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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

固溶温度对TC18钛合金组织与力学性能的影响

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热处理技术与装备 2018年第3期39卷 25-30页

作者：王大宏孙先成王铮晁耀杰张金卓晁耀辉大连长丰实业总公司辽宁大连116038 郑州工业应用技术学院河南郑州451000

研究了不同固溶温度条件下TC18钛合金的组织与力学性能。采用光学显微镜、维氏显微硬度仪、电子万能试验机、疲劳试验机和扫描电子显微镜(SEM)对不同温度固溶处理条件下TC18钛合金试样的显微组织、显微硬度、拉伸性能、疲劳性能和微观... 详细信息

研究了不同固溶温度条件下TC18钛合金的组织与力学性能。采用光学显微镜、维氏显微硬度仪、电子万能试验机、疲劳试验机和扫描电子显微镜(SEM)对不同温度固溶处理条件下TC18钛合金试样的显微组织、显微硬度、拉伸性能、疲劳性能和微观疲劳断口特征进行了观测。试验结果表明:随着固溶温度的升高,初生α相含量减少,尺寸变小,当固溶温度超过860℃时,晶粒发生粗化;冲击韧度值先升高后下降,固溶温度860℃左右时,其数值最大;抗拉强度呈现为递减趋势,延伸率呈现为先上升后下降的趋势;冲击断口与拉伸断口均为韧窝形貌,固溶温度的改变对TC18钛合金的断裂模式无影响。

关键词：固溶温度 TC18钛合金组织性能力学性能影响

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轮缘润滑器安装座失效原因分析

失效分析与预防 2016年第5期11卷 322-326,334页

作者：晁耀杰李宏佳刘雪松哈尔滨工业大学先进焊接与连接国家重点实验室哈尔滨150001

轮缘润滑器安装座故检过程中,渗透检测发现T型焊缝处出现宏观裂纹,该结构材料为Q345钢。通过外观检测、裂纹宏观形貌观察、裂纹断口形貌观察、焊接微观组织观察、冲击断口观察等试验,对结构的开裂原因进行分析。试验结果表明:焊接接头... 详细信息

轮缘润滑器安装座故检过程中,渗透检测发现T型焊缝处出现宏观裂纹,该结构材料为Q345钢。通过外观检测、裂纹宏观形貌观察、裂纹断口形貌观察、焊接微观组织观察、冲击断口观察等试验,对结构的开裂原因进行分析。试验结果表明:焊接接头微观组织良好,无明显焊接缺陷,可排除由于组织原因引起构件失效的可能;对比裂纹断口形貌与焊缝金属冲击断口形貌,两者存在较大差异,可排除由于承受较大冲击载荷开裂的可能;裂纹微观断口存在大量疲劳条带,表明结构为疲劳开裂;综合考虑裂纹启裂位置的受力情况,可以判定疲劳开裂的原因是承受载荷部位的应力集中问题。

关键词：轮缘润滑器安装座失效原因疲劳开裂应力集中

Study of the formation and dynamic characteristics of the vortex in the pump sump by CFD and experiment

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Journal of Hydrodynamics 2021年第6期33卷 1202-1215页

作者： Xi-jie Song Rao yao Liu chao Zheng-wei Wang State Key Laboratory of Hydro-science and Engineering Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Hydraulic Energy and Power Engineering Yangzhou UniversityYangzhou 225100China

The formation mechanism and the dynamic characteristics of the floor-attached vortex(FAV)in the pump sump are analyzed,with the velocity gradient as the key *** FAV is shown to be formed when the velocity gradient in the singular point area reaches a certain *** evolution of the FAV is accompanied by the energy accumulation and dissipation in the vortex *** generated FAV is in the form of the vortex pair at the initial stage,with opposite directions of *** vortex with the same rotating direction as the impeller is strong because the rotational kinetic energy is easy to *** circumferential velocity of the FAV first increases and then decreases with the radius of the vortex core,indicating the FAV is a kind of forced *** radius with the largest velocity gradient is the radius of the vortex core.

