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Vortex identification based on the Liutex method and its effect on fish passage upstream

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Journal of Hydrodynamics 2024年第1期36卷 130-141页

作者： Chun-ying Shen Rui-guo yang Xiao-tao shi ming-ming Wang shi-hua He Faculty of Electrical Power Engineering Kunming University of Science and TechnologyKunming650500China Hubei International Science and Technology Cooperation Base of Fish Passage China Three Gorges UniversityYichang443002China Shanghai Investigation Design and Research Institute Co.LtShanghai200434China

Fishway research is important for mitigating the fragmentation of river habitats caused by hydraulic *** vertical slit fishway is a broadly used fishway type because of its high efficiency and adaptability to water ***,the resulting vortex current disrupts the fish passage hence directly affecting fish *** study aims to accurately capture the vortex structure in the fishway and analyze the effect of vortex elements(vortex structure,vortex intensity,etc.)on *** conducted an analysis of the 3-D current flow field in the fishway through the utilization of an experimental model and the large eddy simulation(LES)***,we captured the vortex information in the fishway at different flow rates using the Liutex vortex identification method and investigated the effect of the vortex on fish *** results revealed that the structures inside the fishway pool occupy most of the room,however,the areas with higher vortex strength were primarily located in the vortex near the vertical seam and the mainstream,the vortex strength inside the fishway gradually increases with increasing flow,suppressing fish *** experienced significantly increased resistance when encountering strong *** suggests that the vortex may act as a physical barrier to fish *** findings highlight the potential negative effects of vortex on fish movement and reiterate the importance of understanding vortex dynamics for aquatic environmental *** an effective tool for identifying vortices in fluid flow,the Liutex method demonstrates features of vortex within the fishway,thereby providing important insights into the interaction between fluid dynamics and aquatic organisms.

关键词： Vertical slit fishway vortex identification method Liutex large eddy simulation(LES) fish experiment computational fluid dynamics

The effect of Hath1 over-expression in of guinea pig cochlea at one month after noise damage

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Journal of Otology 2010年第1期5卷 30-33页

作者： GUO Wei-wei yang shi-ming Department of Otolaryngology Head&Neck SurgeryInstitute of OtolaryngologyChinese PLA General HospitalBeijing 100853China

Objective To study effects of Adenovirus -mediated Hath1 expression in guinea pig cochlea at one month after exposure to intensive noise. Methods Normal hearing guinea pigs, weighing 250-300g, received exposure to 200 rounds of impulse noise at 170 dB sound pressure level (SPL). The virus vector was inoculated into the left cochlea 1 month after noise exposure. Animals were tested using ABR and prepared for morphological examinations includeing immunocytochemistry and SEM 4 weeks after vector inoculation. Results The adenovirus mediated report gene expressed in the damaged area. There were no significant differences between treated and control animal in ABR threshold and morphologic changes. No new hair cells appeared in the Hath1 treated animals. Conclusion Forced hath1 over-expression in the cochlea 1 month after noise exposure does not lead to appearance of new hair cells.

关键词： hair cell damage Hath1 noise

Quantitative Relations between Outer Hair Cell Electromotility and Nonlinear Capacitance

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Journal of Otology 2012年第1期7卷 45-53页

作者： WANG Xiang GUO Wei-Wei yang shi-ming Department of Otolaryngology Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China

The electrically evoked somatic motility of outer hair cells （OHC）, briefly termed OHC electromotility, plays a crucial role in cochlear amplification that underlies the remarkably high sensitivity and frequency selectivity of the mammalian hearing. Accompanying OHC electromotility is a voltage-dependent gating charge movement within the cell lateral membrane, manifested as a measurable nonlinear capacitance （NLC） in OHCs. The electromotility and NLC of OHCs are highly correlated by sharing a common molecular substrate, the motor protein prestin. In this study, we systematically characterized the quantitative relationship between OHC electromotility and NLC in their voltage dependences for the purpose of further understanding the electromechanical transduction in OHCs. The results demonstrated that the two possess differing voltage dependences with the V^2 of electromotility consistently being -20 mV depolarized in comparison with that of NLC although their slope factors a are statistically identical. Further investigations showed that the initial state of OHCs influences the voltage dependence of electromotility but not that of NLC, indicating that some biophysical factors other than the motor protein per se are involved in the process of OHC length changes. We proposed that the cytoskeletal spectrin-actin framework underneath the OHC plasma membrane and the cell＇ s turgor are the two most probable factors that cause the voltage-dependence discrepancy between OHC electromotility and NLC.

关键词： Outer hair cell Electromotility Nonlinear Capacitance Prestin Cochlea

Analysis of microRNA expression in organ of Corti in neonatal and adult rats

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Journal of Otology 2012年第1期7卷 4-8页

作者： GUO Wei-wei Hou Zhao-hui yang shi-ming Department of Otolaryngology Head&Neck SurgeryInstitute of OtolaryngologyChinese PLA General HospitalBeijing 100853China

Objective To characterize microRNA （miRNA） expression profile in microdissected auditory epithelia from the Corti＇ s Organ in new born and adult rats. Methods The TaqMan（R） MicroRNA Arrays were used to identify expres- sion of microRNA in the new born and adult groups. GO analysis was applied to analyze the main function of the differen- tial expression genes according to the Gene Ontology which is the key functional classification of NCBI. Similarly, Pathway analysis was used to find out the significant pathway of the differential genes according to KEGG, Biocarta and Reatome. Results Increased expression was seen in 16 miRNAs in mature rat compared to new born rats, with increased folding ranging from 17 to 600 folds. Expression levels in 2 miRNAs were reduced in mature rats, namely rno-miR-29c and rno-miR-29a. The high-enrichment GOs targeted by over-expressed miRNAs were negative regulation of epithelial cell differentiation, common-partner SMAD protein phosphorylation, mesenchymal-epithelial cell signaling, regulation of transforming growth factor beta2 production, etc. Functional analysis of miRNAs by KEGG revealed that 19 signal transduction pathways were upregulated and 14 were downregulated. Conclusions The difference in miRNA expression patterns in the organ of Corti between neonatal and adult rats may be closely related to maturation of the organ of Corti and loss of proliferative capacity of inner ear hair cells, and TGFβ signaling may play an important role in hair cells regeneration.

