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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng ni Xiong zhao Meng yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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密度对谷物混合颗粒分层影响的分析

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农机化研究 2025年第4期47卷 35-41,49页

作者：张妍王子谦张延胡欣宇赵湛江苏大学农业工程学院江苏镇江212013

采用离散元模拟了垂直振动下具有相同尺寸、不同密度的谷物混合颗粒分层过程,结果表明:小密度颗粒倾向于向上运动形成单一颗粒层,而大密度颗粒与部分小密度颗粒停留在单一颗粒层下,组成混合状态。为此,提出相应评价指标,定量描述混合物... 详细信息

采用离散元模拟了垂直振动下具有相同尺寸、不同密度的谷物混合颗粒分层过程,结果表明:小密度颗粒倾向于向上运动形成单一颗粒层,而大密度颗粒与部分小密度颗粒停留在单一颗粒层下,组成混合状态。为此,提出相应评价指标,定量描述混合物分层程度,并讨论了混合颗粒密度比对分层速度的影响。结合混合物分层中空隙填充及动能理论,分析了密度影响分层机理,结果表明:在不同密度谷物混合颗粒分层过程中,随密度比增加小密度颗粒组成的单一颗粒层厚度增加并趋于饱和;混合层占总层数比率随密度比增加而减少并趋于稳定;颗粒分层速度随着密度比增加而增加,当密度比大于10时密度比对分层速度影响减弱;在混合物分层过程中,大密度颗粒较为活跃,且动能大于小密度颗粒的动能。

关键词：谷物颗粒分层密度数值模拟离散元法

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Medaka fish stem cells and their applications

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Science China(Life Sciences) 2010年第4期53卷 426-434页

作者： YI MeiSheng HONG ni LI ZhenDong yan yan WANG DanKe zhao HaoBin HONG YunHan Department of Biological Sciences National University of Singapore10 Kent Ridge CrescentSingapore 119260Singapore Division of Bioengineering School of Chemical and Biomedical EngineeringNanyang Technological UniversitySingapore 637457Singapore Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesHuazhong Normal UniversityWuhan 430079China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China

Stem cells are present in developing embryos and adult tissues of multicellular organisms. Owing to their unique features, stem cells provide excellent opportunities for experimental analyses of basic developmental processes such as pluripotency control and cell fate decision and for regenerative medicine by stem cell-based therapy. Stem cell cultures have been best studied in 3 vertebrate organisms. These are the mouse, human and a small laboratory fish called medaka. Specifically, medaka has given rise to the first embryonic stem (ES) cells besides the mouse, the first adult testis-derived male stem cells spermatogonia capable of test-tube sperm production, and most recently, even haploid ES cells capable of producing Holly, a semi-cloned fertile female medaka from a mosaic oocyte created by microinjecting a haploid ES cell nucleus directly into a normal oocyte. These breakthroughs make medaka a favoring vertebrate model for stem cell research, the topic of this review.

关键词： medaka stem cells pluripotency chimera nuclear transplant semi-cloning

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Modeling and simulation of muzzle flow field of railgun with metal vapor and arc

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Defence Technology（防务技术） 2020年第4期16卷 802-810页

作者： Yuan Gao yan-jie ni zhao-xin Wang Ying-tao Xu Yong Jin Bao-ming Li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094JiangsuChina China Academy of Ordnance 100089BeijingChina

During the electromagnetic railgun launching process,there will be a complex flow field with high temperature in the muzzle area because of the high-speed friction,transition and seco ndary *** paper models the muzzle area of railgun when the projectile is far away from the muzzle,and the dynamic simulation of the flow field with secondary arc in the muzzle area is carried out based on the magneto hydrodynamic ***,a multi-component plasma transport model is used to analyze the muzzle arc plasma flow process of the mixed gas of Al vapor and the ***,the pressure boundary conditions are fitted by the dynamic mesh simulation *** current and voltage of the muzzle are obtained through the emission experiment of the railgun experimental *** load the current data into the simulation model and the voltage of experiments and simulations are compared,which proves the accuracy of the *** the plasma temperature and the composition of Al vapor in the muzzle flow process are analyzed in-depth.

关键词： Railgun Flow field Muzzle Plasma Simulation Al vapor

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Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway

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Zoological Research 2022年第6期43卷 989-1004页

作者： Rong-Jun ni Tian-Hao Gao Yi-yan Wang yang Tian Jin-Xue Wei Lian-Sheng zhao Pei-yan ni Xiao-Hong Ma Tao Li Psychiatric Laboratory and Mental Health Center West China Hospital of Sichuan UniversityChengduSichuan 610041China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhouZhejiang 310013China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Science and Brain-machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310014China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence GuangzhouGuangdong 510799China

Ketamine, a rapid-acting antidepressant drug, has been used to treat major depressive disorder and bipolar disorder(BD). Recent studies have shown that ketamine may increase the potential risk of treatment-induced mania in patients. Ketamine has also been applied to establish animal models of mania. At present, however, the underlying mechanism is still unclear. In the current study, we found that chronic lithium exposure attenuated ketamine-induced mania-like behavior and c-Fos expression in the medial prefrontal cortex(mPFC) of adult male mice. Transcriptome sequencing was performed to determine the effect of lithium administration on the transcriptome of the PFC in ketamine-treated mice, showing inactivation of the phosphoinositide 3-kinase(PI3K)-protein kinase B(AKT) signaling pathway. Pharmacological inhibition of AKT signaling by MK2206(40 mg/kg), a selective AKT inhibitor, reversed ketamine-induced ***, selective knockdown of AKT via AAVAKT-sh RNA-EGFP in the mPFC also reversed ketamine-induced mania-like behavior. Importantly,pharmacological activation of AKT signaling by SC79(40 mg/kg), an AKT activator, contributed to mania in low-dose ketamine-treated mice. Inhibition of PI3K signaling by LY294002(25 mg/kg), a specific PI3K inhibitor, reversed the mania-like behavior in ketamine-treated mice. However, pharmacological inhibition of mammalian target of rapamycin(mTOR)signaling with rapamycin(10 mg/kg), a specific mTOR inhibitor, had no effect on ketamine-induced mania-like behavior. These results suggest that chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway, which may be a novel target for the development of BD treatment.

关键词： Lithium Ketamine Medial prefrontal cortex Bipolar disorder Manic PI3K-AKT signaling pathway

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Development of a DFN-based probabilistic block theory approach for bench face angle design in open pit mining

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3047-3062页

作者： Jianhua yan Xiansen Xing Zhihai Li Weida ni Liuyuan zhao Chun Zhu Yuanyuan He School of Earth Sciences and Engineering Hohai UniversityNanjing210098China POWERCHINA Huadong Engineering Corporation Limited Hangzhou311122China Zhejiang Huadong Construction Corporation Limited Hangzhou310004China The Seventh Geological Brigade of Hubei Geological Bureau Yichang443000China

In open pit mining,uncontrolled block instabilities have serious social,economic and regulatory consequences,such as casualties,disruption of operation and increased regulation *** this reason,bench face angle,as one of the controlling parameters associated with block instabilities,should be carefully designed for sustainable *** study introduces a discrete fracture network(DFN)-based probabilistic block theory approach for the fast design of the bench face angle.A major advantage is the explicit incorporation of discontinuity size and spatial distribution in the procedure of key blocks *** proposed approach was applied to a granite mine in ***,DFN models were generated from a multi-step modeling procedure to simulate the complex structural characteristics of pit ***,a modified key blocks searching method was applied to the slope faces modeled,and a cumulative probability of failure was obtained for each ***,a bench face angle was determined commensurate with an acceptable risk level of *** simulation results have shown that the number of hazardous traces exposed on the slope face can be significantly reduced when the suggested bench face angle is adopted,indicating an extremely low risk of uncontrolled block instabilities.

关键词： Open pit mine Bench face angle Block theory Probabilistic approach Discrete fracture network modeling Fractured rock slope

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Biased Learning Creates Overconfidence

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Journal of Systems Science & Complexity 2018年第6期31卷 1603-1617页

作者： ni Xuanming WU Chen zhao Huimin School of Software and Microelectronics Peking UniversityBeijing 100871China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China. Business School Sun Yat-Sen UniversityGuangzhou 510275China

The aim of this paper is to develop a multi-period economic model to interpret how the people become overconfident by a biased learning that people tend to attribute the success to their abilities and failures to other *** authors suppose that the informed trader does not know the distribution of the precision of his private signal and updates his belief on the distribution of the precision of his knowledge by Bayer's *** informed trader can eventually recognize the value of the precision of his knowledge after an enough long time biased learning,but the value is overestimated which leads him to be ***,based on the definition on the luckier trader who succeeds the same times but has the larger variance of the knowledge,the authors find that the luckier the informed trader is,the more overconfident he will be;the smaller the biased learning factor is, the more overconfident the informed trader *** authors also obtain a linear equilibrium which can explain some anomalies in financial markets,such as the high observed trading volume and excess volatility.

