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Meticulously engineered three-dimensional-printed scaffold with microarchitecture and controlled peptide release for enhanced bone regeneration

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Biomaterials Translational 2024年第1期5卷 69-83页

作者： yang j. Fatima K. Zhou X. He C. Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai China

The repair of large load-bearing bone defects requires superior mechanical strength, a feat that a single hydrogel scaffold cannot achieve. The obj.ctive is to seamlessly integrate optimal microarchitecture, mechanical robustness, vascularisation, and osteoinductive biological responses to effectively address these critical load-bearing bone defects. To confront this challenge, three-dimensional (3D) printing technology was employed to prepare a polycaprolactone (PCL)-based integrated scaffold. Within the voids of 3D printed PCL scaffold, a methacrylate gelatin (GelMA)/methacrylated silk fibroin (SFMA) composite hydrogel incorporated with parathyroid hormone (PTH) peptide-loaded mesoporous silica nanoparticles (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/PCL (PM@GS/PCL) scaffold. The feasibility of fabricating this functional scaffold with a customised hierarchical structure was confirmed through meticulous chemical and physical characterisation. Compression testing unveiled an impressive modulus of 17.81 ± 0.83 MPa for the composite scaffold. Additionally, in vitro angiogenesis potential of PM@GS/ PCL scaffold was evaluated through Transwell and tube formation assays using human umbilical vein endothelium, revealing the superior cell migration and tube network formation. The alizarin red and alkaline phosphatase staining assays using bone marrow-derived mesenchymal stem cells clearly illustrated robust osteogenic differentiation properties within this scaffold. Furthermore, the bone repair potential of the scaffold was investigated on a rat femoral defect model using micro-computed tomography and histological examination, demonstrating enhanced osteogenic and angiogenic performance. This study presents a promising strategy for fabricating a microenvironment-matched composite scaffold for bone tissue engineering, providing a potential solution for effective bone defect repair. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserve

关键词： angiogenesis bone regeneration methacrylated gelatin methacrylated silk fibroin osteogenesis PTH

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Large eddy simulation of turbulent diffusion flame combustion using a conserved scalar methodology

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航空动力学报 2007年第7期22卷 1106-1117页

作者： K. Wang Z. yang j. j. McGuirk Department of Aeronautical and Automotive EngineeringLoughborough University Loughborough Leicestershire LE11 3TU UK

The present paper describes an LES prediction of turbulent diffusion flame combustion in a simplifled axi-symmetric combustor *** calculations are carried out using a well-tested finite volume incompressible LES code which has been modified to handle variable density and reacting *** basic mixture fraction conserved scalar method *** with the chemical state relationships described by fast *** turbulence-chemistry interaction is modelled by a sub-grid PDF method and the PDF is assumed to follow a Beta-function *** LES predictions have been time-averaged over 3.5 flow-through times to generate the mean radial profiles of mixture fraction,product mass fraction,temperature,axial velocity and axial *** agreement of the LES predictions with the experimental data is good for all the above quantities at four different axial positions with largest differences at the first measurement *** LES method also provides information on the unsteady nature of turbulent diffusion *** turbulent reacting flows with large density ratio,it was found necessary to use a relaxation method in order to remove unphysical high-frequency fluctuations and to maintain numerical stability.

关键词：大涡模拟湍流扩散数量方法论弛豫法燃烧理论

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基于参考文献的论文跨学科性、跨时域性及其影响力研究

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情报学报 2024年第9期43卷 1003-1014页

作者：杨杰王左戎邓三鸿王昊章学周南京大学信息管理学院南京210023 数据工程与知识服务省高校重点实验室(南京大学) 南京210023 江苏省质量和标准化研究院南京210004

本文在跨学科性概念的基础上,提出了跨时域性的测度框架,并将其量化为时域丰富性、时域非均衡性、时域差异性和时域深度4个维度。本文对微软学术数据库中1950—2020年38879575篇论文的跨学科性和跨时域性的时间趋势、分布特征以及科学... 详细信息

本文在跨学科性概念的基础上,提出了跨时域性的测度框架,并将其量化为时域丰富性、时域非均衡性、时域差异性和时域深度4个维度。本文对微软学术数据库中1950—2020年38879575篇论文的跨学科性和跨时域性的时间趋势、分布特征以及科学家的生涯演化模式进行了细致分析,并进一步研究了跨学科性、跨时域性与科学影响力的关系。研究发现:①论文的跨学科性和跨时域性呈现一致的增长趋势和不一致的领域分布;②跨学科性和跨时域性指标具有无标度分布等异质性分布特征,且跨学科性和跨时域性的相关性并不强;③科学家生涯中后期的跨学科性和跨时域性明显增强,这种趋势在很大程度上可以归因于其引用行为的变化;④跨学科性和跨时域性对科学影响力有着相反的作用效应,即跨学科性显著促进科学影响力,跨时域性显著抑制科学影响力,较强的跨学科性和较弱的跨时域性组合成为颠覆性热点论文的概率最高。本文提出的跨时域性测度框架丰富了知识融合和跨学科理论,并为科技政策和学术评价提供了启示。

关键词：跨学科性跨时域性引文网络科学家生涯

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Chinese life cycle impact assessment factors

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j.urnal of Environmental Sciences 2001年第2期13卷 205-209页

作者： yang, j.-X. Nielsen, P.H. Research Cntr. for Eco-Envtl. Sci. Chinese Academy of Sciences Beijing 100085 China

The methodological basis and procedures for determination of Chinese normalization references and weighting factors according to the EDIP-method is described. According to Chinese industrial development intensity and population density, China was divided into three regions and the normalization references for each region were calculated on the basis of an inventory of all of the region's environmental emissions in 1990. The normalization reference was determined as the total environmental impact potential for the area in question in 1990(EP(j.90) divided by the population. The weighting factor was determined as the normalization reference (ER(j.90) divided by society's target contribution in the year 2000 based on Chinese political reduction plans, ER(j.T2000. This paper presents and discuss results obtained for eight different environmental impact categories relevant for China: global warming, stratospheric ozone depletion, acidification, nutrient enrichment, photochemical ozone formation and generation of bulk waste, hazardous waste and slag and ashes.

关键词： Environmental impact Global warming Life cycle Ozone Sustainable development

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A Bayesian Network Approach for Offshore Risk Analysis Through Linguistic Variables

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China Ocean Engineering 2007年第3期21卷 371-388页

作者： Ren j. Wang j. j.nkinson I. Xu D. L. yang j. B. School of Engineering Liverpool John Moores University Liverpool L 3 3 AF UK Manchester Business School The University of Manchester Manchester M 60 1 QD UK

This paper presents a new approach for offshore risk analysis that is capable of dealing with linguistic probabilities in Bayesian networks （ BNs）. In this paper, linguistic probabilities are used to describe occurrence likelihood of hazardous events that may cause possible accidents in offshore operations. In order to use fuzzy information, an f-weighted valuation function is proposed to transform linguistic j.dgements into crisp probability distributions which can be easily put into a BN to model causal relationships among risk factors. The use of linguistic variables makes it easier for human experts to express their knowledge, and the transformation of linguistic j.dgements into crisp probabilities can significantly save the cost of computation, modifying and maintaining a BN model. The flexibility of the method allows for multiple forms of information to be used to quantify model relationships, including formally assessed expert opinion when quantitative data are lacking, or when only qualitative or vague statements can be made. The model is a modular representation of uncertain knowledge caused due to randomness, vagueness and ignorance. This makes the risk analysis of offshore engineering systems more functional and easier in many assessment contexts. Specifically, the proposed f-weighted valuation function takes into account not only the dominating values, but also the a-level values that are ignored by conventional valuation methods. A case study of the collision risk between a Floating Production, Storage and Off-loading （FPSO） unit and the anthorised vessels due to human elements during operation is used to illustrate the application of the proposed model.

关键词： Risk analysis fiweighted valuation function Bayesian networks fuzzy number linguistic probability off-shore engineering systems

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CONSTITUTIVE RELATIONSHIP OF IN718 ALLOY FOR THERMOVISCOPLASTIC AND MICROSTRUCTURE EVOLUTION COUPLED ANALYSIS

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Acta Metallurgica Sinica(English Letters) 2007年第5期20卷 373-379页

作者： D. Liu Y.H. yang j. Geng Z.j. Luo School of Materials Science Northwestern Polytechnical University Xi＇an 710072 China

The interaction between thermomechanical parameters and microstructure evolution is so intense that it must be considered during the finite element method （FEM） simulation of the hot plastic working process, for materials that are difficult to deform. Taking the microstructure evolution into account, a novel type of constitutive relationship has been put forward for the IN718 alloy. The microstructure evolution model was first established for the dominant microstructure evolution processes. Then the microstructure evolution models and the method to determine the local flow stress of the corresponding microstructure for current thermomechanical parameters and deformation history were presented. Once the local flow stresses of different structures and their volume contributions were defined, the apparent flow stress of the material could be determined as the weighted sum of the local flow stresses and volume contributions. To validate the proposed method, a thermoviscoplastics and microstructure evolution coupled analysis for a forging process of a critical IN718 disk forging was performed. The predicting results were in close agreement with the experimental data.

关键词： constitutive relationship microstructure evolution numerical simulation IN718 alloy

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The calcium sensing receptor: from calcium sensing to signaling

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Science China(Life Sciences) 2015年第1期58卷 14-27页

作者： ZHANG Chen MILLER Cassandra Lynn BROWN Edward M yang j.nny j. Department of Chemistry Georgia State University Center for Diagnostics and Therapeutics Georgia State University Division of Endocrinology Diabetes and HypertensionDepartment of MedicineBrigham and Women's Hospital

The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of *** in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic *** evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological *** this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated *** systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling.