关键词： miRNA microarray Rat cochlear TGFβ

Multimodal Fusion of Brain Imaging Data: Methods and Applications

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Machine Intelligence Research 2024年第1期21卷 136-152页

作者： Na Luo Weiyang shi Zhengyi yang ming Song Tianzi Jiang Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Institute of AutomationChinese Academy of SciencesBeijing 100190China Research Center for Augmented Intelligence Zhejiang LaboratoryHangzhou 311100China

Neuroimaging data typically include multiple modalities,such as structural or functional magnetic resonance imaging,dif-fusion tensor imaging,and positron emission tomography,which provide multiple views for observing and analyzing the *** lever-age the complementary representations of different modalities,multimodal fusion is consequently needed to dig out both inter-modality and intra-modality *** the exploited rich information,it is becoming popular to combine multiple modality data to ex-plore the structural and functional characteristics of the brain in both health and disease *** this paper,we first review a wide spectrum of advanced machine learning methodologies for fusing multimodal brain imaging data,broadly categorized into unsupervised and supervised learning *** by this,some representative applications are discussed,including how they help to under-stand the brain arealization,how they improve the prediction of behavioral phenotypes and brain aging,and how they accelerate the biomarker exploration of brain ***,we discuss some exciting emerging trends and important future ***,we intend to offer a comprehensive overview of brain imaging fusion methods and their successful applications,along with the chal-lenges imposed by multi-scale and big data,which arises an urgent demand on developing new models and platforms.

关键词： Multimodal fusion supervised learning unsupervised learning brain atlas cognition brain disorders

Measurement of Ca^(2+) Flow in Cochlear Cells Using Non-Invasive Micro-Test Technique

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Journal of Otology 2010年第2期5卷 90-96页

作者： CHEN shi-qin YU Ning YE Sheng-nan yang shi-ming ZHAI Suo-qiang Department of Otolaryngology Head and Neck Surgery Oto-Neurobiology CentreInstitute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Department of Otolaryngology Affiliated First HospitalFujian Medical UniversityFuzhou 350005China

Objective To test Calcium ion(Ca2+) flow at the head and end of outer hair cells(OHCs) in resting state and in response to Nimodipine *** Non-invasive micro-test techniques were used to study Ca2+ in isolated OHCs in adult guinea *** Four types of Ca2+ transport were identified in OHCs on basilar membrane tissue fragments:influx at the head of with efflux at the bottom(type 1):efflux at the head of OHCs with influx at the bottom(type 2);influx at the both head and bottom(type 3);and efflux at the both head and bottom(type 4).However,only type 1 and type 3 of Ca2+ ion transport were detected in the *** propose that Ca2+ ion transport exists in adult guinea pig cochlear OHCs in resting state and is ***2 + flow in OHC can be inhibited by Nimodipine in resting state.

关键词： Guinea pig outer hair cells Ca2+ ion non-invasive micro-test technique nimodipine.

The progenitors of inner ear hair cells and their regulating genes

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Journal of Otology 2010年第1期5卷 34-39页

作者： SHU Wei-ning ZHAO Li-dong ZHANG Xiao-bing yang shi-ming Department of Otolaryngology Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China The First Affiliated Hospital of Lanzhou University Lanzhou 730000China

Hair cells in the mammalian inner ear are very fragile and are often injured as a result of acoustic trauma or exposure to ototoxic drugs (cisplatin, aminoglycosides, etc) [1]. In amphibians and birds, spontaneous

关键词： Hair cell Regeneration Progenitor cell Inner ear

Effects of combined administration of furosemide and kanamycin on rat auditory nerve

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Journal of Otology 2011年第1期6卷 26-30页

作者： GUO Weiwei YUAN Fen-qian LIU Hui-zhan yang shi-ming Department of Otolaryngology Head ＆ Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 P.R. China Department of Head and Neck Surgery Jiangxi Cancer Hospital Nanchang 330029 China

Objective To determine the effects of combined administration of furosemide and kanamycin on inner ear structures and the auditory nerve in rats. Methods The rats in the treatment group received intravenous injections of combined furosemide and kanamycin sulfate, and the rats in the normal control group received no treatment. The auditory brainstem response （ABR） test was carried out 7 days after drug administration to determine the effects of drug administration on hearing. Cochlear slice and cochlear wholcmount were prepared after 7 days of drug treatment. Results After 7 days of drug administration, ABR thresholds were significantly higher in the treatment group than in the control group and neurofilaments were significantly reduced, although the number of spiral ganglia showed no decrease and there were no signs of supporting cell injury. Conclusions Combined administration of furosemide and kanamyein sulfate has an apparent synergistic ototoxic effect. Although spiral ganglion damage may not be apparent within a short time period of drug administration, damage to auditory nerve fibers is obvious.

关键词： kanamycin furosemide deafness model hair cell injury

Selective nano-buckling improves the performance of graphene logic transistors

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National Science Review 2024年第2期11卷 95-96页

作者： Tong yang ming yang Department of Applied Physics The Hong Kong Polytechnic University Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University

The massive integration of silicon-based transistors into modern electronic devices greatly increases power consumption and heat generation/dissipation[1]. In this concern, transistors based on atomically-thin graphene that exhibit high electric and thermoelectric conductivities with negligible contact resistance,

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