关键词： Bayes'rule biased learning overconfidence

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Thermal conductivity characterization of ultra-thin silicon film using the ultra-fast transient hot strip method

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Chinese Physics B 2019年第7期28卷 499-503页

作者： yan-yan Zhang Ran Cheng Dong ni Ming Tian Ji-Wu Lu Yi zhao College of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China State Key Laboratory of Industrial Control Technology Zhejiang University Hangzhou 310027 China Shanghai Huali Microelectronics Corporation Shanghai 200120 China College of Electrical and Information Engineering Hunan University Changsha 410082 China

Thermal conductivity is an important material parameter of silicon when studying the performance and reliability of devices or for guiding circuit design when considering heat dissipation, especially when the self-heating effect becomes prominent in ultra-scaled *** cross-plane thermal conductivity of a thin silicon film is lacking due to the difficulty in sensing high thermal conductivity in the vertical *** this paper, a feasible method that utilizes an ultra-fast electrical pulse within 20 μs combined with the hot strip technique is *** the best of our knowledge, this is the first work that shows how to extract the cross-plane thermal conductivity of sub-50 nm(30 nm, 17 nm, and 10 nm)silicon films on buried *** ratio of the extracted cross-plane thermal conductivity of the silicon films over the bulk value is only about 6.9%, 4.3%, and 3.8% at 300 K, *** the thickness of the films is smaller than the phonon mean free path, the classical heat transport theory fails to predict the heat dissipation in nanoscale ***, in this study, a ballistic model, derived from the heat transport equation based on extended-irreversible-hydrodynamics(EIT), is used for further investigation, and the simulation results exhibit good consistence with the experimental *** extracted effective thermal data could provide a good reference for precise device simulations and thermoelectric applications.

关键词： cross-plane thermal conductivity ultra-fast transient hot strip method

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Collision-induced Rotational Energy Transfer in an Atom-Diatom System

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Chinese Journal of Chemical Physics 2008年第5期21卷 457-462页

作者： yan-qing ni Jian Li Feng-cai Ma Department of Physics Liaoning University Shenyang 110036 China Department of Science Shenyang Institute of Aeronautical Engineering Shengyang 110036 China

As a further theoretical study of the collision-induced quantum interference on rotational energy transfer in an atom-diatom system, based on the first-Born approximation of time-dependent perturbation theory, taking into account the anisotropic Lennard-Jones interaction potential and the long-range interaction potential, the differential interference angles in singlet-triplet mixed states of CO A^1Π（v=9）-e3∑-（v=1） system in collision with He, Ne, Ar, and other partners were calculated theoretically. The relationships of differential interference angle versus impact parameters, including collision parameter b and velocity, are obtained.

关键词： Rotational energy transfer Collision-induced quantum interference Interference angle

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The Arabidopsis CROWDED NUCLEI genes regulate seed germination by modulating degradation of ABI5 protein

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Journal of Integrative Plant Biology 2016年第7期58卷 669-678页

作者： Wenming zhao Chunmei Guan Jian Feng yan Liang ni Zhan Jianru Zuo Bo Ren State Key Laboratory of Plant Genomics and National Plant Gene Research Center Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049china Institute of Microbiology Chinese Academy of SciencesBeijing 100101China John Innes Centre Norwich NR4 7UHUnited Kingdom Institute of Biotechnology Zhejiang UniversityHangzhou 310058China

In Arabidopsis, the phytohormone abscisic acid （ABA） plays a vital role in inhibiting seed germination and in postgermination seedling establishment. In the ABA signaling pathway, ABI5, a basic Leu zipper transcription factor, has important functions in the regulation of seed germination. ABI5 protein localizes in nuclear bodies, along with AFP, COP1, and SIZ1, and was degraded through the 26S proteasome pathway. However, the mechanisms of ABI5 nuclear body formation and ABI5 protein degradation remain obscure. In this study, we found that the Arabidopsis CROWDED NUCLEI （CRWN） proteins, predicted nuclear matrix proteins essential for maintenance of nuclear morphology, also participate in ABA-controlled seed germination by regulating the degradation of ABI5 protein. During seed germination, the crwn mutants are hypersensitive to ABA and have higher levels of ABI5 protein compared to wild type. Genetic analysis suggested that CRWNs act upstream of ABIS. The observation that CRWN3 colocalizes with ABI5 in nuclear bodies indicates that CRWNs might participate in ABI5 protein degrada- tion in nuclear bodies. Moreover, we revealed that the extreme C-terminal of CRWN3 protein is necessary for its function in the response to ABA in germination. Our results suggested important roles of CRWNs in ABI5 nuclear body organization and ABI5 protein degradation during seed germination.

关键词： ABI5 Arabidopsis CROWDED NUCLEI germination nuclear body

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