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BmMD-2A responds to 20-hydroxyecdysone and regulates Bombyx mori silkworm innate immunity in larva-to-pupa metamorphosis

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Insect Science 2023年第2期30卷 411-424页

作者： Ruonan Zhang Xue Chen Yuan Wang Xu Bai qiong yang yangjin Zhong Xiao-Qiang Yu Fengliang Jin Wanying yang Guangdong Laboratory for Lingnan Modern Agriculture Laboratory of Insect Molecular Biology and BiotechnologyGuangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular BreedingCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou510642China Guangdong Laboratory of Bio-Pesticide Creation and Application of Guangdong Province College of Plant ProtectionSouth China Agricultural UniversityGuangzhou510642China The Sericultural and Agri-Food Research Institute of the Guangdong Academy of Agricultural Sciences GuangzhouChina Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina

20E-hydroxyecdysone(20E)plays important roles in larval molting and metamorphosis in insects and is also involved in the insect innate immune *** metamorphosis is a highly successful strategy for environmental adaptation and is the most vulnerable stage during which the insect is susceptible to various pathogens.20E regulates a series of antimicrobial peptides(AMPs)through the immunodeficiency(IMD)pathway activation in Drosophila;nevertheless,whether other immune pathways are involved in 20E-regulated insect immunity is *** previous studies showed that BmMD-2A is a member of the MD-2-related lipid recognition(ML)family of proteins that are involved in the Bombyx mori innate immunity Toll signaling *** this study,we further demonstrate that BmMD-2A is also positively regulated by 20E,and the BmMD-2A neutralization experiment suggested that 20E activates some downstream immune effect factors,the AMP genes against Escherichia coli and Staphylococcus aureus,through the regulation of BmMD-2A in larval metamorphosis,implying that *** may use the Toll-ML signaling pathway to maintain innate immune balance in the larval-pupal metamorphosis stage,which is a different innate immunity pathway regulated by 20E compared to the IMD pathway in Drosophila.

关键词： AMPs BmMD-2A 20E innate immune metamorphosis

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A new cyclopeptide from Dianthus caryophyllus

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Chinese Chemical Letters 2008年第2期19卷 193-195页

作者： Fei Li Feng Mei Zhang Ya Bin yang Xue qiong yang Qiu E. Cao Zhong Tao Ding Key Laboratory of Medicinal Chemistry for Nature Resource Ministry of Education School of Chemical Science and Technology Yunnan University # 2 Green Lake North Road Kunming 650091 China

A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo （-Thr-Gly-Pro-Tyr-Phe-）（1） and cyclo （-Ala-Gly-Ser-IIe-P... 详细信息

关键词： Caryophyllaceae Dianthus caryophyllus Cyclopeptide Caryophllusin A

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A thermodynamic potential for barium zirconate titanate solid solutions

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npj Computational Materials 2018年第1期4卷 110-118页

作者： Jinlin Peng Dongliang Shan Yunya Liu Kai Pan Chihou Lei Ningbo He Zhenyu Zhang qiong yang Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education School of Materials Science and EngineeringXiangtan UniversityHunan 411105China Department of Aerospace and Mechanical Engineering Saint Louis UniversitySaint LouisMO 63103USA

Barium zirconate titanate[Ba(ZrxTi_(1−x))O_(3)]solid solutions are promising lead-free ferroelectric materials that have received substantial *** analysis based on phenomenological Landau–Devonshire theory is a powerful method for theoretical investigation of ferroelectric materials,but cannot be applied to Ba(ZrxTi1−x)O3 because there is no thermodynamic *** this paper,a thermodynamic potential for Ba(ZrxTi_(1−x))O_(3)(0≤x≤0.3)solid solutions is constructed,and then a thermodynamic analysis carried *** results accurately reproduce known phase structures and their transition temperatures,with good agreement with experimentally measured polarization,dielectric,and piezoelectric *** is found that Ba(ZrxTi_(1−x))O_(3) solid solutions at room temperature have three phase boundaries,including a tetragonal–orthorhombic phase boundary at x=0.013,an orthorhombic–rhombohedral phase boundary at x=0.0798,and a rhombohedral–paraelectric phase boundary at x=*** results also indicate that the chemical composition-induced ferroelectric–paraelectric phase boundary has superior electromechanical properties,suggesting a new way to enhance electromechanical coupling in Ba(ZrxTi_(1−x))O_(3) solid solutions.

关键词： thermodynamic ferroelectric solutions

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All-inorganic transparent Hf_(0.85)Ce_(0.15)O_(2)ferroelectric thin films with high flexibility and stability

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Nano Research 2023年第4期16卷 5065-5072页

作者： Sheng-Tao Mo Kai-Ming Feng Jing-Lin Pang Kuo Ouyang Li-Mei Jiang qiong yang Biao Zhang Jie Jiang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Hunan Provincial Key Laboratory of Thin Film Materials and Devices Xiangtan UniversityXiangtan 411105China Key Laboratory of Low Dimensional Materials and Application Technology Ministry of EducationXiangtan UniversityXiangtan 411105China

Electronic devices that are transparent and flexible have a wide range of applications in the domains of vital sign parameter monitoring,health management,and so *** memory is a revolutionary nonvolatile memory that is ideal for data storage and processing in transparent flexible electronic *** this study,Ce-doped hafnium oxide ferroelectric thin film is manufactured on mica substrate by the chemical solution deposition with transparent indium tin oxide(ITO)thin films as the bottom *** transmittance of mica/ITO/Hf_(0.85)Ce_(0.15)O_(2)thin film is over 80%.The 2Pr of the transparent flexible Hf_(0.85)Ce_(0.15)O_(2)ferroelectric thin film is increased by about 22.4%and the Ec is reduced by 26.7%compared with those of Hf_(0.85)Ce_(0.15)O_(2)ferroelectric thin film grown on p+-Si *** transparent flexible Hf_(0.85)Ce_(0.15)O_(2)ferroelectric thin film can remain keeping good quality when being bent under±2.5 mm bending ***,degradation of polarization,retention,and endurance performance was not obvious even at a bending radius of 5.0 mm after 104 bending *** research provides a new strategy and an important experimental basis for the development and implementation of transparent flexible ferroelectric memories.

关键词： flexible Hf_(0.85)Ce_(0.15)O_(2)thin films transparent thin films ferroelectric properties

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Analysis of the Development of China＇s Pension Industry

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International English Education Research 2015年第7期 97-99页

作者： yang qiong Shanghai University of Engineering Science Shanghai 201600 CHINA

This document explains and demonstrates the current situation and some problems of China＇s pension industry, also, offer some advises to its development. China is the world＇s most populous developing country, with large population basement and the rapidly aging population. Traditional model of family pension is in decline, thus social security system is a general tendency. Social supporting is facing tremendous pressure. In China＇s pension services, the market development is not perfect, and government responsibility is not in place, also, the pension service is at a low level as a result, aged care industry developed slowly, but social care service demand is increasingly strong, so there is a serious contradiction between supply and demand, therefore promote the health of pension industry into a vigorous development is imminent.

关键词： Pension industry Pension model Pension service Pension industry market.

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TRANSFORMATION AND INNOVATION OF THE GLOBAL GOVERNANCE SYSTEM:CHINAS REGIONAL AND INTERNATIONAL COOPERATIONS Introduction

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Social Sciences in China 2021年第3期42卷 138-139页

作者： Wei Ling School of International Relations University of International Business and Economics

The contributions in this issue reflect China’s interaction with the international system from three perspectives:international trade governance,East Asian cooperation models,and regional security *** show structural changes and the process of evolution at the international and regional levels,discussing strategic and policy options for China to adjust itself,participate in shaping relevant international and regional processes,promote the transformation of the global governance system,and contribute to building sustainable development and sustainable security.

关键词： policy adjust sustainable

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Neopeapyran, an unusual furo[2,3b]pyran analogue and turnagainolide C from a soil Streptomyces sp. S2236

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Chinese Chemical Letters 2016年第7期27卷 1044-1047页

作者： Hao Zhou Ya-Bin yang Rong-Ting Duan Xue-qiong yang Ju-Cheng Zhang Xiao-Guang Xie Li-Xing Zhao Zhong-Tao Ding Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education School of Chemical Science and Technology Yunnan University Yunnan Institute of Microbiology Yunnan University

Neopeapyran（1）,an unusual furo[2,3b]pyran analogue,together with a new cyclopeptide,turnagainolide C（2）,were isolated from Streptomyces sp.S2236 associated with the rhizosphere soil of Panax *** planar structure and relative configuration of neopeapyran（1） were elucidated on the basis of spectroscopic techniques,while the absolute configuration was determined by TDDFT *** absolute configuration of turnagainolide C（2） was determined by partial hydrolysis,together with the advanced Marfey’s method and spectroscopic *** antimicrobial activities of these two compounds were also investigated.

关键词： Streptomyces sp. Furo[2,3b]pyran analogue Cyclopeptide Structure elucidation Antimicrobial activity

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Bakry-Emery型Ricci曲率下两类抛物方程正解的梯度估计

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数学学报（中文版） 2022年第3期65卷 461-474页

作者：杨琼武汉大学数学与统计学院武汉430072

本文考虑完备黎曼流形上,在Bakry-Emery型Ricci曲率有下界的条件下两类抛物方程■u/■t=△Vu+au log u和(△V-■/■t)u(x,t)+p(x,t)u^(β)(x,t)+q(x,t)u(x,t)=0正解的梯度估计,这里α,β∈R,△V(•):=△+〈V,▽(•)〉.由于引入了△V,相应地,在梯度估计证明的过程中用V-Laplace比较定理代替Laplace比较定理.作为梯度估计的应用,导出了Harnack不等式和Liouville定理.

关键词：梯度估计抛物方程 Bakry-Emery型Ricci曲率 Harnack不等式 Liouville定理

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Multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers

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Chinese Science Bulletin 2013年第8期58卷 873-878页

作者： XING BaoLing SONG JinZhao GE SuMei TANG ZhengHua LIU MengLu yang qiong Lü FengTing LIU LiBing WANG Shu Department of Pathology Changzhou Wommen and Children Health Hospital Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences

The mutation detections of KRAS and BRAF genes are of significant importance to predict the responses to anti-cancer therapy and develop new drugs. In this paper, we developed a multi-step fluorescence resonance energy transfer (FRET) assay for multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers (CCP). The newly established detection system could detect as low as 2% mutant DNAs in DNA admixtures. By triggering the emission intensity change of CCP and the dyes labeled in the DNA, four possible statuses (three mutations and one wildtype) can be differentiated in one extension reaction. The detection efficiency of this new method in clinical molecular diagnosis was validated by determining KRAS and BRAF mutations of 51 formalin-fixed paraffin-embedded (FFPE) ovary tissue samples. Furthermore, the result of the CCP-based multi-step FRET assay can be directly visualized under UV light so that no expensive instruments and technical expertise are needed. Thus, the assay provides a sensitive, reliable, cost-effective and simple method for the detection of disease-related gene mutations.

关键词：基因突变检测共轭聚合物阳离子多重荧光共振能量转移中国共产党 DNA FRET

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The impact of China’s high-speed rail investment on regional economy and air pollution emissions

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Journal of Environmental Sciences 2023年第9期131卷 26-36页

作者： qiong yang Yuqing Wang Ying Liu Junfeng Liu Xiurong Hu Jianmin Ma Xuejun Wang Yi Wan Jianying Hu Zhaobin Zhang Xilong Wang Shu Tao Laboratory for Earth Surface Processes College of Urban and Environmental SciencesPeking UniversityBeijing 100871China School of Statistics University of International Business and EconomicsBeijing 100029China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The high-speed rail(HSR)network in China has experienced rapid development since the *** 2016,the State Council of the People’s Republic of China issued a revised version of the“Mid-and Long-term Railway Network Plan”,detailing the expansion of the railway network and construction of an HSR *** the future,the HSR construction efforts in China will further increase,which is considered to impact regional development and air pollutant ***,in this paper,we apply a transportation network-multiregional computable general equilibrium(CGE)model to estimate the dynamic effects of HSR projects on economic growth,regional disparities,and air pollutant emissions in *** results indicate that HSR system improvement could generate a positive economic impact but could also increase *** gross domestic product(GDP)growth per unit investment cost stimulated by HSR investment is found to be the largest in eastern China but the smallest in the northwest ***,HSR investment in Northwest China contributes to a substantial reduction in regional disparities in terms of the GDP per *** regard to air pollution emissions,HSR construction in South-Central China results in the largest increase in CO_(2) and NO_(X) emissions,while for CO,SO_(2),and fine particulate matter(PM_(2.5))emissions,the largest increase occurs due to HSR construction in Northwest *** the regional level,the provinces with large changes in accessibility also experience large changes in their air pollutant emissions.

关键词： Computable general equilibrium model High-speed rail investment Economic impact Regional disparity Air pollution emissions

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