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World Journal of Gastroenterology 2017年第12期23卷 2175-2184页

作者： Jie Han Ji-Hong li guang Bai Guo-Shun Shen Jing Chen Jia-Nan liu Shuo Wang Xian-Jun liu Key Laboratory of Zoonosis of liaoning Province College of Animal Science and Veterinary MedicineShenyang Agricultural University Department of Pharmacy Affiliated HospitalLiaoning University of Traditional Chinese Medicine Department of Gastroenterology Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Testing and Analysis Center Shenyang Agricultural University

AIM To examine the effects of Acanthopanax senticosus polysaccharides(ASPS) on intestinal tight junction(TJ) disruption and nuclear factor-kappa B(NF-κB)/myosin light chain kinase(MLCK) activation in *** BALB/C mice(6-8-weeks-old) received continuous intragastric gavage of ASPS for 7 d before injection of lipopolysaccharide(LPS), or received ASPS once after LPS injection. Blood and intestinal mucosal samples were collected 6 h after LPS challenge. Clinical symptoms, histological injury, intestinal permeability,TJ ultrastructure, and TJ protein expression were *** Compared with mice in the LPS group, pretreatment with ASPS improved clinical and histological scores by 390.9%(P lity change in endotoxemic mice was shown by a 61.93% reduction in reduced leakage of fluorescein isothiocyanate-dextran 6 h after LPS injection(P light-chain-2 by 16.06%(P lioration of LPS-induced TJ dysfunction of intestinal epithelium in endotoxemia.

关键词： Acanthopanax senticosus polysaccharide Intestinal permeability Tight junction Nuclear factorkappa B Myosin light chain kinase

Highly-sensitive NO,NO2,and NH3 measurements with an open-multipass cell based on mid-infrared wavelength modulation spectroscopy

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Chinese Physics B 2018年第4期27卷 250-257页

作者： Xiang Chen Chen-guang yang Mai Hu Jian-Kang Shen Er-Chao Niu Zhen-Yu Xu Xue-li Fan Min Wei Lu Yao Ya-Bai He Jian-Guo liu Rui-Feng Kan Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 2300314 China University of Science and Technology of China Hefei 230022 China Jiangsu Environmental Monitoring Center Nanjing 210036 China

A compact prototype based on mid-infrared wavelength modulation spectroscopy（WMS）is developed for the simul-taneous monitoring of NO,NO2,and NH3 in the urban *** quantum cascade lasers（QCLs）with central frequencies around 1900.0 cm^-1,1600.0 cm^-1,and 1103.4 cm^-1are used for NO,NO2,and NH3detections,respectively,by timedivision *** open-path multi-pass cell of 60-m optical path length is applied to the instrument for high sensitivity and reducing the response time to less than 1 *** prototype achieves a sub-ppb detection limit for all the three target gases with an average time of about 100 *** instrument is installed in the Jiangsu environmental monitoring center to conduct performance tests on ambient *** 24-hour measurements show good agreement with the results of a reference instrument based on the chemiluminescence technique.

关键词： wavelength modulation spectroscopy optical sensing atmospheric monitoring time division multiplexing quantum cascade laser mid-infrared laser spectroscopy

Characteristics of discontinuities in Heifangtai landslide area in Gansu,China

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Applied Geophysics 2020年第5期17卷 857-869,904,905页

作者： li Bin Xu Qiang Cheng Qiang liu Tian-Xiang Tang Ming-Gao Zheng guang Wang Hai-Yan Chengdu University of Technology State Key Laboratory of Geohazard Prevention and Geoenvironment ProtectionSichuanChengdu 610059China Sichuan Highway Planning SurveyDesign and Research Institute Ltd.SichuanChengdu 610041China

Loesses are widely distributed all over the world,especially in ***,long-term agricultural irrigation and extreme climate changes have led to frequent geological disasters in the Heifangtai area of Lanzhou,Gansu,*** these,landslides are one of the most frequent types of disasters that are harmful to humans and the environment.A landslide is closely related to the lithology,structure,and groundwater of the site and consists of a combination of structure units divided by discontinuities,such as faults,joints,and fi ***,geological surveys,engineering drilling,and trenching are typically used to identify the stratum lithology,structure,and groundwater in order to visually display underground information within a limited depth ***,these methods have *** particular,geological surveys can only describe geological phenomena on the surface,while the cost of drilling and trenching may be high,along with the ineffi ciency of *** this research,the integrated geophysical exploration method was used to analyze the hidden joints,cracks,and other discontinuities and geophysical features of the *** results were verified by trench exploration,and large amounts of underground information were obtained,especially the spread and distribution of discontinuities in landslide *** information can be effectively used for carrying out and providing meaningful experiences and lessons in future comprehensive geophysical processing and interpretations related to the prediction and evaluation of landslides.

关键词： Loess landslide discontinuities geophysics engineering geology

Patellofemoral MRI Alterations Following Single Bundle ACL Reconstruction with Hamstring Autografts Are Associated with Quadriceps Femoris Atrophy

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Current Medical Science 2019年第6期39卷 1029-1036页

作者： Wei-song CAI Hao-huan li Shin-ichi KONNO Hironori NUMAZAKI Si-qi ZHOU Yu-biao ZHANG guang-tao HAN Department of Orthopedics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Orthopedics Fukushima Medical University School of MedicineFukushima 960-1295Japan

High incidence of patellofemoral pain and patellofemoral joint osteoarthritis was found following anterior cruciate ligament(ACL)*** unstability of patellofemoral joint might be an important contribution *** study was designed to define the relationship between the unstability of patellofemoral joint and quadriceps femoris *** patients underwent MRI scan before ACL reconstruction and every two weeks after surgery,until 12 *** merchant’s patellar congruence angle,lateral inclination angle,and quadriceps femoris muscle cross-sectional area were measured and the relationship between the changes of angles and the ratio of quadriceps femoris atrophy was studied by multiple regression *** quadriceps femoris atrophy was observed after ACL reconstruction during the follow-up period of 12 *** merchant’s patellar congruence angle and lateral inclination angle significantly changed after *** alterations of the merchant’s patellar congruence angle were significantly correlated with the atrophy ratio of vastus medialis(coefficient=-5.76)and vastus lateralis(coefficient=8.35)during the follow-up period of 12 *** alterations of lateral inclination angle were significantly correlated with the atrophy ratio of vastus medialis(coefficient=20.62),vastus lateralis(coefficient=-11.38)and rectus femoris(coefficient=-0.469)during the follow-up period 12 *** sum up,ACL reconstruction can alleviate the dysfunction of patellofemoral joint to a certain ***,the unbalanced atrophy of quadriceps femoris once again destroyed the stability of patellofemoral joint following the operation,which might be one cause of patellofemoral joint pain and early onset of osteoarthritis after ACL ***,rehabilitation training that focuses on quadriceps femoris especially the vastus medialis shortly following operation is suggested.

关键词： patellofemoral joint osteoarthritis quadriceps femoris atrophy joint instability anterior cruciate ligament reconstruction

改进的禁忌搜索算法及其在电磁场逆问题中的应用

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电力系统保护与控制 2010年第24期38卷 30-33页

作者：安斯光杨仕友李桃浙江大学电气学院浙江杭州310027 中国计量学院机电工程学院浙江杭州310018 水利部产品质量标准研究所浙江杭州310012

针对求解多极值点目标函数的电磁场逆问题,提出了一种改进的禁忌搜索算法。为提高算法的全局寻优能力和减少寻优计算的时间,改进算法在结构上提出了不同状态的新转移规则:步长向量选取原则和不同循环起始点选择的新规则。避免了重复或... 详细信息

针对求解多极值点目标函数的电磁场逆问题,提出了一种改进的禁忌搜索算法。为提高算法的全局寻优能力和减少寻优计算的时间,改进算法在结构上提出了不同状态的新转移规则:步长向量选取原则和不同循环起始点选择的新规则。避免了重复或无意义中间点的产生,使算法能够有效地跳出局部极值点,迅速收敛到全局最优点。给出的典型数学函数验证了算法的快速性和有效性,电磁场逆问题算例TEAMWorkshop问题22的结果表明算法的优越性和工程应用价值。

关键词：禁忌算法 Matlab Ansys 电磁场逆问题全局最优化

The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch

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Neuroscience Bulletin 2023年第12期39卷 1807-1822页

作者： Juan Yao Xuan li guang-Yan Wu Bing Wu Jun-Hui Long Pu-Jun Wang Shu-Lei liu Jie Gao Jian-Feng Sui Experimental Center of Basic Medicine Army Medical UniversityChongqing400038China Department of Physiology College of Basic Medical SciencesArmy Medical UniversityChongqing400038China Department of Dermatology The 958th Army Hospital of the People’s Liberation ArmyChongqing400020China State Key Laboratory of Trauma Burns and Combined InjuryArmy Medical Centre of the PLAInstitute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing400042China

Itch is an unpleasant sensation that urges people and animals to *** studies on itch have yielded extensive correlations with diverse cortical and subcortical regions,including the insular ***,the role and functional specificity of the insular cortex(IC)and its subdivisions in itch mediation remains ***,we demonstrated by immunohistochemistry and fiber photometry tests,that neurons in both the anterior insular cortex(AIC)and the posterior insular cortex(PIC)are activated during acute itch *** experiments revealed that nonselective inhibition of global AIC neurons,or selective inhibition of the activity of glutaminergic neurons in the AIC,reduced the scratching behaviors induced by intradermal injection of 5-hydroxytryptamine(5-HT),but not those induced by compound 48/***,both nonselective inhibition of global PIC neurons and selective inhibition of glutaminergic neurons in the PIC failed to affect the itching-scratching behaviors induced by either 5-HT or compound 48/*** addition,pharmacogenetic inhibition of AIC glutaminergic neurons effectively blocked itch-associated conditioned place aversion behavior,and inhibition of AIC glutaminergic neurons projecting to the prelimbic cortex significantly suppressed 5-HT-evoked *** findings provide preliminary evidence that the AIC is involved,at least partially via aversive emotion mediation,in the regulation of 5-HT-,but not compound 48/80-induced itch.

关键词： Itch-Insular cortex Prelimbic cortex Conditioned place aversion Pharmacogenetic inhibition

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安顺地区结核分枝杆菌基因分型及耐药性分析

贵州医科大学学报 2024年第6期49卷 852-858,872页

作者：刘洪飞徐彬佟玉峰孙广李小多张彪蒋红梅贵州医科大学医学检验学院贵州贵阳550000 安顺市人民医院医学检验科贵州安顺561000 安顺市人民医院呼吸内科贵州安顺561000

目的研究贵州省安顺地区结核分枝杆菌(MTB)主要基因分型及耐药性。方法采用RD105基因缺失法和双重PCR法对安顺地区152株MTB临床分离株进行基因分型、药物敏感试验分析耐药性,采用基因测序技术对北京型MTB利福平耐药基因RNA聚合酶β亚基(... 详细信息

目的研究贵州省安顺地区结核分枝杆菌(MTB)主要基因分型及耐药性。方法采用RD105基因缺失法和双重PCR法对安顺地区152株MTB临床分离株进行基因分型、药物敏感试验分析耐药性,采用基因测序技术对北京型MTB利福平耐药基因RNA聚合酶β亚基(rpoB)进行测序。结果152株MTB中,122株(80.26%)为北京型、30株(19.74%)为非北京型;108株MTB对抗结核药物敏感,44株对16种抗结核药物耐药,总耐药率为28.95%;44株MTB耐药菌株中31例对利福平耐药,占70.45%,北京型MTB对利福平耐药率显著高于非北京型(χ^(2)=6.896,P=0.009),非利福平耐药结核菌株共13株、占耐药结核菌株的29.55%;北京型MTB利福平耐药rpoB基因测序结果表明,相关位点突变共15株,其中最显著的突变位点是rpoB450、为Ser450Leu,共7株(7/15,46.67%)。结论贵州省安顺地区MTB主要为北京型,主要对利福平耐药,耐药基因rpoB的突变位点为Ser450Leu。

关键词：结核分枝杆菌基因分型耐药性基因测序 RD105 双重PCR

基于双层超表面的宽带、高效透射型轨道角动量发生器

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物理学报 2021年第3期70卷 246-253页

作者：高喜唐李光广西科技大学电气与信息工程学院柳州545006

提出一种宽带、高传输效率的双层超表面,其单元结构是在介质层两边对称刻蚀结构参数相同的十字型金属贴片且将两层超表面沿y方向错位半个周期长度形成.通过引入y方向的错位,双层超表面的透射带宽得到大幅度提升.同时,采用等效电路理论... 详细信息

提出一种宽带、高传输效率的双层超表面,其单元结构是在介质层两边对称刻蚀结构参数相同的十字型金属贴片且将两层超表面沿y方向错位半个周期长度形成.通过引入y方向的错位,双层超表面的透射带宽得到大幅度提升.同时,采用等效电路理论分析了该双层超表面的带宽展宽机理.在此基础上,进一步结合Pancharatnam-Berry相位原理,实现了宽带轨道角动量波束生成器.实验和仿真结果表明,在11-12.8 GHz的频率范围内,器件能够将左旋圆极化波转换为携带轨道角动量的右旋圆极化波.

关键词：双层超表面宽带 Pancharatnam-Berry相位轨道角动量

Fabrication of a Bi-layer Tubular Scaffold Consisted of a Dense Nanofibrous Inner Layer and a Porous Nanoyarn Outer Layer for Vascular Tissue Engineering

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Journal of Donghua University(English Edition) 2014年第5期31卷 718-722页

作者： CHEN Jian-feng liU Wei WU Tong li Da-wei ZHANG Jian-guang WANG Nan-ping MO Xiu-mei State KeyLaboratory for Modifications of Chemical Fibers and Polymer Materials- Coilege of Material Science and EngineeringDonghua University Shanghai 201620 China Biomaterials and Tissue Engineering Laboratory College of Chemistry Chemical Engineering and Biotechnology DonghuaUniversity Shanghai 201620 China Shanghai Fisheries Research Institute Shanghai 201620 China

Recent years, it has attracted more attentions to increase the porosity and pore size of nanofibrous scaffolds to provide the for the cells to grow into the small-diameter vascular grafts. In this study, a novel bi-layer tubular scaffold with an inner layer and an outer layer was fabricated. The inner layer was random collagen/poly （ L-lactide-co-caprolactone ） I P （ LLA- CL） ] nanofibrous mat fabricated by conventional electrospinning and the outer layer was aligned collagen/P （LLA-CL） nanoyarns prepared by a dynamic liquid dectrospinning method. Fourier transform infrared spectroscopy （FTIR） was used to characterize the chemical structure. Scanning electron microscopy （ SEM ） was employed to observe the morphology of the layers and the cross- sectioned bi-layer tubular scaffold. A liquid displacement method was employed to measure the porosities of the inner and outer layers. Stress-strain curves were obtained to evaluate the mechanical properties of the two different layers and the bi-layer membrane. The diameters of the nanofibers and the nanoyarns were （480 ± 197 ） nm and （ 19.66 ± 4.05 ） μm, respectively. The outer layer had a significantly higher porosity and a larger pore size than those of the inner layer. Furthermore, the bi-layer membrane showed a good mechanical property which was suitable as small-diameter vascular graft. The results indicated that the bi-layer tubular scaffold had a great potential application in small vascular tissue engineering.

关键词： nanoyarn poly ( L-lactide-co-caprolactone ) [ P ( LLA-CL ) ] bi-layer tubular scaffold porous structure small vascular tissueengineering

Better performance of PIVKA-II for detecting hepatocellular carcinoma in patients with chronic liver disease with normal total bilirubin

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World Journal of Gastroenterology 2023年第8期29卷 1359-1373页

作者： Xiang-Jun Qian Zhu-Mei Wen Xiao-Ming Huang Hui-Juan Feng Shan-Shan lin Yan-Na liu Sheng-Cong li Yu Zhang Wen-guang Peng Jia-Rui yang Zhe-Yu Zheng Lei Zhang Da-Wei Zhang Feng-Min Lu li-Juan liu Wei-Dong Pan Department of Pancreatic Hepatobiliary Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Microbiology&Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Department of Laboratory Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350025Fujian ProvinceChina Johns Hopkins Bloomberg School of Public Health Johns Hopkins UniversityBaltimoreMD 21205United States

BACKGROUND Serum protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) is a promising biomarker for hepatocellular carcinoma(HCC) *** To identify the contributing factors related to the abnormal elevation of PIVKA-Ⅱ level and assess their potential influence on the performance of PIVKA-Ⅱ in detecting *** This study retrospectively enrolled in 784 chronic liver disease(CLD) patients and 267 HCC patients in Mengchao Hepatobiliary Hospital of Fujian Medical University from April 2016 to December 2019. Logistic regression and the area under the receiver operating characteristic curve(AUC) were used to evaluate the influencing factors and diagnostic performance of PIVKA-Ⅱ for HCC, *** Elevated PIVKA-Ⅱ levels were independently positively associated with alcohol-related liver disease, serum alkaline phosphatase(ALP), and total bilirubin(TBIL) for CLD patients and aspartate aminotransferase(AST) and tumor size for HCC patients(all P limit of normal(ULN), TBIL ≤ 1 × ULN, and AST ≤ 1 × ULN than in those with nonviral disease and abnormal ALP, TBIL, or AST(all P 1 × ULN(0.817 vs 0.669, P = 0.015), while the difference between ALP ≤ 1 × ULN and ALP > 1 × ULN was not statistically significant(0.783 vs 0.729, P = 0.398). These trends were then more prominently perceived in subgroups of patients with viral etiology and HBV *** Serum PIVKA-Ⅱ has better performance in detecting HCC at an early stage for CLD patients with normal serum TBIL.

关键词： Protein induced by vitamin K absence or antagonist-II Chronic liver disease Total bilirubin Hepatocellular carcinoma Diagnosis Hepatitis B virus