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NUMERICAL SIMULATION OF SCOURING PROCESS UNDER SPILLWAY

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Journal of Hydrodynamics 2001年第4期13卷 55-59页

作者： yang jian-ming, Wu jian-hua Nanjing Hydraulic Research Institute, Nanjing 210029, China Nanjing Hydraulic Res. Inst. Nanjing 210029 China

The scour problem under spillway has received a lot of attention in the past decades. For such a complicated problem, most numerical modeling presented only dealt with the water flows in equilibrium scour pools without considering the changing topography of the riverbed. In this paper, the dynamic process is handled with moving grids, and the governing equations are solved using finite volume method with colocated variable arrangement on boundary-fitted non-orthogonal grids. The results show that the given method is efficient, with which the variation of flow parameters, such as mean velocity and mean pressure, etc., can be computed correctly.

关键词： scour pool numerical simulation space conservation law moving grids

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基于路径约束的无人机进离场程序设计

航空计算技术 2024年第5期54卷 89-93页

作者：杨鸣剑田文周雪芳张轶宁杨磊南京航空航天大学江苏南京211000 空中交通管理系统全国重点实验室江苏南京211000

在整个城市空中交通系统中,起降场终端区作为重要一环,其间的无人机进离场安全和效率至关重要。针对这一环,需要设计合理的空域结构和排序策略,以确保无人机进离场的安全和效率。从空域设计和排序策略等方面,考虑进离场路径约束,设计无... 详细信息

在整个城市空中交通系统中,起降场终端区作为重要一环,其间的无人机进离场安全和效率至关重要。针对这一环,需要设计合理的空域结构和排序策略,以确保无人机进离场的安全和效率。从空域设计和排序策略等方面,考虑进离场路径约束,设计无人机进离场程序。首先建立无人机进离场空域模型,设计飞行程序;采用先到先服务排序策略,按计划排序策略和诚信原则排序策略进行仿真实验,并从延误时间和模型稳定性等方面分析,得到三种排序策略中先到先服务排序策略与模型匹配度最高。

关键词：无人机空域设计排序策略匹配度

植物群落沿海拔梯度的分布规律——以滇西北哈巴雪山东坡矿场路为例

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安徽农业科学 2024年第5期52卷 116-120页

作者：原日强杨建明李建伟党雪芳周幸杜凡西南林业大学云南昆明650224

[目的]探究哈巴雪山东坡矿场路植物群落在遭受破坏后,植物群落沿海拔的演替规律及种群的更新能力。[方法]以哈巴雪山东坡矿场路沿海拔梯度设置23个样方,分析哈巴雪山东坡矿场路植物群落生物多样性指数垂直分布格局。[结果]23个样地中,乔... 详细信息

[目的]探究哈巴雪山东坡矿场路植物群落在遭受破坏后,植物群落沿海拔的演替规律及种群的更新能力。[方法]以哈巴雪山东坡矿场路沿海拔梯度设置23个样方,分析哈巴雪山东坡矿场路植物群落生物多样性指数垂直分布格局。[结果]23个样地中,乔木27种,灌木65种,草本196种。物种丰富度呈明显的单峰分布格局,峰值最大出现在中海拔群落,乔木层和草本层植物的物种丰富度随海拔先升高后降低,而灌木层植物的物种丰富度随海拔的上升呈明显下降的格局。α多样性随海拔梯度的变化与物种丰富度相似,β多样性基本也符合单峰格局,但是受矿厂区干扰峰值波动起伏较大。[结论]海拔梯度、人为干扰、小地形破坏对群落物种多样性都有着重要影响。

关键词：物种多样性海拔人为干扰环境因子哈巴雪山

Variability Analysis for a Two-station Queueing Network in Heavy Traffic with Arrival Processes Driven by Queues

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 445-466页

作者： jian CAO Yong-jiang GUO Kai-ming yang School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China

The law of the iterated logarithm(LIL)for the performance measures of a two-station queueing network with arrivals modulated by independent queues is developed by a strong approximation *** convenience,two arrival processes modulated by queues comprise the external system,all others are belong to the internal *** is well known that the exogenous arrival has a great influence on the asymptotic variability of performance measures in *** the considered queueing network in heavy traffic,we get all the LILs for the queue length,workload,busy time,idle time and departure processes,and present them by some simple functions of the primitive *** LILs tell us some interesting insights,such as,the LILs of busy and idle times are zero and they reflect a small variability around their fluid approximations,the LIL of departure has nothing to do with the arrival process,both of the two phenomena well explain the service station’s situation of being busy all the *** external system shows us a distinguishing effect on the performance measures:an underloaded(overloaded,critically loaded)external system affects the internal system through its arrival(departure,arrival and departure together).In addition,we also get the strong approximation of the network as an auxiliary result.

关键词： two-station queueing network the law of the iterated logarithm(LIL) strong approximation fluid approximation

家庭环境对语前聋儿童人工耳蜗植入后言语能力影响研究

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中国听力语言康复科学杂志 2024年第1期22卷 79-81,98页

作者：李晓静夏余芝郁梦梦杨见明安徽医科大学第二附属医院耳鼻喉科合肥230601

目的探讨家庭环境对语前聋儿童人工耳蜗植入后言语功能康复的影响。方法选择2021年10月~2023年3月在本院行人工耳蜗植入的84例语前聋儿童为调查对象,术后1、3、6个月采用家庭环境量表中文版(fmily environment scaleChinese version,FES... 详细信息

