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Universal synthesis of metallophthalocyanine covalent organic frameworks as ultra-sensitive multifaceted electrochemical sensor

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Science China Chemistry 2024年第6期67卷 2092-2101页

作者： Qi liu Qiqi Sun Yuming Zhang Hao li Wenmiao Chen Yuexing Zhang Sirong Yu yanli Chen Jianzhuang Jiang School of Materials Science and Engineering China University of Petroleum(East China)Qingdao266580China Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing100083China College of Chemistry and Chemical Engineering Dezhou UniversityDezhou253023China

The universal synthesis of highly stable covalent organic frameworks(COFs)for ultra-sensitive and multi-component electrochemical detection in different scenarios remains a great ***,a series of metallophthalocyanine-based twodimensional(2D)dioxin(DXI)-linked metalophthalocyanine(MPc)-n DXI-COFs(M=Ni,Zn;n=1,2)are afforded in high yield(80%-96%)by a facile trace-quinoline assisted one-pot condensation of tetracarbonitrile *** X-ray diffraction and electron microscopy investigations disclose their lamellar texture 2D network with AA stacking *** and calculation results elucidate that the 2DXI-linked MPc-2DXI-COFs provide the stronger built-in electronic field and more electrostatic/hydrogen bonding adsorption sites than DXI-linked MPc-DXI-COFs,and the lower electrode reaction Gibbs free energy and stronger adsorption of analytes at Ni Pc than Zn Pc unit,which grants Ni Pc-2DXI-COF excellent sensing properties for various analytes including neurotransmitters,organic pollutants,and heavy metal ions,with high sensitivity and low detection limit of 0.53 to 25.66 *** in binary and ternary systems and even in real-world conditions,simultaneous multi-component detection could be achieved.

关键词： covalent organic framework metallophthalocyanine 2D materials electrochemical sensors multi-component detection

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Comprehensive understanding of glioblastoma molecular phenotypes:classification,characteristics,and transition

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Cancer Biology & Medicine 2024年第5期21卷 363-381页

作者： Can Xu Pengyu Hou Xiang li Menglin Xiao Ziqi Zhang Ziru li Jianglong Xu Guoming liu yanli Tan Chuan Fang School of Clinical Medicine Hebei UniversityDepartment of NeurosurgeryAffiliated Hospital of Hebei UniversityBaoding 07100China Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding 071000China School of Basic Medical Sciences Hebei UniversityBaoding 07100China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 07100China

Among central nervous system-associated malignancies,glioblastoma(GBM)is the most common and has the highest mortality *** high heterogeneity of GBM cell types and the complex tumor microenvironment frequently lead to tumor recurrence and sudden relapse in patients treated with *** precision medicine,research on GBM treatment is increasingly focusing on molecular subtyping to precisely characterize the cellular and molecular heterogeneity,as well as the refractory nature of GBM toward *** understanding of the different molecular expression patterns of GBM subtypes is *** have recently proposed tetra fractional or tripartite methods for detecting GBM molecular *** various molecular subtypes of GBM show significant differences in gene expression patterns and biological *** subtypes also exhibit high plasticity in their regulatory pathways,oncogene expression,tumor microenvironment alterations,and differential responses to standard ***,we summarize the current molecular typing scheme of GBM and the major molecular/genetic characteristics of each ***,we review the mesenchymal transition mechanisms of GBM under various regulators.

关键词： Glioblastoma molecular phenotype classification characteristic mesenchymal transition

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Protective effects of Humanin on hypoxia-induced neuronal death

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Neural Regeneration Research 2009年第1期4卷 5-9页

作者： Yunqi Zhu yanli li Jingyi liu Xiaorong Yang Ce Zhang Department of Physiology and Neurobiology Shanxi Medical University Taiyuan 030001 Shanxi Province China

BACKGROUND： Humanin is a 24-amino acid peptide isolated from the brain of an Alzheimer’s disease patient. Several studies have indicated that Humanin can protect cells against cytotoxicity induced by various insults. OBJECTIVE： To investigate the protective role of Humanin on hypoxia-induced neuronal death, and to determine the most appropriate therapeutic concentration of Humanin. DESIGN, TIME AND SETTING： Neuropathophysiological, randomized, controlled experiment, conducted at the Department of Physiology and Neurobiology, Shanxi Medical University, between March 2007 and October 2007. MATERIALS： Newborn Wistar rats, 5,5＇,6,6＇ tetrachloro-1,1＇,3,3＇-tetraethyl- benzimidazolylcarbo- cyanine iodide （JC-1, USA）, calcein-acetoxymethylester （calcein-AM, USA）, and Humanin （Shanghai, China） were used in this study. METHODS： Primary cortical neurons were cultured with dulbecco＇s modified eagle＇s medium containing 15% fetal bovine serum. Cultures were divided into three groups： control, hypoxia, and hypoxia ＋ Humanin. Various concentrations of Humanin （1, 10, and 20 μmol/L） were added to the cultures 16 hours prior to hypoxia induction. For hypoxic conditions, cells were maintained at 37 ℃ within an incubator chamber filled with 95% N2 and 5% CO2 for 24 hours. Cells in the control group were cultured in normal oxygen. MAIN OUTCOME MEASURES： Cell viability was determined through the use of the vital dye calcein-AM, and the number of live cells was determined. Mitochondrial membrane potential （△Ψm） was assessed using the fluorescent probe JC-1. Mitochondrial permeability transition pore （mPTP） opening was determined with calcein-AM in the presence of cobalt chloride.RESULTS：（1） Cell viability： Hypoxia for 24 hours induced death in a large number of neurons. Pre- treatment with 10 μmol/L and 20 μmol/L Humanin, 16 hours prior to hypoxia, protected cells against hypoxia. However, 1 μmol/L Humanin provided little protection. （2） △Ψm： △Ψm was re-duced after 24-hour hypo

关键词： hypoxia Humanin protection mitochondria

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Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

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Protein & Cell 2019年第2期10卷 137-142页

作者： Guangshun Zhang Junyuan Cao Yan Cai Yang liu yanli li Peilin Wang Xiaoying Jia Mengmeng Zhang Gengfu Xiao Yu Guo Wei Wang State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300450China University of the Chinese Academy of Sciences Beijing 100049China Drug Discovery Center for Infectious Disease Nankai UniversityTianjin 300071China Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of BiomedicineTianjin 300450China

Dear Editor,Lassa virus(LASV)belongs to the Mammarenavirus genus,Arenaviridae *** are classified into two main groups-Old World(OW)and New World(NW)-based on virus genetics,serology,antigenic properties and geographical *** OW LASV and Lujo virus(LUJV),as well as NW Jurn'n virus(JUNV),Machupo virus(MACV),Guanarito virus(GTOV),Sabia virus(SABV)and Chapare virus(CHAPV),are known to cause severe hemorrhagic fever and are listed as biosafety level 4(BSL-4)*** arenavirus glycoprotein complex(GPC)contains three subunits-the retained stable-signal peptide(SSP),the receptor-binding subunit GP1,and the membrane fusion subunit GP2(Lenz et al.,2001).Notably,the proximate external membrane region and TM of GP2,together with the ectodomain loop and TMs of SSP,form an SSP-GP2 interface,playing essential roles in regulating membrane fusion,and providing targets for distinct fusion inhibitors(Larson et al.,2008;Lee et al.,2008;York et al.,2008;York and Nunberg,2009;Thomas et al.,2011;Burgeson et al.,2013a;Shankar et al.,2016;Wang et al.,2016;Wang et al.,2018).Among these inhibitors,ST-161 is LASV specific(Burgeson et al.,2013a).In this study,we conducted structure-activity relationship(SAR)optimization of *** a result,21 derivatives with IC50 values<1 pmol/L are presented in Table *** compounds 21,29 and 57 exhibiting robust inhibition of the LASV pseudotype virus(LASVpv,VSV backbone enveloped by LASV GPC with single cycle infection)entry with IC50 values lower than 0.2 nmol/L(Figs.1A and S1),as well as hit compound 72 with an ester bond instead of acylhydrazone,were further *** test whether the four hit compounds inhibit LASV entry by blocking the GPC-mediated membrane fusion,the inhibition effects of these compounds against LASV GPC mediated fusion were quantitatively determined by dual-luciferase assay(Thomas et al.,2011;Wang et al.,2018).

关键词： Editor World MACV

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老年男性2型糖尿病患者血糖波动与住院跌倒风险的相关性

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上海护理 2024年第7期24卷 41-44页

作者：缪婕计莹沈琳辉何玉婷曹伟伟李艳莉上海交通大学医学院附属瑞金医院上海200025

目的通过调查了解老年男性2型糖尿病(T2DM)患者血糖波动与跌倒风险间的关系,为临床早期评估及护理提供参考。方法以2020年1月至2021年12月收治于上海交通大学医学院附属瑞金医院老年病科的132例老年男性T2DM住院患者作为调查对象。通过7... 详细信息

目的通过调查了解老年男性2型糖尿病(T2DM)患者血糖波动与跌倒风险间的关系,为临床早期评估及护理提供参考。方法以2020年1月至2021年12月收治于上海交通大学医学院附属瑞金医院老年病科的132例老年男性T2DM住院患者作为调查对象。通过72 h动态血糖监测了解患者血糖波动情况,并采用Morse跌倒评估量表评估其跌倒风险等级。比较跌倒中高风险组及跌倒低风险组患者的血糖波动情况,并通过多元logistic回归分析可能的影响因素。结果①跌倒中高风险组老年男性T2DM患者的餐后2 h血糖水平及使用胰岛素比率均高于低风险组(P0.05)。②与跌倒低风险组患者相比,跌倒中高风险组患者的葡萄糖目标范围内时间(TIR)明显降低[(49.8±5.1)%vs(68.8±6.4)%],而葡萄糖低血糖时间(TBR)[(20.8±3.9)%vs(6.3±1.9)%]、血糖变异率(CV)[(45±3.9)%vs(34±4.5)%]、平均血糖(MAGE)[(5.6±1.8)mmol/L vs(4.1±1.2)mmol/L]明显升高,差异均有统计学意义(P<0.05)。③二分类logistic回归分析结果显示,应用胰岛素、TIR、TBR、CV、MAGE均是老年男性T2DM患者跌倒中高风险的独立危险因素。结论老年男性T2DM患者血糖波动与跌倒中高风险增加密切相关。在临床工作中,护理人员应重视该类患者血糖波动情况,准确评估其跌倒风险并进行早期干预。

关键词： 2型糖尿病老年男性住院血糖波动跌倒风险

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北方春玉米选育方法

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耕作与栽培 2024年第1期44卷 135-137页

作者：胡洪林关涛高伟政李艳丽张阔吴成龙王玮黑龙江省农垦科学院黑龙江佳木斯154007 国家现代玉米产业体系佳木斯综合试验站黑龙江佳木斯154007 铁岭市农业科学院辽宁铁岭112001

玉米是中国第一大作物,北方春玉米区是中国玉米生产优势区域,玉米品种市场竞争日趋激烈,却无法满足产业需求。因此,针对北方春玉米区的需求,融合常规育种与单倍体育种方法,注重高产高效、耐逆、抗倒伏、脱水快、宜机收种质创新和品种选... 详细信息

玉米是中国第一大作物,北方春玉米区是中国玉米生产优势区域,玉米品种市场竞争日趋激烈,却无法满足产业需求。因此,针对北方春玉米区的需求,融合常规育种与单倍体育种方法,注重高产高效、耐逆、抗倒伏、脱水快、宜机收种质创新和品种选育。本文概述了选育玉米品种的有效方法,主要有早晚杂交,优系复选,多部抉选等,旨在助力北方春玉米种质资源创新及新品种选育,为中国的粮食安全作出贡献。

关键词：北方春玉米选育方法高产高效

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Breeding dominant genic male sterility restorer line of Brassica napus L.

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Oil Crop Science 2020年第2期5卷 90-95页

作者： Junying Zhang Jianxia Jiang liyong Yang Meiyan Jiang yanli li Weirong Wang Chaocai Sun Jifeng Zhu Xirong Zhou Crop Breeding and Cultivation Research Institute Shanghai Academy of Agricultural SciencesShanghaiChina

To facilate breeding process of Brassica napus,a microspore culture and molecular marker-assisted screening combined system were proposed in this *** early flowering stage,F1 offspring of hybridized combination HY15 A×HF06 was used as donor for microspore culture to analyze effects of colchicine concentration on embryogenic and diploid rates of *** with 50 mg/L colchicine resulted in embryogenic rate of3.56 embryos/bud,which was substantially higher than control(0.78 embryos/bud).A total of 1,387 embryos and 862 single plants were obtained after induction *** detection was performed for the regenerated plants by flow *** rates of microspores treated with 50 mg/L and 70 mg/L colchicine were 17.2%and 21.0%respectively,which was significantly higher than control(10.5%).Totally 108 single plants that doubled successfully were randomly selected and screened using molecular marker *** 54 of108 plants generated a 305 bp amplification product,whereas the other 54 plants showed a 398 bp band,thereby satisfying 1:1 separation ratio(x0.052=0.0093).These coincided with field identification *** of this study indicated that homozygous breeding material could be obtained by microspore culture in a short time,thereby remarkably accelerate breeding.