关键词： the Ca2+-sensing receptor(the Ca SR) Ca2+ signaling extracellular domain(ECD) Ca2+-binding sites

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The Characterization of Sputtered Zr-Ge-N Thin Films as Diffusion Barriers Between Copper and Silicon

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稀有金属材料与工程 2012年第S1期41卷 120-123页

作者： yang, j. j. Liu, B. Liao, X. D. j.ao, G. H. Xu, K. W. Sichuan Univ Inst Nucl Sci & Technol Minist Educ Key Lab Radiat Phys & Technol Chengdu 610064 Peoples R China CAS Xian Inst Opt & Precis Mech State Key Lab Transient Opt & Photon Xian 710049 Peoples R China Xi An j.ao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China

The main purpose of the present micro-structural analysis by transmission electron microscopy(TEM)and X-ray diffraction(XRD)was to investigate whether amorphous Zr-Ge-N films are a potential candidate as a diffusion barrier for Cu wiring used in Si *** Zr-Ge-N films were prepared by a radio frequency(RF)reactive magnetron sputter-deposition technique using N2 and Ar mixed gas,and the film structure was found to be sensitive to the gas flow ratio of N2 *** during *** Zr-Ge-N films were obtained when the N2/(Ar+N2)ratio was smaller than 0.2 and amorphous-like Zr-Ge-N films were obtained when the ratio was larger than *** barrier test was performed by annealing the Cu/Zr-Ge-N/Si film stack under Ar *** deposited Zr-Ge-N(C)films remained amorphous even after high temperature *** Cu diffusion profile in the film was assessed by the Auger electron spectroscopy(AES).The results indicate that Cu diffusion was minimal in amorphous Zr-Ge-N(C)films even at high annealing temperatures of 800℃.

关键词： Zr-Ge-N films diffusion barrier micro-structural thermal stability

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Single　Frequency　Operation　of　Diode－pumped　Intracavity　Frequency　Doubled　Nd：YAG　Laser　With　Tilted　KTP　Crystal：　Theoretical　Study

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Chinese j.urnal of Lasers 1996年第3期B5卷 199-204页

作者： YAO j. Q. yang j. B. SHENG W.D. ZHENG Y.(Institute of Laser and Opto-electronics, Tian j.n University, Tianj.n 300072, China)ZHENG H. yang H.G.(Institute of Physics, Academia Sinica, Beij.ng 100080, China) Tianj.n Univ Tianjin China

Ｓｉｎｇｌｅ　Ｆｒｅｑｕｅｎｃｙ　Ｏｐｅｒａｔｉｏｎ　ｏｆ　Ｄｉｏｄｅ－ｐｕｍｐｅｄ　Ｉｎｔｒａｃａｖｉｔｙ　Ｆｒｅｑｕｅｎｃｙ　Ｄｏｕｂｌｅｄ　Ｎｄ：ＹＡＧ　Ｌａｓｅｒ　Ｗｉｔｈ　Ｔｉｌｔｅｄ　ＫＴＰ　Ｃｒｙｓｔａ... 详细信息

Ｓｉｎｇｌｅ　Ｆｒｅｑｕｅｎｃｙ　Ｏｐｅｒａｔｉｏｎ　ｏｆ　Ｄｉｏｄｅ－ｐｕｍｐｅｄ　Ｉｎｔｒａｃａｖｉｔｙ　Ｆｒｅｑｕｅｎｃｙ　Ｄｏｕｂｌｅｄ　Ｎｄ：ＹＡＧ　Ｌａｓｅｒ　Ｗｉｔｈ　Ｔｉｌｔｅｄ　ＫＴＰ　Ｃｒｙｓｔａｌ：　Ｔｈｅｏｒｅｔｉｃａｌ　Ｓｔ...

关键词： single-frequency Nd:YAG laser diode-pumped intracavity frequency Doubling

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The study of fluorescence characteristics and biochemical composition of a marine diatom Thalassiosira pseudonana 3H in light and dark cyclesI. The effects of nutrients

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Acta Oceanologica Sinica 1992年第4期11卷 593-602页

作者： Zhu Mingyuan, yang Xiaolong and j. j. Cullen 1. First Institute of Oceanography, State Oceanic Administration, Qingdao 266003, China2. Bigelow Laboratory for Ocean Sciences, U. S. A.

The effects of nutrients on the fluorescence characteristics and biochemical composition of marine diatom Thalassiosira pseudonana 3H in light and dark cycles were investigated with continuous culture. The results show that with the increase of nutrient deficiency, the ratio of enhanced fluorescence to fluorescence (Fd/F), cellular chloropyll-a and protein content of the algae decline, but the fluorescence yield (F/Chl) , DCMU enhanced fluorescence yield (Fd/Chl) , cellular carbohydrate content, carbohydrate/Chl, protein/Chl, carbohydrate/protein increase. The changing amplitude of each parameter is different at different nutrition status, sampling time and different light intensity.

关键词： The study of fluorescence characteristics and biochemical composition of a marine diatom Thalassiosira pseudonana 3H in light and dark cyclesI The effects of nutrients

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