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Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece yau working group sexual and reproductive health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before *** found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

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辅助生殖助孕患者妊娠风险等级评估标准及使用建议

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中华生殖与避孕杂志 2024年第7期44卷 668-678页

作者：辅助生殖助孕患者妊娠风险评估标准及使用建议编写组李蓉不详北京大学第三医院妇产科生殖医学中心国家妇产疾病临床研究中心北京市人类辅助生殖技术质量控制和改进中心

人类辅助生殖技术(assisted reproductive technology,ART)是运用医学技术和方法对配子、合子、胚胎进行人工操作,以达到受孕目的的技术。为加强医疗质量安全管理,保障接受ART治疗患者助孕期间及妊娠期的安全,北京市人类辅助生殖技术质... 详细信息

人类辅助生殖技术(assisted reproductive technology,ART)是运用医学技术和方法对配子、合子、胚胎进行人工操作,以达到受孕目的的技术。为加强医疗质量安全管理,保障接受ART治疗患者助孕期间及妊娠期的安全,北京市人类辅助生殖技术质量控制和改进中心结合国家卫生健康委员会印发的孕产妇妊娠风险评估与管理工作规范(孕产妇妊娠风险评估五色球管理),拟定本标准及其使用建议。本评估方法通过对接受辅助生殖治疗的女性进行妊娠相关风险的筛查、评估和管理,及时发现并干预相关风险因素,防范不良妊娠结局,保障母婴安全。

关键词：生殖技术,辅助妊娠风险评估专家建议

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Machine learning approach to assess the association between anthropometric,metabolic,and nutritional status and semen parameters

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Asian Journal of Andrology 2024年第4期26卷 349-355页

作者： Guillaume Bachelot Antonin Lamaziere Sebastien Czernichow Celine Faure Chrystelle Racine Rachel Levy Charlotte Dupont Nutrition and Fertility(ALIFERT)group Author Information Sorbonne University School of Medicine Saint-Antoine Research CenterINSERM UMR 93827 rue ChalignyParis 75012France reproductive Biology Department-CECOS Tenon HospitalAP-HP.Sorbonne UniversityParis 75020France Clinical Metabolomics Department Saint-Antoine HospitalAP-HP27 rue ChalignyParis 75012France Nutrition Department Obesity Specialist CentreGeorges Pompidou European HospitalAP-HPParis 75015France 不详

Many lifestyle factors,such as nutritional imbalance leading to obesity,metabolic disorders,and nutritional deficiency,have been identified as potential risk factors for male *** aim of this study was to evaluate the relationship between semen parameters and anthropometric,metabolic and nutritional *** was first assessed individually,then after the application of a previously constructed and validated machine learning score that allows their ***,metabolic,antioxidant,micronutrient,and sperm parameters from 75 men suffering from idiopathic infertility from four infertility centers in France(Jean-Verdier ART Center Hospital,Bondy;North Hospital ART Center,Saint-Étienne;Navarre Polyclinic ART Center,Pau;and Cochin Hospital ART Center,Paris)between September 2009 and December 2013 were *** assessing standard correlation analysis,a previously built machine learning model,providing a score ranging from 0(the poorest)to 1(the most favorable),was calculated for each man in the study *** machine learning model,which separates infertile/fertile men with unexplained infertility on the basis of their bioclinical signature,provides a more holistic evaluation of the influence of the considered markers(anthropometric,metabolic,and oxidative status).We observed a significant correlation of some anthropometric,metabolic,and nutritional disorders with some sperm ***,an unfavorable machine learning score was associated with a high level of sperm DNA *** anthropometric,metabolic,and oxidative patterns,which may reflect an appropriate lifestyle,appear to positively impact overall health,in particular reproductive *** study,consistent with previous publications,suggests that beyond semen quality parameters,in an essential assessment of male fertility,other key factors should be taken into *** this regard,the application of emerging artificial intelligence t

关键词： lifestyle machine learning metabolism nutrition sperm DNA fragmentation

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中国杜氏肌营养不良携带者筛查的临床实践指南

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国际神经病学神经外科学杂志 2024年第1期51卷 1-6页

作者：《中国杜氏肌营养不良携带者筛查的临床实践指南》制订组杨飞曹雅不详解放军总医院第一医学中心

杜氏肌营养不良(DMD)是一种X连锁隐性遗传的单基因病,多以男性起病,表现为严重的、进行性加重的肌无力。其致残致死性高,目前尚无有效治疗。越来越多的临床证据表明,女性携带者亦可出现不同程度的临床症状。因此,DMD携带者筛查是降低患... 详细信息

杜氏肌营养不良(DMD)是一种X连锁隐性遗传的单基因病,多以男性起病,表现为严重的、进行性加重的肌无力。其致残致死性高,目前尚无有效治疗。越来越多的临床证据表明,女性携带者亦可出现不同程度的临床症状。因此,DMD携带者筛查是降低患儿出生率的关键。该实践指南目的旨在快速明确DMD的病因,及早干预,并指导家系成员再生育,进一步促进DMD的规范化防控。

关键词：杜氏肌营养不良杜氏肌营养不良携带者 X连锁隐性遗传病遗传咨询临床实践指南

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Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 1-10页

作者： Yue-hong LU1,2, Hui-juan GAO1, Bai-jia LI1, Ying-ming ZHENG1, Ying-hui YE1, Yu-li QIAN1, Chen-ming XU1, He-feng HUANG1, Fan JIN1 (1Department of reproductive Endocrinology, Key Laboratory of reproductive Genetics, Ministry of Education, and Key Laboratory of Women’s reproductive health of Zhejiang Province, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China) (2Department of reproductive health, Shaoxing Women and Children Hospital, Shaoxing 312000, China) Department of reproductive Endocrinology Key Laboratory of Reproductive Genetics Ministry of Education Women's Hospital School of Medicine Zhejiang University Hangzhou 310006 China.

