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自制新型骨钻应用于L_(5)/S_(1)椎间盘突出症手术的效果

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局解手术学杂志 2024年第7期33卷 610-613页

作者：赵阳阳范东娇樊格林张健李博文聂志红邢台市人民医院脊柱骨一科河北邢台054000 邢台市人民医院超声科河北邢台054000

目的探讨经皮椎间孔镜椎间盘切除术中应用自制新型骨钻治疗L_(5)/S_(1)椎间盘突出症的有效性及安全性。方法回顾性分析我院收治的52例L_(5)/S_(1)椎间盘突出症患者的临床资料,患者均行经皮椎间孔镜椎间盘切除术治疗,术中均使用自制新型... 详细信息

目的探讨经皮椎间孔镜椎间盘切除术中应用自制新型骨钻治疗L_(5)/S_(1)椎间盘突出症的有效性及安全性。方法回顾性分析我院收治的52例L_(5)/S_(1)椎间盘突出症患者的临床资料,患者均行经皮椎间孔镜椎间盘切除术治疗,术中均使用自制新型骨钻行椎间孔成形。记录手术情况及并发症发生情况。术前、术后3 d、术后3个月、术后6个月及术后1年采用视觉模拟量表(VAS)评估患者疼痛情况;采用Oswestry功能障碍指数(ODI)评价手术前后神经功能改善情况。结果所有患者手术均顺利完成,未发生严重并发症,术后均未出现复发。术后3 d、术后3个月、术后6个月及术后1年患者VAS、ODI评分均较术前显著降低(P<0.05)。结论自制新型骨钻可明显提高椎间孔成形效率,保证手术安全性,早期临床效果满意。

关键词：腰椎间盘突出症经皮椎间孔镜椎间盘切除术椎间孔成形术自制骨钻镜下环锯

A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression

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Genes & Diseases 2023年第3期10卷 654-656页

作者： Jing Jin Mingjun Ma Bingru Yan botao Qiu Shounan Lu Lin yang Yuzhe nie Sheng Tai Ze Yu Chun-bo Teng College of Life Science Northeast Forestry UniversityHarbinHeilongjiang 150040China Department of Minimally Invasive Hepatic Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150007China Department of Hepatic Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China

Although the role of copper (Cu) in promoting KRas- or BRaf-mutation driven cancers via activating MEK1/2 kinases is known, the mechanism by which the copper transporter SLC31A1 (CTR1) is upregulated in pancreatic cancer (PDAC, KRas mutation) is not defined. In this study, we provide evidence that MEK signal maintains a high level of SLC31A1 through silencing the expression of miR-124-3P (miR-124) via a novel MEK-DNMT1-miR-124 feedback loop in PDAC cells. Further, we reveal that miR-124 directly targets suppression of SLC31A1, and miR-124 introduction together with tetrathiomolybdate (TM) treatment hampered pancreatic cancer growth in vitro and in vivo. Our results demonstrate that a SLC31A1-MEK-DNMT1-miR-124 feedback loop is an important pathway to maintain copper absorption and promote pancreatic cancer progression, and we hope to provide a Cu-chelation as an adjuvant treatment strategy, to block the progression in Kras mutant PDAC patients.

关键词： DNMT1 SLC treatment

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组团式城市快速路网布局思路

交通企业管理 2024年第3期39卷 98-101页

作者：田伦聂华波骆中林中交第二公路勘察设计研究院有限公司

随着我国城市化和机动化水平的不断提升,城市道路交通拥堵成为制约城市社会经济快速发展的重要因素。尤其是对于组团式空间结构布局的城市而言,组团间交通联系集中于有限的通道资源内,极易造成组团间道路交通供需失衡。而快速路作为城... 详细信息

随着我国城市化和机动化水平的不断提升,城市道路交通拥堵成为制约城市社会经济快速发展的重要因素。尤其是对于组团式空间结构布局的城市而言,组团间交通联系集中于有限的通道资源内,极易造成组团间道路交通供需失衡。而快速路作为城市干线道路的重要组成,承担城市中长距离联系交通,是支撑城市交通高质量发展的关键抓手。在《国家综合立体交通网规划纲要(2021—2050年)》中也提出“推动城市道路网结构优化,形成级配合理、接入顺畅的路网系统”。由此,开展组团式空间结构布局城市的快速路网体系研究对支撑城市经济社会发展具有重要意义。

关键词：城市快速路路网规划组团式城市空间结构客流分布特征布局思路漳州市

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A study of antineutrino spectra from spent nuclear fuel at Daya Bay

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Chinese Physics C 2012年第1期36卷 1-5页

作者： ZHOU Bin RUAN Xi-Chao nie yang-bo ZHOU Zu-Ying AN Feng-Peng CAO Jun Science and Technology on Nuclear Data Laboratory China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China

The Daya Bay Reactor Antineutrino Experiment is designed to determine the as yet unknown neutrino mixing angle,θ13,by measuring the disappearance of electron antineutrinos from several nuclear reactor *** projected sensitivity in sin2（2θ13） of better than 0.01 at a 90% CL should be achieved after three years of *** emitted from spent nuclear fuel （SNF） distort the soft part of the energy *** this article,a calculation of the antineutrino spectra from the long-life isotopes in SNF is performed.A non-equilibrium generation of long half-life isotopes during the running time of the reactor is also ***,we show that the antineutrino event rate contribution from SNF,which has been stored in the SNF pool for several years,may be non-negligible.

关键词： spent nuclear fuel antineutrino spectrum non-equilibrium event rate

Negative effects of enlarging internal limiting membrane peeling for idiopathic macular hole surgery

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1806-1813页

作者： Ze-Tong nie bo-Shi Liu Yong Wang Qiong Chen Jiao-Ting Wei Meng yang Shao-Fang Pang Xiao-Rong Li bo-Jie Hu Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University EyeHospitalTianjin 300384China

AIM: To observe the effects of the different extents of internal limiting membrane(ILM) peeling on the surgical success and anatomical and functional outcomes of idiopathic macular hole(IMH).METHODS: In this retrospective cohort study, 36 patients were reviewed and divided into two groups according to the extent of ILM peeling: group A(18 patients), with the peeling area within one-half of the optic disc macular distance as the radius;group B(18 patients), with the peeling area larger than that of group A but did not exceed the optic disc macular distance as the radius. The main outcomes included the best corrected visual acuity(BCVA), light-adaptive electroretinography, macular hole(MH) closure rate, central macular thickness(CMT), retinal nerve fiber layer(RNFL) and ganglion cell complex(GCC) thickness [nine regions based on the Early Treatment of Diabetic Retinopathy Study(ETDRS) ring] before and 1, 3, and 6mo after ***: The closure rate was 94.4%(17/18) both in groups A and B. The BCVA in both groups improved significantly compared with the preoperative values, but there was no difference between the two groups. The b-wave amplitude of the electroretinogram analysis was significantly improved in both groups compared to that of the preoperative period, with a greater increase in group A than in group B at 6mo(P=0.017). The CMT in both groups gradually decreased after surgery, and there was no difference between the two groups. The RNFL thickness of the temporal outer ring region in group B was significantly lower than that in group A at 3 and 6mo after surgery(P=0.010, 0.032). The GCC thickness of the temporal outer ring region in group B was significantly lower than that in group A at 6mo after surgery(P=0.038).CONCLUSION: Enlarging the extent of ILM peeling doesn’t affect the IMH closure rate and visual acuity recovery, but the greater the extent of peeling, the greater the damage to the inner retinal structures.

关键词： idiopathic macular hole internal limiting membrane light-adapted electroretinography retinal nerve fiber layer ganglion cell complex

In memory of Professor Pierluigi Cecchi

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Pediatric Investigation 2022年第3期6卷 231-232页

作者： bo Hu Xiaoying nie Administration Office Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Since the end of 2019,a sudden outbreak and pandemic of a newinfectiousdisease—coronavirusdisease2019(COVID-19)has spread all over the world,causing serious loss of life and property in many *** distinguished intimat... 详细信息

关键词： disaster Cec friend

Basic and Clinical Evidence of an Alternative Method to Produce Vivo Nanofat

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Chinese Medical Journal 2018年第5期131卷 588-593页

作者： Hong-Sen Bi Chen Zhang Fang-Fei nie bo-Lin Pan E Xiao Department of Plastic Surgery Peking University Third Hospital Beijing 100191 China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Beijing 100081 China

Background： Fat grafting technologies are popularly used in plastic and reconstructive surgery. Due to its size limitation, it is hard to directly inject untreated iht tissue into the dermal layer. Nanolht, which was introduced by Tonnard, solves this problem by mechanically emulsifying fat tissue. However, the viability of the cells was greatly destroyed. In this study, we reported a new method by ＂gently＂ digesting the fat tissue to produce viable adipocytes, progenitors, and stromal stem cells using collagenase I digestion and centrifugation. This was named ＂Vivo nanofat＂. Methods： Human liposuction aspirates were obtained from five healthy female donors with mean age of 28.7±5.6 years. Colony-forming assay, flow cytometry analysis, and adipogenic and osteogenic induction of the adherent cells from the Vivo nanofat were used to characterize the adipose mesenchymal stem cells （MSCs）. To investigate in vivo survival, we respectively injected Vivo nanofat and nanofat subcutaneously to the back of 8-week-old male BALB/c nude mice. Samples were harvested 2 days, 2 weeks, and 4 weeks postiniection for measurement, hematoxylin and eosin staining, and immunostaining. Results： Our results showed that the Vivo nanofat contained a large number ofcolony-fbrming cells. These cells expressed MSC markers and had multi-differentiative potential. In vivo transplantation showed that the Vivo nanofat had lower resorption ratio than that of nanofat. The size of the transplanted nanofat was obviously smaller than that of Vivo nanofat 4 weeks postinjection （0.50±0.17 cm vs. 0.81 ± 0.07 cm, t = -5783, P- 0.01）. Conclusion： Vivo nanofat may serve as a cell fraction injectable through a fine needle; this could be used for cosmetic applications.

关键词： Adipose Tissue Cell Therapy Mesenchymal Stromal Cells Rejuvenation

1961—2021年世界油菜生产时空演变特征及我国油菜优势度分析

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南方农业学报 2024年第07期55卷 2181-2191页

作者：何锋朱杰周勇蒋梦蝶朱波聂江文刘章勇长江大学湿地生态与农业利用教育部工程研究中心湖北省襄阳市农业科学院湖北工程学院生命科学技术学院

【目的】分析世界油菜生产的时空演变格局，为我国油菜产业的可持续发展提供参考。【方法】基于联合国粮农组织（FAO）发布的1961—2021年世界油菜收获面积、单产和总产量等相关数据，运用一元线性回归模型和优势指标体系，分析世界油... 详细信息

【目的】分析世界油菜生产的时空演变格局，为我国油菜产业的可持续发展提供参考。【方法】基于联合国粮农组织（FAO）发布的1961—2021年世界油菜收获面积、单产和总产量等相关数据，运用一元线性回归模型和优势指标体系，分析世界油菜生产上时空变化特征。【结果】世界油菜发展在1980和2000年出现明显的时空演变特征，整个发展过程可分为3个阶段。总体来看，世界油菜生产重心始终集中于亚洲、欧洲和美洲，且收获面积、单产和总产量均呈稳定增长的趋势。其中，阶段Ⅰ（1961—1980年），亚洲总产量高于欧洲15.2%，尽管亚洲的收获面积比欧洲高460.9%，但欧洲的单产比亚洲高250.7%；阶段Ⅱ（1981—2000年）和阶段Ⅲ（2001—2021年），亚洲总产量仍高于欧洲，且在阶段Ⅱ收获面积增长明显。整个过程美洲收获面积中等，大洋洲和非洲的收获面积和总产量占世界的比例较小。同时，在阶段Ⅰ，中国、加拿大和印度等9个国家的油菜总产量占世界的89.7%，收获面积占世界的92.5%；阶段Ⅱ，加拿大和中国的油菜发展最为迅速；阶段Ⅲ，仅加拿大收获面积和总产量增幅大。此外，巴基斯坦和瑞典在阶段Ⅰ和阶段Ⅱ出现油菜发展退步的现象，德国、中国和英国在阶段Ⅲ也出现此现象。贡献度分析表明，与加拿大和印度等主产国相比，我国油菜生产的效率和规模上均不具备优势，但是油菜生产效率优势在每个阶段依次递增。【建议】我国需要充分利用先进的信息技术和自动化设备监测油菜生产过程，扩大油菜的种植比例和收获面积，同时还要注重油菜价值发掘，开发深加工产品，加大集约化、规模化种植，采取合理的种植模式和施肥处理，从而进一步提升我国油菜的竞争力。

关键词：油菜时空变化效率优势规模优势贡献度分析

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肺腺癌组织lncRNA CCAT1、ZEB1表达与患者临床病理参数和预后的关系

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现代生物医学进展 2024年第13期24卷 2560-2564,2531页

作者：李方李延波聂佳侯晓明河北省邯郸市中心医院肿瘤内三科河北邯郸056000 河北省邢台市信都区人民医院普通内科河北邢台054001 河北省中医院呼吸内科河北石家庄050000 河北工程大学附属医院普外科河北邯郸056000

目的:探讨肺腺癌组织中长链非编码RNA(LncRNA)结肠癌相关转录因子1(CCAT1)、锌指结合蛋白1(ZEB1)表达及与患者临床病理参数和预后的关系。方法:选取2017年2月至2020年2月期间我院收治的138例肺腺癌患者。取手术切除的癌组织以及癌旁组织... 详细信息

目的:探讨肺腺癌组织中长链非编码RNA(LncRNA)结肠癌相关转录因子1(CCAT1)、锌指结合蛋白1(ZEB1)表达及与患者临床病理参数和预后的关系。方法:选取2017年2月至2020年2月期间我院收治的138例肺腺癌患者。取手术切除的癌组织以及癌旁组织(距离癌组织边缘2 cm以上)。采用实时荧光定量聚合酶链反应检测癌组织及癌旁组织中lncRNA CCAT1、ZEB1mRNA表达。分析癌组织lncRNA CCAT1、ZEB1 mRNA表达之间的相关性及与肺腺癌患者临床病理参数的关系。Kaplan-Meier法分析lncRNA CCAT1(高低表达)、ZEB1 mRNA(高低表达)肺腺癌患者的预后。多因素Cox比例风险模型分析影响肺腺癌患者预后因素。结果:肺腺癌癌组织lncRNA CCAT1、ZEB1 mRNA相对表达量分别高于癌旁组织(P<0.05)。肺腺癌患者癌组织lncRNA CCAT1与ZEB1 mRNA相对表达量呈正相关(r=0.532,P<0.05)。肿瘤TNM分期Ⅲa期、淋巴结转移肺腺癌患者lncRNA CCAT1、ZEB1 mRNA相对表达量高于Ⅰ~Ⅱ期、无淋巴结转移患者(P<0.05)。lncRNA CCAT1高表达组和低表达组3年总生存例数分别为39(60.00)、65(92.86);ZEB1 mRNA高表达组和低表达组3年总生存例数分别为41(62.12)、63(91.30)。与lncRNA CCAT1低表达组、ZEB1 mRNA低表达组相比,lncRNA CCAT1高表达组、ZEB1 mRNA高表达组3年累积生存率更低(P<0.05)。lncRNA CCAT1高表达、ZEB1 mRNA高表达以及淋巴结转移是肺腺癌患者不良预后的独立危险因素(P<0.05)。结论:肺腺癌组织中lncRNA CCAT1、ZEB1 mRNA表达上调,两者表达上调与淋巴结转移有关,且可导致不良预后,有望成为评估肺腺癌患者预后的潜在标志物。

关键词：肺腺癌 lncRNA CCAT1 ZEB1 病理参数预后