Neoadjuvant chemotherapy for patients with locally advanced penile cancer:an updated evidence
作者机构：Department of UrologyInstitute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of UrologyPeople’s Hospital of Deyang CityDeyang 618000China Department of Endocrinology and MetabolismWest China Hospital of Sichuan UniversityChengdu 610041China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2022年第24卷第2期
页 面：180-185页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was supported by grants from National Natural Science Foundation of China(No.82070784 and No.81974099) a grant from 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYGD18011)to HL
主 题：chemotherapy regimen locally advanced penile cancer neoadjuvant chemotherapy response rate
摘 要：Neoadjuvant chemotherapy(NAC)has shown promising results in patients with locally advanced penile ***,no consensus exists on its applications for locally advanced penile ***,it is unclear which kind of chemotherapy regimen is the best ***,a systematic search of PubMed,Web of Science,and EMBASE was performed in March 2021 to assess the efficacy and safety of NAC for the treatment of patients with locally advanced penile *** Newcastle–Ottawa Scale was used to assess the risk of bias in each *** study synthesized 14 published *** study revealed that patients who achieved an objective response to NAC obtained a better survival outcome compared with those who did not achieve an objective *** addition,the objective response rates(ORRs)and pathological complete response(pCR)rates were 0.57 and 0.11,*** incidence of grade≥3 toxicity was *** analysis found that the ORR and pCR of the taxane–platinum(TP)regimen group performed better than those of the nontaxane–platinum(NTP)regimen group(0.57 vs 0.54 and 0.14 vs 0.07,respectively).Moreover,the TP regimen group had more frequent toxicity than the NTP regimen group(0.41 vs 0.26).However,further studies were warranted to confirm the findings.
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