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Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer

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World Journal of Gastroenterology 2017年第40期23卷 7232-7241页

作者： yan-hui yang Jiang-Bo Liu yang Gui Liang-Liang Lei Shui-Jun Zhang Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou University Department of Hepatobiliary Surgery First Affiliated Hospital College of Clinical Medicine Henan University of Science and Technology Department of General Surgery First Affiliated Hospital College of Clinical Medicine Henan University of Science and Technology Henan Key Laboratory of Digestive Organ Transplantation Open and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities Zhengzhou Key Laboratory of Hepatobiliary Pancreatic Diseases and Organ Transplantation

AIM To investigate the relationship between autophagy and perineural invasion(PNI), clinical features, and prognosis in patients with pancreatic cancer. METHODS Clinical and pathological data were retrospectively collected from 109 patients with pancreatic ductal adenocarcinoma who underwent radical resection at the First Affiliated Hospital of Zhengzhou University from January 2011 to August 2016. Expression levels of the autophagy-related protein microtubuleassociated protein 1 A/1 B-light chain 3(LC3) and PNI marker ubiquitin carboxy-terminal hydrolase(UCH) in pancreatic cancer tissues were detected by immunohistochemistry. The correlations among LC3 expression, PNI, and clinical pathological features in pancreatic cancer were analyzed. The patients were followed for further survival analysis. RESULTS In 109 cases of pancreatic cancer, 68.8%(75/109) had evidence of PNI and 61.5%(67/109) had high LC3 expression. PNI was associated with lymph node metastasis, pancreatitis, and CA19-9 levels(P < 0.05). LC3 expression was related to lymph node metastasis(P < 0.05) and was positively correlated with neural invasion(P < 0.05, r = 0.227). Multivariate logistic regression analysis indicated that LC3 expression, lymph node metastasis, pancreatitis, and CA19-9 level were factors that influenced neural invasion, whereas only neural invasion itself was an independent factor for high LC3 expression. Univariate analysis showed that LC3 expression, neural invasion, and CA19-9 level were related to the overall survival of pancreatic cancer patients(P < 0.05). Multivariate COX regression analysis indicated that PNI and LC3 expression were independent risk factors for poor prognosis in pancreatic cancer(P < 0.05). CONCLUSION PNI in patients with pancreatic cancer is positively related to autophagy. Neural invasion and LC3 expression are independent risk factors for pancreatic cancer with a poor prognosis.

关键词： Pancreatic cancer Perineural invasion Autophagy Clinical pathological features Prognosis

Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3

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World Journal of Gastroenterology 2019年第17期25卷 2086-2098页

作者： yan-hui yang Yu-Xiang Zhang yang Gui Jiang-Bo Liu Jun-Jun Sun Hua Fan Department of Hepatobiliary Surgery First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and Technology Department of Urology Surgery First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and Technology Department of General Surgery First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and Technology First Affiliated Hospital College of Clinical MedicineHenan University of Science and Technology

BACKGROUND Pancreatic cancer is a highly invasive malignant tumor. Expression levels of the autophagy-related protein microtubule-associated protein 1 A/1 B-light chain 3(LC3) and perineural invasion(PNI) are closely related to its occurrence and development. Our previous results showed that the high expression of LC3 was positively correlated with PNI in the patients with pancreatic cancer. In this study, we further searched for differential genes involved in autophagy of pancreatic cancer by gene expression profiling and analyzed their biological functions in pancreatic cancer, which provides a theoretical basis for elucidating the pathophysiological mechanism of autophagy in pancreatic cancer and *** To identify differentially expressed genes involved in pancreatic cancer autophagy and explore the pathogenesis at the molecular *** Two sets of gene expression profiles of pancreatic cancer/normal tissue(GSE16515 and GSE15471) were collected from the Gene Expression *** analysis of microarrays algorithm was used to screen differentially expressed genes related to pancreatic cancer. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis were used to analyze the functional enrichment of the differentially expressed genes. Protein interaction data containing only differentially expressed genes was downloaded from String database and screened. Module mining was carried out by Cytoscape software and ClusterOne plug-in. The interaction relationship between the modules was analyzed and the pivot nodes between the functional modules were determined according to the information of the functional modules and the data of reliable protein interaction *** Based on the above two data sets of pancreatic tissue total gene expression, 6098 and 12928 differentially expressed genes were obtained by analysis of genes with higher phenotypic correlation. After extracting the intersection of the two differen

