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中国鼻咽癌流行概况

中国肿瘤 2016年第11期25卷 835-840页

作者：梁锌杨剑高婷张志超陈艳佳郑荣寿国家癌症中心/中国医学科学院北京协和医学院肿瘤医院北京100021

通过国际癌症研究所(IARC)发布的全球鼻咽癌数据库,获取中国及世界部分其它地区或国家的鼻咽癌发病、死亡数据库,分析比较中国与全球不同地区的鼻咽癌流行情况,了解中国与全球其他地区的鼻咽癌负担情况。研究发现,中国鼻咽癌分别占全球... 详细信息

通过国际癌症研究所(IARC)发布的全球鼻咽癌数据库,获取中国及世界部分其它地区或国家的鼻咽癌发病、死亡数据库,分析比较中国与全球不同地区的鼻咽癌流行情况,了解中国与全球其他地区的鼻咽癌负担情况。研究发现,中国鼻咽癌分别占全球鼻咽癌发病和死亡的38.29%和40.14%,发病率和死亡率高于世界平均水平(1.2/10万,0.7/10万),分别位列发病和死亡顺位的第18位和23位,且男性高于女性。中国的鼻咽癌发病以青壮年人口为主,死亡以中老年人口为主,但发病率和死亡率都是在老年人口(65岁以上)相对较高。鼻咽癌预后相对较差,生存率相对较低,我国鼻咽癌负担相对较重,应该在该人群中积极开展鼻咽癌筛查和诊治工作,同时鉴于鼻咽癌的地域性发病差异,应该在我国两广地区加强鼻咽癌的防控工作。

关键词：鼻咽癌发病率死亡率中国

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颅脑手术后持续性植物状态患者促醒性的治疗

潍坊医学院学报 2006年第4期28卷 274-275页

作者：刘伟贾丽燕张贺杨廷舰曹波潍坊医学院附属医院神经外科山东潍坊261031 潍坊医学院附属医院急诊科

目的探讨临床药物促醒性治疗的疗效预测方法,旨在建立脑电图反应性与颅脑手术后持续性植物状态(PVS)患者预后关系。方法将40例PVS患者按其静脉滴注盐酸纳洛酮的脑电图反应情况分为甲乙两组,甲组为脑电图有明显反应者,乙组为脑电图无明... 详细信息

目的探讨临床药物促醒性治疗的疗效预测方法,旨在建立脑电图反应性与颅脑手术后持续性植物状态(PVS)患者预后关系。方法将40例PVS患者按其静脉滴注盐酸纳洛酮的脑电图反应情况分为甲乙两组,甲组为脑电图有明显反应者,乙组为脑电图无明显反应者,其后给予相同剂量的治疗,观察并分析疗效。结果甲组12例患者中9例促醒成功,意识转清率为75.0%;乙组28例患者中3例促醒成功,意识转清率为10.7%;统计学分析认为甲组意识转清率明显高于乙组。结论利用患者对促醒性药物的脑电图反应情况可以大致评价PVS患者的预后,其弥补了按Synek脑电图分级分析预后的不足,同时,进一步研究可能指导促醒性治疗的药物选择。

关键词：持续性植物状态促醒性治疗盐酸纳洛酮脑电图

基于Internet的矿井提升设备远程选型设计

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太原理工大学学报 2003年第2期34卷 150-153页

作者：段雷杨兆建陶挺太原理工大学机械工程学院山西太原030024

论述了矿井提升设备远程选型设计的基本理论与方法 ,利用 Microsoft的 ASP技术以及 ODBC工业标准数据库接口 ,研制了基于 Internet的矿井提升设备远程选型设计计算软件。

关键词： ASP Internet 矿井提升设备远程选型设计

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Flt-1对胶质瘤细胞侵袭及迁移的影响

潍坊医学院学报 2017年第5期39卷 351-353页

作者：张振国贾丽燕杨廷舰刘伟潍坊医学院外科学教研室山东潍坊261031 潍坊医学院附属医院神经外科

目的观察Flt-1表达降低对胶质瘤细胞株的生长侵袭性和迁移能力的生物学影响,探讨Flt-1对胶质瘤侵袭以及迁移过程的作用。方法 (1)体外培养大鼠神经胶质瘤C6细胞,利用腺病毒载体小RNA干扰技术,建立Flt-1表达降低的细胞株。(2)通过脑立体... 详细信息

