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配有制冷背心的隔绝式防护服的传热模型

华南理工大学学报（自然科学版） 2010年第8期38卷 17-22页

作者：鄢瑛张会平华南理工大学化学与化工学院广东广州510640

采用芯材为石蜡、壁材为密胺树脂的微胶囊相变材料制备制冷背心样衣,与隔绝式防护服配套使用.在室温36℃、相对湿度60%的条件下,测定穿着未配有和配有制冷背心的隔绝式防护服时人体胸温、背温、手温、腿温和肛温等的变化;结合人体产热... 详细信息

采用芯材为石蜡、壁材为密胺树脂的微胶囊相变材料制备制冷背心样衣,与隔绝式防护服配套使用.在室温36℃、相对湿度60%的条件下,测定穿着未配有和配有制冷背心的隔绝式防护服时人体胸温、背温、手温、腿温和肛温等的变化;结合人体产热、散热经验式与伍德科克人体散热理论建立模型,探讨人体穿着配有制冷背心的隔绝式防护服后人体平均体温随穿着时间的变化.发现穿着配有制冷背心的隔绝式防护服后,人体胸温、背温、手温、腿温和肛温明显下降.建模计算分析表明,穿着配有制冷背心的隔绝式防护服后,人体平均体温随穿着时间的变化关系的计算值与实验测试结果吻合.

关键词：微胶囊相变材料制冷背心生理评价隔绝式防护服传热模型

Influences of Chloropazine, Nimodipine and Their Combination on the Toxic Effects of Cadmium in Liver and Kidney of Mice

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Biomedical and Environmental Sciences 1999年第3期12卷 212-221页

作者： tang LINC-FANG yanG YONC-NIAN CHEN yan-MENG ZHANG ZHEN-LING SONG LINGAND FENG ZHI-YING(Department of Toxicology, Nanjing Medical University, 140 Hanzhong Road,Nanjing 210029, China) Department of Toxicology Nanjing Medical University China

The influences of the calmodulin antagonist chlorpromazine (CPZ), and calcium channel blocker nimodipine (NIMO) and their combination on cadmium (Cd) poisoning of mice were studied. A seties of biochemical parameters including urinary enzyme activities, blood and urine Cd levels, metallothionein (MT) contents in liver and kidney, hepatic ultrastructure and Ca2+ -Mg2+ AT-Pase activity in erythrocyte membrane were determined. Animal models for Cd poisoning were established by peritoneal injection of 1/5 LD50 CdCl2. The experimental groups were protected by administration of CPZ, NIMO and CPZ and NIMO in combination l h before the injection of CdCl2. Five days later, samples were collected for analysis. The data showed that Crs could protect kidney tissue against Cd-induced damage, as the urinary γ-glutamyl traspepti dase (γ- GT ) and N- acetyl-β-D-glucosaminidase (NAG) activities were reduced significantly. There was neither evidence of the protective effect of NIMO on kidney tissue nor an indication of a synergistic effecf of Crs and *** CPZ and NIMO showed a considerable protective effect against the deerease in Ca2+ -Mg2+ AT-Pase activity, and a synergistic action was observed. Cd content in blood was reduced significanily by CPZ or the combination of CPZ and NIMO, but elevated by NIMO. Both CPZ and NIMO consideraby increased MT contents in livers and kidneys and ameliorated damaged to the hepatic ultrastructures caused by Cd. The results indicated that these inhibitors could protect mice against the toxic effects of Cd in liver and kidney tissues, while CPZ was more efficient than NIMO. The combination of CPZ and NIMO exerted a synergistic action. The protective action of these two drugs might be relevent to the function of MT.

关键词： Influences of Chloropazine Nimodipine and Their Combination on the Toxic Effects of Cadmium in Liver and Kidney of Mice

Pathobiology of ovarian carcinomas

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Chinese Journal of Cancer 2015年第1期34卷 50-55页

作者： Yuankai Shi ping Zhou Xiaohong Han Xiaohui He Shengyu Zhou Peng Liu Jianliang yang Changgong Zhang Lin Gui yan Qin Sheng yang Liya Zhao Jiarui Yao Shuxiang Zhang Department of Medical Oncology Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers(carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.

关键词：卵巢癌病理学卵巢肿瘤上皮细胞分子检测生殖细胞免疫组化靶向治疗

Efficient WENOCU4 scheme with three different adaptive switches

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2020年第9期21卷 695-720页

作者： Liang LI Hong-bo WANG Guo-yan ZHAO Ming-bo SUN Da-peng XIONG Tao tang Science and Technology on Scramjet Laboratory National University of Defense TechnologyChangsha 410073China

Although classical WENOCU schemes can achieve high-order accuracy by introducing a moderate constant parameter C to increase the contribution of optimal weights,they exhibit distinct numerical dissipation in smooth *** study presents an extension of our previous research which confirmed that adaptively adjusting parameter C can indeed overcome the inadequacy of the usage of a constant small *** is applied near a discontinuity while Cmax is used elsewhere and they are switched according to the variation of the local flow-field *** study provides the reference values of the adaptive parameter C of WENOCU4 and systematically evaluates the comprehensive performance of three different switches(labeled as the binary,continuous,and hyperbolic tangent switches,respectively)based on an optimized efficient WENOCU4 scheme(labeled as EWENOCU4).Varieties of 1D scalar equations,empirical dispersion relation analysis,and multi-dimensional benchmark cases of Euler equations are ***,the dissipation and dispersion properties of these three switches are ***,employing the binary switch,EWENOCU4 achieves the best comprehensive ***,the binary switch can efficiently filter more misidentifications in smooth regions than others do,particularly for the cases of 1 D scalar equations and Euler ***,the computational efficiency of the binary switch is superior to that of the hyperbolic tangent ***,the optimized scheme exhibits high-resolution spectral properties in the wavenumber ***,employing the binary switch is a more cost-effective improvement for schemes and is particularly suitable for the simulation of complex shock/turbulence *** study provides useful guidance for the reference values of parameter C and the evaluation of adaptive switches.

关键词： WENOCU4 Shock-capturing schemes Adaptive switch Numerical robustness Dissipation

Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

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Science China(Life Sciences) 2024年第7期67卷 1325-1337页

作者： Chengcheng Song Yingying Qin yan Li Bingyi yang Ting Guo Wenqing Ma Dian Xu Keyan Xu Fangfang Fu Li Jin yanhua Wu Shuyan tang Xiaojun Chen Feng Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China Department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of *** represents a significant detriment to female ***,the known POI-causative genes currently account for only a fraction of *** elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in *** a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 *** variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 ***,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling *** analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and *** further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian ***,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse *** conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

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核电汽轮发电机定子线棒换位及相关因素分析

浙江大学学报（工学版） 2014年第4期48卷 616-624,640页

作者：吴磊梁艳萍哈尔滨理工大学电气与电子工程学院黑龙江哈尔滨150080

为了保障核电汽轮发电机的绝缘安全和提高运行效率,在工程中一般采用定子双罗贝尔换位线棒来减小股线环流损耗.针对传统解析法无法精确计算股线沿换位路径所有的漏磁分布情况,以一台600 MW汽轮发电机为例,建立齿槽定子线棒双罗贝尔换位... 详细信息

为了保障核电汽轮发电机的绝缘安全和提高运行效率,在工程中一般采用定子双罗贝尔换位线棒来减小股线环流损耗.针对传统解析法无法精确计算股线沿换位路径所有的漏磁分布情况,以一台600 MW汽轮发电机为例,建立齿槽定子线棒双罗贝尔换位方式三维实体模型,结合场路耦合法进行数值计算.通过对线棒不同换位编织方式的对比分析得出,采用不等换位节距,长换位节距越靠近槽中心段,股线数目越少,空心股线空心率越高,则槽中心线磁通密度Bx分量沿轴向的"凸起状"越不明显,股线电流有效值的差异性越小,股线的环流损耗越小.

