Clinical outcomes of moderate to severe COVID-19 patients receiving invasive vs. non-invasive ventilation

作     者：Zubia Jamil Samreen Khalid Shahid Mumtaz Abbasi Yasir Waheed Jamal Ahmed Zubia Jamil;Samreen Khalid;Shahid Mumtaz Abbasi;Yasir Waheed;Jamal Ahmed

作者机构：Department of MedicineFoundation University Medical CollegeFoundation UniversityDHA Phase 1 Islamabad 44000Pakistan Fauji Foundation HospitalRawalpindi 46000Pakistan Department of Multidisciplinary LabFoundation University Medical CollegeFoundation UniversityDHA Phase 1 Islamabad 44000Pakistan Department of PulmonologyFauji Foundation HospitalRawalpindi 46000Pakistan 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2021年第14卷第4期

页      面：176-182页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：COVID-19 SARS-CoV-2 Non-invasive ventilation Respiratory insufficiency Hypoxia Mechanical ventilation 

摘      要：Objective:To evaluate the in-hospital outcome of moderate to severe COVID-19 patients admitted in High Dependency Unit(HDU)in relation to invasive ***-invasive mode of ***:In this study,the patients required either non-invasive[oxygen≤10 L/min or10 L/min through mask or nasal prongs,rebreather masks and bilevel positive airway pressure(BiPAP)]or invasive *** analysis of 30-day in hospital mortality in relation to use of different modes of oxygen,Kaplan Meier and log rank analyses were *** the end,independent predictors of survival were determined by Cox regression ***:Invasive ventilation was required by 15.1%patients while 84.9%patients needed non-invasive *** with evidence of thromboembolism,high inflammatory markers and hypoxemia mainly required invasive *** 30-day in hospital mortality was 72.7%for the invasive group and 12.9%for the non-invasive group(1.8%oxygen10 L/min,3.6%rebreather mask and 4.5%BiPAP).The median time from hospital admission to outcome was 7 days for the invasive group and 18 days for the non-invasive group(P0.05).Age,presence of co-morbidities,number of days requiring oxygen,rebreather,BiPAP and invasive ventilation were independent predictors of ***:Invasive mechanical ventilation is associated with adverse outcomes possibly due to ventilator associated lung ***,protective non-invasive ventilation remains the necessary and safe treatment for severely hypoxic COVID-19 patients.