To evaluate the effects of sperm with different parameters and sources on the outcomes of intracytoplasmic sperm injection (ICSI), 1972 ICSI cycles were analyzed retrospectively. groups 1 to 5 were composed of cycles using ejaculated sperm and were grouped according to sperm quantity, quality, and morphology into normal (288 cycles), or mild (329 cycles), moderate (522 cycles), severe (332 cycles), and extremely severe (171 cycles) oligozoospermia and/or asthenozoospermia and/or teratozoospermia (OAT) groups. group 6 was composed of 250 cycles using testicular or epididymal sperm, and group 7 consisted of 80 cycles using frozen-thawed sperm. We found that fertilization rates were gradually reduced from groups 1 to 6, and reached statistical difference in groups 5 and 6 (Pgroup 1 than in groups 2, 3, 5, 6, and 7 (Pgroups (P>0.05). A total of nine cases of malformation were observed, with a malformation rate of 1.25% (9/719). In conclusion, different sperm sources and parameters can affect ICSI outcomes before embryo implantation. A full assessment of offspring mal-formation will require further study using a larger sample size.

关键词：精子数量胚胎植入注射低出生体重使用周期胞浆 ICSI 畸形精子

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sexual Behaviour of Rural College Youth in Maharashtra, India: An Intervention Study

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Journal of Reproduction and Contraception 2008年第3期19卷 167-189页

作者： Mohan Ghule Balaiah Donta National Institute for Research in reproductive health Mumbai 400012 Maharashtra India

Objective To promote healthy sexual behaviour among rural college youth. Methods The intervention study consisted a sample of 1 500 （800 male and 700female） in baseline and 1 953 （1 022 male and 931 female） college going students in post intervention, in the age groups 15-24 years from 8 colleges in Thane district of Maharashtra. The interventions included dissemination of lEC （Information, Education and Communication）, counselling in colleges and provision of health care services at rural health centers in the experimental area. Male and female teachers and peer leaders were trained to provide IEC. Chi-square test was carried out to find out the association between contributing factors and sexual behaviour. Results Post intervention results showed that overall any sexual experience （coital/ non-coital） increased by 2.6% and 1.0% among male students and 4.6% and 0.8% among female students in control and experimental groups respectively which suggests that in the control area physical closeness and sexual relationship has increased between sexes. A significant improvement was noted in the usage of condom during their sexual intercourse in experimental group. The provision of IEC in college settings, peer leader training and orientation to teachers helped students and teachers to initiate a dialogue on reproductive health issues. Intervention programs helped college youth to develop the skills, make informed decisions about engaging in sexual intercourse and using contraceptives in a social context that sometimes encourages risky sexual behaviour. The study found that peer interaction was exposure to erotic material; habits and working status among boys and peer interaction and place of study among girls were closely associated with their coital and non-coital sex experience. Conclusion A scientifically developed, need based and demand driven reproductive health service package for male and female students in colleges can help them to develop their knowledge, sk

关键词： sexual behaviour rural youth interventions reproductive health youth sexuality sexual health

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Birth Defects in Assisted reproductive Technology and Spontaneously Conceived Children:A Meta-analysis

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Journal of Reproduction and Contraception 2013年第4期24卷 237-252页

作者： Yan JIA Li-hong GENG Ying ZHONG reproductive Centre Jinjiang Maternal and Child Health Hospital

Objective To evaluate the risk of birth defects in children born following assisted reproductive technology （ART） and spontaneous conceptions. Methods This study carried out an updated systematic review to identify papers published by August 2013 with data relating to birth defects of children conceived using ART （IVF and for ICSI） compared with those spontaneously conceived and also compared birth defects between subgroups of lVF and ICSI. Results Totally 76 studies were identified for review. The individual relative risk （RR） estimated for these studies ranged from 0.44 to 5.51, a signifieantly increased risk of birth defects was observed （RR=l.36, 95%CI=1.25-1.47） in ART compared with the spontaneously conceived group, which was also evident in the subgroup analysis. Among these studies, 16 studies simultaneously gave data of birth defects comparing IVF and ICSI children, which showed no difference in risk of combined effects （RR=0.90, 95%CI=0.80 1.02）, but ICSI had a higher risk in subgroups of clinical research （RR=O. 76, 95%CI=0.65-0.89） and crude RR value （RR=O. 78, 95%CI=0.67 0.91）. Conclusion Pooled results from all suitable published studies suggested that children born following ART were at increased risk of birth defects compared with spontaneous conceptions. There is no difference in birth defect risk between children conceived by IVF or 1CS1 using a summative analysis, however, 1CS1 had a significant higher risk in birth defect risk comparing with 1VF when using subgroup analyses of sample size and RR value.

