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Piper betle leaf extract enhances the cytotoxicity effect of 5-fluorouracil in inhibiting the growth of HT29 and HCT116 colon cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第8期15卷 692-700页

作者： Pek Leng NG Nor Fadilah RAJAB Sue Mian THEN yasmin anum mohd yusof Wan Zurinah WAN NGAH Kar Yong PIN Mee Lee LOOI Department of Biomedical Sciences Faculty of Allied Health Universiti Kebangsaan Malaysia (UKM) Jalan Raja Muda Abdul Aziz50300 Kuala Lumpur Malaysia UKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia (UKM) Jalan Yaacob Latiff Bandar Tun Razak Cheras56000 Kuala Lumpur Malaysia School of Biomedical Science University of Nottingham Malaysia Campus43500 Semenyih Selangor Malaysia Department of Biochemistry Faculty of Medicine Universiti Kebangsaan Malaysia (UKM) Jalan Raja Muda Abdul Aziz50300 Kuala Lumpur Malaysia Forest Research Institute Malaysia (FRIM) 52109 Kuala Lumpur Kepong Malaysia School of Biosciences Taylor’s University Lakeside Campus47500 Subang Jaya Selangor Malaysia

Objective： The combination effect of Piperbetle （PB） and 5-fluorouracil （5-FU） in enhancing the cytotoxic potential of 5-FU in inhibiting the growth of colon cancer cells was investigated. Methods： HT29 and HCT116 cells were subjected to 5-FU or PB treatment. 5-FU and PB were then combined and their effects on both cell lines were observed after 24 h of treatment. PB-5-FU interaction was elucidated by isobologram analysis. Apoptosis features of the treated cells were revealed by annexin V/PI stain. High-performance liquid chromatography （HPLC） was performed to exclude any possible chemical interaction between the compounds. Results： In the presence of PB extract, the cytotoxicity of 5-FU was observed at a lower dose （IC^0 12.5 pmol/L） and a shorter time （24 h） in both cell lines. Both cell lines treated with 5-FU or PB alone induced a greater apoptosis effect compared with the combination treatment. Isobologram analysis indicated that PB and 5-FU interacted synergistically and antagonistically in inhibiting the growth of HT29 and HCT116 cells, respectively. Conclusions： In the presence of PB, a lower dosage of 5-FU is required to achieve the maximum drug effect in inhibiting the growth of HT29 cells. However, PB did not significantly reduce 5-FU dosage in HCT116 cells. Our result showed that this interaction may not solely contribute to the apoptosis pathway.

关键词： Piperaceae Piper beUe L. 5-Fiuorouracil Isobologram analysis Herb-drug interaction

Simultaneous effects of Hall current and thermal deposition in peristaltic transport of Eyring-Powell fluid

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International Journal of Biomathematics 2015年第2期8卷 173-200页

作者： T. Hayat anum Tanveer Humaira yasmin Fuad Alsaadi Department of Mathematics Quaid-I-Azam University 45320 Islamabad 44000 Pakistan Department of Electrical and Computer Engineering Faculty of Engineering King Abdulaziz University Jeddah 21589 Saudi Arabia Department of Mathematics COMSATS Institute of Information Technology G. T. Road Wah Cantt 47040 Pakistan

Peristaltic flow by a sinusoidal traveling wave in the walls of two-dimensional channel with wall properties is investigated. The channel is filled with incompressible Eyring-Powell fluid. Mathematical modeling is developed through aspects of Hall current, thermal deposition and convection. Long wavelength and low Reynolds number considerations are adopted. Perturbation solutions to the resulting problem for small material parameter of fluid are obtained. Expressions of velocity, temperature, concentration and stream function are derived. Variations of pertinent parameters on the physical quantities of interest are explored in detail. The present analysis is especially important to predict the rheological characteristics in engineering applications by peristalsis.

关键词： Hall current thermal deposition MHD Eyring-Powell fluid.

Liver Tumor Decision Support System on Human Magnetic Resonance Images:A Comparative Study

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Computer Systems Science & Engineering 2023年第8期46卷 1653-1671页

作者： Hiam Alquran Yazan Al-Issa Mohammed Alslatie Isam Abu-Qasmieh Amin Alqudah Wan Azani Mustafa yasmin mohd Yacob Department of Biomedical Systems and Informatics Engineering Yarmouk University 556Irbid21163Jordan Department of Biomedical Engineering Jordan University of Science and TechnologyIrbid22110Jordan Department of Computer Engineering Yarmouk University 556Irbid21163Jordan The of Biomedical Technology King Hussein Medical CenterRoyal Jordanian Medical ServiceAmman11855Jordan Faculty of Electrical Engineering&Technology Campus Pauh PutraUniversiti Malaysia PerlisArau02600PerlisMalaysia Faculty of Electronic Engineering&Technology Campus Pauh PutraUniversiti Malaysia PerlisArau02600PerlisMalaysia Advanced Computing Centre of Excellence(CoE)Universiti Malaysia PerlisArau02600PerlisMalaysia