目的观察Flt-1表达降低对胶质瘤细胞株的生长侵袭性和迁移能力的生物学影响,探讨Flt-1对胶质瘤侵袭以及迁移过程的作用。方法 (1)体外培养大鼠神经胶质瘤C6细胞,利用腺病毒载体小RNA干扰技术,建立Flt-1表达降低的细胞株。(2)通过脑立体定向技术将Flt-1表达降低的胶质瘤C6细胞(实验组A)和未作特殊处理的C6细胞(对照组B)注射到SD大鼠右侧尾状核部,相同营养条件下饲养两组SD大鼠,借助磁共振平扫观察SD大鼠颅内肿瘤的生长侵袭情况。20d后处死SD大鼠,并冠状切开注射胶质瘤C6细胞部位的颅脑组织,制备石蜡切片,HE染色,计数切片中注射部位及周边的肿瘤卫星结节数量。(3)把Flt-1表达降低的胶质瘤C6细胞(实验组C)和未经特殊处理的C6细胞(对照组D)分别制造细胞划痕,记录6h,12h,18h两组划痕的宽度。结果实验组A切片标本中肿瘤卫星结节的数量(29.0±17.3)明显少于对照组B切片标本中的结节数量(84.0±20.5),Flt-1表达降低的胶质瘤C6细胞的生长侵袭性明显降低(P<0.05);实验组C 6h划痕宽度(547±45.8μm)、12h划痕宽度(433±42.2μm)、18h划痕宽度(268±43.7μm)分别明显大于对照组D中相应的6h划痕宽度(470±43.6μm)、12h划痕宽度(357±45.6μm)、18h划痕宽度(195±44.6μm),Flt-1表达降低的胶质瘤C6细胞株的迁移能力明显降低(P<0.05)。结论 Flt-1可能提高神经胶质瘤细胞的生长侵袭性和迁移能力,二者之间有着密切的关系。

关键词： Flt-1 神经胶质瘤生长侵袭迁移

Study of customer acquisition support system for mobile operators

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The Journal of China Universities of Posts and Telecommunications 2007年第3期14卷 123-128页

作者： ZHANG Xiao-hang LV ting-jie yang Tian-jian School of Economics and Management Beijing University of Posts andTelecommunications Beijing 100876 China

The mobile operators are struggling for improving the market share and the revenues. One important method is to acquire the potential customers from the competitors. This article presents a whole acquisition process and an integrated framework for customer acquisition support system （CASS）. The core of the system is the customer acquisition identification models which are built based on data mining technologies. The CASS can automate the acquisition process and decrease the cost and implement precise marketing strategy for mobile operators.

关键词： CASS data mining mobile

A Simple-Prepared and Multi-Reusable Adhesive Based on Epoxy Vitrimer

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Chinese Journal of Polymer Science 2024年第10期42卷 1589-1594,I0015页

作者： Yu-ting Wang Huan Liang Yen Wei jian-Long Wang Xiang-Ming He yang yang Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China

Adhesives play an important role in modern society's production and daily *** robust and sustainable adhesives remains a great *** we report a sustainable epoxy-vitrimer adhesive with high adhesive strength(about 10 MPa)and reusability(82%strength after 3 times).This adhesive can be fabricated from commercially available products through a straightforward hot-pressing method without the need of *** adhesive process is also simple,requiring only 30 min at 180℃.In addition,the vitrimer adhesive has the advantages of both erasability for reuse and excellent water *** work provides a facile strategy to fabricate high-strength adhesive that ensures reusability,recyclability,low cost of raw materials,and simple processing ***,it expands the range of potential applications for epoxy vitrimers.

关键词： Epoxy Vitrimer Adhesive Reusable Sustainable

Performance in Grain Yield and Physiological Traits of Rice in the yangtze River Basin of China During the Last 60 yr

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Journal of Integrative Agriculture 2013年第1期12卷 57-66页

作者： ZHANG Hao CHEN ting-ting LIU Li-jun WANG Zhi-qin yang jian-chang ZHANG jian-hua Key Laboratory of Crop Genetics and Physiology Education Department of Jiangsu Province/College of Agriculture Yangzhou University School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong

Knowledge on the performance in grain yield and physiological traits is essential to understand the main yield-limiting factor and make strategies for breeding and crop management in rice （Oryza sativa L.）. This study investigated the changes in grain yield and associated physiological traits of rice in the yangtze River Basin of China during the last 60 yr. Thirteen mid-season indica and 12 japonica rice cultivars that were popularly used were grown in the field in 2008 and 2009. The grain yield and yield components, biomass, leaf area, leaf photosynthesis, root oxidation activity, and harvest index were examined. The results showed that grain yield and grain yield per day have progressively increased during the years and such increases are mainly attributed to the expanded sink size as a result of more spikelets per panicle, especially for the case of super rice. Both biomass and harvest index were increased with the improvement of cultivars. Increase in biomass for modern rice cultivars was associated with an enhancement of leaf area and photosynthesis, root dry weight, and root oxidation activity, although the indica super rice cultivars showed a lower leaf photosynthetic rate and root oxidation activity than the semi-dwarf cultivars during the grain filling period. Both indica and japonica super rice cultivars exhibited a low percentage of filled grains, which may limit their great yield potential. All the data suggested that grain yield have been substantially improved during the 60 yr of rice breeding in the yangtze River Basin. Expanded sink size, increased dry matter production and harvest index, and enhanced leaf area and photosynthesis, root dry weight, and root oxidation activity contribute to the improvement in grain yield. Increase in filling efficiency could realize the great yield potential in super rice.

关键词： rice yield performance grain filling physiological traits super rice

凸面脑膜瘤增殖细胞核抗原表达与其硬脑膜侵袭性的临床研究

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中国医师进修杂志（外科版） 2008年第8期31卷 9-11页

作者：宋浩青刘伟张贺杨廷舰张月梅潍坊医学院附属医院神经外科 261031

目的探讨凸面脑膜瘤增殖细胞核抗原（PCNA）表达与其硬脑膜侵袭性的关系。方法选取经手术和病理证实的凸面脑膜瘤患者51例，术中均切取肿瘤基底周围至少15mm的硬脑膜，随机切取0～1、2、5、6～10、〉10mm 4段，瘤体标本均行病理切片HE... 详细信息

目的探讨凸面脑膜瘤增殖细胞核抗原（PCNA）表达与其硬脑膜侵袭性的关系。方法选取经手术和病理证实的凸面脑膜瘤患者51例，术中均切取肿瘤基底周围至少15mm的硬脑膜，随机切取0～1、2、5、6～10、〉10mm 4段，瘤体标本均行病理切片HE染色光镜检查，亦行PC—NA免疫组化染色观察，并进行统计学分析。结果硬脑膜有肿瘤细胞侵袭者PCNA标记指数（u）为10．32±6．74，硬脑膜无肿瘤细胞侵袭者PCNALI为2．16±4．93，两者比较差异有统计学意义（t=0．876，P〈0．05）。非典型性脑膜瘤瘤周硬脑膜受侵袭率明显高于其他病理分型脑膜瘤。结论PCNA免疫组化表达强度与瘤周硬脑膜受侵袭情况存在相关性，这可能与肿瘤病理分级有关。

关键词：脑膜瘤病理学外科免疫组织化学增殖细胞核抗原

Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

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Chinese Journal of Chemical Engineering 2021年第2期34卷 46-53页

作者： ting-ting Liu Han Xiao jian-Hui Xiao jian-jiang Zhong State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesLaboratory of Molecular Biochemical Engineering and Advanced Fermentation TechnologyDepartment of BioengineeringSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Zunyi Municipal Key Laboratory of Medicinal Biotechnology Center for Translational MedicineAffiliated Hospital of Zunyi Medical UniversityZunyi 563003China

Terpenoids are a class of high value-added natural products with a variety of biological *** engineered microorganisms,such as those of Escherichia coli and Saccharomyces cerevisiae,have merits in producing plant or fungus-derived terpenoids,due to their mature genetic manipulation,simple nutrient demand and fast ***,as a key environmental factor,is particularly important to microbial metabolism and growth,and suitable oxygen supply is viewed as a prerequisite for realizing highly efficient production of terpenoids by engineered *** this article,the role of oxygen in regulating terpenoid bioproduction is overviewed from the viewpoints of cellular carbon metabolism,energy metabolism and terpenoid *** on adjusting oxygen availability to microorganisms,including genetic modification of cellular metabolism related with oxygen utilization,are summarized and discussed,to provide helpful information for further improvement of terpenoid biosynthesis by microbes.

关键词： Terpenoid Microorganisms Oxygen supply Chassis modification