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Clickable,Oxidation-Responsive and Enzyme-Degradable Polypeptide:Synthesis,Characterization and Side Chain Modification

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Chinese Journal of Polymer Science 2022年第11期40卷 1360-1368页

作者： yan-zhi lu An-Qi Gu Tian-lun Shen Ji-Hong Sun Jun Ling Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Radiology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Modifications at polypeptide side chains have been found to affect conformational and properties,which is a vital strategy to prepare functional *** contribution describes the synthesis of homo and co-polypeptides containing unsaturated bonds and thioether moieties,poly(S-allylcysteine)(PAC).The pendant vinyl groups provide an active binding site which are able to be further modified with cysteine by thiol-ene click *** sulfoxide from thioether oxidation bestows the polypeptide water solubility and enzymatic catalytic *** selfassembly micelles of PEG-b-PAC are ruptured along with oxidation to release the Nile red ***,poly(S-allyl-cysteine sulfoxide),***,is the oxidation product of PAC which undergoes side chain cleavage catalyzed by alliinase *** polypeptides are biocompatible as confirmed by cell viability assays and may find applications in drug delivery,biosensing and nanoreactor.

关键词： Polypeptides Ring-opening polymerization Stimuli-responsive polymers N-carboxy anhydrides N-phenoxycarbonylα-amino acids

Preparation of Mg-Li alloys by electrolysis in molten salt at low temperature

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Chinese Chemical Letters 2007年第3期18卷 329-332页

作者： Mi Lin Zhang Yong De yan zhi Yao Hou lu An Fan Zeng Chen Ding Xiang Tang College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China

A new technology for preparation of low cost Mg-Li alloys was studied. The alloys were prepared by electrolysis in molten LiCl-KCl （weight ratio is 1：1） electrolyte with Mg rod severing as the consumed cathode. Main factors that affect current efficiency were investigated, and optimal electrolysis parameters were obtained. Mg-Li alloys with low lithium Content （about 25%） were prepared by the unique method of a higher post-thermal treatment temperature after electrolysis at low temperature. The results showed that the electrolysis can be carried out at low temperature, which resulted in reducing preparation cost due to energy saving. The new technology for the oreoaration of Mg-Li alloy by electrolysis in molten salt was laroved to be feasible.

关键词： Mg-Li alloys Molten salt electrolysis Low temperature Current efficiency

THE INFluENCES OF FORCED OSCILLATIONS TOWARD VORTEX-BREAKDOWN

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Chinese Journal of Aeronautics 1991年第4期6卷 327-332页

作者： Chen yan-qiu, lu zhi-yong and Lee Chun-hianBeijing University of Aeronautics and Astronautics

The experimental results on the influences of oscillating leading edge vortex-flaps of triangular wing toward the vortex breakdown are presented in this paper. The results reveal that forced oscillationscan delay the breakdown of concentrated vortices, and large reversed-flow-regions which originally appear at the upper surface of the fixed wing at high angles of attack would be suppressed to some extent, depending on the oscillation frequencies. As a consequence, the influences can be optimized by selecting proper oscillation frequencies.

关键词： Flow down THE INFluENCES OF FORCED OSCILLATIONS TOWARD VORTEX-BREAKDOWN

Syntheses and Crystal Structures of Complexes Based on Pyrazolecarboxylic Acid Ligands

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Syntheses and Crystal Structures of Complexes Based on Pyraz...

基于Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)对称固体氧化物燃料电池的性能优化研究

中国化学会第五届全国结构化学学术会议

作者： Chang-Xue An yan-Chun lu zhi-Hui Zhang~* Department of Chemistry,Nankai University,Tianjin 300071,

＜正＞The design of crystalline materials or crystal engineering is an important and rapidly growing area owing to the intriguing structural features and potential application as functional materials. To investigate t...

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无机材料学报 2017年第3期32卷 235-240页

作者：杨洋田冬丁岩芝卢肖永林彬陈永红安徽理工大学化学工程学院淮南232001 淮南师范学院淮南低温共烧材料安徽省重点实验室淮南232038

采用柠檬酸-硝酸盐自蔓延燃烧法分别合成了Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)(PSCF)和Gd_(0.2)Ce_(0.8)O_(2-δ)(GDC)粉体,高温固相法合成La_(0.9)Sr_(0.1)Ga_(0.8)Mg_(0.2)O_(3-δ)(LSGM)电解质粉体。以LSGM为电解质,PSCF同时作为阴极和阳极,GDC作为功能层材料,构建了对称固体氧化物燃料电池PSCF│GDC│LSGM│GDC│PSCF。利用X射线衍射法研究材料的成相以及相互间的化学稳定性,交流阻抗法记录界面极化行为,用扫描电子显微镜观察电池的断面微结构,用自组装的测试系统评价电池输出性能。结果表明,合成的PSCF粉体呈立方钙钛矿结构,具有良好的氧化–还原可逆性。使用GDC功能层明显改善了氢气环境下PSCF与LSGM材料间的化学相容性以及电池的输出性能,800℃时,电极│电解质界面极化电阻从6.892?·cm^2下降到0.314?·cm^2;以加湿H_2(含体积分数3%的水蒸气)为燃料气,空气为氧化气时,单电池输出功率密度由269 m W/cm2增大至463 m W/cm^2。研究结果显示,PSCF是对称固体氧化物燃料电池良好的候选电极材料,GDC功能层对改善电池长期稳定性能具有潜在的应用价值。

关键词：对称固体氧化物燃料电池氧化–还原可逆性 Pr0.6Sr0.4Co0.2Fe0.8O3-δ GDC功能层

Comparison and Correlation of Magnetic Resonance Imaging and Clinical Severity in Nonhuman Immunodeficiency Virus Patients with Cryptococcal Infection of Central Nervous System

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Chinese Medical Journal 2018年第24期131卷 2930-2937页

作者： Xue-Qin Li Shuang Xia Jian-Song Ji Yong-Hua Tang Mei-Zhu Zheng Yong-Mei Li Fei Shan zhi-yan lu Jian Wang Jin-Kang Liu Hui-Juan Zhang Yu-Xin Shi Hong-Jun Li Department of Radiology Beijing Youan Hospital Affiliated to Capital Medical UniversityBeijing 100069China Department of Radiology Shengli Clinical Medical College of Fujian Medical UniversityFuJian Provincial Hospital South BranthFuzhouFujian 350004China Department of Radiology Tianjin First Central HospitalTianjin 300192China Department of Radiology Lishui Municipal Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiang University Lishui Hospital LishuiZhejiang 323000China Department of Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China Department of Radiology Tianjin Third Central HospitalTianjin 300170China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Imaging Center First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830054China Department of Radiology Xiangya Hospital Affiliated of Central South UniversityChangshaHunan 410013China

Background:The incidence of cryptococcal meningitis among immunocompetent patients increases,especially in China and imaging plays an important *** current study was to find the correlation between magnetic resonance imaging (MRI)manifestation and clinical severity in nonhuman immunodeficiency virus patients with cryptococcal infection of central nervous system (CNS). Methods:A total of 65 patients with CNS cryptococcal infection from August 2014 to October 2016 were retrospectively included in this *** the patients had MRI data and clinical *** patients were divided into two groups according to whether the patients were confirmed with identifiable underlying *** and correlation of MRI and clinical data in both groups were investigated using independent sample t-test,Chi-square test,Mann-Whitney test and Spearman rank correlation analysis. Results:In all 65 patients,41 cases (41/65,63.1%;Group 1)had normal immunity and 24 cases (24/65,36.9%;Group 2)had at least one identifiable underlying ***,higher percentage of neutrophil (NEUT)in white blood cell (WBC),and increased cell number of cerebral spinal fluid (CSF)were much common in patients with underlying disease (Group 1 *** 2:Fever:21/41 vs.21/24,x^2 =8.715,P =0.003;NEUT in WBC:73.15%vs.79.60%,Z=-2.370,P =0.018;cell number of CSF:19 vs.200,Z=-4.298,P lusions:With the increased number of the involved brain areas in patients with identifiable underlying disease,the body has lower immunity against the organism which might result in higher intracr

关键词： Central Nervous System Clinical Status Cryptococcal Meningitis Immunity Magnetic Resonance Imaging

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang zhi-Lai Zhan Guang-lu Chang yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

基于KBE和CAE结合的液压机结构柔性模块创建

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天津大学学报（自然科学与工程技术版） 2003年第2期36卷 179-182页

作者：郑辉徐燕申侯亮谢艳卢志永天津大学先进陶瓷与加工技术教育部重点实验室天津300072 天津锻压机床总厂天津300070

以广义模块化设计理论为基础,结合液压机机身结构的特点,将知识工程和有限元分析应用于液压机柔性模块创建,并以三梁四柱式锻造液压机为例,介绍了一种基于VisualC++语言开发液压机本体设计专家系统的方法,建立了一套基于KBE和CAE技术的... 详细信息

以广义模块化设计理论为基础,结合液压机机身结构的特点,将知识工程和有限元分析应用于液压机柔性模块创建,并以三梁四柱式锻造液压机为例,介绍了一种基于VisualC++语言开发液压机本体设计专家系统的方法,建立了一套基于KBE和CAE技术的液压机机身计算机辅助设计系统.实践证明,将KBE技术和CAE技术集于一体,能够较好地解决液压机的模块化快速响应设计问题.

关键词：柔性模块液压机知识工程计算机辅助工程

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao zhimin Zhang Han Lin Qixin yan Xiangyu lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis