Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

作     者：Ting-Ting Liu Han Xiao Jian-Hui Xiao Jian-Jiang Zhong Ting-Ting Liu;Han Xiao;Jian-Hui Xiao;Jian-Jiang Zhong

作者机构：State Key Laboratory of Microbial MetabolismJoint International Research Laboratory of Metabolic and Developmental SciencesLaboratory of Molecular Biochemical Engineering and Advanced Fermentation TechnologyDepartment of BioengineeringSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Zunyi Municipal Key Laboratory of Medicinal BiotechnologyCenter for Translational MedicineAffiliated Hospital of Zunyi Medical UniversityZunyi 563003China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2021年第34卷第2期

页      面：46-53页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 081702[工学-化学工艺] 0817[工学-化学工程与技术] 08[工学] 0703[理学-化学] 

基　　金：This work was supported by the National Key R&D Program of China(Nos.2019YFA0904800 and 2018YFA0901900) the National Natural Science Foundation of China(No.31770037) 

主　　题：Terpenoid Microorganisms Oxygen supply Chassis modification 

摘      要：Terpenoids are a class of high value-added natural products with a variety of biological *** engineered microorganisms,such as those of Escherichia coli and Saccharomyces cerevisiae,have merits in producing plant or fungus-derived terpenoids,due to their mature genetic manipulation,simple nutrient demand and fast ***,as a key environmental factor,is particularly important to microbial metabolism and growth,and suitable oxygen supply is viewed as a prerequisite for realizing highly efficient production of terpenoids by engineered *** this article,the role of oxygen in regulating terpenoid bioproduction is overviewed from the viewpoints of cellular carbon metabolism,energy metabolism and terpenoid *** on adjusting oxygen availability to microorganisms,including genetic modification of cellular metabolism related with oxygen utilization,are summarized and discussed,to provide helpful information for further improvement of terpenoid biosynthesis by microbes.