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World Journal of Gastroenterology 2014年第16期20卷 4771-4777页

作者： yan-min zhang Shu-Kun zhang Nai-Qiang Cui Tianjin Medical University Intensive Care UnitTianjin Nankai Hospital Tianjin Nankai Hospital Department of Surgery Tianjin Nankai Hospital

AIM: To investigate whether mesenteric lymph from rats with severe intraperitoneal infection (SII) induces lung injury in healthy rats.

关键词： Severe intraperitoneal infection, Mesenteric lymph, Acute lung injury, Toll-like receptor 4, Nuclear factor κ B

Function of myeloid cell leukaemia-1 and its regulative relations with hepatocellular carcinoma

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Hepatoma Research 2017年第7期3卷 129-140页

作者： Man Zhu yan-min zhang School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an 710061ShaanxiChina

Hepatocellular carcinoma (HCC) remains a challenging disease with a high recurrence rate after surgery and there is an imminent need to identify new treatments. Currently, adjuvant therapy like chemotherapeutics arises to counteract the malignant trait escaping from apoptosis of tumors induced by overexpressed anti-apoptotic factors in HCC. Myeloid cell leukaemia-1 (Mcl-1) as an anti-apoptotic member of Bcl-2 is highly expressed in diverse human cancers, which contributes to cancer cell survival and the resistance to diverse chemotherapeutic agents. It is confirmed that Mcl-1 protein expression is quite enhanced in human HCC tissue compared to adjacent non-tumor tissue. Correspondingly, forced Mcl-1 down-regulation leads to prominent apoptosis of HCC cells and a sensitization towards chemotherapeutic drug-induced apoptosis, which indicates Mcl-1 is indeed a crucial regulatory factor of HCC. Hence, this review highlights the function of Mcl-1 on HCC progression, how it is regulated in HCC and the recent anti-hepatoma drug research and development down-regulation of Mcl-1 or targeting on Mcl-1. Meanwhile, the authors discuss Mcl-1 as an essential regulatory factor in HCC can be designed as target for drugs to improve the survival of HCC patients.

关键词： Myeloid cell leukaemia-1 apoptosis hepatocellular carcinoma target

Design,synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

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Chinese Chemical Letters 2014年第2期25卷 351-354页

作者： Zeng Wu ming yan Shi-He Hu Zhi-Cheng Yu Yong Zhu Ya-Dong Cheng Hai-Chun Liu yan-min zhang Si-Hui Yao Wei-Fang Tang Tao Lu Department of Organic Chemistry China Pharmaceutical University National Nanjing Center for Drug Screening China Pharmaceutical University Laboratory of Molecular Design and Drug Discovery School of SciencesChina Pharmaceutical University State Key laboratory of Natural Medicines China Pharmaceutical University The Headmaster's Office China Pharmaceutical University

A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which sho... 详细信息

关键词： B-Raf kinase inhibitors Receptor-based drug discovery Indole derivatives Biological evaluation

Research on Optimal Design of the Transmission Mechanism of a Pressure Meter

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International Journal of Plant Engineering and Management 2009年第3期14卷 189-192页

作者： WANG yan-min zhang Bo Luohe Vocational and Technical College Luohe 462002 P. R. China

The actuating mechanism of a manometer is to magnify and transform the small displacement generated by elastic components, and then the pressure value is indicated by the deflection angle of the pointer. The error between the indicated and actual pressure value can be large without giving sufficient consideration to the displacement of the elastic component and the inherent non-linearity of a actuating mechanism in its traditional design. In this paper, in order to increase the accuracy and rationality of transmission, the elastic component and transmission non-linearity is fitted and the mathematical models are constructed based on centre displacement of elastic instru- ment components. An optimum program is compiled by MATIABS. O, the optimal parameters to compensate the non- linear displacement of a crank link in two groups to spring is obtained. The error analysis of the manometer shows that it is an efficient method to reduce the errors caused by the elastic components and the non-liner characteristic of actuating a mechanism through the optimized design.

关键词： manometer actuating mechanism optimization design

Human telomerase disease mutants and its relation with hepatocarcinoma

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Hepatoma Research 2016年第1期2卷 109-113页

作者： Yin-Nan Chen yan-min zhang School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi’an 710061ShaanxiChina School of Molecular Sciences Arizona State UniversityTempeAZ 85287USA

Telomerase is a special reverse transcriptase,which adds telomeric DNA repeats to the ends of chromosome to offset loss.A vast majority of cancer cells have been shown that their telomerase was up-regulated and sustain proliferation and *** carcinoma(HCC)is one of the most commonly occurring cancers *** is also one of the leading causes of cancer death,and is connected with abnormal telomerase ***,reports about the telomerase mutations and HCC are still *** this review,the structure and mechanism of action of telomerase,inherited disorders caused by its mutations,hepatocarcinoma,and drug development targeting telomerase are ***,further investigations are needed to elucidate human telomerase RNA gene regulation for initiation and progression of the liver cancer.

关键词： Telomerase mutants hepatocarcinoma target

Design of occlusion pressure testing system for infusion pump

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Journal of Biomedical Science and Engineering 2009年第6期2卷 431-434页

作者： Peng zhang Shu-Yi Wang Chuan-Yi Yu min-yan zhang 不详

Reliability of medical devices such as infusion pumps is extremely important because these devices are being used in patients who are in critical condition. Occlusion pressure, as an important parameter of infusion pumps, should be detected when an occlusion occurred. How-ever, infusion pumps’ occlusion pressure could not be tested and the performance of these pumps is not known to us. In order to test the occlusion pressure of infusion pump, a testing system has been put forward according to standards of IEC 60601-2-24:1998/ GB 9706.27- 2005. The system is comprised of sensor, acquisition card, three-way tap and so on;this system is controlled by a PC. At the same time, sampling rate could be changed if necessary and test time could be recorded. And then the characteristics of this system were studied, such as linear, effects of pump rates and different pumps. The system remained linear in a given environment. The higher is the pump rate, the faster is the time to reach occlusion condi-tion. The testing system has been proved to be effective in testing the occlusion pressure of infusion pumps and the accuracy error of pressure is content the demand of ±1% of range.

关键词： Infusion Pump Occlusion Pressure Testing System

A high expression EGFR/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Rhizoma Polygoni Cuspidati

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Acta Pharmaceutica Sinica B 2011年第2期1卷 115-120页

作者： Meng Sun yan-min zhang Jie zhang Si-cen Wang Lang-chong He School of Medicine Xi’an Jiaotong UniversityXi’an 710061China

The epidermal growth factor receptors(EGFRs)in some tumor cells are significant targets for drug *** this work,we have developed an EGFR cell membrane chromatography and online high performance liquid chromatography/mass spectrometry system for screening active component from Rhizoma Polygoni *** a result,resveratrol from Rhizoma Polygoni Cuspidati was found to be the active component acting on EGFR like *** was a good relationship between their inhibiting effects on EGFR secretion and HEK293 EGFR cell growth in *** EGFR/CMC-online-HPLC/MS system demonstrated fast and effective characteristics for screening leading compounds from traditional Chinese medicine.

关键词： EGFR cell membrane chromatography HPLC/MS Anti-EGFR antagonists Rhizoma Polygoni Cuspidati

Effect of wire diameter compression ratio on drawing deformation of micro copper wire

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2605-2618页

作者： Tao HUANG Han-jiang WU Ke-xing SONG yan-min zhang yan-jun ZHOU Shao-lin LI School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Henan Key Laboratory of Advanced Conductor Materials Institute of MaterialsHenan Academy of SciencesZhengzhou 450000China

A crystal plasticity finite element model was developed for the drawing deformation of pure copper micro wire,based on rate-dependent crystal plasticity *** impact of wire diameter compression ratio on the micro-mechanical deformation behavior during the wire drawing process was *** indicate that the internal deformation and slip of the drawn wire are unevenly distributed,forming distinct slip and non-slip ***,horizontal strain concentration bands develop within the drawn *** the wire diameter compression ratio increases,the strength of the slip systems and the extent of slip zones inside the deformation zone also ***,the fluctuating stress state,induced by contact pressure and frictional stress,results in a rough and uneven wire surface and diminishes the stability of the drawing process.

关键词： micro copper wire drawing deformation crystal plasticity finite element slip mode

Coagulase-negative staphylococcus and enterococcus as predominant pathogens in liver transplant recipients with Gram-positive coccal bacteremia

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Chinese Medical Journal 2010年第15期123卷 1983-1988页

作者： SHI Shao-hua KONG Hai-shen JIA Chang-ku XU Jian zhang Wen-jin WANG Wei-lin SHEN yan zhang min ZHENG Shu-sen Department of Hepatobiliary Surgery and Center of Liver Transplantation First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

Background Gram-positive bacteria such as Staphylococcus aureus have been a common cause of infection among liver transplant （LT） recipients in recent decades. The understanding of local epidemiology and its evolving trends with regard to pathogenic spectra and antibiotic susceptibility is beneficial to prophylactic and empiric treatment for LT recipients. This study aimed to investigate etiology, timing, antibiotic susceptibility and risk factors for multidrug resistant （MDR） Gram-positive coccal bacteremia after *** A cohort analysis of prospectively recorded data was performed to investigate etiologies, timing, antibiotic susceptibility and risk factors for MDR Gram-positive coccal bacteremia in 475 LT *** In 475 LT recipients in the first six months after LT, there were a total of 98 episodes of bacteremia caused by Gram-positive cocci in 82 （17%） patients. Seventy-five （77%） bacteremic episodes occurred in the first post-LT *** most frequent Gram-positive cocci were methicillin-resistant coagulase-negative staphylococcus （CoNS, 46 isolates）,methicillin-resistant Staphylococcus aureus （MRSA, 13） and enterococcus （34, E. faecium 30, E. faecalis 4）. In all Gram-positive bacteremic isolates, 59 of 98 （60%） were MDR. Gram-positive coccal bacteremia and MDR Gram-positive coccal bacteremia predominantly occurred in patients with acute severe exacerbation of chronic hepatitis B and with fulminant/subfulminant hepatitis. Four independent risk factors for development of bacteremia caused by MDR Gram-positive coccus were： LT candidates with encephalopathy grades Ⅱ-Ⅳ （P=0.013, OR： 16.253, 95% CI：1.822-144.995）, pre-LT use of empirical antibiotics （P=0.018, OR： 1.029, 95% CI： 1.002-1.057）, post-LT urinary tract infections （P 〈0.001, OR： 20.340, 95% CI： 4.135-100.048） and abdominal infection （P=0.004, OR： 2.820, 95% CI：1.122-10.114）. The main infectious manifestations were coinfections due to gram-positive cocci and gram-negative ***

关键词： drug resistance, multiple Gram-positive coccus risk factors bacteremia liver transplantation

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang yanyu zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress