检索结果-南通市图书馆

Low-dose immune tolerance induction for severe hemophilia A inhibitor patients:Immunosuppressants are generally not necessary for inhibitor-titer below 200 BU/mL

引用

Pediatric Investigation 2024年第2期8卷 91-100页

作者： Zhengping Li Jie Sun Zekun Li Zhenping Chen Guoqing Liu Wanru Yao Xiaoling Cheng Gang Li Yingzi Zhen Di Ai yaohan zhou Qianqian Mao Man-Chiu Poon Runhui Wu Hemophilia Comprehensive Care Center Hematology DepartmentHematology CenterBeijing Key Laboratory of Pediatric Hematology-OncologyKey Laboratory of Major Diseases in ChildrenNational Key Discipline of Pediatrics(Capital Medical University)Ministry of EducationBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Hematologic Disease Laboratory Hematology DepartmentHematology CenterBeijing Key Laboratory of Pediatric Hematology-OncologyKey Laboratory of Major Diseases in ChildrenNational Key Discipline of Pediatrics(Capital Medical University)Ministry of EducationBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Pharmacy Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Departments of Medicine Pediatrics and OncologyUniversity of Calgary Cumming School of MedicineCalgaryCanada

Importance:It remained unclear that the efficacy comparison between low-dose immune tolerance induction(LD-ITI)incorporating immunosuppressants(IS)when severe hemophilia A(SHA)patients had inhibitor-titer≥200 Bethesda Units(BU)/mL(LD-ITI-IS^(200) regimen)and LD-ITI combining with IS when SHA patients had inhibitor-titer≥40 BU/mL(LD-ITI-IS^(40) regimen).Objective:To compare the efficacy of the LD-ITI-IS^(200) regimen with that of the LD-ITI-IS^(40) regimen for SHA patients with high-titer ***:A prospective cohort study on patients receiving LD-ITI-IS^(200) compared to those receiving LD-ITI-IS^(40) from January 2021 to December *** received LD-ITI[FVIII 50 IU/kg every other day].IS(rituximab+prednisone)was added when peak inhibitor tier≥200 BU/mL in the LD-ITI-IS^(200) regimen and≥40 BU/mL in the LD-ITI-IS^(40) *** is defined as a negative inhibitor plus FVIII recovery≥66%of the ***:We enrolled 30 patients on LD-ITI-IS^(200) and 64 patients on LD-ITI-IS^(40),with similar baseline clinical characteristics.A lower IS-use rate was discovered in the LD-ITI-IS^(200) regimen compared to the LD-ITI-IS^(40) regimen(30.0%vs.62.5%).The two regimens(LD-ITI-IS^(200) ***-ITI-IS^(40))had similar success rate(70.0%vs.79.7%),median time to success(9.4 vs.10.6 months),and annualized bleeding rate during ITI(3.7 vs.2.8).The cost to success was lower for LD-ITI-IS^(200) than for LD-ITI-IS^(40)(2107 vs.3256 US Dollar/kg).Among patients with peak inhibitor-titer 40-199 BU/mL,10 non-IS-using(on LD-ITI-IS^(200) regimen)and 28 IS-using(on LD-ITI-IS^(40) regimen)had similar success rates(70.0%vs.78.6%)and time to success(9.0 vs.8.8 months).Interpretation:In LD-ITI,IS are not necessary for inhibitor titer<200 BU/mL.

关键词： Hemophilia A High-titer inhibitor Immune tolerance induction Immunosuppressant Low-dose

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

上海疾控机构纵向型伦理审查委员会建设重要性、可行性与建设思路

引用

中国医学伦理学 2024年第8期37卷 903-907页

作者：吴悦杨青袁政安祖平肖萍周瑶涵上海市疾病预防控制中心上海200336

上海疾控机构纵向型伦理审查委员会建设将是公共卫生伦理在疾病预防控制领域的重要探索,能够为强化疾控系统公共卫生伦理规范和管理、提升从业人员公共卫生伦理认知提供实践场域,对疾控机构开展现代化公共卫生治理有着积极的作用。研究... 详细信息

上海疾控机构纵向型伦理审查委员会建设将是公共卫生伦理在疾病预防控制领域的重要探索,能够为强化疾控系统公共卫生伦理规范和管理、提升从业人员公共卫生伦理认知提供实践场域,对疾控机构开展现代化公共卫生治理有着积极的作用。研究从公共卫生的概念、学科范畴和治理实践等三方面论证出建设的重要性,即纵向型伦理审查委员会是公共卫生治理遵循公共卫生伦理约束和规范的有形手段和工具,是践行公共卫生伦理人群健康价值取向的约束型载体和集中体现。随后,阐明疾控机构的紧密型关系提供纵向型伦理审查委员会建设的社会环境可行性,疾控机构实践和科研的同质性特点促成工作场景与场域可行性。进而,从管理学视角,论证系统原理、人本原理、责任原理和效益原理等建设原理,从建设目标、主体、客体和规范等方面提出建设框架,为区域公共卫生伦理委员会建设设想提供实践经验。

关键词：疾病预防控制机构公共卫生伦理伦理审查科技伦理公共卫生治理

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The noise spectral characteristics and noise reduction schemes of screw air-source heat pump:A case study

引用

Building Simulation 2024年第1期17卷 53-70页

作者： Dongsheng Liu yaohan Feng Jikang Jia Pengfei Si Ya Feng China Southwest Architecture Design and Research Institute Co.Ltd. Chengdu 610041China CSCEC Green Construction Engineering Research Center Chengdu 610041China

The screw air-source heat pump can cause incessant high noise levels during operation,which might hinder adoption of this energy-efficient heat ***,acoustic measurements and comparison testing were performed in this *** measurements revealed that the compressor is the main noise source of the heat pump,and it shows a multipeak frequency distribution and a wide frequency spectrum under different work conditions,with multiple peaks at 63,250,and 1000 ***,a compressor sound insulation cover with broadband absorption was proposed,and it was experimentally proven that the insulation cover can reduce the maximum sound pressure level of one unit from 89.8 dBA to 79.1 ***,we proposed several noise reduction strategies and compared their noise reduction effects using computer *** results showed that the noise problem can be effectively improved through the rational design of the sound barrier and the layout and opening options of heat *** distance between the sound barrier and heat pump and the sound attenuation due to diffraction ALa exhibit a U-shaped *** buildings of different heights,the optimal heights of noise barrier are *** 5.5-meter is the optimal height of the sound barrier for single-story *** conclusions can be applied to other building projects for heat pump noise reduction.

关键词： acoustic simulation broadband noise noise reduction air-source heat pump sound barrier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly stable side-chain-type cardo poly(aryl ether ketone)s membranes for vanadium flow battery

引用

Chinese Chemical Letters 2024年第3期35卷 167-170页

作者： Ziming Zhao Qing Dai Sihan Huang Wenjing Lu yaohan Chen Jifu Zheng Suobo Zhang Shenghai Li Xianfeng Li Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Vanadium flow batteries(VFBs)have drawn considerable attention as an emerging technology for largescale energy storage systems(ESSs).One of the pivotal challenges is the availability of eligible ion exchange membranes(ICMs)that provide high ion selectivity,proton conductivity,and stability under rigorous ***,a‘side-chain-type’strategy has been employed to fabricate highly stable phenolphthalein-based cardo poly(arylene ether ketone)s(PAEKs)membrane with low area resistance(0.058Ωcm^(2)),in which flexible alkyl spacers effectively alleviated inductive withdrawing effect from terminal ion exchange groups thus enabling a stable *** assembled VFBs based on PAEKs bearing pendent alkyl chain terminated with quaternary ammonium(Q-PPhEK)demonstrated an energy efficiency above 80%over 700 cycles at 160 mA/cm^(2).Such a remarkable results revealed that the side-chain-type strategy contributed to enhancing the ICMs stability in strong oxidizing environment,meanwhile,more interesting backbones would be woken with this design engaging in stable ICMs for VFBs.

