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Mechano-active biomaterials for tissue repair and regeneration

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Journal of Materials Science & Technology 2020年第24期59卷 227-233页

作者： Xiao Lin yanjie bai Huan Zhou Lei Yang Orthopaedic Institute and Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou 215006China School of Public Health Soochow UniversitySuzhou 215123China Center for Health Science and Engineering(CHSE) School of Materials Science and EngineeringTianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologyHebei University of TechnologyTianjin 300401China

There is a lack of effective tissue repair and regeneration strategies in current clinical *** studies have suggested that smart or responsive biomaterials possessing the ability to respond to endogenous stimuli in vivo may positively mediate the tissue micro-environment towards a tissue repair or *** stimuli,which constantly exist in a wide range of biological systems and are involved in almost all the physiological processes,belong to such stimuli to which responsive biomaterials can *** recent studies,a new type of smart biomaterials,which can dynamically adapt to the mechanical stimuli in vivo and thus has specific functionality consistently mediated by such mechanical stimuli,has *** contrast to common biomaterials that passively react to the mechanical environment of an implantation site,such mechano-active biomaterials have enabled various active or automatic strategies for tissue repair or regeneration,such as providing precise spatial-temporal controls on delivery of drugs or cells in the organs of the musculoskeletal and the circulatory systems;in situ reconstructing the original or a favorable mechanical environment at a lesion site;and accelerating the tissue remodeling or healing process via a mechanobiological *** article elucidates a perspective of perfecting tissue repair or regeneration using mechano-active biomaterials,especially highlighting the rationale behind the concept of mechano-active biomaterials and their potential in the repair or regeneration of musculoskeletal and cardiovascular *** outstanding challenges and unknowns,the emergence of mechano-active biomaterials has become a new avenue for tissue engineering and regenerative medicine.

关键词： Mechano-active Smart biomaterials Tissue engineering and regeneration Mechanobiology Gel-point adhesive hydrogel

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水下修复材料的黏结强度与变形性能研究进展

混凝土与水泥制品 2024年第6期 31-36页

作者：马豪达陈波白银白延杰张丰张晓闯南京水利科学研究院水灾害防御全国重点实验室江苏南京210029

介绍了常用的几种水下修复材料的性能,分析了其作用机理,强调了黏结强度和变形性能的重要性,指出了各水下修复材料在接缝修复中存在的问题及优缺点,并提出了未来重点研究方向。

关键词：混凝土接缝水下修复材料黏结强度变形性能

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矿粉和高温影响下混凝土力学性能统计研究

山西建筑 2024年第12期50卷 110-114,164页

作者：白彦杰邹文燕杜云胡兵兵中铁二十四局集团南昌铁路工程有限公司江西南昌330002 中国铁路南昌局集团有限公司南昌工务段江西南昌330002 南昌金开环保工程有限公司江西南昌330013 南昌铁路天河建设有限公司江西南昌330002

针对矿粉掺量和夏季施工现场高温环境对混凝土力学性能的影响,开展了不同试验工况下混凝土抗压强度的统计研究,试验变量包括四种配合比(0%,10.42%,20.83%,25%的S95级矿粉掺量)以及两种养护条件(标准养护和现场高温养护)。在试验研究基础... 详细信息

针对矿粉掺量和夏季施工现场高温环境对混凝土力学性能的影响,开展了不同试验工况下混凝土抗压强度的统计研究,试验变量包括四种配合比(0%,10.42%,20.83%,25%的S95级矿粉掺量)以及两种养护条件(标准养护和现场高温养护)。在试验研究基础上,采用回归拟合分析,提出了考虑矿粉掺量和养护温度的混凝土抗压强度的概率模型,并运用已有文献数据进行了该概率模型的验证。结果表明,矿粉掺量对混凝土初期抗压强度的影响比其对混凝土后期抗压强度的影响更强,现场高温养护条件下混凝土抗压强度均值和变异系数比标准养护条件下混凝土抗压强度均值和变异系数要大,文中提出的考虑矿粉掺量和养护温度的混凝土抗压强度概率模型具有较好适用性,可以为相同或近似配合比的混凝土抗压强度预测提供理论参考。

关键词：矿粉高温养护高强混凝土统计研究

星形胶质细胞外囊泡在卒中后认知障碍中的研究进展

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中国全科医学 2024年第20期27卷 2551-2556页

作者：肖雨倩白艳杰王岩孙可心万俊陈淑颖陈丽敏河南中医药大学河南省郑州市450000 河南中医药大学第一附属医院河南省郑州市450000

卒中后认知障碍(PSCI)是卒中患者的常见并发症,以认知功能障碍为特征,直接影响患者生活质量。既往研究发现,星形胶质细胞在PSCI发病机制中发挥重要作用。此外,细胞外囊泡(EVs)已被公认为细胞间通讯中的重要递质,并通过携带和运输各种货... 详细信息

卒中后认知障碍(PSCI)是卒中患者的常见并发症,以认知功能障碍为特征,直接影响患者生活质量。既往研究发现,星形胶质细胞在PSCI发病机制中发挥重要作用。此外,细胞外囊泡(EVs)已被公认为细胞间通讯中的重要递质,并通过携带和运输各种货物参与各种病理生理过程。星形胶质细胞外囊泡(ADEVs)可能与其他脑细胞进行交流,通过增强突触可塑性、调控神经炎症、调节血管生成和细胞自噬等过程改善PSCI。本综述阐明了ADEVs对PSCI发展的多方面影响,为研究PSCI的潜在机制提供新的策略,并进一步探讨ADEVs作为新型药物和生物标志物在诊断和治疗PSCI方面的潜在用途。

关键词：卒中认知障碍星形胶质细胞外囊泡突触可塑性神经炎症

Effect of surgical factors on the augmentation of cementinjectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite

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Frontiers of Medicine 2019年第5期13卷 590-601页

作者： Haolin Sun Chun Liu Shunlun Chen yanjie bai Huilin Yang Chunde Li Lei Yang Department of Orthopedics Peking University First Hospital Beijing 100034China Orthopedic Institute Department of OrthopedicsFirst Affiliated HospitalSoochow UniversitySuzhou 215006China School of Public Health Medical CollegeSoochow UniversitySuzhou 215100China International Research Center for Translational Orthopedics Suzhou 215006China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

Bone cement-augmented pedicle screw system demonstrates great efficacy in spinal disease treatments. However, the intrinsic drawbacks associated with clinically used polymethylmethacrylate (PMMA) cement demands for new bone cement formulations. On the basis of our previous studies, a novel injectable and biodegradable calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was systematically evaluated for its surgical feasibility and biomechanical performance by simulated and animal osteoporotic bone models, and the results were compared with those of clinical PMMA cement. ASTM-standard solid foam and open-cell foam models and decalcified sheep vertebra models were employed to evaluate the augmentation effects of CPN on bone tissue and on the cement-injected cannulated pedicle screws (CICPs) placed in osteoporotic bone. Surgical factors in CICPs application, such as injection force, tapping technique, screw diameter, and pedicle screw loosening scenarios, were studied in comparison with those in PMMA. When directly injected to the solid foam model, CPN revealed an identical augmentation effect to that of PMMA, as shown by the similar compressive strengths (0.73 ± 0.04 MPa for CPN group vs. 0.79 ± 0.02 MPa for PMMA group). The average injection force of CPN at approximately 40-50 N was higher than that of PMMA at approximately 20 N. Although both values are acceptable to surgeons, CPN revealed a more consistent injection force pattern than did PMMA. The dispersing and anti-pullout ability of CPN were not affected by the surgical factors of tapping technique and screw diameter. The axial pullout strength of CPN evaluated by the decalcified sheep vertebra model revealed a similar augmentation level as that of PMMA (1351.6 ± 324.2 N for CPN vs. 1459.7 ± 304.4 N for PMMA). The promising results of CPN clearly suggest its potential for replacing PMMA in CICPs augmentation application and the benefits of further study and development for

关键词： bone cement pedicle screw degenerative spinal diseases calcium phosphate injectable

长链非编码RNA与缺血性脑卒中后的神经免疫炎症及相关信号通路

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中国组织工程研究 2024年第20期28卷 3265-3271页

作者：万俊白艳杰王岩陈淑颖陈丽敏肖雨倩孙可心河南中医药大学河南省郑州市450046 河南中医药大学第一附属医院河南省郑州市450000

背景:长链非编码RNA作为炎症反应的重要调节因子,可参与缺血性脑卒中后免疫-炎症-脑串扰机制,具有成为治疗缺血性脑卒中后神经功能障碍的潜能。目的:将长链非编码RNA作用神经胶质细胞参与缺血性脑卒中后神经免疫炎症级联反应的分子机制... 详细信息

背景:长链非编码RNA作为炎症反应的重要调节因子,可参与缺血性脑卒中后免疫-炎症-脑串扰机制,具有成为治疗缺血性脑卒中后神经功能障碍的潜能。目的:将长链非编码RNA作用神经胶质细胞参与缺血性脑卒中后神经免疫炎症级联反应的分子机制及其调控的相关信号通路进行分析总结,指出长链非编码RNA具有调节缺血性卒中后炎症的潜力。方法:以“ischemic stroke,long non-coding RNA,neuroinflammation,immune function,signal pathway,microglia,astrocytes,oligodendrocyte,mechanism”为检索词在PubMed数据库中进行检索,最终纳入63篇相关文献进行综述分析。结果与结论:①在缺血性脑卒中发生早期,神经细胞因缺血缺氧死亡激活大脑先天免疫应答,促进炎症因子的分泌,诱导血脑屏障损伤及一系列炎症级联反应的发生。②神经免疫炎症级联反应作为缺血性脑卒中的重要发病因素,已被证实严重影响缺血性脑卒中患者的预后,需要在发病早期及时抑制。③缺血性脑卒中后神经炎症通常诱导大量长链非编码RNA的异常表达,这些长链非编码RNA通过调节小胶质细胞、星形胶质细胞、少突胶质细胞的极化介导一系列神经-免疫-炎症串扰机制,发挥脑卒中后神经保护作用。④长链非编码RNA作为炎症反应的重要调节因子,通过调控核转录因子κB、长链非编码RNA-miRNA-mRNA轴、Rho-ROCK、MAPK、AKT及ERK等信号通路抑制缺血性脑卒中后神经免疫炎症级联反应,有效改善缺血性脑卒中后神经功能损伤。⑤大多数长链非编码RNA与缺血性脑卒中相互作用的实验研究中是基于大脑中动脉闭塞模型或者脑缺血再灌注损伤模型进行的,并未进行临床试验,所以关于长链非编码RNA是否可以安全应用到临床治疗中还有待进一步探索。⑥目前有关治疗缺血性脑卒中的药物有许多,但是通过组织工程技术应用长链非编码RNA及外泌体等移植技术治疗缺血性脑卒中的研究相对较少,还需进一步探索。⑦长链非编码RNA以其相对稳定性和高度特异性的特点成为治疗缺血性脑卒中的重要靶点。在未来的研究中应继续探索更多在缺血缺氧条件下发挥作用的炎性长链非编码RNA类型,以期为治疗缺血性脑卒中后神经炎症提供新的研究方向。

关键词：缺血性脑卒中长链非编码RNA 神经炎症免疫功能信号通路神经胶质细胞炎症因子机制

Starch-based adhesive hydrogel with gel-point viscoelastic behavior and its application in wound sealing and hemostasis

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Journal of Materials Science & Technology 2021年第4期63卷 228-235页

作者： Yuxuan Mao Peng Li Jiewei Yin yanjie bai Huan Zhou Xiao Lin Huilin Yang Lei Yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteSoochow UniversitySuzhou215000China Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou215000China School of Public Health Soochow UniversitySuzhou215000China Center for Health Science and Engineering(CHSE) School of Materials Science and EngineeringHebei University of TechnologyTianjin300000China School of Mechanical Engineering Jiangsu University of TechnologyChangzhou213000China

Hydrogels with tissue adhesiveness have demonstrated great promise for wearable electronics,artificial skin,soft robotics,and tissue ***,adhesive hydrogels that are capable of sealing and hemostasis of wound with severe hemorrhage still *** this purpose,a series of ionically crosslinked starch hydrogels were developed *** viscoelastic properties and tissue adhesiveness of the starch hydrogels were *** is shown that the starch and cross linkers had significant influence on the viscoelastic properties of the starch hydrogels,which further resulted in varied tissue *** the starch gels,there was one exhibiting a unique and stable"Gel Point"viscoelastic characteristic and it was named as gel-point adhesive hydrogel(GPAH).GPAH showed electrical conductivity,high tissue adhesiveness,high stretch-ability,self-healing capability,injectability,and *** GPAH also exhibited high cytocompatibility,low hemolysis risk,and strong antibacterial *** wound sealing and hemostatic performance of GPAH was further evaluated by a rat femoral artery injury *** blood loss after the sealing of GPAH(2.4±1.3 g)was significantly decreased compared to the group using gauze for sealing(6.3±1.5 g).Meanwhile,GPAH did not cause pathological changes of the soft tissues surrounding the *** above results indicate that GPAH,with high tissue adhesiveness,suitable viscoelastic property,strong antibacterial capacity,as well as electro-conductivity,bears great potential for the applications in smart wound management.

关键词： sealing viscoelastic hydrogel

兼具显影与成骨功能多聚磷酸锶在磷酸钙骨水泥中的应用

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中国组织工程研究 2024年第22期28卷 3539-3547页

作者：唐子牛褚凤成吴康张林白艳洁林潇杨惠林周欢刘慧玲杨磊苏州大学附属第一医院江苏省苏州市215006 苏州大学骨科研究所江苏省苏州市215006 河北工业大学化工学院天津市300131 河北工业大学生命科学与健康工程学院天津市300131

背景:课题组前期研究发现,添加硫酸钡可以提高磷酸钙骨水泥的力学性能与显影性能,但伴随磷酸钙降解残存的显影剂难以降解,在植入部位产生的占位效应及破骨效应影响骨修复进程,因此需要开发一种可生物降解的新型显影材料。目的:探讨生物... 详细信息

背景:课题组前期研究发现,添加硫酸钡可以提高磷酸钙骨水泥的力学性能与显影性能,但伴随磷酸钙降解残存的显影剂难以降解,在植入部位产生的占位效应及破骨效应影响骨修复进程,因此需要开发一种可生物降解的新型显影材料。目的:探讨生物活性可降解材料多聚磷酸锶的显影能力及其对磷酸钙骨水泥理化性能与成骨效应的影响。方法:①分别制备磷酸钙骨水泥(CPC)、淀粉改性磷酸钙骨水泥(CPS)与含多聚磷酸锶(占骨水泥粉末的质量分数为20%)淀粉改性磷酸钙骨水泥(20%SrPP-CPN),表征3组骨水泥的理化性能。②将3组骨水泥浸提液分别与大鼠骨髓间充质干细胞共培养,检测细胞增殖、能量代谢与成骨分化能力。③在24只SD大鼠颅顶部两侧各制作直径5 mm的骨缺损,随机分为对照组(不进行任何干预)、CPC组、CPS组与20%SrPP-CPN组进行干预,每组6只。干预4,12周后取材进行相关检测。结果与结论:①与其他两组骨水泥比较,20%SrPP-CPN的显影能力增强、抗压强度与降解速率升高、固化时间延长,并且20%SrPP-CPN在降解过程中可稳定释放Sr^(2+)。②CCK-8实验显示20%SrPP-CPN不影响骨髓间充质干细胞的增殖;细胞饥饿实验(无血清培养)显示相较于其他两组骨水泥,20%SrPP-CPN可促进骨髓间充质干细胞的增殖;相较于其他两组骨水泥,20%SrPP-CPN可提升骨髓间充质干细胞内ATP浓度。碱性磷酸酶与茜素红染色显示,相较于其他两组骨水泥,20%SrPP-CPN可促进骨髓间充质干细胞的成骨分化。③在大鼠颅骨缺损实验中,Micro-CT扫描、组织学(苏木精-伊红、Masson染色)观察显示相较于CPC组、CPS组,20%SrPP-CPN组骨水泥降解明显,并且大量新生骨组织分散于降解的骨水泥中;免疫组化染色显示相较于CPC组、CPS组,20%SrPP-CPN组缺损处Runx2蛋白表达升高(P<0.01)。④结果表明,20%SrPP-CPN具有良好的显影性能与促成骨性能。

关键词：多聚磷酸锶磷酸钙骨水泥显影剂生物相容性降解成骨性能

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程序性细胞死亡在脑卒中后认知障碍中的研究进展

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中国比较医学杂志 2024年第3期34卷 161-171页

作者：孙可心肖雨倩万俊陈淑颖陈丽敏王岩白艳杰河南中医药大学郑州450000 河南中医药大学第一附属医院郑州450000

脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)是脑卒中后常见并发症之一,对卒中患者的生活质量影响较大,但发病机制尚未能完全解释清楚。越来越多的证据表明,程序性细胞死亡(programmed cell death,PCD)机制与PSCI有关,包... 详细信息

脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)是脑卒中后常见并发症之一,对卒中患者的生活质量影响较大,但发病机制尚未能完全解释清楚。越来越多的证据表明,程序性细胞死亡(programmed cell death,PCD)机制与PSCI有关,包括细胞凋亡、坏死性凋亡、细胞焦亡、泛凋亡、PARP-1依赖性细胞死亡和铁死亡等。因此,清楚了解各种PCD机制及其与PSCI的关系,阐明PCD在疾病发病机制中的作用至关重要。文章综述了与PSCI相关的6种PCD途径,总结其在PSCI中的作用机制,并阐述了不同途径之间可能存在的串扰,以期为临床靶向PCD途径的调节因子来治疗PSCI提供资料依据。

关键词：脑卒中后认知障碍程序性细胞死亡 caspase-8 串扰