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Chinese Chemical Letters 2024年第6期35卷 201-205页

作者： jiao Li Chenyang Zhang Chuhan Wu yan Liu Xuejian Zhang Xiao Li Yongtao Li Jing Sun Zhongmin Su School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130018China School of Chemical and Environmental Engineering Changchun University of Science and TechnologyChangchun 130022China

Hydrogen evolution electrocatalysts derived from metal-organic crystalline frameworks can inherit the merits of ordered and adjustable structures with high surface *** this paper,organic-octamolybdate crystalline superstructures(OOCS)with a fixed stoichiometric ratio of Mo_(8)(L)_(2) and high Mo content(>40 wt%)were synthesized using flexible ligands with controllable lengths(named as OOCS-1-3).Then,molybdenum carbides coated with carbon layers as electrocatalysts(Mo_(2)C@C-1-3)can be obtained directly from a one-step high-temperature carbonization process using OOCS-1-3 as *** a typical example,Mo_(2)C@C-3 exhibits satisfactory hydrogen evolution activity with a low overpotential of 151 m V(1.0 mol/L KOH)at 10 m A/cm^(2) and stability for 24 *** electrocatalytic activity is mainly from the synergistic interactions between the carbon layers and molybdenum carbide ***,compared with the initial content of C,N,Mo in OOCS and Mo_(2)C@C,the catalytic activity increases with the N *** work makes organic-octamolybdate crystalline superstructures used as general precursors to product high Mo content electrocatalysts applied in energy storage and conversion fields.

关键词： Molybdenum carbides Electrocatalysts Organic-octamolybdate crystalline superstructures Synergistic interactions Hydrogen evolution reaction(HER)

Overview of ectopic pancreas

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 284-288页

作者： Chang-Fei Li Qiu-Ru Li Miao Bai Yuan-Shi Lv yan.jiao Patient Service Center The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Neurology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Fundus Disease The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Thyroid Head and Neck Surgery Jilin Cancer HospitalChangchun 130000Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

This editorial discusses the article written by Zheng et al that was published in the latest edition of the World Journal of Gastrointestinal *** primary focus is on the causes,location,diagnosis,histological classification,and therapy of ectopic *** pancreas refers to the presence of pancreatic tissue that is situated in a location outside its usual anatomical placement,and is not connected to the normal pancreas in terms of blood supply or anatomical ***,the embryological origin of ectopic pancreas remains *** most prevalent form of ectopic pancreatic is gastric ectopic *** ultrasonography examination can visualize the morphological charac-teristics of the ectopic pancreatic lesion and pinpoint its anatomical *** histological categorization of ectopic pancreas *** treatment has been widely advocated in ectopic pancreas.

关键词： Pancreas Gastric ectopic pancreas Diagnosis Treatment Anatomy

Is there a place for endoscopic management in postcholecystectomy iatrogenic bile duct injuries?

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1218-1222页

作者： Hong-Qiao Cai Guo-Qiang Pan Shou-Jing Luan Jing Wang yan.jiao Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of General Surgery Qilu HospitalShandong UniversityJinan 250000Shandong ProvinceChina Department of Endocrinology and Metabolism Weifang People’s HospitalWeifang 261041Shandong ProvinceChina Shandong Medical College Jinan 250000Shandong ProvinceChina

In this editorial we comment on the article by Emara et al published in the recent issue of the World Journal of Gastrointestinal ***,surgery was the primary treatment for bile duct injuries(BDI).The treatment of BDI has advanced due to technological breakthroughs and minimally invasive *** and percutaneous treatments have largely supplanted surgery as the primary treatment for most instances in recent *** management,including the specific technique,is typically impacted by local knowledge and the kind and severity of the *** therapy is a highly successful treatment for postoperative benign bile duct stenosis and offers superior long-term outcomes compared to surgical *** on the damage features of BDI,therapeutic options include endoscopic duodenal papillary sphincterotomy,endoscopic nasobiliary drainage,and endoscopic biliary stent implantation.

