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High-quality micro-shape fabrication of monocrystalline diamond by nanosecond pulsed laser and acid cleaning

International Journal of Extreme Manufacturing 2022年第2期4卷 173-183页

作者： yasuhiro okamoto Tubasa Okubo Atsuya Kajitani Akira Okada Graduate School of Natural Science and Technology Okayama UniversityOkayamaJapan

The flat plane of small surface roughness below 0.1μm average roughness was obtained for monocrystalline diamond by nanosecond pulsed laser irradiation of 1060 nm and post-process acid cleaning,at a laser fluence around the material removal threshold *** glossy and flat plane at the bottom of the micro-groove was parallel to the top surface of the specimen,although the round beam of Gaussian mode was irradiated in the direction perpendicular to the top surface of *** square beam of top-hat mode produced a shallower micro-groove with a wider,flatter bottom compared with the round beam in Gaussian *** creation method of the flat plane with small surface roughness was discussed in the arrangement strategy of linear micro-grooving by the square beam of top-hat *** side-by-side repetition of linear micro-grooving did not create a flat plane with constant ***,a two-step scanning method was proposed in order to overcome the problem in the normal side-by-side repetition of liner ***-removal areas were partly retained between the processing lines in the first step,and the laser scanning was conducted on the retained area in the second *** newly proposed two-step scanning method was practical and useful to create a widely flat plane with small surface roughness,and the two-step scanning method provided superior control over the micro-groove *** proposed method can reduce the surface roughness in addition to the shape creation of monocrystalline diamond,and it can be used as a high-quality micro-shape fabrication method of monocrystalline diamond.

关键词： monocrystalline diamond nanosecond pulsed laser flat surface smooth surface micro-grooving

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Fundamental Study on High-quality Dicing Method for Semiconductor Package by Fiber Laser 16th

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第十六届国际电加工会议

作者： Ryoji Kitada yasuhiro okamoto Yoshiyuki Uno Takuya Ikeda Graduate School of Natural Science ＆ Technology Okayama University 3-1-1 TsushimanakaKita-kuOkayama 700-8530Japan

ISBN: (纸本)9787313056306

＜正＞Recently,the laser dicing method has been expected to replace a blade dicing method because of its high ***,in the laser dicing,the heat affected zone yielding heat damage should be reduced in order to prevent the deterioration of semiconductor devices consisting of silicon ***,the reduction of heat affected zone was experimentally investigated by using cooled assist *** is clarified that the combination of nitrogen assist gas in the coaxial direction of laser beam and cooled assist gas from the rear side of cutting direction led to the better cutting results with low heat affected zone.

关键词： Semiconductor package Laser dicing High-quality Single-mode fiber laser Cooled assist gas Heat affected zone

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How are multiple satellites seen from the ground? Relative apparent motion and formation stabilization

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Astrodynamics 2024年第1期8卷 121-134页

作者： Kenta Nakajima yasuhiro Yoshimura Hongru Chen Toshiya Hanada Department of Aeronautics and Astronautics Kyushu University744 Motooka Nishi-kuFukuoka819-0395Japan

This paper answers how multiple satellites are seen from the ground. This question is inspired by space-advertising, a public exhibition in the night sky using a dot matrix of satellites that are bright enough to be seen by the naked eye. Thus, it is important for space advertisement that the specific dot matrix is seen. Moreover, the stability of the dot matrix during a visible span is very valuable. To stabilize the dot matrix, this study formulates an apparent position of a dot from a representative dot seen from the ground. The formulation, linear functions of a set of relative orbital elements, reveals the appearance of the dot matrix. The proposed relative variable in the formulation drives the instability of the dot matrix, thereby revealing an initial stable configuration of deputies from a chief. The arbitrary dot matrix designed using the configuration is stable even at low elevations without orbital control during the visible span.

关键词： formation flying relative motion stabilization astrodynamics multi-apparent motions space advertisement

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Liver biopsy in the post-hepatitis C virus era in Japan

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World Journal of Gastroenterology 2024年第14期30卷 1949-1957页

作者： Yoshihiro Ikura Takako Okubo yasuhiro Sakai Department of Pathology Takatsuki General HospitalTakatsuki 569-1192Osaka PrefectureJapan Department of Pathology Kansai Medical University Medical CenterMoriguchi 570-8507Japan

In Japan,liver biopsies were previously crucial in evaluating the severity of hepatitis caused by the hepatitis C virus(HCV)and diagnosing HCV-related hepatocellular carcinoma(HCC).However,due to the development of effective antiviral treatments and advanced imaging,the necessity for biopsies has significantly *** change has resulted in fewer chances for diagnosing liver disease,causing many general pathologists to feel less confident in making liver biopsy *** article provides a comprehensive overview of the challenges and potential solutions related to liver biopsies in ***,it highlights the importance of considering steatotic liver diseases as independent conditions that can coexist with other liver diseases due to their increasing ***,it emphasizes the need to avoid hasty assumptions of HCC in nodular lesions,because clinically diagnosable HCCs are not targets for ***,the importance of diagnosing hepatic immune-related adverse events caused by immune checkpoint inhibitors is increasing due to the anticipated widespread use of these *** conclusion,pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.

