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铸造 2006年第9期55卷 956-958页

作者：倪志全朱年根李鉴仪王燕照无锡申达铸件厂江苏无锡214192 无锡锡脉铸造有限公司江苏无锡214046

铁型覆砂铸造技术是一种清洁、高效的铸造技术,采用铁型覆砂技术生产中硅钼铁素体球铁增压器涡轮壳,铸件尺寸精度、表面质量、内部质量均有明显改善,已铸造增压器涡轮壳20余万件,效果良好,对铁型覆砂铸造工艺的应用有良好参考价值。

关键词：铁型覆砂增压器涡轮壳无冒口铸造

Two-state energy model and experimental study of coal adsorb methane

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Journal of Coal Science & Engineering(China) 2013年第4期19卷 488-492页

作者： Zeng-Chao FENG Dong zhao Zhi-Xiang LIU yan-Qi WANG Hong-Qiang GOU Mining Technology Institute Taiyuan University of Technology Taiyuan 030024 China

There are two states of methane existing in coal, free methane and adsorptive methane. The two states of methane exchanged with each other which need the energy exchange with outside. It is released heat when methane adsorption on coal, instead of absorbed heat. According to the gas molecules Boltzmann energy distribution, is obtained the equilibrium equations of the two states of methane in coal, as well as the heat of adsorption equation when exchanged into each other. At the same time, high temperature experiments of methane adsorption on coal have been certificated to the theoretical model. At last the experimental results presented that： the two-state energy model could be accurately described the distribution of the two states of methane in the coal; the adsorption heat is related to the initial equilibrium state of methane adsorption; the adsorption heats are different with different coal ranks.

关键词： two-state energy model adsorption heat chemical potential experimental study

Age-dependent changes of total and differential white blood cell counts in children

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Chinese Medical Journal 2020年第16期133卷 1900-1907页

作者： Kun Li Ya-Guang Peng Ruo-Hua yan Wen-Qi Song Xiao-Xia Peng Xin ni Center for Clinical Epidemiology and Evidence-based Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children HealthBeijing 100045China Department of Epidemiology and Health Statistics School of Public HealthCapital Medical UniversityBeijing 100069China Department of Clinical Laboratory Center Beijing Children’s HospitalCapital Medical UniversityNational Center for Children HealthBeijing 100045China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and NeckSurgeryBeijing Children’s HospitalCapital Medical UniversityNational Center for Children HealthBeijing 100045China

Background:Total and differential white blood cell counts are important for the diagnostic evaluation of suspected *** facilitate the interpretation of total and differential white blood cell counts in pediatric patients,the present study investigated agedependent changes in total and differential white blood cell counts in healthy reference ***:Data were obtained from the Pediatric Reference Intervals in China study(PRINCE),which aims to establish and verify pediatric reference intervals for Chinese children based on a nationwide multicenter cross-sectional study from January 2017 to December *** curves were calculated using the generalized additive models for location,shape,and scale *** 2.5th,50th,and 97.5th quantile curves were calculated for both total and differential white blood *** of stacked area charts were used to demonstrate the proportions of differential white blood *** statistical analyses were performed using R ***:Both 50th and 97.5th quantiles of total white blood cell count and monocyte count were highest at birth,then rapidly decreased in the first 6 months of life;relatively slow reduction continued until 2 years of *** lymphocyte count was low during infancy and increased to its highest level at 6 months of age;it then exhibited moderate and continuous reduction until approximately 9 years of *** pattern of neutrophil count changed with age in a manner opposite to that of lymphocyte ***,there were two inter-sections of lymphocyte count and neutrophil count during infancy and at approximately 5 years of age,based on locally weighted regression(LOESS)*** were no apparent age-related changes in eosinophil or basophil ***:These data regarding age-related changes in total and differential white blood cell counts can be used to assess the health of pediatric patients and guide clinical decisions.

关键词： Leukocyte count Trends Pediatrics Development Growth

不同上部刚度对木框架剪力墙受力性能影响的试验研究

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土木工程学报 2008年第11期41卷 63-70页

作者：刘雁 ni Chun 卢文胜吕西林周定国扬州大学江苏扬州225009 FP Innovations Wood Product Division Vancouver V6T 1WS B.C. Canada 同济大学上海200092 南京林业大学江苏南京210037

木框架剪力墙试验研究时,荷载传递梁的刚度对木框架剪力墙的破坏模式以及侧向荷载承载力有直接的影响,当木框架剪力墙墙端以及墙中洞口边未采用墙端锚栓时,这种影响更甚。当墙顶连接铰接荷载传递梁时,在水平荷载作用下,木框架剪力墙的... 详细信息

木框架剪力墙试验研究时,荷载传递梁的刚度对木框架剪力墙的破坏模式以及侧向荷载承载力有直接的影响,当木框架剪力墙墙端以及墙中洞口边未采用墙端锚栓时,这种影响更甚。当墙顶连接铰接荷载传递梁时,在水平荷载作用下,木框架剪力墙的墙端易于被上拔而与墙基础分离,此时试验所得到的木框架剪力墙的侧向荷载承载力接近于下限值;反之,刚性荷载传递梁所得到的木框架剪力墙的侧向荷载承载力接近于上限值。主要通过22片墙体的试验研究来了解上层墙体、楼盖刚度对下层木框架剪力墙受力性能的影响。其中16片为6m长2.44m高的单层足尺木框架剪力墙,墙顶一半采用铰接荷载传递梁一半采用刚性荷载传递梁,4片为足尺典型二层墙体,另外2片为增加了墙端锚栓的单层足尺木框架剪力墙。对试验结果从初始刚度、极限荷载、极限位移、能量耗散以及锚栓内力等方面进行分析,最后形成了采用刚性荷载传递梁和二层墙体均能增加墙体侧向荷载承载力的结论。

关键词：木框架剪力墙受力性能刚度

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三轴跟踪平台算法研究

国防科技大学学报 2005年第1期27卷 115-118页

作者：倪谷炎华卫红姜宗福赵伊君国防科技大学理学院湖南长沙410073

为研究三轴跟踪平台的过顶问题,讨论了退化α型跟踪算法,提出了完全退化型算法和三步跟踪算法,并从理论上证明了所给出的算法可以解决过顶问题。对距离地球表面大约2000km星体,应用完全退化型算法进行计算机观测仿真,计算数据表明,运用... 详细信息

为研究三轴跟踪平台的过顶问题,讨论了退化α型跟踪算法,提出了完全退化型算法和三步跟踪算法,并从理论上证明了所给出的算法可以解决过顶问题。对距离地球表面大约2000km星体,应用完全退化型算法进行计算机观测仿真,计算数据表明,运用完全退化型算法可以使三轴的转动角速度控制在0.56((°)s)以内。随后将三步跟踪算法应用到三轴自动跟踪平台试验,试验表明三步跟踪算法可以解决过顶跟踪问题。

关键词：三轴平台天文观测算法数值仿真跟踪

Secondary genomic findings in the 2020 China Neonatal Genomes Project participants

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World Journal of Pediatrics 2022年第10期18卷 687-694页

作者： Hui Xiao Jian-Tao Zhang Xin-Ran Dong Yu-Lan Lu Bing-Bing Wu Hui-Jun Wang Zheng-yan zhao Lin yang Wen-Hao Zhou Department of Neonatology Children’s Hospital of Fudan UniversityShanghaiChina Center for Molecular Medicine Children’s Hospital of Fudan UniversityShanghaiChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Pediatric Endocrinology and Inherited Metabolic Diseases Children’s Hospital of Fudan UniversityShanghaiChina

Background During next generation sequencing(NGS)data interpretation in critically ill newborns,there is a potential for recognizing and reporting secondary findings(SFs).Early awareness of SFs may provide clues for disease *** this study,we assessed the frequency of SFs in the China Neonatal Genomes Project(CNGP)*** A total of 2020 clinical exome sequencing(CES)datasets were screened for variants from a list of 59 genes recommended by the American College of Medical Genetics and Genomics(ACMG)for secondary findings reporting v2.0(ACMG SF v2.0).Identified variants were classified according to the evidence-based guidelines reached by a joint consensus of the ACMG and the Association for Molecular Pathology(AMP).Results Among the 2020 CES datasets,we identified 23 ACMG-reportable genes in 61 individuals,resulting in an overall frequency of SFs at 3.02%.A total of 53 unique variants were identified,including 35 pathogenic and 18 likely pathogenic *** common disease categories of SFs associated were cardiovascular and cancer *** SF results affected the medical management and follow-up strategy in 49(80.3%)*** We presented the frequency of SFs and their impact on clinical management strategies in CNGP *** study demonstrated that SFs have important practical value in disease prevention and intervention at an early stage.

关键词： Genetics secondary findings Neonate Next generation sequencing

Effect of growth hormone-releasing peptide on cardiac cholinergic nerve fiber density distribution in a rat model of heart failure

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Neural Regeneration Research 2009年第4期4卷 271-275页

作者： Guozhong Tian Xiuqin ni Yong zhao Jia Feng yanjun Li Zhenya Zhong Shuling Bai Department of Anatomy Basic College of Jiamusi University Jiamusi 154007 Heilongjiang Province China Department of Anatomy Basic College of China Medical University Shenyang 110001 Liaoning Province China Department of Anatomy Daqing Branch School of Harbin Medical University Daqing 163100 Heilongjiang Province China

BACKGROUND： Changes in the cardiac autonomic nerve are considered to be important factors in the mechanisms of heart failure. It is possible to reduce or slow down nerve degeneration and necrosis, provided that patients take effective neuroprotectants during the early stages of heart failure. Moreover, it is possible to relieve the pathological process and reduce the risk of death. OBJECTIVE： To study the effect of growth hormone releasing peptide （GHRP） on cardiac cholinergic nerve fiber density distribution in a rat model of heart failure, and verify whether GHRP can ameliorate denervation. DESIGN, TIME AND SETTING： A randomized controlled study was performed at the Key Laboratory of Anatomy, Harbin Medical University, between June and October 2009. MATERIALS： Fifty adult, healthy, female, Wistar rats, weighing （200± 20） g, were randomly divided into GHRP （n = 30）, model （n = 10）, and sham operation （n = 10） groups. GHRP-2 was made in Shanghai, China （batch No. z071212-03）. METHODS： Acute myocardial infarction was established by ligating the left anterior descending coronary artery in the GHRP and model groups. Five weeks later, myocardial function was detected using color ultrasound electrocardiograph a successful marker of chronic heart failure models Ejection fraction 〈 60% was considered to be However, the left anterior descending coronary artery was not ligated in the sham operation group. The GHRP group was injected with 100 μ g/kg GHRP-2, and the other two groups were injected with the same volume of physiological saline, once per day. MAIN OUTCOME MEASURES： After 4 weeks, pathological changes in cardiac cholinergic nerve fibers were detected under optic microscopy following hematoxylin/eosin staining. In addition, density distribution was measured using a multi-function color pathological image system. RESULTS： In the sham operation group, myocardial cells were regular, uniformly stained, and no inflammatory cells were present. In the model group, myocardi

关键词： growth hormone releasing peptide heart failure cholinergic nerve nerve fiber

Simultaneous gene editing of three homoeoalleles in self-incompatible allohexaploid grasses

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Journal of Integrative Plant Biology 2021年第8期63卷 1410-1415页

作者： Liang Zhang Tao Wang Guangyang Wang Aoyue Bi Misganaw Wassie yan Xie Liwen Cao Huawei Xu Jinmin Fu Liang Chen yang zhao Tao Hu CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenThe Innovative Academy of Seed DesignThe Chinese Academy of SciencesWuhan430074 China Center of Economic Botany Core Botanical GardensThe Chinese Academy of SciencesWuhan430074 China University of Chinese Academy of Sciences Beijing100049 China Shanghai Center for Plant Stress Biology and CAS Center of Excellence in Molecular Plant SciencesThe Chinese Academy of SciencesShanghai200032 China College of Agriculture Henan University of Science and TechnologyLuoyang471023 China School of Resources and Environmental Engineering Ludong UniversityYantai264011 China

Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system has been widely used for precise gene editing in ***,simultaneous gene editing of multiple homoeoalleles remains challenging,especially in self-incompatible polyploid ***,we simultaneously introduced targeted mutations in all three homoeoalleles of two genes in the self-incompatible allohexaploid tall fescue,using both CRISPR/Cas9 and LbCas12a(LbCpf1)***-of-function mutants of FaPDS exhibited albino leaves,while knockout of FaHSP17.9 resulted in impaired heat resistance in T0 generation of tall ***,these mutations were *** findings demonstrate the feasibility of generating loss-of-function mutants in T0 generation polyploid perennial grasses using CRISPR/Cas systems.

关键词： allohexaploid Cas12a(Cpf1) CRISPR/Cas9 self-incompatible tall fescue

Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-κB ligand pathway in rabbits with knee osteoarthritis induced by modified Videman method

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Journal of Traditional Chinese Medicine 2022年第3期42卷 389-399页

作者： QIN Luxue GUO Changqing zhao Ruili WANG Tong WANG Junmei GUO yan ZHANG Wei HU Tingyao CHEN Xilin ZHANG Qian ZHANG Dian XU Yue School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China the First People's Hospital of Dongcheng District Beijing 100050China Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China the Third Affiliated Hospital of Beijing Universality of Chinese Medicine Beijing 100029China

OBJECTIVE:To investigate the effects of acupotomy on inhibiting abnormal formation of subchondral bone in rabbits with knee osteoarthritis(KOA).METHODS:A total of 24 New Zealand rabbits were randomly divided into four groups of 6 rabbits each[control,model,electroacupuncture(EA)and acupotomy].Eighteen KOA model rabbits were established using a modified Videman *** in EA and acupotomy groups received the intervention for 3 ***,the cartilage and subchondral bone unit were obtained and the histomorphological changes were ***(OPG)and receptor activator of nuclear factor-κB ligand(RANKL)in subchondral bone were evaluated by Western blotting,real-time polymerase chain reaction and ***:Compared with the model group,both the acupotomy and EA groups showed a significant decrease in the Lequesne index(both Pnificant,while these parameters were not significantly changed in the EA group compared with the model ***:In the rabbit model of KOA,acupotomy inhibits aberrant formation of subchondral bone by suppressing OPG/RANKL ratio as a potential therapy for KOA.

关键词： acupuncture therapy osteogenesis osteoarthritis,knee subchondral bone

Estimating Photosynthetic Attributes from High-Throughput Canopy Hyperspectral Sensing in Sorghum

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Plant Phenomics 2022年第1期4卷 324-341页

作者： Xiaoyu Zhi Sean Reynolds Massey-Reed Alex Wu Andries Potgieter Andrew Borrell Colleen Hunt David Jordan yan zhao Scott Chapman Graeme Hammer Barbara George-Jaeggli The University of Queensland Queensland Alliance for Agriculture and Food Innovation(QAAFI)Hermitage Research FacilityWarwickQLDAustralia The University of Queensland Queensland Alliance for Agriculture and Food Innovation(QAAFI)St LuciaQLDAustralia The University of Queensland Queensland Alliance for Agriculture and Food Innovation(QAAFI)GattonQLDAustralia Agri-Science Queensland Department of Agriculture and Fisheries(DAF)Hermitage Research FacilityWarwickQLDAustralia School of Agriculture and Food Sciences The University of QueenslandGattonQLDAustralia

Sorghum,a genetically diverse C_(4) cereal,is an ideal model to study natural variation in photosynthetic *** leaf nitrogen(SLN)and leaf mass per leaf area(LMA),as well as,maximal rates of Rubisco carboxylation(V cmax),phosphoenolpyruvate(PEP)carboxylation(V pmax),and electron transport(J max),quantified using a C_(4) photosynthesis model,were evaluated in two field-grown training sets(n=169 plots including 124 genotypes)in 2019 and 2020.

关键词： capacity maximal Sorghum