关键词： Post-cholecystectomy Iatrogenic Bile duct injuries Endoscopic management Benign bile duct stenosis

Carbon efficiency evaluation method for urban energy system with multiple energy complementary

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Global Energy Interconnection 2024年第2期7卷 142-154页

作者： Xianan jiao Jiekang Wu Yunshou Mao Mengxuan yan School of Automation Guangdong University of TechnologyGuangzhou 510006P.R.China Guangzhou Power Supply Bureau Guangdong Power Grid CompanySouth China Power GridGuangzhou 510660P.R.China School of Electronic Information and Electrical Engineering Huizhou UniversityHuizhou 516007P.R.China

Urban energy systems(UESs)play a pivotal role in the consumption of clean energy and the promotion of energy cascade *** the context of the construction and operation strategy of UESs with multiple complementary energy resources,a comprehensive assessment of the energy efficiency is of paramount ***,a multi-dimensional evaluation system with four primary indexes of energy utilization,environmental protection,system operation,and economic efficiency and 21 secondary indexes is constructed to comprehensively portray the *** that the evaluation system may contain a large number of indexes and that there is overlapping information among them,an energy efficiency evaluation method based on data processing,dimensionality reduction,integration of combined weights,and gray correlation analysis is *** method can effectively reduce the number of calculations and improve the accuracy of energy efficiency ***,a demonstration project for a UES in China is *** energy efficiency of each scenario is assessed using six operational *** results show that Scenario 5,in which parks operate independently and investors build shared energy-storage equipment,has the best results and is best suited for green and low-carbon *** results of the comparative assessment methods show that the proposed method provides a good energy efficiency *** study provides a reference for the optimal planning,construction,and operation of UESs with multiple energy sources.

关键词： Urban energy systems(UESs) Multiple energy complementary system Carbon efficiency evaluation Data downscaling Subjective and objective weight Gray correlation analysis

Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries

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Particuology 2024年第2期85卷 146-154页

作者： Zhihong Luo Weiyong Li Chong Guo Ya Song Mingxia Zhou yan Shi Jing Xu Long Li Bin Shi Quansheng Ouyang jiao-jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Advanced Chemical Power Sources Zunyi563003China Graphene Materials Engineering Research Center of Guizhou Colleges and Universities Guiyang550025China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate Schoo Tsinghua UniversityShenzhen518055China

Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal *** oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical ***,two-dimensional holey silica nanosheets(2D-HSN)as the fillers,together with LiNO_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-HFP)blended polymer matrix to obtain a *** incorporation of HSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium *** HSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger Li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and HSN can promote the formation of more stable solid electrolyte interphase(SEI)*** as-assembled LiFePO4||Li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.

关键词： Vermiculite nanosheets Two-dimensional silica Solid polymer electrolytes FillersLithium metal batteries

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian jiao Lai Xu Zhen Gu Hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification

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World Journal of Diabetes 2024年第3期15卷 530-551页

作者： Meng-Ying Che Ling Yuan jiao Min Duo-Jie Xu Dou-Dou Lu Wen-Jing Liu Kai-Li Wang yan-yan Wang Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Endocrinology Yinchuan Hospital of Traditional Chinese MedicineYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic kidney disease(DKD)is one of the serious complications of diabetes mellitus,and the existing treatments cannot meet the needs of today's *** Chinese medicine has been validated for its efficacy in DKD after many years of clinical ***,the specific mechanism by which it works is still *** the molecular mechanism of the Nardostachyos Radix et Rhizoma-rhubarb drug pair(NRDP)for the treatment of DKD will provide a new way of thinking for the research and development of new *** To investigate the mechanism of the NRDP in DKD by network pharmacology combined with molecular docking,and then verify the initial findings by in vitro *** The Traditional Chinese Medicine Systems Pharmacology(TCMSP)database was used to screen active ingredient targets of *** for DKD were obtained based on the Genecards,OMIM,and TTD *** VENNY 2.1 database was used to obtain DKD and NRDP intersection targets and their Venn diagram,and Cytoscape 3.9.0 was used to build a"drug-component-target-disease"*** String database was used to construct protein interaction *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology analysis were performed based on the DAVID *** selecting the targets and the active ingredients,Autodock software was used to perform molecular *** experimental validation using renal tubular epithelial cells(TCMK-1),we used the Cell Counting Kit-8 assay to detect the effect of NRDP on cell viability,with glucose solution used to mimic a hyperglycemic *** cytometry was used to detect the cell cycle progression and *** blot was used to detect the protein expression of STAT3,p-STAT3,BAX,BCL-2,Caspase9,and *** A total of 10 active ingredients and 85 targets with 111 disease-related signaling pathways were obtained for *** analysis of KEGG pathways was performed to determ

关键词： Nardostachyos Radix et Rhizoma-rhubarb Diabetic kidney disease Molecular docking Network pharmacology Experimental validation

Neogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1326-1359页

作者： Tao DENG Xiaomin FANG Qiang LI Shiqi WANG Feixiang WU Sukuan HOU jiao MA Qigao JIANGZUO Danhui SUN yan ZHENG Qinqin SHI Boyang SUN Lu LI Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Tibetan Plateau Earth Sciences and Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China