目的探讨家庭环境对语前聋儿童人工耳蜗植入后言语功能康复的影响。方法选择2021年10月~2023年3月在本院行人工耳蜗植入的84例语前聋儿童为调查对象,术后1、3、6个月采用家庭环境量表中文版(fmily environment scaleChinese version,FES-CV)评估患儿家庭环境;采用听觉能力分级标准(CAP)及言语可懂度分级评估标准(SIR)评估患儿术后听觉言语能力,检验FES-CV各维度与CAP、SIR的相关性。结果语前聋儿童在人工耳蜗植入后6个月CAP、SIR评分显著提升;植入后1、3、6个月家庭环境中亲密度、情感表达、独立性、知识性及娱乐性维度与CAP、SIR评分呈正相关,矛盾性与之呈负相关,差异具有统计学意义(P<0.05)。结论临床医护人员可通过制订以家庭为单位的康复训练计划,调动儿童术后康复训练的积极性,提升言语康复效果。

关键词：人工耳蜗植入语前聋家庭环境康复训练言语能力

A Simple-Prepared and Multi-Reusable Adhesive Based on Epoxy Vitrimer

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Chinese Journal of Polymer Science 2024年第10期42卷 1589-1594,I0015页

作者： Yu-Ting Wang Huan Liang Yen Wei jian-Long Wang Xiang-ming He yang yang Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China

Adhesives play an important role in modern society's production and daily *** robust and sustainable adhesives remains a great *** we report a sustainable epoxy-vitrimer adhesive with high adhesive strength(about 10 MPa)and reusability(82%strength after 3 times).This adhesive can be fabricated from commercially available products through a straightforward hot-pressing method without the need of *** adhesive process is also simple,requiring only 30 min at 180℃.In addition,the vitrimer adhesive has the advantages of both erasability for reuse and excellent water *** work provides a facile strategy to fabricate high-strength adhesive that ensures reusability,recyclability,low cost of raw materials,and simple processing ***,it expands the range of potential applications for epoxy vitrimers.

关键词： Epoxy Vitrimer Adhesive Reusable Sustainable

Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3312-3326页

作者： Fan yang ming-Han Cheng Hai-Feng Pan jian Gao Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei 230022China

Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关键词： Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway

Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation

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Journal of Integrative Medicine 2024年第2期22卷 188-198页

作者： Meng Li yang Zhou Hui Zhu Lie-ming Xu jian Ping Institute of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Preventive Treatment Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437 China Department of Gastroenterology Suzhou Traditional Chinese Medicine HospitalSuzhou 215000Jiangsu ProvinceChina Shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 201203China Key Laboratory of Liver and Kidney Diseases(Ministry of Education) Shanghai 201203China

Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compoundbased Chinese medicine formula,in the treatment of cholestatic liver ***:In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout(Mdr2-/-)mice as an animal model of cholestatic liver *** was administered orally for 8 weeks,and its impact on cholestatic liver fibrosis was evaluated by assessing liver function,liver histopathology,and the expression of liver fibrosis-related ***-time polymerase chain reaction,Western blot,immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA H19(H19)and signal transducer and activator of transcription 3(STAT3)phosphorylation in the liver tissue of Mdr2-/-*** addition,cholangiocytes and hepatic stellate cells(HSCs)were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and H19 *** overexpressing H19 were constructed,and a conditioned medium containing H19 was collected to measure its effects on STAT3 protein expression and cell *** intervention effect of DHQ on these processes was also *** overexpressing H19 were constructed to measure the impact of H19 on cell activation and assess the intervention effect of ***:DHQ alleviated liver injury,ductular reaction,and fibrosis in Mdr2-/-mice,and inhibited H19expression,STAT3 expression and STAT3 *** formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of H19,inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium,and decreased the expression of activation markers in *** overexpression of H19 in a human HSC line confirmed that H19 promoted STAT3 phosphorylation and HSC activation,and DHQ was able to successfully inhibit these ***:DHQ effectively alleviated spontaneous cholestatic liver fibrosis in Md

关键词： Liver cirrhosis biliary Long non-coding RNA H19 Danhongqing formula Cholangiocyte Hepatic stellate cells STAT3 transcription factor

Pathotypes and Genetic Diversity of Blumeria graminis *** in the Winter Barley Regions in China

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Agricultural Sciences in China 2010年第12期9卷 1787-1798页

作者： ZHU Jing-huan WANG Jun-mei JIA Qiao-jun yang jian-ming ZHOU Yi-jun LIN Feng HUA Wei SHANG Yi College of Plant Protection Nanjing Agricultural University Nanjing 210095 P.R.China National Barley Improvement Center Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P.R. China Institute of Plant Protection Jiangsu Academy of Agricultural Sciences Nanjing 210014 P.R. China

Barley powdery mildew caused by Blumeria graminis f. sp. hordei （Bgh） is one of the most destructive foliar diseases of barley in the winter barley region of China. The evaluation and assessment of the virulence and diversity of Bgh populations help to determine effective sources of resistance to the pathogen. 515 isolates were collected from seven populations of Bgh on cultivated barley in seven geographically distant locations in 2006. Their virulence was determined by inoculation onto 26 differential host lines. All of the isolates belonged to 58 pathotypes and 13 of which included 81% of these isolates. The most abundant pathotype was pathotype 0047 （18.3%）, the second most abundant was pathotype 0045 （11.8%） and the third most abundant was pathotype 0057 （7.8%）. Most of virulent genes investigated in this study showed similar frequencies in the seven different areas. These indicate that the seven locations may be in a uniform epidemiological region and barley cultivars in these areas may have similar genetic background. Diversities within these populations and distances between these populations measured by KOIND package were different. Correlations were not found between the genetic distance and the geographical distances between different locations. This suggested that long distance spread and local epidemics existed in the major winter barley growing regions in China.

关键词： Blumeria graminis f. sp. hordei powdery mildew pathotype virulence frequency diversity barley China