The calcium sensing receptor: from calcium sensing to signaling

作     者：ZHANG Chen MILLER Cassandra Lynn BROWN Edward M YANG Jenny J. 

作者机构：Department of ChemistryGeorgia State University Center for Diagnostics and TherapeuticsGeorgia State University Division of EndocrinologyDiabetes and HypertensionDepartment of MedicineBrigham and Women's Hospital 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2015年第58卷第1期

页      面：14-27页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the US National Institutes of Health(GM081749 and EB007268) a Center for Diagnostics and Therapeutics fellowship(to Zhang Chen) funds from the Georgia Research Alliance 

主　　题：the Ca2+-sensing receptor(the Ca SR) Ca2+ signaling extracellular domain(ECD) Ca2+-binding sites 

摘      要：The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of *** in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic *** evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological *** this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated *** systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling.