Mechano-active biomaterials for tissue repair and regeneration

作     者：Xiao Lin Yanjie Bai Huan Zhou Lei Yang Xiao Lin;Yanjie Bai;Huan Zhou;Lei Yang

作者机构：Orthopaedic Institute and Department of OrthopaedicsThe First Affiliated HospitalSoochow UniversitySuzhou 215006China School of Public HealthSoochow UniversitySuzhou 215123China Center for Health Science and Engineering(CHSE)School of Materials Science and EngineeringTianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologyHebei University of TechnologyTianjin 300401China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2020年第59卷第24期

页      面：227-233页

核心收录：

学科分类：0806[工学-冶金工程] 0817[工学-化学工程与技术] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0802[工学-机械工程] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：sponsored by the National Natural Science Foundation of China(Nos.81622032,31801585,81930070and 51672184) Suzhou Science and Technology Project(No.SYS2019022) Natural Science Foundation of Jiangsu Province(Nos.BK20180837 and BK20181045) Postdoctoral Science Foundation(No.2018T110546) Natural Science Research of Jiangsu Higher Education Institutions(No.17KJA180011) the Priority Aca-demic Program Development of Jiangsu High Education Institutions(PAPD) 

主　　题：Mechano-active Smart biomaterials Tissue engineering and regeneration Mechanobiology Gel-point adhesive hydrogel 

摘      要：There is a lack of effective tissue repair and regeneration strategies in current clinical *** studies have suggested that smart or responsive biomaterials possessing the ability to respond to endogenous stimuli in vivo may positively mediate the tissue micro-environment towards a tissue repair or *** stimuli,which constantly exist in a wide range of biological systems and are involved in almost all the physiological processes,belong to such stimuli to which responsive biomaterials can *** recent studies,a new type of smart biomaterials,which can dynamically adapt to the mechanical stimuli in vivo and thus has specific functionality consistently mediated by such mechanical stimuli,has *** contrast to common biomaterials that passively react to the mechanical environment of an implantation site,such mechano-active biomaterials have enabled various active or automatic strategies for tissue repair or regeneration,such as providing precise spatial-temporal controls on delivery of drugs or cells in the organs of the musculoskeletal and the circulatory systems;in situ reconstructing the original or a favorable mechanical environment at a lesion site;and accelerating the tissue remodeling or healing process via a mechanobiological *** article elucidates a perspective of perfecting tissue repair or regeneration using mechano-active biomaterials,especially highlighting the rationale behind the concept of mechano-active biomaterials and their potential in the repair or regeneration of musculoskeletal and cardiovascular *** outstanding challenges and unknowns,the emergence of mechano-active biomaterials has become a new avenue for tissue engineering and regenerative medicine.