关键词： Vanadium flow battery Energy storage technology Ion exchange membrane Ion transport mechanism Poly(arylene ether ketone)s(PAEKs)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

引用

Science China Life Sciences 2024年

作者： yaohan Jiang Xiao Chen Chundi Wang Liping Lyu Saleh A.Al-Farraj Naomi A.Stover Feng Gao Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Marine College Shandong University Zoology Department College of Science King Saud University Department of Biology Bradley University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all *** protists, which contain both germline and somatic genomes within a single cell, have evolved a special form of sexual reproduction called conjugation that involves mitosis, meiosis, fertilization, nuclear differentiation, genome rearrangement, and the development of unique cellular structures. The molecular basis and mechanisms of conjugation vary dramatically among ciliates, and many details of the process and its regulation are still largely unknown. In order to better comprehend these processes and mechanisms from an evolutionary perspective, this study provides the first comprehensive overview of the transcriptome and proteome profiles during the entire life cycle of the newly-established marine model ciliate Euplotes vannus. Transcriptome analyses from 14 life cycle stages(three vegetative stages and 11sexual stages) revealed over 26,000 genes that are specifically expressed at different stages, many of which are related to DNA replication,transcription, translation, mitosis, meiosis, nuclear differentiation, and/or genome rearrangement. Quantitative proteomic analyses identified 338 proteins with homologs associated with conjugation and/or somatic nuclear development in other ciliates, including dicer-like proteins, Hsp90 proteins, RNA polymerase II and transcription elongation factors, ribosomal-associated proteins, and ubiquitin-related proteins. Four of these homologs belong to the PIWI family, each with different expression patterns identified and confirmed by RT-qPCR,which may function in small RNA-mediated genome rearrangement. Proteins involved in the nonhomologous end-joining pathway are induced early during meiosis and accumulate in the developing new somatic nucleus, where more than 80% of the germline sequences are eliminated from the somatic genome. A number of new candidate genes and proteins likely t

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

唐代赋税“脚钱”研究

引用

史学月刊 2024年第10期 21-34页

作者：吴姚函中国社会科学院古代史研究所、敦煌学研究中心北京100101

唐代“脚钱”是指官方的水陆运输费用,其中运输赋税钱物的脚钱是核心内容。唐前期赋税脚钱由百姓承担,官方向课户征收租庸调脚钱,按丁征收,数额以户等为差,有粟、米、布、绢、麻等折纳形态。唐后期两税等赋税脚钱名义上由官方承担,但实... 详细信息

唐代“脚钱”是指官方的水陆运输费用,其中运输赋税钱物的脚钱是核心内容。唐前期赋税脚钱由百姓承担,官方向课户征收租庸调脚钱,按丁征收,数额以户等为差,有粟、米、布、绢、麻等折纳形态。唐后期两税等赋税脚钱名义上由官方承担,但实际上有多种支费方式。不同时期、不同地域的水陆脚价各有不同,正州与羁縻府州的脚钱征纳形式亦有差异。为节省脚钱支费,减轻官民负担,官方曾实行赋税折纳、调整航运、和籴出粜、打击脚钱贪污等举措,部分官员制定的脚钱改革方案收到一定成效。唐代国家为应对脚钱问题提出的改革举措,为后世漕运改革所承继,对古代王朝治理具有重要影响。

关键词：唐代脚钱赋税租庸调两税

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

《四时纂要》所载唐代用盐问题探略

引用

中国科技史杂志 2024年第2期45卷 309-320页

作者：吴姚函中国社会科学院古代史研究所

《四时纂要》是内容丰富的唐代农书，其中关于盐的内容值得关注。本书记载了最早的民间人工精制药盐。牲畜用盐有喂养增肥与疾疗之功用，汉唐马病药方不断改进，选材从戎盐到普通白盐，疾疗用盐比例提高。与《齐民要术》对比，豉酱脯制... 详细信息

《四时纂要》是内容丰富的唐代农书，其中关于盐的内容值得关注。本书记载了最早的民间人工精制药盐。牲畜用盐有喂养增肥与疾疗之功用，汉唐马病药方不断改进，选材从戎盐到普通白盐，疾疗用盐比例提高。与《齐民要术》对比，豉酱脯制作的用盐变化体现了技术简化流程、普及民间的过程。本书月令占候的盐价变化，承袭了《开元占经》的占卜方式，是农家生活经验的体现，内容上能弥补正史盐时价记载的不足。从医药、饮食、价格三方面，《四时纂要》所载的用盐知识内容丰富，可窥知唐代盐业、饮食医药、监牧马政的发展情况。