关键词： Brassica napus L. Microspores Double haploid Restorer line Colchicine

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Microscopic phase-field simulation including elastic strain energy for early precipitation process of Ni-Al alloys with medium Al content

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Progress in Natural Science:Materials International 2005年第12期15卷 1104-1109页

作者： LU yanli,CHEN Zheng,li Yongsheng,WANG Yongxin and CHU Zhong State Key Laboratory of Solidification Processing,School of Materials Science and Engineering,Northwestern Polytechnical University,Xi’an 710072,China State Key Laboratory of Solidification Processing School of Materials Science and Engineering Northwestern Polytechnical University Xi''an 710072 China

The early precipitation process of Ni-Al alloy was studied on the atomic scale based on the microscopic phase-field kinetic *** investigated the effect of elastic strain energy on precipitation mechanism and morphological evolution of the *** results show that at the early stage of precipitation,γ’ ordered phase presents non-directional and irregular shape during the process of aging,the γ’ ordered phases change into the quadrate shape and their orientations become more obvious; at the later stage,the γ’ precipitates present quadrate shape with round corner and align along the [100] and [010] *** mechanism of early precipitation for Ni-13at.%A1 alloy is the mixed mechanism of non-classical nucleation growth and spinodal decomposition and near to non-classical nucle-ation growth,and the mechanism of early precipitation for Ni-15.8at.% Al alloy is the mixed mechanism of non-classical nucleation growth and spinodal decomposition and near to spinodal decomposition.

关键词： Ni-Al alloy early precipitation microscopic phase-field simulation elastic strain energy

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Influence of surface acidity and chemical valence on low temperature activity over Pt-HSiW/CeO_(2) for catalytic combustion of chlorobenzene

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Journal of Rare Earths 2024年第9期42卷 1693-1703,I0002页

作者： Zhongxian Song Zepeng liu Xuejun Zhang yanli Mao Wei liu Chunxiang Gao Haiyang li Xia Zhang Changrui Han Zhenzhen Huang Key Laboratory of Carbon Emission Reduction and Combined Air Pollution Control Technology Faculty of Environmental and Municipal EngineeringHenan University of Urban ConstructionPingdingshan467036China College of Environmental and Safety Engineering Shenyang University of Chemical TechnologyShenyang110142China

Pt-HSiW/CeO_(2) catalysts were prepared for chlorobenzene(CB) catalytic combustion by hydrothermal method at different calcination temperatures,and the effects of the surface acidity and chemical valence on the catalytic activity were *** results show that the catalyst calcined at 450℃(Cat-B)exhibits the outstanding catalytic performance,and the Cat-B catalyst possesses 90% conversion of CB at148℃.The excellent catalytic activity of Cat-B is attributed to more Ce^(3+)/(Ce^(3+)+Ce^(4+)),Pt~0/(Pt^(0)+Pt^(2+)),O_(ads)/(O_(latt)+O_(ads)) and Lewis acid *** degradation mechanism is proposed based on the analysis of the intermediates with the following reaction pathway:chlorobenzene→phenates/benzoquinone→acetate→maleate→CO_(2)+H_(2)O.

关键词： Pt-HSiW/CeO_(2) Catalytic combustion Chlorobenzene Acid sites Rare earths

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稳健的球面全景图全自动生成算法

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计算机辅助设计与图形学学报 2007年第11期19卷 1393-1398页

作者：李艳丽向辉山东大学计算机科学与技术学院

提出一种基于尺度不变特征变换特征点的全自动球面全景图生成算法,将原始图像投影到同一个虚拟球面上,再对球面展开图融合拼接,以避免叠加误差;并设计了一种非匹配点剔除方法,比常用的RANSAC算法提高了效率和准确性.实验验证了该算法的... 详细信息

提出一种基于尺度不变特征变换特征点的全自动球面全景图生成算法,将原始图像投影到同一个虚拟球面上,再对球面展开图融合拼接,以避免叠加误差;并设计了一种非匹配点剔除方法,比常用的RANSAC算法提高了效率和准确性.实验验证了该算法的稳健性和快速性.

关键词：球面全景图稳健性图像拼接尺度不变特征变换特征点

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