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有机化学 2023年第2期43卷 679-685页

作者： yasir mumtaz 刘杰黄鑫南京理工大学化学与化工学院南京210094 浙江师范大学先进催化材料教育部重点实验室浙江金华321004

报道了铜促进的芳基三氟甲基硫醚的合成方法,其中廉价易得的三氟甲基亚磺酸钠(CF_(3)SO_(2)Na)作为三氟甲硫基源,苯胺类化合物为起始原料,在膦还原剂的条件下实现了一锅两步的芳环三氟甲硫基化反应.反应中铜盐促进了三氟甲硫基阴离子的... 详细信息

报道了铜促进的芳基三氟甲基硫醚的合成方法,其中廉价易得的三氟甲基亚磺酸钠(CF_(3)SO_(2)Na)作为三氟甲硫基源,苯胺类化合物为起始原料,在膦还原剂的条件下实现了一锅两步的芳环三氟甲硫基化反应.反应中铜盐促进了三氟甲硫基阴离子的转化生成,该反应为合成三氟甲硫基取代苯类衍生物提供了高效方便的方法.

关键词：苯胺三氟甲基亚磺酸钠膦还原剂三氟甲硫基化

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Photocatalyzed Dual-Oxidative Trifluoromethylthio-Trifluoromethylation of Alkenes with CF3SO2Na

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CCS Chemistry 2021年第12期3卷 265-273页

作者： Shuaishuai Liang Jingjing Wei Lvqi Jiang Jie Liu yasir mumtaz Wenbin Yi School of Chemical Engineering Nanjing University of Science and TechnologyNanjingJiangsu 210094 Key Laboratory of Organofluorine Chemistry Shanghai Institute Organic ChemistryChinese Academy of SciencesShanghai 200032

A novel photocatalyzed trifluoromethylthio-trifluoromethylation of alkenes has been developed,using CF_(3)SO_(2)Na as both CF_(3) and SCF_(3) *** photocatalyzed dual-oxidative strategy,which combines two parallel oxidative events,provides a facile method to synthesize a series of vicinal trifluoromethylthio-trifluoromethylated *** reaction is operationally simple,proceeds under mild conditions and exhibits exceptional substrate generality and functional group compatibility.

关键词： trifluoromethyl trifluoromethylthio photochemistry difunctionalization alkene

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Transition Metal Catalyzed Direct C-2 Alkynylation of Indole

Transition Metal Catalyzed Direct C-2 Alkynylation of Indole

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作者： yasir mumtaz 南京理工大学

学位级别：硕士

This thesis investigated,palladium-catalyzed direct C2 alkynylation of N-2-pyrimidyl indoles,affording a series of C2 alkynylated indole derivatives in good *** addition we developed the direct alkynylation of *** main contents are outlined as follows:Indole derivatives are a kind of organic heterocyclic compounds with physiological activity and important drug *** a parent,nuclear structure is commonly used in anticancer drugs with high activity,and N-pyrimidine indole is used as ***,a palladium-catalyzed direct C2 alkynylation of N-2-pyrimidyl indoles was described by using 2-Bromo-l-triisopropylsilyl acetylene as an alkyne *** reaction exhibited excellent regioselectivity of indoles by using the pyrimidine moiety as the directing group,and the desired mono-substituted alkynylated products were obtained in high *** reaction proceeded smoothly under the following given conditions and showed good functional group compatibility as shown in Figure *** 0.1 Direct C2 alkynylation of N-2-pyrimidyl indole

关键词： Alkynylation Palladium-catalyzed N-2-pryimidyl indole C-H bond activation

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Clinical outcomes of moderate to severe COVID-19 patients receiving invasive vs. non-invasive ventilation

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 176-182页

作者： Zubia Jamil Samreen Khalid Shahid mumtaz Abbasi yasir Waheed Jamal Ahmed Department of Medicine Foundation University Medical CollegeFoundation UniversityDHA Phase 1 Islamabad 44000Pakistan Fauji Foundation Hospital Rawalpindi 46000Pakistan Department of Multidisciplinary Lab Foundation University Medical CollegeFoundation UniversityDHA Phase 1 Islamabad 44000Pakistan Department of Pulmonology Fauji Foundation HospitalRawalpindi 46000Pakistan

Objective:To evaluate the in-hospital outcome of moderate to severe COVID-19 patients admitted in High Dependency Unit(HDU)in relation to invasive ***-invasive mode of ***:In this study,the patients required either non-invasive[oxygen≤10 L/min or>10 L/min through mask or nasal prongs,rebreather masks and bilevel positive airway pressure(BiPAP)]or invasive *** analysis of 30-day in hospital mortality in relation to use of different modes of oxygen,Kaplan Meier and log rank analyses were *** the end,independent predictors of survival were determined by Cox regression ***:Invasive ventilation was required by 15.1%patients while 84.9%patients needed non-invasive *** with evidence of thromboembolism,high inflammatory markers and hypoxemia mainly required invasive *** 30-day in hospital mortality was 72.7%for the invasive group and 12.9%for the non-invasive group(1.8%oxygen10 L/min,3.6%rebreather mask and 4.5%BiPAP).The median time from hospital admission to outcome was 7 days for the invasive group and 18 days for the non-invasive group(P<0.05).Age,presence of co-morbidities,number of days requiring oxygen,rebreather,BiPAP and invasive ventilation were independent predictors of ***:Invasive mechanical ventilation is associated with adverse outcomes possibly due to ventilator associated lung ***,protective non-invasive ventilation remains the necessary and safe treatment for severely hypoxic COVID-19 patients.

关键词： COVID-19 SARS-CoV-2 Non-invasive ventilation Respiratory insufficiency Hypoxia Mechanical ventilation

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