关键词：《四时纂要》唐代药盐盐价

来源：

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

数字普惠金融背景下中小工业企业高质量发展研究

引用

现代工业经济和信息化 2024年第9期14卷 19-21,27页

作者：关瑶涵王帆长春理工大学经济管理学院吉林长春130000

通过探讨数字普惠金融背景下中小工业企业高质量发展的现状,发现数字普惠金融能够助推中小工业企业高质量发展,且这种助推效应主要通过缓解融资约束、助力数字化转型、促进技术创新和提高风险承担能力来实现。与此同时,在研究中也发现... 详细信息

通过探讨数字普惠金融背景下中小工业企业高质量发展的现状,发现数字普惠金融能够助推中小工业企业高质量发展,且这种助推效应主要通过缓解融资约束、助力数字化转型、促进技术创新和提高风险承担能力来实现。与此同时,在研究中也发现了数字普惠金融助推中小工业企业高质量发展面临着地域数字差距明显、人才短缺流失严重、数据安全问题严峻、监管体系完善滞后等现实问题,并在此基础上提出了相应的对策建议。

关键词：数字普惠金融中小工业企业高质量发展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fluorescent sensing of anions based on excited state intramolecular proton transfer in N-(3-hydroxy-2- naphthamido)-N′-phenylthiourea

引用

Science China Chemistry 2009年第6期52卷 786-792页

作者： LI Zhao CHEN yaohan JIANG YunBao Department of Chemistry College of Chemistry and Chemical Engineering and the MOE Key Laboratory of Analytical SciencesXiamen UniversityXiamen 361005China

A neutral N-amidothiourea-based excited state intramolecular proton transfer (ESIPT) anion receptor bearing an o-hydroxynaphthamide fluorophore and a thiourea binding site, N-(3-hydroxy-2-naphthamide)-N’-phenylthiourea (1a), was designed and synthesized. Fluorescence and absorption response of 1a toward anions were assessed in acetonitrile. IR and NMR experiments indicated that the "OH…O=C" intramolecular hydrogen bond (IHB) in 1a was weak so that it only exhibited the short-wavelength normal emission other than ESIPT fluorescence. Due to the high anion binding affinity of the N-amidothiourea binding site and the formation of a hydrogen binding network in the 1a-anion c omplex, 1a underwent structural change upon anion binding that strengthens the "OH…O=C" IHB, leading to the ESIPT and the observation of the long-wavelength ESIPT emission whereas the normal fluorescence is quenched. On the basis of NMR and fluorescence titrations and control experiments with model compounds, a sensing mechanism of the anion-binding-induced ESIPT was proposed.

关键词： fluorescent sensing anion hydrogen bonding excited-state proton transfer N-(3-hydroxy-2-naphthamido)-N′-phenylthiourea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

自然声干预对妊娠晚期孕妇焦虑抑郁的影响研究

引用

护理学杂志 2024年第13期39卷 10-13页

作者：李屿珊谢辉刘晓娟冯瑶函重庆大学建筑城规学院重庆400045 重庆大学附属三峡医院产科

目的探究自然声对妊娠晚期孕妇焦虑和抑郁情绪的干预效果,促进该群体的心理健康。方法将60名妊娠晚期孕妇随机分为对照组与试验组各30名。试验组孕妇每天收听20 min的自然声,连续28 d。对照组在相同时间段安静休息。干预前后采用焦虑自... 详细信息

目的探究自然声对妊娠晚期孕妇焦虑和抑郁情绪的干预效果,促进该群体的心理健康。方法将60名妊娠晚期孕妇随机分为对照组与试验组各30名。试验组孕妇每天收听20 min的自然声,连续28 d。对照组在相同时间段安静休息。干预前后采用焦虑自评量表和抑郁自评量表对两组孕妇进行调查。结果对照组与试验组分别有19、18名完成研究。干预后试验组焦虑、抑郁得分显著低于对照组(均P<0.05)。结论自然声干预作为一种非药物方法,可以有效减轻妊娠孕妇的焦虑、抑郁情绪。

关键词：妊娠晚期孕妇焦虑抑郁自然声微信小程序居家护理心理护理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：