The remarkable uplift of the Tibetan Plateau in the Neogene had great impacts on the climate and environment of East Asia and even the ***,establishment of the Neogene stratigraphic framework of the Tibetan Plateau is of great significance to research in various fields of *** on marine sediments,the international chronostratigraphic system of the Neogene is divided into six stages in the Miocene and two stages in the *** the beginning of the Cenozoic,the share of terrestrial strata on continents has increased *** the Neogene,it had far exceeded that of marine strata,and almost all deposits on the Tibetan Plateau and its surrounding areas were terrestrial *** China,the Miocene includes five stages and the Pliocene includes two *** for the Tunggurian of the Miocene,which has a lower boundary at 15 Ma,the other stages have the same paleomagnetic definitions and time intervals as the corresponding international marine *** fossils play a very important role in the division and correlation of Cenozoic terrestrial strata,and rodent,carnivore,proboscidean,perissodactyl and artiodactyl fossils are especially important in Neogene terrestrial *** are many basins with well-exposed strata and abundant mammalian fossils in the Tibetan *** lower boundary stratotype sections of the Neogene Xiejian and Bahean stages are located respectively in the Xining and Linxia basins,and there are precise paleomagnetic dates in coordination with mammalian *** lower boundary stratotypes of other stages can also be effectively determined in the Tibetan *** first appearing mammalian genera in East Asia also appeared in the Tibetan Plateau and its surrounding areas,especially in the Linxia Basin on the northeast margin and in the Siwaliks on the southwest *** them,Prodeinotherium first appeared at the bottom of the Miocene in the Siwaliks,and the earliest Hipparion of the Old

关键词： Tibetan Plateau Neogene Terrestrial stratum Mammalian fossil Paleomagnetism

C—F Bond Insertion into Indoles with CHBr_(2)F:An Efficient Method to Synthesize Fluorinated Quinolines and Quinolones

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Chinese Journal of Chemistry 2024年第10期42卷 1128-1132页

作者： Chao Li Lei Chen Hongye Wang Zixi yan Bin Lyu Weiping Lyu Changwei Jiang Dehua Lu Jiaxing Li Ning jiao Song Song State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityXue Yuan Rd.38Beijing 100191China

A mild and practical method for synthesizing fluorinated quinoline derivatives,which have a wide range of applications in pharmaceuticals,materials,and organic synthesis,was described through C—F bond insertion into indoles using CHBr_(2)*** simple conditions,readily availability of CHBr_(2)F,as well as the versatility of the transformations make this strategy very powerful in synthesizing 3-fluoroquinoline and *** mechanistic studies reveal that bromofluorocarbene generated in-situ under basic condition was the key intermediate.

关键词： Skeleton edit Fluorocarbene Ring expansion Quinoline Quinolone

Targeted mutations of BnPAP2 lead to a yellow seed coat in Brassica napus L.

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Journal of Integrative Agriculture 2024年第2期23卷 724-730页

作者： Wei Huang Ruyu jiao Hongtao Cheng Shengli Cai Jia Liu Qiong Hu Lili Liu Bao Li Tonghua Wang Mei Li Dawei Zhang Mingli yan Hunan Research Center of Heterosis Utilization in Rapeseed/Crop Research Institute Hunan Academy of Agricultural SciencesChangsha 410125China Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization/School of Life and Health Science Hunan University of Science and TechnologyXiangtan 411201China Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural Affairs/Oil Crops Research InstituteChinese Academy of Agricultural SciencesWuhan 430062China

The yellow seed trait is preferred by breeders for its potential to improve the seed quality and commercial value of Brassica *** the present study,we produced yellow seed mutants using a CRISPR/Cas9 system when the two BnPAP2 homologs were knocked *** staining of the seed coat demonstrated that proanthocyanidin accumulation was significantly reduced in the pap2 double mutants and decreased specifically in the endothelial and palisade layer cells of the seed *** and metabolite profiling analysis suggested that disruption of the BnPAP2 genes could reduce the expression of structural and regulated genes in the phenylpropanoid and flavonoid biosynthetic *** broad suppression of these genes might hinder proanthocyanidin accumulation during seed development,and thereby causing the yellow seed trait in *** results indicate that BnPAP2 might play a vital role in the regulatory network controlling proanthocyanidin accumulation.

关键词： yellow seed BnPAP2 proanthocyanidins CRISPR/Cas9