关键词： Liver biopsy Alteration Post-hepatitis C virus era Steatotic liver disease Hepatic tumors Immune checkpoint inhibitors

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High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

High resolution HLA-matched unrelated donor hematopoietic st...

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中华医学会第十七次全国儿科学术大会

作者： yasuhiro okamoto Godfrey Chi-fung CHAN Suradej Hongeng TAN Poh Lin TAN Ah Moy Kleebsabai Sanpakit Anselm LEE Shanghai Jiao Tong University School of Medicine Shanghai Children Prince of Wales Hospital Hong Kong Kagoshima University Medical and Dental Hospital Japan Queen Mary Hospital the University of Hong Kong Faculty of Medicine Ramathibodi Hospital Mahidol University Thailand National University Health System Singapore KK Women’s and Children’s Hospital Singapore Faculty of Medicine Siriraj hospital Mahidol UniversityThailand Nanfang Hospital Southern Medical University China Mount Elizabeth Hospital Singapore

From August 2000 to November 2011,127 children under the age of 18 years with acquired severe aplastic anemia(SAA) received hematopoietic stem cell transplantation(HSCT) in one of the 10 Asia Pacific institutions of the VABMT Consortium,including 53 with matched sibling donor(MSD) and 74 with alternative donor(AD).Among these 74 AD,22 were matched unrelated donor(MUD), 32 were mismatched unrelated donor(MMUD) and 20 were mismatched related donor(MMRD).

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Geomorphological evidence inconvenient for the antecedent rivers of the Arun and Tista across the Himalayan range

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Journal of Mountain Science 2024年第9期21卷 3001-3017页

作者： NAKATA Takashi KUMAHARA yasuhiro NAIK Sambit Prasanajit SAKAI Harutaka Graduate School of Humanities and Social Sciences Hiroshima UniversityHigashi-Hiroshima 739-8522Japan Active Fault and Earthquake Hazard Mitigation Research Center Pukyong National UniversityBusan 48513South Korea Department of Petroleum Engineering and Earth Sciences University of Petroleum and Energy StudiesDehradun 248007India Graduate School of Science Kyoto UniversityKyoto 606-8502Japan

The Arun and Tista Rivers,which flow across the Himalayas,are commonly known as antecedent valleys that overcame the rapid uplift of the Higher Himalayan *** clarify whether the idea of antecedent rivers is acceptable,we investigated the geomorphology of the Himalayas between eastern Nepal and Bhutan *** southern part of Tibetan Plateau,extending across the Himalayas as tectonically un-deformed glaciated terrain named as'Tibetan Corridor,'does not suggest the regional uplift of the Higher *** 8,000-m class mountains of Everest,Makalu,and Kanchenjunga are isolated residual peaks on the glaciated terrain composed of mountain peaks of 4,000–6,000 m *** Tibetan glaciers commonly beheaded by Himalayan glaciers along the great watershed of the Himalayas suggest the expansion of Himalayan river drainage by *** the narrow upstream regions of the Arun and Tista Rivers with less precipitation behind the range,it is hard to collect enough water for the power of down-cutting their channels against the uplifting *** fission track ages of the Higher Himalayan Crystalline Nappe suggest that the Himalayas attained their present altitude by 11–10 Ma,and the Arun and Tista Rivers formed deep gorges across the Himalayas by headward erosion.

关键词： Himalaya Antecedent river Geomorphology AW3D30 DSM Glacier piracy

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Modelling the preventive treatment under media impact on tuberculosis:A comparison in four regions of China

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Infectious Disease Modelling 2024年第2期9卷 483-500页

作者： Jun Zhang yasuhiro Takeuchi Yueping Dong Zhihang Peng School of Mathematics and Statistics and Key Laboratory of Nonlinear Analysis&Applications(Ministry of Education)Central China Normal UniversityWuhan430079China College of Science and Engineering Aoyama Gakuin UniversityKanagawa252-5258Japan National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijing102206China

Preventive treatment for people with latent Tuberculosis infection(LTBI)has aroused our great *** this paper,we propose and analyze a novel mathematical model of TB considering preventive treatment with media *** basic reproduction number R_(0)is defined by the next generation matrix *** the case without media impact,we prove that the disease-free equilibrium is globally asymptotically stable(unstable)if R_(0)1).Furthermore,we obtain that a unique endemic equilibrium exists when R_(0)>1,which is globally asymptotically stable in the case of permanent immunity and no media *** fit the model to the newly reported TB cases data from 2009 to 2019 of four regions in China and estimate the *** we estimatedR_(0)=0.50131 in Henan,R_(0)=1.282>1 in Jiangxi andR_(0)=1.930>1 in Xinjiang imply that TB will continue to persist in these three regions without further prevention and control ***,sensitivity analysis is carried out to illustrate the role of model parameters for TB *** finding reveals that appropriately improving the rate of timely treatment for actively infected people and increasing the rate of individuals with LTBI seeking preventive treatment could achieve the goal of TB *** addition,another interesting finding shows that media impact can only reduce the number of active infections to a limited extent,but cannot change the prevalence of TB.

关键词： Latent tuberculosis infection Preventive treatment Media impact Mathematical model Tuberculosis elimination

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High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

High resolution HLA-matched unrelated donor hematopoietic st...

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2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者： Jing Chen Cheng Juan Luo Chi Kong LI yasuhiro okamoto Godfrey Chi-fung CHAN Suradej Hongeng TAN Poh Lin TAN Ah Moy Kleebsabai Sanpakit Chun Fu LI Shanghai Jiao Tong University School of Medicine Shanghai Children’s Medical Centre Prince of Wales Hospital Kagoshima University Medical and Dental Hospital Japan Queen Mary Hospital the University of Hong Kong Faculty of Medicine Ramathibodi Hospital Mahidol University Thailand National University Health System KK Women’s and Children’s Hospital Faculty of Medicine Siriraj hospital Mahidol University Nanfang Hospital Southern Medical University Mount Elizabeth Hospital Singapore Anselm LEE and for Viva-Asia Blood and Marrow Transplantation (VABMT) Group

From August 2000 to November 2011, 127 children under the age of 18 years with acquired severe aplastic anemia (SAA) received hematopoietic stem cell transplantation (HSCT) in one of the 10 Asia Pacific institutions of the VABMT Consortium, including 53 with matched sibling donor (MSD) and 74 with alternative donor (AD). Among these 74 AD, 22 were matched unrelated donor (MUD), 32 were mismatched unrelated donor (MMUD) and 20 were mismatched related donor (MMRD). Although the MSD group developed less grade

关键词： HLA High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

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Mechanocatalysis of CO to CO_(2)on TiO_(2)surface controlled at atomic scale

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Nano Research 2024年第7期17卷 5826-5834页

作者： Yuuki Adachi Robert Turanský Ján Brndiar Kamil Tokár Qiang Zhu Huan Fei Wen yasuhiro Sugawara IvanŠtich Yan Jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Institute of Physics Slovak Academy of SciencesBratislava 84511Slovakia Institute of Informatics Slovak Academy of SciencesBratislava 84507Slovakia Faculty of Natural Sciences University of Ss.Cyril and MethodiusTrnava 91701Slovakia Key Laboratory of Instrumentation Science and Dynamic Measurement School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China

The common ways to activate a chemical reaction are by heat,electric current,or ***,mechanochemistry,where the chemical reaction is activated by applied mechanical force,is less common and only poorly understood at the atomic *** we report a tip-induced activation of chemical reaction of carbon monoxide to dioxide on oxidized rutile TiO_(2)(110)*** activation is studied by atomic force microscopy,Kelvin probe force microscopy under ultrahigh-vacuum and liquid nitrogen temperature conditions,and density functional theory(DFT)*** reaction is inferred from hysteretic behavior of frequency shift signal further supported by vector force mapping of vertical and lateral forces needed to trigger the chemical reaction with torque motion of carbon monoxide towards an oxygen *** reaction is found to proceed stochastically at very small tip-sample ***,the local contact potential difference reveals the atomic-scale charge redistribution in the reactants required to unlock the *** results open up new insights into the mechanochemistry on metal oxide surfaces at the atomic scale.

关键词： atomic resolution mechanochemistry atomic force microscopy Kelvin probe force microscopy density functional theory(DFT)simulation CO oxidation catalysis rutile TiO_(2)surface

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Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity

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Engineering 2024年第7期38卷 113-123页

作者： Xiangyang Liu Fei-Peng Zhao Tian Tian Wei-Chen Wang Zaizhou Liu Qiang Zhou Xian-Feng Hou Jing Wang Wenli Guo Shuangjun Lin yasuhiro Igarashi Gong-Li Tang State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Microbial Metabolism&Joint International Research Laboratory on Metabolic and Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Biotechnology Research Center Toyama Prefectural UniversityImizu 939-0398Japan

A 61-kb biosynthetic gene cluster(BGC),which is accountable for the biosynthesis of hibarimicin(HBM)B from Microbispora rosea *** TP-A0121,was heterologously expressed in Streptomyces coelicolor M1154,which generated a trace of the target products but accumulated a large amount of shunt *** on rational analysis of the relevant secondary metabolism,directed engineering of the biosynthetic pathways resulted in the high production of HBM B,as well as new HBM derivates with improved antitumor *** results not only establish a biosynthetic system to effectively synthesize HBMs-a class of the largest and most complex Type-Ⅱpolyketides,with a unique pseudo-dimeric structure-but also set the stage for further engineering and deep investigation of this complex biosynthetic pathway toward potent anticancer drugs.

关键词： Hibarimicin Biosynthesis Heterologous expression Biosynthetic gene cluster Rational engineering Type-II polyketide

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