Liver cancer is the second leading cause of cancer death *** tumor detection may help identify suitable treatment and increase the survival *** imaging is a non-invasive tool that can help uncover abnormalities in human *** Resonance Imaging(MRI),in particular,uses magnetic fields and radio waves to differentiate internal human organs ***,the interpretation of medical images requires the subjective expertise of a radiologist and ***,building an automated diagnosis computer-based system can help specialists reduce incorrect *** paper proposes a hybrid automated system to compare the performance of 3D features and 2D features in classifying magnetic resonance liver tumor *** paper proposed two models;the first one employed the 3D features while the second exploited the 2D *** first system uses 3D texture attributes,3D shape features,and 3D graphical deep descriptors beside an ensemble classifier to differentiate between four 3D tumor *** top of that,the proposed method is applied to 2D slices for comparison *** proposed approach attained 100%accuracy in discriminating between all types of tumors,100%Area Under the Curve(AUC),100%sensitivity,and 100%specificity and precision as well in 3D liver *** the other hand,the performance is lower in 2D *** maximum accuracy reached 96.4%for two classes and 92.1%for four *** top-class performance of the proposed system can be attributed to the exploitation of various types of feature selection methods besides utilizing the ReliefF features selection technique to choose the most relevant features associated with different *** novelty of this work appeared in building a highly accurate system under specific circumstances without any processing for the images and human input,besides comparing the performance between 2D and 3D *** the future,the presented work can be extended to be

关键词： Liver tumors ensemble classifier 3D shape features 3D cooccurrence matrix ResNet101

T6SS-5 and the cGAS-STING pathway in Burkholderia pseudomallei infection and immunity

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Asian Pacific Journal of Tropical Biomedicine 2023年第3期13卷 94-103页

作者： Noreafifah Semail Nik mohd Noor Nik Zuraina yasmin Khairani Muhammad Ismadi Nurul Iman Mohamad Azian Harun Ismail Aziah Zakuan Zainy Deris Department of Medical Microbiology and Parasitology School of Medical SciencesUniversiti Sains Malaysia16150 Kubang KerianKelantanMalaysia School of Biology Faculty of Applied ScienceUniversiti Teknologi MaraShah Alam40450 SelangorMalaysia Institute for Research in Molecular Medicine Universiti Sains Malaysia16150 Kubang KerianKelantanMalaysia

Burkholderia pseudomallei is a causative agent of melioidosis that can infect humans and animals in endemic countries,specifically in Southeast Asia and tropical Australia.A fundamental component for the pathogenesis of Burkholderia pseudomallei is the capability of the bacterium to enter,survive,replicate,and cause disease in a host cell by inducing the host cell *** fusion results in multinucleated-giant cell formation,thus enabling the dissemination of Burkholderia pseudomallei *** reacts to Burkholderia pseudomallei infection by activating the cGAS-STING pathway and subsequently limiting host's aberrant cell division and cellular replication by inducing autophagic cell *** this review,we discuss the host-pathogen interactions between the typeⅥsecretion system 5(T6SS-5)of Burkholderia pseudomallei and human cGAS pathway in melioidosis *** T6SS-5 is a main virulent factor in Burkholderia pseudomallei and the c GAS pathway is vital for host immune response,elucidating their functions is important for better understanding the pathogenesis of Burkholderia pseudomallei.

关键词： Burkholderia pseudomallei Melioidosis T6SS-5 c GAS-STING IFN-1

Arsenic Detection Using Surface Plasmon Resonance Sensor With Hydrous Ferric Oxide Layer

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Photonic Sensors 2022年第3期12卷 30-37页

作者： yasmin MUSTAPHA KAMIL Sura Hmoud AL-REKABI Muhammad Hafiz ABU BAKAR Yap Wing FEN Husam Abduldaem MOHAMMED Nor Hafizah MOHAMED HALIP Mohammed Thamer ALRESHEEDI mohd Adzir MAHDI inLAZER Dynamics Sdn Bhd InnoHub UnitPutra Science ParkUniversiti Putra MalaysiaSerdang 43400Malaysia Electrical Engineering Department Al Suwayrah Technical InstituteMiddle Technical UniversityBaghdad 10074Iraq Wireless and Photonic Networks Research Centre Faculty of EngineeringUniversiti Putra MalaysiaSerdang 43400Malaysia Institute of Advanced Technology Universiti Putra MalaysiaSerdang 43400Malaysia Department of Physics Faculty of ScienceUniversiti Putra MalaysiaSerdang 43400Malaysia Electronic and Communication Engineering Department College of EngineeringUniversity of BaghdadBaghdad 10071Iraq Department of Electrical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Kingdom of Saudi Arabia

The lethality of inorganic arsenic(As)and the threat it poses have made the development of efficient As detection systems a vital *** research work demonstrates a sensing layer made of hydrous ferric oxide(Fe_(2)H_(2)O_(4))to detect As(Ⅲ)and As(Ⅴ)ions in a surface plasmon resonance *** sensor conceptualizes on the strength of Fe_(2)H_(2)O_(4) to absorb As ions and the interaction of plasmon resonance towards the changes occurring on the sensing *** sensitivity values for As(Ⅲ)and As(Ⅴ)were 1.083°·ppb^(–1) and 0.922°·ppb^(-1),respectively,while the limit of detection for both ions was 0.6 *** findings support the feasibility and potential of the sensor configuration towards paving future advancement in As detection systems.

关键词： Surface plasmon resonance di-iron trioxide hydrate arsenic heavy metals ion optical sensor