关键词： birth defects assisted reproductive technology (ART) IVF ICSI Meta-analysis

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低强度脉冲式超声波(LIPUS)治疗勃起功能障碍中国专家共识

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中国男科学杂志 2024年第1期38卷 15-21页

作者：中国医疗保健国际交流促进会泌尿生殖分会《低强度脉冲式超声波(LIPUS)治疗勃起功能障碍中国专家共识》编写组中国医疗保健国际交流促进会泌尿生殖分会《低强度脉冲式超声波(LIPUS)治疗勃起功能障碍中国专家共识》编写组

为了规范低强度脉冲式超声波(Low intensity pulsed ultrasound,LIPUS)治疗勃起功能障碍(Erectile dysfunction,ED)研究及临床应用,中国医疗保健国际交流促进会泌尿男性生殖医学分会、天津市中西医结合学会生殖与性医学专业委员会、北... 详细信息

为了规范低强度脉冲式超声波(Low intensity pulsed ultrasound,LIPUS)治疗勃起功能障碍(Erectile dysfunction,ED)研究及临床应用,中国医疗保健国际交流促进会泌尿男性生殖医学分会、天津市中西医结合学会生殖与性医学专业委员会、北京中科京附国际男科医学研究院和《中国男科学杂志》编辑部组织国内泌尿外科及男科学专家,通过文献复习及临床工作中获得的循证医学证据和临床应用经验,编写了《低强度脉冲式超声波(LIPUS)治疗勃起功能障碍中国专家共识》。本共识将从微能量LIPUS机械力物理生物学效应、治疗ED作用机制、临床适应证和禁忌证、治疗方法、安全性和有效性评估,以及未来LIPUS治疗其他器官疾病应用展望等,为LIPUS在治疗ED时提供诊疗规范,以推动微能量医学新技术在再生医学领域的应用,惠及广大患者。

关键词：低强度脉冲式超声波康复勃起功能障碍专家共识

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青春期多囊卵巢综合征诊治共识

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生殖医学杂志 2016年第9期25卷 767-770页

作者： reproductive Endocrinology group,Chinese Maternal & Child health Industry Association,National Association of health Industry & Enterprise Management 全国卫生产业企业管理协会妇幼健康产业分会生殖内分泌学组

对于青春期女性的多囊卵巢综合征(PCOS),目前国内外尚无公认的统一诊断标准,且治疗方案的选择也不尽相同。为使国内各级妇产科医师更好地诊治和管理青春期PCOS患者,更新知识,并与国际接轨,国内该领域的专家在参考国外相关共识及指南后,... 详细信息

对于青春期女性的多囊卵巢综合征(PCOS),目前国内外尚无公认的统一诊断标准,且治疗方案的选择也不尽相同。为使国内各级妇产科医师更好地诊治和管理青春期PCOS患者,更新知识,并与国际接轨,国内该领域的专家在参考国外相关共识及指南后,结合我国的具体情况,编写了"青春期多囊卵巢综合征诊治共识",以改变临床医生对PCOS的传统认识,达到规范诊断和治疗青春期PCOS患者的目的。

关键词：青春期女性多囊卵巢综合征诊断及治疗专家共识

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子宫癌肉瘤诊治中国专家共识(2024年版)

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中国癌症防治杂志 2024年第4期16卷 385-391页

作者：中国医师协会微无创医学专业委员会妇科肿瘤专业委员会(学组) 中国优生科学协会生殖道疾病诊治分会中国优生科学协会肿瘤生殖学分会张师前阳志军薛凤霞不详

子宫癌肉瘤是一种高度侵袭性肿瘤,预后较差。2020年,中国医师协会微无创医学专业委员会妇科肿瘤专业委员会(学组),中国优生科学协会生殖道疾病诊治分会,中国优生科学协会肿瘤生殖学分会组织领域内相关专家撰写了《子宫癌肉瘤诊治中国专... 详细信息

子宫癌肉瘤是一种高度侵袭性肿瘤,预后较差。2020年,中国医师协会微无创医学专业委员会妇科肿瘤专业委员会(学组),中国优生科学协会生殖道疾病诊治分会,中国优生科学协会肿瘤生殖学分会组织领域内相关专家撰写了《子宫癌肉瘤诊治中国专家共识(2020年版)》,为该疾病的临床诊治提供指导。本共识在原共识的基础上,结合近年来国内外研究进展及我国临床实践,就该病的概况、临床特征、临床诊断与分期、治疗等内容进行更新和补充。本共识建议,子宫癌肉瘤需要更积极的综合规范治疗,并参考分子特征进行分层管理,以改善患者的预后;推荐所有子宫癌肉瘤患者进行HER2检测,HER2高表达的复发性子宫癌肉瘤患者推荐靶向HER2的抗体偶联药物。

关键词：子宫癌肉瘤诊断治疗专家共识

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