Comparison and Correlation of Magnetic Resonance Imaging and Clinical Severity in Nonhuman Immunodeficiency Virus Patients with Cryptococcal Infection of Central Nervous System

作     者：Xue-Qin Li Shuang Xia Jian-Song Ji Yong-Hua Tang Mei-Zhu Zheng Yong-Mei Li Fei Shan Zhi-Yan Lu Jian Wang Jin-Kang Liu Hui-Juan Zhang Yu-Xin Shi Hong-Jun Li Li Xue-Qin;Xia Shuang;Ji Jian-Song;Tang Yong-Hua;Zheng Mei-Zhu;Li Yong-Mei;Shan Fei;Lu Zhi-Yan;Wang Jian;Liu Jin-Kang;Zhang Hui-Juan;Shi Yu-Xin;Li Hong-Jun

作者机构：Department of RadiologyBeijing Youan Hospital Affiliated to Capital Medical UniversityBeijing 100069China Department of RadiologyShengli Clinical Medical College of Fujian Medical UniversityFuJian Provincial Hospital South BranthFuzhouFujian 350004China Department of RadiologyTianjin First Central HospitalTianjin 300192China Department of RadiologyLishui Municipal Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiang University Lishui Hospital LishuiZhejiang 323000China Department of RadiologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China Department of RadiologyTianjin Third Central HospitalTianjin 300170China Department of RadiologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of RadiologyZhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Imaging CenterFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830054China Department of RadiologyXiangya Hospital Affiliated of Central South UniversityChangshaHunan 410013China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2018年第131卷第24期

页      面：2930-2937页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by grants from the Natural Scientific Foundation of China the Beijing Natural Scientific Foundation Beijing Important Medical Plan 

主　　题：Central Nervous System Clinical Status Cryptococcal Meningitis Immunity Magnetic Resonance Imaging 

摘      要：Background:The incidence of cryptococcal meningitis among immunocompetent patients increases,especially in China and imaging plays an important *** current study was to find the correlation between magnetic resonance imaging (MRI)manifestation and clinical severity in nonhuman immunodeficiency virus patients with cryptococcal infection of central nervous system (CNS). Methods:A total of 65 patients with CNS cryptococcal infection from August 2014 to October 2016 were retrospectively included in this *** the patients had MRI data and clinical *** patients were divided into two groups according to whether the patients were confirmed with identifiable underlying *** and correlation of MRI and clinical data in both groups were investigated using independent sample t-test,Chi-square test,Mann-Whitney test and Spearman rank correlation analysis. Results:In all 65 patients,41 cases (41/65,63.1%;Group 1)had normal immunity and 24 cases (24/65,36.9%;Group 2)had at least one identifiable underlying ***,higher percentage of neutrophil (NEUT)in white blood cell (WBC),and increased cell number of cerebral spinal fluid (CSF)were much common in patients with underlying disease (Group 1 *** 2:Fever:21/41 vs.21/24,x^2 =8.715,P =0.003;NEUT in WBC:73.15%vs.79.60%,Z=-2.370,P =0.018;cell number of CSF:19 vs.200,Z=-4.298,P 0.001;respectively).Compared to the patients with normal immunity,the lesions are more common in the basal ganglia among patients with identifiable underlying disease (Group 1 *** 2:20/41 vs.20/24,x^2 =7.636,P =0.006).The number of the involved brain areas in patients with identifiable underlying disease were well correlated with the number of cells and pressure of CSF (r =-0.472,P =0.031,r =0.779,P =0.039;respectively). Conclusions:With the increased number of the involved brain areas in patients with identifiable underlying disease,the body has lower immunity against the organism which might result in higher intracr