关键词： Floor-attached vortex rotational kinetic energy multiphase flow computational fluid dynamics(CFD) experiment

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-Liang Gong Hong-jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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Huber inversion-based reverse-time migration with de-primary imaging condition and curvelet-domain sparse constraint

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Petroleum Science 2022年第4期19卷 1542-1554页

作者： Bo Wu Gang yao Jing-jie Cao Di Wu Xiang Li Neng-chao Liu State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China Unconventional Petroleum Research Institute China University of Petroleum(Beijing)Beijing102249China Key Laboratory of Intelligent Detection and Equipment for Underground Space of Beijing-Tianjin-Hebei Urban Agglomeration Ministry of Natural ResourcesHebei GEO University050031China Hebei Key Laboratory of Strategic Critical Mineral Resources Hebei GEO UniversityShijiazhuangHebei050031China College of Geophysics China University of Petroleum(Beijing)Beijing102249China

Least-squares reverse-time migration(LSRTM) formulates reverse-time migration(RTM) in the leastsquares inversion framework to obtain the optimal reflectivity image. It can generate images with more accurate amplitudes, higher resolution, and fewer artifacts than RTM. However, three problems still exist:(1) inversion can be dominated by strong events in the residual;(2) low-wavenumber artifacts in the gradient affect convergence speed and imaging results;(3) high-wavenumber noise is also amplified as iteration increases. To solve these three problems, we have improved LSRTM: firstly, we use Hubernorm as the objective function to emphasize the weak reflectors during the inversion;secondly, we adapt the de-primary imaging condition to remove the low-wavenumber artifacts above strong reflectors as well as the false high-wavenumber reflectors in the gradient;thirdly, we apply the L1-norm sparse constraint in the curvelet-domain as the regularization term to suppress the high-wavenumber migration noise. As the new inversion objective function contains the non-smooth L1-norm, we use a modified iterative soft thresholding(IST) method to update along the Polak-Ribie re conjugate-gradient direction by using a preconditioned non-linear conjugate-gradient(PNCG) method. The numerical examples,especially the Sigsbee2 A model, demonstrate that the Huber inversion-based RTM can generate highquality images by mitigating migration artifacts and improving the contribution of weak reflection events.

关键词： Least-squares reverse-time migration Huber-norm Sparse constraint Curvelet transform Iterative soft thresholding

Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

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Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan yao jie Xia Lizhen Wang Yuanming Gao Xili Ding chao Wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

Environmental significance of levoglucosan records in a central Tibetan ice core

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Science Bulletin 2019年第2期64卷 122-127页

作者： chao You Tandong yao chao Xu Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences

The environmental significance of levoglucosan(LEV) records in Tibetan glacier ice layers on sub-annual to annual scales, in particular their suitability as a specific biomarker for indicating past fire changes, is poorly understood at present. In this work, a continuous LEV record was reconstructed in a central Tibetan ice core for the period 1990–2012. The LEV record was classified into two categories based on its LEV concentrations: background levels and extreme events. Annually-resolved LEV records and background levels in the ice core were strongly correlated with satellite observations of fire occurrence frequency over the northern Indian peninsula between 2003 and 2012, especially for strong fire events during the pre-monsoon season(March–May). In addition, peaks in LEV concentrations may represent extreme fire events in regions around the Tibetan Plateau. LEV records in the ice core reflect a longterm increasing trend in fire background and also an increase in fire extreme events, across the Tibetan Plateau and its surroundings. We therefore conclude that LEV records in Tibetan ice cores can be used as a powerful tool for calibrating and reconstructing past fire changes over subtropical Asia.

关键词： Fire variation Levoglucosan Ice core Tibetan Plateau Subtropical Asia

Scale-free brain ensemble modulated by phase synchronization

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 821-831页

作者： Dan WU chao-yi LI jie LIU Jing LU De-zhong yao Department of Biomedical Engineering School of Computer and Information TechnologyBeijing Jiaotong University NeuroInformation of Ministry of Education University of Electronic Science and Technology of China

To listen to brain activity as a piece of music, we proposed the scale-free brainwave music(SFBM) technology, which could translate the scalp electroencephalogram(EEG) into music notes according to the power law of both EEG and music. In the current study, this methodology was further extended to a musical ensemble of two channels. First, EEG data from two selected channels are translated into musical instrument digital interface(MIDI) sequences, where the EEG parameters modulate the pitch, duration, and volume of each musical note. The phase synchronization index of the two channels is computed by a Hilbert transform. Then the two MIDI sequences are integrated into a chorus according to the phase synchronization index. The EEG with a high synchronization index is represented by more consonant musical intervals, while the low index is expressed by inconsonant musical intervals. The brain ensemble derived from real EEG segments illustrates differences in harmony and pitch distribution during the eyes-closed and eyes-open states. Furthermore, the scale-free phenomena exist in the brainwave ensemble. Therefore, the scale-free brain ensemble modulated by phase synchronization is a new attempt to express the EEG through an auditory and musical way, and it can be used for EEG monitoring and bio-feedback.

关键词： Brainwave Ensemble Music Scale-free Synchronization