matrix production by the encapsulated hMeSPCs,which gradually compensates for the hydrogel loss in the *** findings demonstrate the strong tissue-forming ability of hMeSPCs,and the importance of mechanical factors in maintaining meniscus homeostasis.

关键词： Human meniscus progenitor cells 3D cell-based constructs Biomimetic cyclic loading GelMA hydrogel Extracellular matrix

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Intra-articular sustained-release of pirfenidone as a disease-modifying treatment for early osteoarthritis

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Bioactive Materials 2024年第9期39卷 255-272页

作者： Xiaobo Zhu Mingde Cao Kejia Li yau-tsz chan Hon-Fai chan Yi-Wah Mak Hao Yao Jing Sun Michael Tim-Yun Ong Kevin Ki-Wai Ho Chien-Wei Lee Oscar Kuang-Sheng Lee Patrick Shu-Hang Yung Yangzi Jiang Institute for Tissue Engineering and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of ChinaChina School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of Chin1China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region of Chin1China Center for Neuromusculoskeletal Restorative Medicine Hong Kong Special Administrative Region of Chin1China Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative Region of Chin1China Department of Orthopaedic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityChina

Osteoarthritis(OA)is a major clinical challenge,and effective disease-modifying drugs for OA are still lacking due to the complicated pathology and scattered treatment *** early treatments are urgently needed to prevent OA *** excessive amount of transforming growth factorβ(TGFβ)is one of the major causes of synovial fibrosis and subchondral bone sclerosis,and such pathogenic changes in early OA precede cartilage *** we report a novel strategy of intra-articular sustained-release of pirfenidone(PFD),a clinically-approved TGFβinhibitor,to achieve disease-modifying effects on early OA *** found that PFD effectively restored the mineralization in the presence of excessive amount of TGFβ1(as those levels found in patients’synovial fluid).A monthly injection strategy was then designed of using poly lactic-co-glycolic acid(PLGA)microparticles and hyaluronic acid(HA)solution to enable a sustained release of PFD(the“PLGA-PFD+HA”strategy).This strategy effectively regulated OA progression in destabilization of the medial meniscus(DMM)-induced OA mice model,including preventing subchondral bone loss in early OA and subchondral bone sclerosis in late OA,and reduced synovitis and pain with cartilage preservation *** finding suggests the promising clinical application of PFD as a novel disease-modifying OA drug.

关键词： TGFβ1 signaling Osteoarthritis Subchondral bone Pirfenidone DMOAD

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HYPOPIGMENTATION AND HEALTHY SKIN PROMOTING EFFECT OF A MODIFIED QI BAI SAN

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World Journal of Traditional Chinese Medicine 2016年第2期 81-82页

作者： Elaine Wat yau tsz chan Tiffany Hoi Ka Tso Chun Fai Ng Ching Po Lau Wing Sum Siu Chun Hay Ko Ka Keung Lau Raymond Hu Clara Bik-San Lau Ping Chung Leung Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong 5100 Cosmetic Company Ltd.

Introduction:Qi Bai San(QBS,七白散)is a traditional Chinese herbal formula used by ancient ladies for healthy skin and *** it is a popular product in the market,it contains animal drug and toxic herbs which

关键词： MSH HYPOPIGMENTATION AND HEALTHY SKIN PROMOTING EFFECT OF A MODIFIED QI BAI SAN

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Printable Kirigami-inspired Flexible and Soft Anthropomorphic Robotic Hand

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Journal of Bionic Engineering 2022年第3期19卷 668-677页

作者： Yunhol chan Zion tsz-Ho Tse Hongliang Ren Department of Biomedical Engineering National University of SingaporeKent Ridge119077Singapore Department of Electronic Engineering The Chinese University of Hong Kong(CUHK)ShatinNew TerritoryHong KongChina Department of Electronic Engineering University of YorkNorth YorkshirefYO105DDUK

We present a kirigami-inspired design scheme for a robotic hand by 3D printable folds and *** unique contribution is the printable flexible hand,which provides flexibility and maneuverability that is unavailable in rigid robotic *** integration of sensors in the robotic system enables force adjustment for robotic systems applicable in the *** experimental results have shown that this design can perform everyday tasks through grasping and pinching different *** fingers can bend from 40 to 100 ***,the direct printable kirigami cuts and folds from soft elastic printable materials have significant potential for prosthetic *** printable kirigami design framework opens the possibility for future developments and modifications in numerous robotic applications.

关键词： Kirigami-inspired design Prosthetic Soft materials Three-dimensional printing

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Improving the Analyses and Forecasts of a Tropical Squall Line Using Upper Tropospheric Infrared Satellite Observations

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Advances in Atmospheric Sciences 2022年第5期39卷 733-746页

作者： Man-yau chan Xingchao CHEN Department of Meteorology and Atmospheric Science and Center for Advanced Data Assimilation and Predictability TechniquesThe Pennsylvania State UniversityUniversity ParkPennsylvaniaPA 16802USA

The advent of modern geostationary satellite infrared radiance observations has noticeably improved numerical weather forecasts and ***,compared to midlatitude weather systems and tropical cyclones,research into using infrared radiance observations for numerically predicting and analyzing tropical mesoscale convective systems remain mostly *** tropical mesoscale convective systems play a crucial role in regional and global weather,this deficit should be *** study is the first of its kind to examine the potential impacts of assimilating all-sky upper tropospheric infrared radiance observations on the prediction of a tropical squall *** though these all-sky infrared radiance observations are not directly affected by lower-tropospheric winds,the high-frequency assimilation of these all-sky infrared radiance observations improved the analyses of the tropical squall line’s outflow *** from that,the assimilation of all-sky infrared radiance observations improved the analyses and prediction of the squall line’s cloud ***,reducing the frequency of assimilating these all-sky infrared radiance observations weakened these improvements to the analyzed outflow position,as well as the analyses and predictions of cloud fields.

关键词： data assimilation infrared satellite observations numerical weather prediction mesoscale convective systems tropical meteorology

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Circular neighbor-balanced designs universally optimal for total effects

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Science China Mathematics 2007年第6期50卷 821-828页

作者： Ling-yau chan Department of Industrial and Manufacturing Systems Engineering The University of Hong KongPokfulam RoadHong KongChina

In many experiments, the performance of a subject may be affected by some previous treatments applied to it apart from the current treatment. This motivates the studies of the residual effects of the treatments in a block design. This paper shows that a circular block design neighbor-balanced at distances up toγ≤k - 1, where k is the block size, is universally optimal for total effects under the linear models containing the neighbor effects at distances up toγamong the class of all circular binary block designs. Some combinatorial approaches to constructing these circular block designs neighbor-balanced at distances up to k - 1 are provided.

关键词： block design circular neighbor-balanced total effect universally optimal 62k15 62k05

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Urocortin and cardiovascular protection

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Acta Pharmacologica Sinica 2004年第3期25卷 3-11页

作者： Chi-wai LAU,yau-chi chan,Suk-ying TSANG,Franky Leung chan The Chinese University of Hong Kong Hong Kong China Department of Anatomy The Chinese University of Hong Kong Hong Kong China Department of Anatomy The Chinese University of Hong Kong Hong Kong China Department of Anatomy The Chinese University of Hong Kong Hong Kong China Department of Anatomy

Urocortin and other hypothalamus corticotropin-releasing factor (CRF) polypeptides play biologically diverse roles in the stress, cardiovascular and inflammatory responses by acting on central and peripheral CRF receptors. Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function. Urocortin is thought to be the endogenous agonist producing the cardiovascular actions previously attributed to CRF. This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action.

关键词： urocortin corticotropin-releasing hormone vascular smooth muscle heart vasodilaion second messenger system protein kinases

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Prediabetes in children and adolescents:An updated review

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World Journal of Clinical Pediatrics 2023年第5期12卷 263-272页

作者： Hak Yung Ng Louis tsz Wang chan Department of Paediatrics and Adolescent Medicine Tseung Kwan O HospitalHong KongChina

Prediabetes,the precursor of type 2 diabetes mellitus,is an intermediate stage between normal glucose homeostasis and overt *** asymptomatic metabolic state is increasingly prevalent in pediatric population and is very difficult to detect without appropriate *** have shown that a certain proportion of children with prediabetes will develop diabetes in a few *** more alarming is the evidence that youth-onset diabetes has a more aggressive clinical course with progressive beta-cell decline and accelerated endorgan *** its importance,several aspects involving prediabetes in childhood are disputed or *** review presents the latest insights into this challenging entity and outlines a simplified screening approach to aid clinical *** summary,childhood prediabetes is an important clinical condition indicating the need for proper screening and timely intervention.

关键词： Prediabetes Screening Diagnosis Management Obesity Type 2 diabetes mellitus Children

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Clinicopathological survey of 23 patients with lacrimal fossa lesions in Hong Kong

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 311-313页

作者： Danny Siu-Chun Ng Edwin chan Kin yau Clement Wai-Nang chan Department of Ophthalmology Tung Wah Eastern Hospital

AIM: To survey the clinicopathological correlations of lacrimal fossa lesions in the Hong Kong population. METHODS: A total of 23 patients with lacrimal fossa lesions were identified radiologically. The mean age at the time of diagnosis was 52 year-old. The medical records of patients diagnosed with lacrimal fossa lesions and subsequently underwent radiological investigations were collected and reviewed retrospectively throughout a six years period from 2000 to 2006 from three regional hospitals (Tung Wah Eastern Hospital, Pamela Youde Nethersole Eastern Hospital and Queen Mary Hospital) belonging to the Hong Kong Mega Cluster. Patient demographics, presenting signs and symptoms, imaging modalities, pathological reports and subsequent management were recorded. RESULTS: The most common initial presenting symptom was upper lid swelling (83%) followed by proptosis (13%). 19 patients (83%) had benign lacrimal fossa lesion and 4 patients (17%) had malignancy. Three of the malignancies were lymphomas and one was adenoid cystic carcinoma. CONCLUSION: Age is an important factor in considering the differential diagnosis of lacrimal fossa lesion. Lymphoproliferative diseases have the highest incidence in patients over 60 years of age while inflammatory lesions are more common in younger patients in Hong Kong.

关键词： lacrimal gland tumor lymphoma

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