关键词：核电汽轮发电机双罗贝尔换位环流损耗

Neoadjuvant chemotherapy for patients with locally advanced penile cancer:an updated evidence

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Asian Journal of Andrology 2022年第2期24卷 180-185页

作者： Xian-yan-Ling Yi De-Hong Cao ping-Hong You Xing-Yu Xiong Xiao-Nan Zheng Ge Peng Da-Zhou Liao Hong Li Lu yang Jian-Zhong Ai Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Urology People’s Hospital of Deyang CityDeyang 618000China Department of Endocrinology and Metabolism West China Hospital of Sichuan UniversityChengdu 610041China

Neoadjuvant chemotherapy(NAC)has shown promising results in patients with locally advanced penile ***,no consensus exists on its applications for locally advanced penile ***,it is unclear which kind of chemotherapy regimen is the best ***,a systematic search of PubMed,Web of Science,and EMBASE was performed in March 2021 to assess the efficacy and safety of NAC for the treatment of patients with locally advanced penile *** Newcastle–Ottawa Scale was used to assess the risk of bias in each *** study synthesized 14 published *** study revealed that patients who achieved an objective response to NAC obtained a better survival outcome compared with those who did not achieve an objective *** addition,the objective response rates(ORRs)and pathological complete response(pCR)rates were 0.57 and 0.11,*** incidence of grade≥3 toxicity was *** analysis found that the ORR and pCR of the taxane–platinum(TP)regimen group performed better than those of the nontaxane–platinum(NTP)regimen group(0.57 vs 0.54 and 0.14 vs 0.07,respectively).Moreover,the TP regimen group had more frequent toxicity than the NTP regimen group(0.41 vs 0.26).However,further studies were warranted to confirm the findings.

关键词： chemotherapy regimen locally advanced penile cancer neoadjuvant chemotherapy response rate

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智力的涌现

生物化学与生物物理进展 2016年第4期43卷 348-353页

作者：李岩张治萍中国科学院生物物理研究所脑与认知科学国家重点实验室北京100101

星海茫茫,地球因智慧生命的存在而与众不同,我们在追寻生命起源的同时,也追问着智力的源头,什么是智力的本质,智力从何涌现?生命大爆炸不仅带来激增的物种数量,也带来专司信息感知、编码和处理的神经系统.在复杂多变的外部环境中,昆虫... 详细信息

星海茫茫,地球因智慧生命的存在而与众不同,我们在追寻生命起源的同时,也追问着智力的源头,什么是智力的本质,智力从何涌现?生命大爆炸不仅带来激增的物种数量,也带来专司信息感知、编码和处理的神经系统.在复杂多变的外部环境中,昆虫已发展演化了近4亿年.在这里,我们借由现代认知神经科学在果蝇中的研究发现,探讨智力的基本层面,提出果蝇的大脑是智力涌现中的一个标杆,是我们揭开智力本质、进入智力王国的第一站.

关键词：智力果蝇编码记忆抉择

A library of carbon-supported ultrasmall bimetallic nanoparticles

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Nano Research 2020年第10期13卷 2735-2740页

作者： Shi-Long Xu Shan-Cheng Shen Ze-Yue Wei Shuai Zhao Lu-Jie Zuo Ming-Xi Chen Lei Wang yan-Wei Ding ping Chen Sheng-Qi Chu Yue Lin Kun Qian Hai-Wei Liang Hefei National Laboratory for Physical Sciences at the Microscale Departm ent of ChemistryUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesCAS Key Laboratory of Materials for Energy Conversion and Department of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Small-sized bimetallic nanoparticles that possess numerous accessible metal sites and optimal geometric/electronic structures show great promise for advanced synergetic catalysis but remain synthetic challenge so ***,an universial synthetic method is developed for building a library of bimetallic nanoparticles on mesoporous sulfur-doped carbon supports,consisting of 24 combinations of 3 noble metals(that is,Pt,Rh,Ir)and 7 other metals,with average particle sizes ranging from 0.7 to 1.4 *** synthetic strategy is based on the strong metal-support interaction arising from the metal-sulfur bonding,which suppresses the metal aggregation during the H2-reduction at 700℃ and ensure the formation of small-sized and alloyed bimetallic *** enhanced catalytic properties of the ultrasmall bimetallic nanoparticles are demonstrated in the dehydrogenation of propane at high temperature and oxidative dehydrogenations of N-heterocycles.

关键词： bimeallic nanoparticles sulfur doped carbon catalysis ultrasmall metal-support interaction