关键词： Pancreatic cancer Autophagy-related protein microtubule-associated protein 1A/1B-light chain 3 Perineural invasion Gene Ontology analysis Kyoto Encyclopedia of Genes and Genomes pathway analysis Ubiquitin C

The abundance, distribution, and enrichment mechanism of harmful trace elements in coals from Guizhou, Southwestern China

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Acta Geochimica 2024年第05期43卷 889-903页

作者： hui Hou Wei Cheng Ruidong yang yan Zhang College of Mining National and Local Joint Laboratory of Engineering for Eff ective Utilization of Regional Mineral Resources from Karst Areas Guizhou Key Laboratory of Comprehensive Utilization of Non-Metallic Mineral Resources College of Resource and Environment Engineering Guizhou University

Coal seams can enrich a variety of harmful trace elements under specifi c geological conditions. The spatial distribution of harmful trace elements in coal is extremely uneven, and the distribution characteristics of each element content are diff erent. The harmful elements released in the process of coal mining and utilization will cause serious harm to the environment and the human body. It is of great resource signifi cance to study the geochemistry of coal that aff ects the enrichment and distribution characteristics of harmful trace elements. Based on the domestic and foreign literature on coal geochemistry in Guizhou published by previous investigators, this study counted 1097 sample data from 23 major coal-producing counties in Guizhou Province,systematically summarized the relevant research results of harmful trace elements in the coal of Guizhou, and revealed the overall distribution and enrichment characteristics of harmful trace elements in the coal of Guizhou. The results show that the average contents of Cd, Pb, Se, Cu,Mo, U, V, As, Hg, and Cr in coal of Guizhou are higher than those in Chinese coal and world coal. A variety of harmful trace elements in the coal of Guizhou have high background values, especially in Liupanshui, Xingyi and Qianbei coalfi eld. The enrichment of various harmful trace elements in the Late Permian coal in Guizhou is mainly related to the combined action of various geological and geochemical factors. The supply of terrigenous debris and sedimentary environment may be the basic background of the enrichment of harmful elements in western Guizhou,while low-temperature hydrothermal activity and volcanic ash deposition may be the main reasons for the enrichment of harmful elements in southwestern Guizhou.

关键词： Distribution characteristics Enrichment law Geological and geochemical features Guizhou Harmful trace elements

Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-yang Wu hui-hui Fang yan-Wu Xu yan-Ling Zhang Shao-Chong Zhang Wei-Hua yang Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 4124 *** 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related *** from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and Chinese institutions have the strongest academic influence in the field from 2013 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

Modified arthroscopic transfer of the long head of the biceps tendon to the conjoint tendon

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Chinese Medical Journal 2009年第6期122卷 745-747页

作者： MA Yong CUI Guo-qing AO Ying-fang XIAO Jian yan hui yang Yu-ping XIE Xing Institute of Sports Medicine Peking University Third Hospital Beijing 100191 China

The long head of the biceps tendon （LHBT） pathology has been implicated as a common source of shoulder pain. The patients may be more resistant to conservative treatment than those with isolated subacromial impingement. Even though, the surgical options of this disease remain controversial. It has been reported that tenotomy and tenodesis of the biceps tendon were usually utilized. However, persistent pain, deformity, and muscle cramping were frequently observed. Transfer of the LHBT to the conjoint tendon was originally described by Post and Benca in 1982.4 Verma et all has performed the transfer under arthroscopy since 2004. Eighty percent of their patients reported good results with a minimum 2 years of follow-up. However, there was a steep learning curve to become proficient in their technique. We devised a more convenient transfer compared with O＇Brien＇s technique. Six patients received our modified arthroscopic transfers from May 2006 to May 2007. All of them obtained good results.

关键词： arthroscopic long head of the biceps tendon conjoint tendon tenodesis

Model-free adaptive robust control method for high-speed trains

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Transportation Safety and Environment 2024年第1期6卷 93-102页

作者： Zhongqi Li Liang Zhou hui yang Yue yan School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang 330013JiangxiChina State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong UniversityNanchang 330013JiangxiChina

Aiming at the robustness issue in high-speed trains(HSTs)operation control,this article proposes a model-free adaptive control(MFAC)scheme to suppress ***,the dynamic linearization data model of train system under the action of measurement disturbance is given,and the Kalman filter(KF)based on this model is derived under the minimum variance estimation ***,according to the KF,an anti-interference MFAC scheme is *** scheme only needs the input and output data of the controlled system to realize the MFAC of the train under strong ***,the simulation experiment of CRH380A HSTs is carried out and compared with the traditional MFAC and the MFAC with attenuation *** proposed control algorithm can effectively suppress the measurement disturbance,and obtain smaller tracking error and larger signal to noise ratio with better applicability.

关键词： automatic train operation(ATO) model-free adaptive control(MFAC) disturbance suppression minimum variance estimation Kalman filtering(KF) partial format data model

Effect of activated NH_3 on SO_2 removal by pulse corona discharge plasma in flue gas

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Journal of Environmental Sciences 2000年第4期12卷 448-451页

作者： LI Jie, WU yan, WANG Ning\|hui, yang Li\|ming (Institute of Electrostatics, Dalian University of Technology, Dalian 116023, China) 大连理工大学辽宁大连 1 1 6 0 2

NH 3 activated electrode is placed in front of the electrode system of pulse corona discharge plasma. There are nozzles on the electrode. Positive DC high\|voltage is applied on the nozzle\|plate gap. NH\-3 is injected into the reactor through nozzles, at the same time, activated and treated. These nozzles were proposed in order to make the additional gas pass through corona discharge regions near the tip of nozzles and increase the mount of radicals. The aim is to improve the De\|SO\-2 efficiency by pulse discharge plasma in flue gas. The following topics are investigated and discussed in the paper: De\|SO\-2 effect of single NH\-3\|activated electrode, De\|SO\-2 effect of activated NH\-3, the relationship between stoichiometric ratio of NH\-3 to SO\-2 and De\|SO\-2 effect of activated NH\-3, mechanism of activated NH\-3 De\|SO\-2 effect. The experimental result indicates that the De\|SO\-2 efficiency can be increased 5%—10% by activated NH\-3 on the original base of De\|SO\-2 efficiency.

关键词： activated NH_3 De-SO_2 pulse discharge

Acupuncture for obesity and related diseases:Insight for regulating neural circuit

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Journal of Integrative Medicine 2024年第2期22卷 93-101页

作者： Lin-yan Jiang Jun Tian Ya-nan yang Shao-hui Jia Qing Shu Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071Hubei ProvinceChina School of Sports Medicine Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina Department of Traditional Chinese Medicine China Resources&Wu Gang General HospitalWuhan 430080Hubei ProvinceChina

Obesity is defined as abnormal or excessive fat accumulation that may impair *** is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related *** comorbidities comprise a significant public health *** anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and *** treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side ***,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural *** this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was *** on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.

关键词： Obesity Acupuncture Neural circuit Appetite Energy metabolism

The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1424-1448页

作者： Heng yang Xiangqi Fan Xiangbing Mao Bing Yu Jun He hui yan Jianping Wang Institute of Animal Nutrition Sichuan Agricultural UniversityKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationKey Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey Laboratory of Animal Disease-Resistant Nutrition of Sichuan ProvinceNo.211Gongpinghuimin RoadWenjiang DistrictChengduSichuan Province 611130People’s Republic of China

Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.

关键词： Diarrhea Piglet Prebiotics Probiotics Rotavirus